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Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults

Biomedical and Environmental Sciences 2009年第5期22卷 442-447页

作者： DONG-SHENG HU jinG XIE DA-HAI YU GuO-HENG XU JIE LU jin-xiu yang CHUN-yang LI YAN-YAN LI Department of Epidemiology College of Public Health Zhengzhou University Zhengzhou 450001 Henan China Population Health Unit Centre for Eye Research Australia University of Melbourne Level 132 Gisborne Street East Melbourne VIC 3002 Australia Department of Evidence-Based Medicine and Division of Population Genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Physiology Beijing University Medical Sciences Center Beijing 100083 China

Objective To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults （157 obese subjects, 322 overweight subjects, and 515 normal controls） were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism （PCR-RFLP）. Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression. Results The three genotypes of,PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC＋TC genotype was 0.8（0.4, 1.4） in women （P=-0.4） and 0.6 （0.3, 1.3） in men （P=-0.2） after adjustment for age, education, household income and alcohol consumption, smoking, and physicalactivity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PLIN1237. PLIN1237 T〉C polymorphism is not significantly associated with obesity in northern Chinese adults.

关键词： Perilipin Polymorphism Obesity

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The role of altered fatty acid in pathological scars and their dermal fibroblasts

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Chinese Journal of Traumatology 2022年第4期25卷 218-223页

作者： jin-xiu yang Shi-Yi Li Min-Liang Chen Le-Ren He Department of Burn and Plastic Surgery The Fourth Medical CentreChinese PLA(People's Liberation Army)General HospitalBeijing100038China th Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing10005China

Purpose The proposed pathological mechanism for scar formation is controversial,and increased attention has been paid to the fatty acids(FAs)in the formation of pathological ***,FAs are known to be important in inflammation and mechanotransduction,which is closely related to scar ***,it is necessary to clarify the roles of FA in scar *** Hypertrophic scar and keloid formed for more than a year and without other treatment,as well as normal skin samples were obtained from patients who underwent plastic ***,keloids(n=10),hypertrophic scars(n=10),and normal skin samples(n=10)were collected under informed *** dermal fibroblasts were isolated and *** amount and variety of FAs were detected by lipid chromatography-mass ***,real-time PCR,and western blotting were used to verify the expression of sterol regulatory element-binding protein-1(SREBP1)and fatty acid synthase(FASN)in the samples and their ***'s t-test,ANOVA,and orthogonal partial least square discriminant analysis were performed for statistical analysis(∗p1.0).The expression of SREBP1 and FASN was lower in pathological scars both at mRNA and protein levels(all∗p0.05).Conclusion FAs involved in pathological scars are abnormally changed in scar ***,fatty acid-derived inflammation and de novo synthes

关键词： Hypertrophic scars Keloids Fatty acids Fibroblasts

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大鼠永久性大脑中动脉阻塞模型的建立

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四川动物 2010年第3期29卷 461-465,F0004页

作者：许金秀杨牧周红电子科技大学生命科学与技术学院神经信息教育部重点实验室成都610054

目的建立稳定可靠的线栓法大鼠大脑中动脉阻塞(MCAO)永久性脑缺血模型。方法对Koizumi和ZeaLonga模型构建方法加以改进。40只雄性SD大鼠随机均分为实验组和假手术组,分别进行模型制作和模型缺血的评价,采用2,3,5-氯化三苯四氮唑(2,3,5-T... 详细信息

目的建立稳定可靠的线栓法大鼠大脑中动脉阻塞(MCAO)永久性脑缺血模型。方法对Koizumi和ZeaLonga模型构建方法加以改进。40只雄性SD大鼠随机均分为实验组和假手术组,分别进行模型制作和模型缺血的评价,采用2,3,5-氯化三苯四氮唑(2,3,5-Triphenyltetrazolium chloride,TTC)染色来计算大鼠脑梗死体积。结果大鼠MCAO模型制作成功率为95%;神经功能缺失评分1～3级百分率为95%。结论实验所采用的改良术式构建大鼠MCAO模型具有稳定性好、可重复率高、操作简便和手术时间短等优点,为基于大鼠永久性脑缺血模型开展的下游相关实验提供了良好的研究平台。

关键词：大鼠永久性大脑中动脉阻塞模型 TTC 梗死体积

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乳腺癌根治术患者围手术期健康教育路径表实施效果评价

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内蒙古民族大学学报（自然科学版） 2017年第2期32卷 170-172页

作者：金秀琴杨雨民内蒙古民族大学附属医院内蒙古通辽028000

目的:探讨健康教育路径对乳腺癌根治术患者康复的影响.方法:将126例行乳腺癌根治术患者随机分成观察组和对照组各63例.对照组采用传统的健康教育方法对患者进行健康教育,观察组采用健康教育路径表对患者实施健康教育,观察两组病人疾病... 详细信息

目的:探讨健康教育路径对乳腺癌根治术患者康复的影响.方法:将126例行乳腺癌根治术患者随机分成观察组和对照组各63例.对照组采用传统的健康教育方法对患者进行健康教育,观察组采用健康教育路径表对患者实施健康教育,观察两组病人疾病健康知识掌握、术后并发症发生情况、患侧肢体功能恢复状况.结果:观察两组病人疾病健康知识掌握情况及患侧肢体功能恢复情况均明显优于对照组,术后并发症发生率明显降低,差别有显著意义(P<0.05).结论:应用健康教育路径表可以保证健康教育实施的有效性,提高患者对疾病相关知识的认识和掌握,促使采用健康行为,有效地促进康复.

关键词：乳腺癌根治术健康教育路径并发症康复

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Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-Ang Nan Qing Li xiufang Li Zi-xiu Lu Linzhe Lü jin Liu Luyao Liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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过表达MicroRNA-199a促进TNFα诱导的脂肪细胞凋亡

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生物技术通报 2017年第3期33卷 180-185页

作者：齐仁立王琪吴永江王敬黄金秀杨飞云重庆市畜牧科学院重庆402460 农业部养猪科学重点实验室重庆402460 西南大学荣昌校区重庆402460

旨为探明micro RNA-199a(mi R-199a)对脂肪细胞凋亡的影响及核转录因子κB(nuclear factorκB,NF-κB)在其中的作用。培养3T3-L1脂肪细胞,使用肿瘤坏死因子α(tumor necrosis factorα,TNFα)诱导细胞凋亡。在此基础上分别使用NF-κB阻... 详细信息

旨为探明micro RNA-199a(mi R-199a)对脂肪细胞凋亡的影响及核转录因子κB(nuclear factorκB,NF-κB)在其中的作用。培养3T3-L1脂肪细胞,使用肿瘤坏死因子α(tumor necrosis factorα,TNFα)诱导细胞凋亡。在此基础上分别使用NF-κB阻断剂PDTC和mi R-199a mimic处理细胞,判断过表达mi R-199a对TNFα诱导的脂肪细胞凋亡的影响及NF-κB在其中的作用。使用流式细胞仪分析细胞凋亡率,试剂盒检测Caspase3/7酶活,双荧光素酶报告系统检测NF-κB活性,q RT-PCR检测mi R-199a的表达水平,Western blotting检测NF-κB相关蛋白变化。结果显示,TNFα可以诱导分化的脂肪细胞凋亡并同时激活NF-κB,激活的NF-κB在TNFα诱导的脂肪细胞凋亡中发挥负调控作用。在脂肪细胞过表达mi R-199a明显抑制NF-κB的激活进而显著促进TNFα诱导的凋亡。mi R-199a通过调控NF-κB活性参与TNFα诱导的脂肪细胞凋亡。

关键词： Mi R-199a 脂肪细胞凋亡 TNFa NF-κB

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上海地区大豆细菌性“叶斑病”病原研究

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上海农业学报 2007年第2期23卷 41-45页

作者：姚红梅谢关林金扬秀上海市农业技术推广服务中心上海201103 浙江大学生物技术研究所杭州310029

从上海地区的大豆叶斑病病株和病种上分离出20个细菌菌株,经菌体形态、培养性状、生理生化、致病性、Biolog和脂肪酸测定,并与12个国际标准菌株比较,在国内首次明确了大豆"叶斑病"是由大豆细菌性疫病菌Pseudomonas savastanoi ***(萨氏... 详细信息

从上海地区的大豆叶斑病病株和病种上分离出20个细菌菌株,经菌体形态、培养性状、生理生化、致病性、Biolog和脂肪酸测定,并与12个国际标准菌株比较,在国内首次明确了大豆"叶斑病"是由大豆细菌性疫病菌Pseudomonas savastanoi ***(萨氏假单胞菌大豆致病变种)引起。种子可带菌和传病,10份自然病种的平均种子带菌率在7.6%,传病率在0.48%。

关键词：大豆大豆细菌性疫病菌细菌学致病性

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ANALYSIS OF SOLUBLE CHEMICAL TRANSFER BY RUNOFF WATER IN FIELD

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Journal of Hydrodynamics 2008年第3期20卷 382-390页

作者： TONG Ju-xiu yang jin-zhong State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan430072 China

In order to determine the main factors influencing soluble chemical transfer and corresponding techniques for reducing fertilizer loss caused by runoff in irrigated fields, a physically based two-layer model was developed with incomplete mixing theory. Different forms of incomplete mixing parameters were introduced in the model, which was successfully verified with previous published experimental data. According to comparison, the chemicals loss of fertilizer is very sensitive to the runoff-related parameter while it is not sensitive to the infiltration-related parameter. The calculated results show that the chemicals in infiltration water play an important role in the early time of rainfall even with saturated soil, and it is mainly in the runoff flow in the late rainfall. Therefore, prevention of shallow subsurface drainage in the early rainfall is an effective way to reduce fertilizer loss, and the coverage on soil surface is another effective way.

关键词： soluble chemical transfer runoff incomplete mixing sensitive infiltration

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某市三级医院护士组织认同与志愿行为的关系研究

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蚌埠医学院学报 2017年第7期42卷 979-982页

作者：徐燕孟贝郭宏艳王金杨秀木蚌埠医学院护理学院安徽蚌埠233030 信阳职业技术学院护理学院河南信阳464000 蚌埠医学院第一附属医院全科医学科安徽蚌埠233004 蚌埠医学院全科医学教育发展研究中心安徽蚌埠233030 安徽省淮北市中医医院妇产科 235000

目的:研究某市三级医院护士组织认同、志愿行为的状况及二者之间的关系。方法:采用便利整群抽样的方法,使用《组织认同量表》和《志愿行为问卷》,对242名三级医院护士进行问卷调查。结果:既往参加过各种志愿服务活动的88人(36.4%),从未... 详细信息

目的:研究某市三级医院护士组织认同、志愿行为的状况及二者之间的关系。方法:采用便利整群抽样的方法,使用《组织认同量表》和《志愿行为问卷》,对242名三级医院护士进行问卷调查。结果:既往参加过各种志愿服务活动的88人(36.4%),从未参加过志愿活动的154人(63.6%);组织认同评分为(31.83±5.27)分,志愿行为评分为(2.20±1.09)分;护理管理者的组织认同评分显著高于护士(P<0.01),≥36岁的护士组织认同评分高于26~35年龄段的护士(P<0.01),工作时间6~10年的护士组织认同评分最低(P<0.01),主管护师及以上职称的护士组织认同评分大于护师(P<0.05);护理管理者的志愿行为评分显著高于护士(P<0.01);护士组织认同与志愿行为成显著正相关关系(r=0.230,P<0.01)。结论:三级医院护士组织认同较积极,志愿行为情况不乐观;组织认同对志愿行为具有一定的预测作用;护理管理者应着力进一步提高护士的组织认同,促使护士参与志愿服务活动。

关键词：护士组织认同志愿行为

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Analysis of soluble chemical transfer from soil to surface runoff and incomplete mixing parameter identification

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Water Science and Engineering 2015年第3期8卷 217-225页

作者： Ju-xiu Tong jin-zhong yang Bill X.Hu State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Key Laboratory of Groundwater Cycle and Environment Evolution Ministry of Education China University of Geosciences School of Water Resources and Environment China University of Geosciences

A two-layer mathematical model proposed by Tong et al. （2010） was used to predict soluble chemical transfer from soil into surface runoff with ponded water on the soil surface. Infiltration-related incomplete mixing parameter γ and runoff-related incomplete mixing parameter a in the analytical solution of the Tong et al. （2010） model were assumed to be constant. In this study, different laboratory experimental data of soluble chemical concentration in surface runoff from initially unsaturated and saturated soils were used to identify the variables γ and a based on the analytical solution of the model. The values of γ and a without occurrence of surface runoff were constant and equal to their values at the moment when the surface runoff started. It was determined from the results that γ decreases with the increase of the ponded water depth, and when the initial volumetric water content is closer to the saturated water content, there is less variation of parameter γ after the occurrence of surface runoff. As infiltration increases, the soluble chemical concentration in surface runoff decreases. The values of parameter a range from 0 to 1 for the fine loam and sand under the controlled infiltration conditions, while it can increase to a very large value, greater than 1, for the sand under the restrained infiltration conditions, and the analytical solution of the model is not valid for experimental soil without any infiltration if a is expected to be less than or equal to 1. The soluble chemical concentrations predicted from the model with variable incomplete mixing parameters γ and α are more accurate than those from the model with constant γ and α values.

关键词： Surface runoff Incomplete mixing parameter Analytical solution Soluble chemical

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