The role of altered fatty acid in pathological scars and their dermal fibroblasts

作     者：Jin-Xiu Yang Shi-Yi Li Min-Liang Chen Le-Ren He Jin-Xiu Yang;Shi-Yi Li;Min-Liang Chen;Le-Ren He

作者机构：Department of Burn and Plastic SurgeryThe Fourth Medical CentreChinese PLA(People's Liberation Army)General HospitalBeijing100038China th Department of Plastic SurgeryPlastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing10005China 

出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)

年 卷 期：2022年第25卷第4期

页      面：218-223页

核心收录：

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：This study was funded by National Natural Science Foundation of China(Grant No.81772085) The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript 

主　　题：Hypertrophic scars Keloids Fatty acids Fibroblasts 

摘      要：Purpose The proposed pathological mechanism for scar formation is controversial,and increased attention has been paid to the fatty acids(FAs)in the formation of pathological ***,FAs are known to be important in inflammation and mechanotransduction,which is closely related to scar ***,it is necessary to clarify the roles of FA in scar *** Hypertrophic scar and keloid formed for more than a year and without other treatment,as well as normal skin samples were obtained from patients who underwent plastic ***,keloids(n=10),hypertrophic scars(n=10),and normal skin samples(n=10)were collected under informed *** dermal fibroblasts were isolated and *** amount and variety of FAs were detected by lipid chromatography-mass ***,real-time PCR,and western blotting were used to verify the expression of sterol regulatory element-binding protein-1(SREBP1)and fatty acid synthase(FASN)in the samples and their *** s t-test,ANOVA,and orthogonal partial least square discriminant analysis were performed for statistical analysis(∗p1.0).The expression of SREBP1 and FASN was lower in pathological scars both at mRNA and protein levels(all∗p0.05).Conclusion FAs involved in pathological scars are abnormally changed in scar ***,fatty acid-derived inflammation and de novo synthes