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Human adipose, placenta, and umbilical cord-derived mesenchymal stem cells ameliorate imiquimod-induced psoriatic mice via reducing T cells infiltration

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BIOCELL 2021年第3期45卷 537-546页

作者： jigang lei ZHENYAO XU SUKE LI MENG LI ZHIKAI WANG PING LI JING WANG YINGLU CHEN X IAOLE SONG CHENGJIE REN MEIPING SHEN CHENGXIANG DAI Cellular Biomedicine Group Shanghai200233China Translational Medicine Center Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200025China Shanghai Institute of Immunology Shanghai Jiaotong University School of MedicineShanghai200025China

Psoriasis is an autoimmune-related chronic inflammatory disease with an approximate prevalence of 2–3%around the world,involving increased keratinocyte ***,Th17 cells and IL-17 play critical roles in the pathogenesis of *** monoclonal antibodies against cytokines have been shown to have effectively immunosuppressive effects on human ***,there are still some patients that have no response to these *** patients have even serious side-effects which may affect their *** stem cells have the ability of immunosuppressive and anti-inflammatory effects,which may be an alternative therapy with more safety and efficacy for human ***,the underlying mechanisms by which the MSCs prevent or ameliorate psoriasis are still poorly ***,we first isolated and characterized human adipose,placenta,and umbilical cord-derived mesenchymal stem cells(haMSCs,hpMSCs,and huMSCs).After that,the animal model of imiquimod(IMQ)-induced psoriasis in C57BL/6 mice was *** investigated the impact of haMSCs,hpMSCs,and huMSCs on this model by H&E staining,immunohistochemistry staining,and quantitative real-time *** analysis showed that mice subcutaneously injected with these MSCs had a significantly decreased epidermal thickness,which was caused by obviously reduced hyper-proliferation of ***,our findings revealed that the infiltration of T cells to psoriatic lesions in IMQ-induced psoriasis mice was markedly downregulated by intradermal administration of haMSCs,hpMSCs,and huMSCs,***,the production of IL-17 from Th17 cells was reduced,which inhibits the proliferation of keratinocytes in lesioned skin of IMQ-induced psoriasis *** data suggest that haMSCs,hpMSCs,and huMSCs can inhibit the effects of proinflammatory Th17 cells on the development of psoriasis,which may be potential therapeutic candidates for skin inflammatory disease or other autoimmune

关键词： Mesenchymal stem cells Psoriasis T cells Skin inflammation Cell therapy

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Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1412-1427页

作者： Jianpei Xu Yinzhe Sun Yang You Yuwen Zhang Dan Huang Songlei Zhou Yipu Liu Shiqiang Tong Fenfen Ma Qingxiang Song Chengxiang Dai Suke Li jigang lei Zhihua Wang Xiaoling Gao Jun Chen Shanghai Pudong Hospital&Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Emergency Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Institute of Science and Technology for Brain-Inspired Intelligence&Department of Neurology Fudan UniversityShanghai 201203China Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 201203China Daxing Research Institute University of Science and Technology BeijingBiomedical Industry BaseZhongguancun Science and Technology ParkBeijing 102600China Cellular Biomedicine Group Inc. Shanghai 201210China

Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical *** levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’*** on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC *** system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective *** this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for ***,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate *** engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 *** vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery.

关键词： Ischemic stroke Mesenchymal stem cell Cell engineering Hormesis effect Bioorthogonal chemistry Microglia Reactive oxygen spices Proinflammatory cytokines

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Expression Characterization of Genes Involved in Auxin Signal Transduction Pathway for Cotton Fiber Development

Expression Characterization of Genes Involved in Auxin Signa...

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第十二届全国植物基因组学大会

作者： Demou Li,Xiaoying Luo,Mi Zhang,jigang lei,Xiaoying He,lei Hou,Xianbi Li,Zaoxia Wang,Qiyuan Zhou,Yan Pei~* Biotechnology Research Center,Southwest University,Chongqing 400716,China

The plant hormone auxin plays a very critical role in fiber development of *** understand the role of auxin signal transduction pathway genes,and explore the regulation mechanism of in cotton fiber development, the expression pattern of cotton homologous genes,involved in auxin signal pathway,in different cotton tissue were analyzed by quantitative real *** of auxin signal pathway genes,GhARF8, GhCUL1,GhSKP1 and GhTIR1 are special expressed in fiber,and at different expression level in fiber growth stage of *** four genes expression are inhibited by IAA in *** 0dpa and 1dpa ovule of

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格子与多尺度分析

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北京机械工业学院学报 1999年第4期14卷 38-41页

作者：项欣雷纪刚北京机械工业学院基础部

以Ｈａａｒ小波为模型，研究小波基应当具备的性质，探索构造小波基的途径，并由此引入了格子的概念。通过格子可以给出更为一般的多尺度分析定义。多尺度分析理论是小波理论的基础，它为寻找和建立满足各种需要的小波基提供了一条途... 详细信息

以Ｈａａｒ小波为模型，研究小波基应当具备的性质，探索构造小波基的途径，并由此引入了格子的概念。通过格子可以给出更为一般的多尺度分析定义。多尺度分析理论是小波理论的基础，它为寻找和建立满足各种需要的小波基提供了一条途径。该定义不但适用于一维小波基的建立，对于建立高维小波基也是适用的，它在急速发展的小波理论中占有重要的地位。

关键词：小波尺度函数格子多尺度分析

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一类数列极限的计算

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高等数学研究 2017年第5期20卷 18-19页

作者：张静华雷纪刚北京信息科技大学理学院北京100192

极限计算是高等数学中的基本计算,虽然计算极限的方法有很多种,但是却不能解决所有的极限问题.在十几年的高等数学教学过程中,我们经常帮助考研的学生解决一些问题,在解决问题的过程中,我们发现有一类数列极限的计算有着共同的特点,本... 详细信息

极限计算是高等数学中的基本计算,虽然计算极限的方法有很多种,但是却不能解决所有的极限问题.在十几年的高等数学教学过程中,我们经常帮助考研的学生解决一些问题,在解决问题的过程中,我们发现有一类数列极限的计算有着共同的特点,本文中我们对这类数列极限的计算方法进行了总结,并给出定理及证明.

关键词：数列极限

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Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen Duan lei Liu Shilong Fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

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刹车装置摩擦噪声的动力学模型及理论分析

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北京机械工业学院学报 1999年第2期14卷 1-5页

作者：韩秋实许宝杰雷纪刚北京机械工业学院机械工程系

对刹车时发出的尖叫摩擦噪声的机理进行研究。首先分析和给出了摩擦表面的接触模型，进一步给出了刹车装置动力学模型，并进行了求解。在此基础上分析和论证了摩擦噪声产生的机理及规律，表明：尖叫摩擦噪声是由摩擦引发的高频自激振动... 详细信息

对刹车时发出的尖叫摩擦噪声的机理进行研究。首先分析和给出了摩擦表面的接触模型，进一步给出了刹车装置动力学模型，并进行了求解。在此基础上分析和论证了摩擦噪声产生的机理及规律，表明：尖叫摩擦噪声是由摩擦引发的高频自激振动所致。

关键词：刹车装置摩擦噪声动力学模型理论分析

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Overexpressing GhTIR1 Gene Influences Ovule Development in Cotton and Tobacco

Overexpressing GhTIR1 Gene Influences Ovule Development in C...

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第十二届全国植物基因组学大会

作者： jigang lei~#,Qiyuan Zhou~#,Zaoxia Wang,Xiaoying Luo,Yan Pei,Demou Li~* Biotechnology Research Center,Southwest University,Key Laboratory of Biotechnology and Crop Quality Improvement,Ministry of Agriculture,Chongqing Key Laboratory of Biotechnology,Chongqing 400716,China

TIR1 protein which is an auxin receptor plays a crucial role in auxin signalling transduction pathway. Cotton is the most important natural fiber crops in the *** analysis of GhTIR1 gene which is an auxin receptor gene,not only contribute to understand the effects of TIR1 protein,which is an important component of auxin signal transduction pathway,on cotton ovule/fiber development,but also to provide a theoretical reference concerned understanding the molecular mechanism which the effects of auxin on the cotton ovule development.

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小波变换与信号的时频分析

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北京机械工业学院学报 1999年第4期14卷 1-4页

作者：彭正旭项欣雷纪刚许宝杰北京机械工业学院

时频分析在信号分析中占有重要地位，而小波分析则是进行信号分析的一种新的方法。小波分析来源于Ｆｏｕｒｉｅｒ分析，通过对Ｆｏｕｒｉｅｒ分析和小波分析的比较，讨论了小波分析在时频分析中的应用，并采用Ｃ语言设计出了小波分... 详细信息

时频分析在信号分析中占有重要地位，而小波分析则是进行信号分析的一种新的方法。小波分析来源于Ｆｏｕｒｉｅｒ分析，通过对Ｆｏｕｒｉｅｒ分析和小波分析的比较，讨论了小波分析在时频分析中的应用，并采用Ｃ语言设计出了小波分析程序，利用这些程序对具体的信号进行了分析，达到了良好的效果。借助于信号的时频分析，能够直观地看出信号的一些重要特征，以便于进一步的处理。

关键词：时频分析小波变换信号分析

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Characterization of GhCUL 1 in Cotton Fiber Development

Characterization of GhCUL 1 in Cotton Fiber Development

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第十二届全国植物基因组学大会

作者： Xiaoying He,Zaoxia Wang,jigang lei,Qiyuan Zhou,Xiaoying Luo,Yan Pei,Demou Li~* Biotechnology Research Center,Southwest University,Key Laboratory of Biotechnology and Crop Quality Improvement,Ministry of Agriculture,Chongqing Key Laboratory of Biotechnology,Chongqing 400716,China

The ubiquitin pathway affects many aspects of plant development by accurately regulating the degradation of key *** of proteins involves the action of three enzymes,ubiquitinactivating enzyme (E1),ubiquitin-conjugating enzyme(E2),and ubiquitin-ligating enzyme(E3).One major class of E3s is the multisubunit SCF *** SCF is composed of four protein subunits:CULLIN(CUL1),SKP1(Arabidopsis thaliana ASK),RING-box1(RBX1),and an F-box *** of Zheng(2002) showed that CUL1 as a scaffold subunit is to bind the RBX1 and the dimer SKP1-FBP.

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