Human adipose, placenta, and umbilical cord-derived mesenchymal stem cells ameliorate imiquimod-induced psoriatic mice via reducing T cells infiltration
作者机构：Cellular Biomedicine GroupShanghai200233China Translational Medicine CenterShanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200025China Shanghai Institute of ImmunologyShanghai Jiaotong University School of MedicineShanghai200025China
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2021年第45卷第3期
页 面：537-546页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学]
基 金：from the National Natural Science Foundation of China(No.81703118)
主 题：Mesenchymal stem cells Psoriasis T cells Skin inflammation Cell therapy
摘 要：Psoriasis is an autoimmune-related chronic inflammatory disease with an approximate prevalence of 2–3%around the world,involving increased keratinocyte ***,Th17 cells and IL-17 play critical roles in the pathogenesis of *** monoclonal antibodies against cytokines have been shown to have effectively immunosuppressive effects on human ***,there are still some patients that have no response to these *** patients have even serious side-effects which may affect their *** stem cells have the ability of immunosuppressive and anti-inflammatory effects,which may be an alternative therapy with more safety and efficacy for human ***,the underlying mechanisms by which the MSCs prevent or ameliorate psoriasis are still poorly ***,we first isolated and characterized human adipose,placenta,and umbilical cord-derived mesenchymal stem cells(haMSCs,hpMSCs,and huMSCs).After that,the animal model of imiquimod(IMQ)-induced psoriasis in C57BL/6 mice was *** investigated the impact of haMSCs,hpMSCs,and huMSCs on this model by H&E staining,immunohistochemistry staining,and quantitative real-time *** analysis showed that mice subcutaneously injected with these MSCs had a significantly decreased epidermal thickness,which was caused by obviously reduced hyper-proliferation of ***,our findings revealed that the infiltration of T cells to psoriatic lesions in IMQ-induced psoriasis mice was markedly downregulated by intradermal administration of haMSCs,hpMSCs,and huMSCs,***,the production of IL-17 from Th17 cells was reduced,which inhibits the proliferation of keratinocytes in lesioned skin of IMQ-induced psoriasis *** data suggest that haMSCs,hpMSCs,and huMSCs can inhibit the effects of proinflammatory Th17 cells on the development of psoriasis,which may be potential therapeutic candidates for skin inflammatory disease or other autoimmune
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