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Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： jiang xiao-ying SHI Li-ping ZHU Jun-long BAI Ren-ren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

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初中听障学生语素意识与阅读理解的关系研究

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中国听力语言康复科学杂志 2024年第3期22卷 235-239页

作者：林逸李欢江小英厦门市思明区特殊教育学校厦门361001 西南大学重庆400715

目的帮助初中听障学生提高阅读理解能力。方法以2所特殊教育学校初中阶段的听障学生为被试,对其语素意识、阅读理解、识字量和词汇知识进行测评,并使用相关分析、分层回归和结构方程模型,探讨语素意识对初中听障学生阅读理解的影响,... 详细信息

目的帮助初中听障学生提高阅读理解能力。方法以2所特殊教育学校初中阶段的听障学生为被试,对其语素意识、阅读理解、识字量和词汇知识进行测评,并使用相关分析、分层回归和结构方程模型,探讨语素意识对初中听障学生阅读理解的影响,以及识字量与词汇知识在其关系中的中介作用。结果在分层回归分析中,听障学生的语素意识对阅读理解能力具有显著的独立预测作用。在构建结构方程模型后,听障学生的语素意识对阅读理解能力具有显著间接效应(P<0.05)。结论语素意识对词汇知识和识字量的直接影响显著,对识字量的影响程度大于对词汇知识的影响程度;语素意识对阅读理解的直接效应具有显著水平。语素意识对阅读理解能力还存在以词汇知识作为中介变量的间接效应。

关键词：语素意识阅读理解识字量词汇知识听障学生

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特殊儿童阅读研究和实践的启示

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中国听力语言康复科学杂志 2024年第3期22卷 225-229页

作者：江小英罗应兰沈剑娜西南大学教育学部特殊教育学院重庆400715 深圳市南山区龙苑学校深圳518000 重庆市教育科学研究院重庆400015

本文介绍了20世纪80年代以来世界3项影响深远的经典研究,即“三千万词汇鸿沟“”触手可读”项目和对话式阅读研究的背景、研究成果和影响,阐述了这些研究对特殊儿童阅读研究和实践的启示:阅读构建丰富的早期语言环境、提供0岁起步的阅... 详细信息

本文介绍了20世纪80年代以来世界3项影响深远的经典研究,即“三千万词汇鸿沟“”触手可读”项目和对话式阅读研究的背景、研究成果和影响,阐述了这些研究对特殊儿童阅读研究和实践的启示:阅读构建丰富的早期语言环境、提供0岁起步的阅读指导和开展对话式阅读有效提升阅读质量。

关键词： “三千万词汇鸿沟” 触手可读对话式阅读特殊儿童

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听障儿童家庭亲子阅读现状调查分析

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中国听力语言康复科学杂志 2024年第3期22卷 240-243,252页

作者：池雨濛罗应兰杨颖江小英浙江省温州市特殊教育学校温州325000 深圳市南山区龙苑学校深圳518000 重庆市涪陵区特殊教育学校重庆408000 西南大学教育学部特殊教育学院重庆400700

目的通过了解听障儿童家庭亲子阅读的现状,分析存在的问题,以期为听障儿童提供科学有效的亲子阅读指导。方法采用自编听障儿童家庭亲子阅读现状调查问卷对118个听障儿童家庭展开调查。结果听障儿童家庭亲子阅读总体平均3.65分,在年... 详细信息

目的通过了解听障儿童家庭亲子阅读的现状,分析存在的问题,以期为听障儿童提供科学有效的亲子阅读指导。方法采用自编听障儿童家庭亲子阅读现状调查问卷对118个听障儿童家庭展开调查。结果听障儿童家庭亲子阅读总体平均3.65分,在年级、亲子阅读陪伴者、亲子阅读交流方式、家长文化程度、家庭藏书量、阅读频率、阅读单次时长、图书形式等方面存在显著差异(P<0.05)。结论听障儿童家庭亲子阅读处于一般水平,图书内容、阅读方法、阅读环境、图书选择等方面亟待改进。阅读环境、图书选择、阅读方法的改善能够提升亲子阅读水平。

关键词：听障儿童亲子阅读阅读指导

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Methods,Mechanisms,and Application Prospects for Enhancing Extracellular Vesicle Uptake

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Current Medical Science 2024年第2期44卷 247-260页

作者： ying-peng XU Tao jiang xiao-fan YANG Zhen-bing CHEN Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Extracellular vesicles(EVs)are considered to be a new generation of bioinspired nanoscale drug delivery systems due to their low immunogenicity,natural functionality,and excellent ***,limitations such as low uptake efficiency,insufficient production,and inhomogeneous performance undermine their *** address these issues,numerous researchers have put forward various methods and applications for enhancing EV uptake in recent *** this review,we introduce various methods for the cellular uptake of EVs and summarize recent advances on the methods and mechanisms for enhancing EV *** addition,we provide further understanding regarding enhancing EV uptake and put forward prospects and challenges for the development of EV-based therapy in the future.

关键词： extracellular vesicles exosomes extracellular vesicle uptake extracellular vesiclebased therapy

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Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling xiao Yue Gong ying-Jia Qi Zhi-Ming Shao Yi-Zhou jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

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发病4.5～6 h急性脑梗死尿激酶溶栓疗效和安全性分析

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医学信息 2024年第7期37卷 98-101页

作者：童玲玲林燕妮朱健清庞家容蒋小英玉林市第一人民医院/广西医科大学第六附属医院神经内科

目的探讨发病4.5～6 h急性脑梗死(ACI)患者尿激酶(UK)溶栓疗效和安全性。方法回顾性分析2020年1月-2022年12月我院收治的128例ACI患者临床资料。根据出院时改良Rankin评分量表(mRS)结果分为预后良好组(m RS≤2分，n=78)和预后不良组(m... 详细信息

目的探讨发病4.5～6 h急性脑梗死(ACI)患者尿激酶(UK)溶栓疗效和安全性。方法回顾性分析2020年1月-2022年12月我院收治的128例ACI患者临床资料。根据出院时改良Rankin评分量表(mRS)结果分为预后良好组(m RS≤2分，n=78)和预后不良组(mRS>2分，n=50)。比较两组临床资料，多因素Logistic分析影响患者预后的危险因素。结果两组意识障碍、血糖控制不佳、症状性颅内动脉狭窄及发病至治疗时间(OTT)比较，差异有统计学意义(P<0.05);Logistic分析显示，意识障碍、血糖控制不佳及OTT均是导致ACI患者预后不良的因素。ACI患者的出入院mRS比较，差异有统计学意义(P<0.05)。结论 ACI发病4.5～6 h的患者进行UK溶栓能明显改善神经功能和减轻致残率，且出血风险低，无严重并发症，相对安全。

关键词：急性脑梗死尿激酶溶栓意识障碍血糖症状性颅内动脉狭窄发病-治疗时间

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Research on the Dynamic Compressibility of Polyurethane Microcellular Elastomer and its Application for Impact Resistance

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CHINESE JOURNAL OF POLYMER SCIENCE 2024年第8期42卷 1185-1197页

作者： Zhao, Zhi-ying jiang, Hao Li, xiao-Dong Zhang, Xu-Dong Su, Xing Zou, Mei-Shuai Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China

The packaging materials with cushioning performance are used to prevent the internal contents from being damaged by the impact and vibration of external forces. The polyurethane microcellular elastomers (PUMEs) can absorb energy through cell collapse and molecular chain creep. In this study, PUMEs with different densities were investigated by scanning electron microscopy, dynamic mechanical analysis and dynamic compression tests. PUMEs exhibited significant impact resistance and the maximum peak stress attenuation ratio reached 73.33%. The protective equipment was made by PUME with the optimal density of 600 kg/m3, and then the acceleration sensing device installed with the same protective equipment fell from a height of 3, 5 and 10 m to evaluate the energy-absorbing property and reusability of PUMEs. The results showed that PUMEs equipment reduced the peak acceleration of the device by 93.84%, with a maximum deviation of 9% between actual test and simulation, and shortened the impact time of first landing by 57.39%. In addition, the equipment PUMEs equipment could effectively reduce the stress on the protected items.

关键词： Polyurethane microcellular elastomer Impact velocity Stress attenuation ratio Impact resistance STRESS-STRAIN BEHAVIOR MECHANICAL-BEHAVIOR ABSORPTION ENERGY FOAMS

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Particle Distribution Informed by Chain Rigidity in Diblock Copolymer Melts: The Effect of Entropy

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Chinese Journal of Polymer Science 2024年第3期42卷 388-399,I0009页

作者： Yuguo Chen Shuanhu Qi ying jiang School of Chemistry Beihang UniversityBeijing 100191China

We study the effect of chain rigidity on tailoring the nanoparticle locations for neutral and selective particles embedded in the lamellar morphology formed by semiflexible diblock copolymer chains using self-consistent field calculations. The nanoparticles are modeled through a cavity function, and the semiflexible chains are represented by the continuous Kratsky-Porod chain model. In general situation, the nanoparticles prefer to stay at the interface in order to reduce the interface areas and thus the system free energy. However, the particle distribution at the domain center is subtle, and the underlying physics is intrinsically different depending on the polymer flexibility. In the case of flexible chains, the entropy just contributes a constant shift to the free energy when the nanoparticles move around the domain center indicating that the local metastable state if appears at the domain center is wholly attributed to the local minimum in the enthalpy. If the polymers are rigid, the variation of the particle distribution at the domain center has a close relation with the polymer rigidity and nanoparticle size. In the case of strongly rigid polymers with small nanoparticles, a nearly uniform particle distribution at the domain center is observed, while in other cases, a local enhancement of particle distribution there is found. In contrast to the case of flexible chains, further analysis reveals the crucial role of entropy in controlling the shape of particle distributions at the phase domain. Specifically, the local metastable state appears in the domain center is determined by the large entropy there which arises from the weak coupling of bond orientations that allows the polymer chains to be relatively relaxed. When the particle becomes selective, its distribution in the phase domain exhibits a shift almost uniformly rather than changes its profile, and the underlying physics still holds. In all, our study establishes a strong coupling between the chain rigi

关键词： Semiflexible diblock copolymer Nanoparticle distribution Self-consistent field theory Entropic effect

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Ultrafast optical investigation of carrier and spin dynamics in low-dimensional perovskites

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Science China(Technological Sciences) 2024年第1期67卷 2-18页

作者： FU JinYue jiang ying FANG HongHua Key Laboratory for Micro-Nano Physics and Technology of Hunan Province School of Physics and ElectronicsHunan UniversityChangsha 410012China State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China

Low-dimensional perovskite(PVK)materials have attracted significant research interest,because of their quantum-confined effect,tunable band gap structures,and higher stability than that of three-dimensional(3D)*** semiconductor optoelectronic devices,high speed and small size are closely *** development of high-speed devices requires researchers to fully understand the properties of materials,especially the dynamic processes such as carrier recombination,separation,and transport,which often play a crucial role in the performance of *** an indispensable part of dynamic research,spin relaxation is also of great significance in studying the properties of materials and explore possible *** halide PVK materials have strong spin-orbit coupling(SOC),which provides a basis for information storage and processing by using spin degrees of ***,studying the carrier and spin dynamics of low-dimensional PVKs is an effective way to understand the internal properties of low-dimensional PVKs *** paper summarizes the latest research progress on the ultrafast carrier and spin dynamics in low-dimensional PVKs,to comprehensively understand their carrier and spin behaviors and present an outlook for relevant studies in this area.

关键词： low-dimensional perovskites carrier dynamics spin dynamics optoelectronic devices

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