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Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population

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Asian Journal of Urology 2019年第1期6卷 114-121页

作者： Liqun Zhou Kaiwei yang xuesong Li yi Ding Dawei Mu Hanzhong Li Yong yan jinyi Li Dongwen wang Wei Li Yulong Cong jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi jiang Weilie Hu Qiang Wei xunbo jin Zhichen Guan Qingyong Liu Danfeng xu Xin Gao Yongguang jiang Weimin Gan Guang Sun Qing wang yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo jin Jiafu Feng Ming Cai zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao xu Chuize Kong Zefeng Kang Yuexin Liu xun Qu Benkang Shi Shaobin zheng yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping wang Jianbo Liang Department of Urology Peking University First HospitalBeijingChina Institute of Urology Peking UniversityBeijingChina National Urological Cancer Center BeijingChina Air Force General Hospital PLABeijingChina Department of Urology Peking Union Medical College HospitalBeijingChina Department of Urology Beijing Chao-Yang HospitalBeijingChina Department of Urology Armed-Police General HospitalBeijingChina Department of Urology Shanxi Medical University First HospitalTaiyuanChina Department of Urology Hebei Medical University Second HospitalShijiazhuangChina Department of Urology The General Hospital of the People’s Liberation ArmyBeijingChina Department of Urology First Affiliated Hospital of Jilin UniversityChangchunChina Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pathology The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina Department of Urology The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Urology General Hospital of Guangzhou Military Command of PLAGuangzhouChina Department of Urology West China School of MedicineChengduChina Department of Urology Shangdong Province-owned HospitalJinanChina Department of Urology Peking University Shenzhen HospitalShenzhenChina Department of Urology The Central Hospital of Jinan CityJinanChina Department of Urology Shanghai Changzheng HospitalShanghaiChina Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Urology Beijing Anzhen Hospital of Capital Medical UniversityBeijingChina Department of Urology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Urology The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Urology People’s Hospital of Xinjiang Uygur Autonomous RegionWulumuqiChina Department of Urology Guangdong General HospitalGuangzhouChina Department of Urology The First Affil

Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder ***:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December *** operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology ***:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised ***,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and *** sensitivity using FISH was obtained in high grade and muscle invasive tumors.

关键词： Bladder transitionalcell carcinoma Fluorescence in situ hybridization Detection Grade Stage

Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion

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World Journal of Gastroenterology 2008年第1期14卷 29-37页

作者： Wei-Xing Chen fang wang, Yu-ying Liu, Qing-jiang Zeng, Kai Sun, Xin xue, Xiang Li, Ji-ying yang, Li-Hua An,Bai-He Hu, jin-Hui yang, Chuan-She wang, Zhi-Xin Li, Lian-yi Liu, yan Li, Jun zheng, Fu-Long Liao, Dong Han,jing-Yu Fan, jing-yan Han fang wang Yu-ying Liu Qing-jiang Zeng Kai Sun Xin xue Xiang Li Ji-ying yang Li-Hua An Bai-He Hu jin-Hui yang Chuan-She wang Zhi-Xin Li Lian-yi Liu yan Li Jun zheng Fu-Long Liao Dong Han jing-Yu Fan jing-yan Han Tasly Microcirculation Research Center Peking University Health Science Center Beijing 100083 China Department of Pharmacology Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Integrated Chinese and Western Medicine School of Basic Medical Sciences Peking University Beijing 100083 China

AIM： To assess the effect of notoginsenoside R1 on hepatic microcirculatory disturbance induced by gut ischemia/reperfusion （I/R） in mice. METHODS： The superior mesenteric artery （SMA） of C57/BL mice was ligated for 15 min to induce gut ischemia followed by 30-rain reperfusion. In another set of experiments, R1 was continuously infused （10 mg/kg per hour） from 10 min before I/R until the end of the investigation to study the influence of R1 on hepatic microcirculatory disturbance induced by gut I/R. Hepatic microcirculation was observed by inverted microscopy, and the vascular diameter, red blood cell （RBC） velocity and sinusoid perfusion were estimated. Leukocyte rolling and adhesion were observed under a laser confocal microscope. Thirty and 60 min after reperfusion, lactate dehydrogenase （LDH）, alanine aminotransferase （ALl＇） and aspartate transaminase （AST） in peripheral blood were determined. The expression of adhesion molecules CD11b/CD18 in neutrophils and tumor necrosis factor- alpha （TNF-α）, interleukin-6 （IL-6） and monocyte chemotactic protein-1 （MCP-1） in plasma were evaluated by flow Oltometry. E-selectin and intercellular adhesion molecule-1 （ICAM-1） in hepatic tissue were examined by ***： After gut I/R, the diameters of terminal portal venules and central veins, RBC velocity and the number of perfused sinusoids were decreased, while the leukocyte rolling and adhesion, the expression of E-selectin in hepatic vessels and CD18 in neutrophils, IL-6, MCP-1, LDH, ALT and AST were increased. R1 treatment attenuated these alterations except for IL-6 and MCP-1. CONCLUSION： R1 prevents I/R-induced hepatic microcirculation disturbance and hepatocyte injury, The effect of R1 is related to its inhibition of leukocyte rolling and adhesion by inhibiting the expression of E-selectin in endothelium and CD18 in neutrophils.

关键词： Ischemia/reperfusion Notoginsenoside R1 Leukoytes adhesion E-selectin Hepatic injury

矿业活动固体废弃物中重金属元素释放机理的浸出实验

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地质通报 2012年第1期31卷 101-107页

作者：徐争启倪师军滕彦国王金生赵永鑫张成江北京师范大学水科院北京100875 成都理工大学地球化学与核资源工程系。四川成都610059

矿业活动中产生的固体废弃物包括废石、尾矿和冶炼废渣。这些固体废弃物堆放于露天环境,经过长期的自然风化作用,会对周围环境产生重要的影响。以攀枝花钒钛磁铁矿矿业活动为例,采集了废石、尾矿和冶炼废渣3种类型的固体废弃物,通过浸... 详细信息

矿业活动中产生的固体废弃物包括废石、尾矿和冶炼废渣。这些固体废弃物堆放于露天环境,经过长期的自然风化作用,会对周围环境产生重要的影响。以攀枝花钒钛磁铁矿矿业活动为例,采集了废石、尾矿和冶炼废渣3种类型的固体废弃物,通过浸出实验,研究了不同粒度、不同pH值条件下这些废弃物中重金属元素的释放机理及其对环境产生的影响。结果表明,大多数元素在pH值条件偏小的环境中浸出率更大,在碱性环境中浸出率更小,但废石中的V、Cr和废渣中的Ti在碱性条件下浸出率更高;细粒样品在相同pH值条件下浸出率较粗粒大,但在pH=12的条件下Ti、V、Ni、Cr和pH=1条件下Ti、Cr的浸出量出现反常,即在粗粒样品中高于细粒样品。固体废弃物释放的重金属元素会对周围环境产生一定的影响,需要加强监测。

关键词：固体废弃物重金属元素粒度攀枝花钒钛磁铁矿

Excess melanin precursors rescue defective cuticular traits in stony mutant silkworms probably by upregulating four genes encoding RR1-type larval cuticular proteins

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Excess melanin precursors rescue defective cuticular traits ...

化学三重表征的研究与展望——基于CiteSpace的可视化分析

中国蚕学会2021年学术年会

作者： Liang Qiao zheng-Wen yan Gao Xiong You-jin Hao Ri-Xin wang Hai Hu jiang-Bo Song Xiao-Ling Tong Lin-rong Che Song-Zhen He Bin Chen James Mallet Cheng Lu fang-yin Dai Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyCollege of Life SciencesChongqing Normal University State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest University Department of Organismic and Evolutionary Biology Harvard University

＜正＞Melanin and cuticular proteins are vital cuticle components in *** defects caused by mutations in cuticular protein-encoding genes can obstruct melanin *** effects of changes in melanin on the expression of cuticular protein-encoding genes,the cuticular and morphological traits,and the origins of these effects are unknown.

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化学教育（中英文） 2022年第5期43卷 121-127页

作者：王蕾杨赟郑雁方杨水金徐明波湖北师范大学化学化工学院湖北黄石435002 汉江师范学院化学与环境工程学院湖北十堰442000 湖北师范大学教育科学学院湖北黄石435002

基于CiteSpace软件,运用知识图谱、关键词聚类分析等方法,分析国内化学三重表征领域的研究现状和前沿热点,将信息可视化,为我国学者进一步完善化学三重表征的研究提供帮助和借鉴。放眼于国际科学教育的趋势和我国化学核心素养的落地,期... 详细信息

基于CiteSpace软件,运用知识图谱、关键词聚类分析等方法,分析国内化学三重表征领域的研究现状和前沿热点,将信息可视化,为我国学者进一步完善化学三重表征的研究提供帮助和借鉴。放眼于国际科学教育的趋势和我国化学核心素养的落地,期望将"化学三重表征"思维方式及策略嵌入日常的教学,成为化学课堂教学的未来景观。

关键词：化学三重表征 CiteSpace 可视化分析思维方式

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丝胶蛋白酶解产物抗氧化活性的研究

食品科学 2008年第5期29卷 250-253页

作者：范金波王芳孙雁姜鹭任发政中国农业大学食品科学与营养工程学院教育部-北京市功能乳品重点实验室中国农业大学食品科学与营养工程学院教育部-北京市功能乳品重点实验室北京100083

本实验采用六种蛋白酶对丝胶蛋白进行酶解,并分析其酶解产物清除二苯代苦味酰基(DPPH)自由基能力。通过脂质过氧化体系、还原力、金属螯合能力评价其酶解4h酶解产物的抗氧化活性。结果表明:各种酶解产物都呈现一定的清除DPPH自由基的能... 详细信息

本实验采用六种蛋白酶对丝胶蛋白进行酶解,并分析其酶解产物清除二苯代苦味酰基(DPPH)自由基能力。通过脂质过氧化体系、还原力、金属螯合能力评价其酶解4h酶解产物的抗氧化活性。结果表明:各种酶解产物都呈现一定的清除DPPH自由基的能力,其中以碱性蛋白酶最强(p<0.05);各种酶解产物都存在抑制脂质过氧化活性,与其他蛋白酶相比碱性蛋白酶的抑制活性显著的高于其他酶(p<0.05);各种蛋白酶解产物具有一定的还原力和金属螯合能力。这些结果表明:六种酶解产物都具有显著的抗氧化活性。

关键词：丝胶蛋白蛋白酶酶解产物抗氧化活性亚油酸

复合工程菌B350处理采油废水的反应动力学特征

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中国给水排水 2006年第17期22卷 70-73页

作者：赵昕汪严明叶正芳徐丽娜倪晋仁北京大学环境工程系北京100871

在对某油田采油废水水质进行监测的基础上,开展了利用复合工程菌B350降解采油废水中有机物的试验研究,并与活性污泥的降解结果进行了对比。经12 h的降解,B350对TOC的去除率为75.3%,而对比的活性污泥仅为55.5%;4 h为必要的反应时间。用Mo... 详细信息

在对某油田采油废水水质进行监测的基础上,开展了利用复合工程菌B350降解采油废水中有机物的试验研究,并与活性污泥的降解结果进行了对比。经12 h的降解,B350对TOC的去除率为75.3%,而对比的活性污泥仅为55.5%;4 h为必要的反应时间。用Monod反应动力学方程进行拟合计算,B350和活性污泥的降解平衡常数Ks、最大基质比去除速度vmax、难降解TOC含量、反应级数b、反应系数a分别为:5.22 mg/L与3.53 mg/L,14.83 h-1与7.71 h-1,8.43 mg/L与16.15 mg/L,0.48与0.48,4.59与3.98。B350处理采油废水的反应程度和速度均优于活性污泥;活性污泥与B350的反应级数相同,说明在低有机物浓度范围内反应速度受浓度的影响较小。

关键词：采油废水复合工程菌活性污泥反应动力学 Monod方程

Efficacy and safety of Firebird sirolimus-eluting stent in treatment of complex coronary lesions in Chinese patients： one-year clinical and eight-month angiographic outcomes from the FIREMAN registry

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Chinese Medical Journal 2011年第6期124卷 817-824页

作者： LI yan LI Cheng-xiang wang Hai-chang xu Bo fang Wei-yi GE Jun-bo wang Wei-min CHEN Jack-P SHEN Wen-kuang jiang Hong CONG Hong-liang PU Xiao-qun QIN Yong-wen jin Hui-gen CAO Yu FIREMAN Investigators Department of Cardiology Xijing Hospital Affiliated to Fourth Military Medical University Xi'an Shaanxi 710032 China Department of Cardiology FuWai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiology Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200030 China Department of Cardiology Shanghai Zhongshan Hospital Affiliated to Shanghai Fudan University School of MedicineShanghai 200032 China Department of Cardiology Peking University People's HospitalBeijing 100044 China Saint Joseph's Heart and Vascular Institute and Northside Hospital Atlanta GA USA Mayo Clinic 200 First St SW Rochester MN 55905 USA Department of Cardiology People's Hopsital Affiliated to Wuhan University Wuhan Hubei 430060 China Department of Cardiology Tianjin Chest Hospital Tianjin 300051China Department of Cardiology Xiangya First Affiliated HospitalCentral South University Changsha Hunan 410008 China Department of Cardiology Changhai Hospital Affiliated to Second Military Medical University Shanghai 200433 China Putuo Districit Central Hospital Shanghai 200060 China Department of Cardiology Xiangya Third Affiliated HospitalCentral South Universtiy Changha Hunan 410008 China Xiangtan Central Hospital Xiangtan Hunan 411100 China

Background Off-label application of drug-eluting stents （DES） during percutaneous coronary intervention （PCI） was not uncommon in daily practice, however DES in treating Chinese patients with complex lesion subset was under-investigated. The primary objective of the FIREMAN registry was to evaluate the long term efficacy and safety of the Firebird sirolimus-eluting stent （SES） in treating patients with complex coronary lesions. Here we report the mid-term of one-year clinical outcomes and eight-month angiographic follow-up results of FIREMAN *** The FIREMAN registry was a prospective multi-center registry, which included 1029 consecutive patients undergoing PCI with Firebird SES implantation between September 2006 and July 2007 in 45 centers in China. The clinical follow-up was designed to be performed at 1, 6, 12, 18, 24, 30 and 36 months post index procedure, and non-mandatory angiographic follow-up at 8 months was planned. One hundred percent site monitoring was *** Long lesions （59.2%）, multi-vessel disease （50.4%）, and small vessel disease （31.6%） were mostly found in angiography. Major adverse cardiac events （MACE） occurred in 51 （5.1%） patients at 1 year clinical follow-up,including cardiac mortality in 6 （0.6%）, non-fatal myocardial infarction in 11 （1.1%）, and target lesion revascularization in 36 （3.5%） of the patients. Definite and probable stent thrombosis （ST） by Academic Research Consortium （ARC） definition occurred in 12 （1.36%） patients at one-year clinical follow-up. The 8-month binary restenosis rate was 5.7% in-segment and 4.3% in-stent, respectively. Late lumen loss was （0.21±0.40） mm in-segment and （0.23±0.36） mm in-stent, respectively. Furthermore, Cox regression analysis revealed that diabetes, small vessel diameter, and chronic total occlusion were independent predictors of *** The results showed that the Firebird SES was effective and safe in treating Chinese patients with complex coronary lesions and oc

关键词： coronary artery disease sirolimus-eluting stent off-label use," clinical outcomes

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预制拼装桥墩体系及其抗震性能研究进展

中国公路学报 2022年第12期35卷 56-76页

作者：陈彦江丁梦佳许维炳王瑾方荣杜修力韩强北京工业大学城市建设学部北京100124

预制拼装桥墩体系(Pre-fabricated Concrete PierSystem,PCP)抗震性能是影响其推广、应用的关键。为加快PCP在中、高烈度等复杂恶劣工程环境中的设计、施工与建造,首先综述了PCP节点连接的接缝形式、连接构造类型及典型工程示例,指出了... 详细信息

预制拼装桥墩体系(Pre-fabricated Concrete PierSystem,PCP)抗震性能是影响其推广、应用的关键。为加快PCP在中、高烈度等复杂恶劣工程环境中的设计、施工与建造,首先综述了PCP节点连接的接缝形式、连接构造类型及典型工程示例,指出了PCP常用3种接缝形式和6种连接构造力学性能的研究现状及其优缺点;其次,系统地梳理了PCP抗震性能的研究进展,分析了不同连接条件下PCP的抗震性能,明晰了现有PCP抗震性能研究的不足及未来研究方向;最后,详细地论述了PCP抗震性能提升方法的研究前沿,探究了耗能延性构造的设置、高性能材料的应用、新型装配式节点构造设计以及新型混合预制桥墩体系的提出等PCP抗震性能提升方法的优缺点和发展方向。结果表明:通过对装配式节点的合理设计以及薄弱区域的预处理,预制拼装桥墩体系的抗震性能能够达到“等同现浇”的设计原则。然而PCP在复杂恶劣工程环境中的推广应用仍面临以下关键问题:PCP既有节点连接方式、体系和改进措施的抗震性能研究成果亟需归纳;新型节点连接方式、新体系和新型改进措施亟待提出,相关抗震性能有待验证;既有和新型PCP抗震性能的理论分析及抗震设计方法尚需完善;适用于复杂恶劣环境的预制拼装桥墩设计、施工标准亟需制定。

关键词：桥梁工程预制拼装桥墩综述抗震性能改进措施