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science {1. Chemistry 2004年第3期47卷 251-256页

作者： jiang yinzhi1,{1., zhejiang university of technology, hangzhou 310032. china 2. department of Applied Chemistry, zhejiang Institute of science and technology, hangzhou 31.033, china 1. department of {1. science Zhejiang University of Technology 310032 Hangzhou China 2. department of Applied Chemistry Zhejiang Institute of Science and Technology 310033 Hangzhou China

The reaction of 3,6-di-(3-methyl-pyridin-2-yI)-s-tetrazine (DMPTZ, II) with CeIII salt [Ce(NO3)3 · 6H2O] generates a new ligand, N-(3-methyl-pyridin-2-yl)-formimidoyl-(3-methyl-pyridin-2-yl) hydrazone (L), and forms a new complex: a mononuclear complex [Ce(L)(NO3)2 (H2O)3] · NO3 (III). Crystal data for III: space group P-1. with a = 0.71.3(4) nm, b = 1.1.39(2) nm, c = 1.4572(3) nm, α= 1.2.1.(2)°, β= 99.81.3)°, γ= 91.1.(3)°, Z = 2, V = 1.1..6(7) nm3, μ = 2.1.3 mm?1.and F(000) = 630. L acts as a tri-dentate chelating ligand in III. There are 1. coordination sites around Ce3+ of III, which are respectively occupied by seven oxygen atoms (four from two nitrate anions and three from three H2O molecules) and three nitrogen atoms (all from L). The cerium atom and three chelating nitrogen atoms are coplanar. The mechanism of the metal assisted decomposition is discussed briefly.

关键词： rare earth, complex, crystal structure, synthesize, 3,6-bis (3-methyl-pyridin-2-yl)-s-tetrazine, N-(3-methyl-pyridin- 2-yl)-formimidoyl-(3-methyl-pyridin-2-yl) hydrazone.

Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora

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Chinese Journal of Natural Medicines 2024年第3期22卷 265-272页

作者： XU Shuangyu ZHANG Feng TAO Linlan {1. Yangming huANG Tao LI Yanan hu Zhanxing YANG Jue HAO Xiao{1. YUAN Chunmao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China School of pharmaceutical {1.s Guizhou Medical UniversityGuiyang 550025China Natural Products Research Center of Guizhou Province Guiyang 550014China State Key Laboratory of Phytochemistry and Plant Resources in West china Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Four new sesquiterpene lactones(SLs)(1.4),along with a biosynthetically related SL(5),have been isolated from the leaves of Magnolia *** A(1.is notable as the first C1. homogemarane type SL,featuring a unique 1.7-dioxaspiro[4.4]nonan-6-one *** 2 and 3,representing the first instances of chlorine-substituted gemarane-type SL analogs in natural products,were also *** structures of these isolates were elucidated through a combination of spectroscopic data analysis,electronic circular dichroism calculations,and X-ray single-crystal diffraction *** isolates demonstrated anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 ***,3–5 showed a significant inhibitory effect on nitric oxide production,with IC50 values ranging from 0.79 to 4.73μmol·L^(−1..Additionally,4 and 5 exhibited moderate cytotoxic activities against three cancer cell lines,with IC50 values between 3.09 and 1..23μmol·L^(−1..

关键词： Magnolia grandiflora Sesquiterpene lactones Isolation and identification Anti-inflammatory activity

Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

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Chinese Chemical Letters 2024年第6期35卷 380-384页

作者： Ji Zhang Tong Zhang Qiao An Peng Zhang Cai-Yan Tian Chun-Mao Yuan Ping Yi Zhan-Xing hu Xiao-jiang Hao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Natural Products Research Center of Guizhou Province Guiyang 550014China School of pharmaceutical {1.s Guizhou Medical UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China State Key Laboratory of Phytochemistry and Plant Resources in West china Kunming Institute of BotanyChinese Academy of ScienceKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesKunming 650201China

Three novel matrine-type alkaloids(1.3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides ***,compound 1.possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system ***,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6tetracyclic *** structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)*** tests indicated that compound 5 displayed significant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

关键词： Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus

A novel FGFR1.inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis

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Genes & Diseases 2024年第1期11卷 479-494页

作者： Yanran Bi Ruiling Zheng Jiahao hu Ruiqing Shi Junfeng Shi Yutao Wang Peng Wang Wenyi {1. Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin School of pharmaceutical {1. Wenzhou Medical UniversityWenzhouZhejiang 325035China College of Pharmacy and Research Institute of Drug Development Chonnam National UniversityGwangju 61186Republic of Korea department of Dermatology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhouZhejiang 325000China zhejiang Lab for Regenerative Medicine Oujiang LaboratoryWenzhouZhejiang 325035China

Glioblastoma(GBM)is a malignant brain tumor that grows quickly,spreads widely,and is resistant to *** growth factor receptor(FGFR)1.is a receptor tyrosine kinase that regulates cellular processes,including proliferation,survival,migration,and ***1.was predominantly expressed in GBM tissues,and FGFR1.expression was negatively correlated with overall *** rationally designed a novel small molecule CYY292,which exhibited a strong affinity for the FGFR1.protein in GBM cell lines in ***292 also exerted an effect on the conserved Ser777 residue of ***292 dose-depen-dently inhibited cell proliferation,epithelial-mesenchymal transition,stemness,invasion,and migration in vitro by specifically targeting the FGFR1.AKT/Snail pathways in GBM cells,and this effect was prevented by pharmacological inhibitors and critical gene *** vivo experiments revealed that CYY292 inhibited U87MG tumor growth more effectively than ***292 also efficiently reduced GBM cell proliferation and increased survival in orthotopic GBM *** study further elucidates the function of FGFR1.in the GBM and reveals the effect of CYY292,which targets FGFR1.on downstream signaling pathways directly reducing GBM cell growth,invasion,and metastasis and thus impairing the recruitment,activation,and function of immune cells.

关键词： Blood-brain barrier EMT FGFR1 FGFR1.inhibitor Glioblastoma

Identification of clinical subphenotypes of sepsis after laparoscopic surgery

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 16-26页

作者： Jie Yang Bo Zhang Chaomin hu Xiaocong {1. Pengfei Shui Jiajie huang Yucai Hong Hongying Ni Zhongheng Zhang department of Emergency Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China department of Emergency Medicine Huzhou Central HospitalHuzhou 313000China department of Critical Care Medicine Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000China

Objective:Some patients exhibit septic symptoms following laparoscopic surgery,leading to a poor *** clinical subphenotyping is critical for guiding tailored therapeutic strategies in these *** identifying predisposing factors for postoperative sepsis,clinicians can implement targeted interventions,potentially improving *** study outlines a workflow for the subphenotype methodology in the context of laparoscopic surgery,along with its practical ***:This study utilized data routinely available in clinical case systems,enhancing the applicability of our *** data included vital signs,such as respiratory rate,and laboratory measures,such as blood sodium *** process of categorizing clinical routine data involved technical complexities.A correlation heatmap was used to visually depict the relationships between *** points were used to identify the clustering structure and combined with Consensus K clustering methods to determine the optimal ***:Our study highlighted the intricacies of identifying clinical subphenotypes following laparoscopic surgery,and could thus serve as a valuable resource for clinicians and researchers seeking to explore disease heterogeneity in clinical *** simplifying complex methodologies,we aimed to bridge the gap between technical expertise and clinical application,fostering an environment where professional medical knowledge is effectively utilized in subphenotyping ***:This tutorial could primarily serve as a guide for beginners.A variety of clustering approaches were explored,and each step in the process contributed to a comprehensive understanding of clinical subphenotypes.

关键词： Laparoscopic surgery Phenotype Precision medicine Sepsis

Ternary-phase layered cathodes toward ultra-stable and highrate sodium ion storage

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Rare Metals 2024年第4期43卷 1589-1598页

作者： Wen-Ji Yin Pei-Dan Su Qi Lu Xiao-Qiong Li Ji-Ming Peng Teng-Fei Zhou Ge-Meng Liang Yu-Liang Cao Hong-Qiang Wang Qing-Yu Li Si-jiang {1. Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin541004China Institutes of Physical science and Information {1. Anhui UniversityHefei230601China department of Chemistry and {1. sciences Guilin Normal CollegeGuilin541199China College of Chemistry and Chemical Engineering Huanggang Normal UniversityHuanggang438000China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide5005Australia Engineering Research Center of Organosilicon Compounds and Materials of Ministry of Education College of Chemistry and Molecular SciencesWuhan UniversityWuhan430072China

With the shortage of lithium resources,sodiumion batteries(SIBs)are considered one of the most promising candidates for lithium-ion batteries.P2-type and O3-type layered oxides are one of the few cathodes that can access high energy ***,they usually exhibit structural change,capacity decay,and slow Na ion ***,we present layered ternary-phase cathodes with P2,P3 and O3 phases by a lattice doping strategy,which is demonstrated by X-ray diffraction(XRD)*** the characteristics of P2,P3 and O3 phases,the layered composites show performance improvement during long-term battery *** particular,Na_(0.7)Li_(0.1.Co_(0.3-)Fe_(0.3)Mn_(0.3)O_(2)(NLCFM)delivers a reversible capacity of1.0.1.mAh·g^(-1.at 0.1.(1.0C=1.5 mA·g^(-1.)with a superior capacity retention of 72.5%after 1.00 cycles *** work offers insights into the development of advanced cathode materials for SIBs.

关键词： Sodium-ion battery Cathode material Layered oxides Lattice doping Mixed phase

Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong He Jinlin Song Min hu Yuehua Liu Yan Liu Jie Guo Fang Jin Yang Cao Lingyong jiang Qingsong Ye Min Zhu Beizhan jiang Wenhua Ruan Xiao Yuan huang Li Rui Zou Yulou Tian Li Gao Rui Shu Jianwei Chen Renkai Liu Shujuan Zou Xiaobing Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&hubei Key Laboratory of Stomatology&{1. of Orthodontics&Center for Dentofacial Development and Sleep Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina department of Orthodontic&Oral Biomedical Engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~260 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis

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Frontiers of Medicine 2024年第1期18卷 68-80页

作者： Yanling Liu Xi He Yanchun Yuan Bin Li Zhen Liu Wanzhen Li Kaixuan Li Shuo Tan Quan Zhu Zhengyan Tang Feng Han Ziqiang Wu Lu Shen Hong jiang Beisha Tang Jian Qiu Zhengmao hu Junling Wang department of Neurology Xiangya HospitalCentral South UniversityJiangxiNational Regional Center for Neurological DiseasesNanchang330038China Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease Department of UrologyXiangya HospitalCentral South UniversityChangsha410078China department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhou310002China department of Neurology Xiangya HospitalCentral South UniversityChangsha410078China National Clinical Research Center for Geriatric Diseases Xiangya HospitalCentral South UniversityChangsha410008China Key Laboratory of hunan Province in Neurodegenerative Disorders Central South UniversityChangsha410008China Center for Medical Genetics School of Life SciencesCentral South UniversityChangsha410008China Engineering Research Center of hunan Province in Cognitive Impairment Disorders Central South UniversityChangsha410078China hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha410078China hunan Key Laboratory of Molecular Precision Medicine Xiangya HospitalCentral South UniversityChangsha410078China

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons,and it demonstrates high clinical heterogeneity and complex genetic architecture.A variation within TRMT2B(c.1.56G>T;p.K452N)was identified to be associated with ALS in a family comprising two patients with juvenile ALS(JALS).Two missense variations and one splicing variation were identified in 1. patients with ALS in a cohort with 91. patients with ALS,and three more variants were identified in a public ALS database including 331. patients with ALS.A decreased number of mitochondria,swollen mitochondria,lower expression of ND1.decreased mitochondrial complex I activities,lower mitochondrial aerobic respiration,and a high level of ROS were observed functionally in patient-originated lymphoblastoid cell lines and TRMT2B interfering HEK293 ***,TRMT2B variations overexpression cells also displayed decreased *** conclusion,a novel JALS-associated gene called TRMT2B was identified,thus broadening the clinical and genetic spectrum of ALS.

关键词： TRMT2B amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen species

Non-proteolytic ubiquitination of HBx controls HBV replication

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Virologica Sinica 2024年第2期39卷 338-342页

作者： Xiangpeng Sheng Yi Yang Min Zhu Linlin Zhou Fang Zhu Yuanfei Zhu Siying Dong hui Kong Honghua Wang Ji jiang Mingyue Wan Mingyang Feng Qiang Deng Yumin Xu Qing You Ronggui hu State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Key Laboratory of Systems Health science of {1. Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China department of Thoracic Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Plant Molecular sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China department of Pathogenic Biology West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China School of Medicine Guizhou UniversityGuiyang 550025China Key Laboratory of Medical Molecular Virology(MOE&MOH) School of Basic Medical SciencesFudan UniversityShanghai 200032China department of Hospital Infection Management Department of Infectious DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health *** HBV infection remains the principal cause of liver cirrhosis and hepatocellular carcinoma(HCC).HBV is a small DNA virus,owning a~3.2 kb genome that encodes several proteins:viral DNA polymerase,core antigen(HBcAg),E antigen(HBeAg),three surface antigens(PreS1.PreS2/HBsAg),and a regulatory X protein(HBx)(Lamontagne et al.,201.).X protein,named for its lack of homology with any known proteins,is a 1.4 aa protein that plays an essential role in HBV biology and regulates the development of HCC(Yang et al.,2022).Although previous studies have strongly expanded our understanding of HBx,the regulation of HBx is not completely elucidated.

关键词： infection cirrhosis

Corrigendum to"A novel FGFR1.inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis"[Genes&Diseases 1.(2024)479-494]

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Genes & Diseases 2024年第3期11卷 485-490页

作者： Yanran Bi Ruiling Zheng Jiahao hu Ruiqing Shi Junfeng Shi Yutao Wang Peng Wang Wenyi {1. Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin School of pharmaceutical {1. Wenzhou Medical UniversityWenzhou 325035China College of Pharmacy and Research Institute of Drug Development Chonnam National UniversityGwangju 61186Republic of Korea department of Dermatology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000China zhejiang Lab for Regenerative Medicine Oujiang LaboratoryWenzhou 325035China

The authors regret that in Figure 3C,the Western Blot(WB)image representing GAPDH levels was mistakenly chosen as the same image for ERK(indicated by the red dotted-line rectangle).We have attached the original WB strip for GAPDH to demonstrate that this was an unintentional error in image ***,we noticed that the Transwell images in the two upper panels of the right column in Figure 4J are misleading due to errors in image *** have attached the original data to show that this was also an unintentional *** assure you that these two corrections do not alter the scientificconclusionof thearticle.

关键词： GSK3β invasion metastasis