Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

作     者：Ji Zhang Tong Zhang Qiao An Peng Zhang Cai-Yan Tian Chun-Mao Yuan Ping Yi Zhan-Xing Hu Xiao-Jiang Hao 

作者机构：State Key Laboratory of Functions and Applications of Medicinal PlantsGuizhou Medical UniversityGuiyang 550014China Natural Products Research Center of Guizhou ProvinceGuiyang 550014China School of Pharmaceutical SciencesGuizhou Medical UniversityGuiyang 550025China School of PharmacyGuizhou University of Traditional Chinese MedicineGuiyang 550025China State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of ScienceKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus ProductsChinese Academy of Medical SciencesKunming 650201China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第6期

页      面：380-384页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：financially supported by the National Natural Science Foundation of China(Nos.32160103 and U1812403) the Science and Technology Department of Guizhou Province(Nos.QKH ZC--YB181,QKH CXTD--007 and QKH ZYD--4015) Guizhou Provincial Engineering Research Center for Natural Drugs 

主　　题：Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus 

摘      要：Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides ***,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system ***,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6tetracyclic *** structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)*** tests indicated that compound 5 displayed significant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.