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Communications in Theoretical Physics 2009年第7期52卷 7-11页

作者： CUI Jin-Chao jia li-qun ZHANG Yao-Yu School of Science Jiangnan University Wuxi 214122 China Electric and Information Engineering College Pingdingshall University Pingdingshan 467002 China

Mei symmetry and Mei conserved quantity for a non-holonomic system of non-Chetaev's type with unilateralconstraints in the Nielsen style are *** differential equations of motion for the system above are *** definition and the criteria of Mei symmetry,conditions,and expressions of Mei conserved quantity deduced directlyfrom the Mei symmetry are *** example is given to illustrate the application of the results.

关键词： Nielscn stylc unilatcral constraint non-holonomic system of non-Chctaev's type Mci conscrvcd quantity

Structural Equation and Mei Conserved Quantity of Mei Symmetry for Appell Equations in Holonomic Systems with Unilateral Constraints

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Communications in Theoretical Physics 2009年第10期52卷 572-576页

作者： jia li-qun ZHANG Yao-Yu CUI Jin-Chao LUO Shao-Kai School of Science Jiangnan University Wuxi 214122 China Electric and Information Engineering College Pingdingshan University Pingdingshan 467002 China Institute of Mathematical Mechanics and Mathematical Physics Zhejiang Sci-Tech University Hangzhou 31001 China

Structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints are investigated. Appell equations and differential equations of motion for holonomie mechanic systems with unilateral constraints axe established. The definition and the criterion of Mei symmetry for Appell equations in holonomic systems with unilateral constraints under the infinitesimal transformations of groups axe also given. The expressions of the structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints expressed by Appell functions are obtained. An example is given to illustrate the application of the results.

关键词： holonomic system with unilateral constraints Appell equation structural equation of Mei symmetry Mei conserved quantity

Efficacy of Wen-Luo-Tong on Peripheral Neuropathy Induced by Chemotherapy or Target Therapy: A Randomized, Double-Blinded, Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第7期28卷 579-585页

作者： DENG Bo jia li-qun WAN Dong-gui WANG Bao-yi CHENG Zhi-qiang DENG Chao Center of Science and Technology China-Japan Friendship HospitalBeijing 100029China Integrative Oncology Department of Chinese Medicine and Western Medicine China-Japan Friendship HospitalBeijing 100029China

Objective: To evaluate the efficacy of Wen-Luo-Tong Granules(WLT) local administration in the treatment of patients with peripheral neuropathy(PN) induced by chemotherapy or target therapy. Methods: This study is a randomized, double-blinded, and placebo-controlled trial. Seventy-eight patients with PN induced by chemotherapy or target therapy were enrolled from China-Japan Friendship Hospital between July 2019 and January 2020. They were randomly assigned to WLT(39 cases) and control groups(39 cases) using a block randomization method. The WLT group received WLT(hand and foot bath) plus oral Mecobalamin for 1 week, while the control group received placebo plus oral Mecobalamin. The primary endpoint was PN grade evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events(NCI-CTCAE). The secondary endpoints included quantitative touch-detection threshold, neuropathy symptoms, Quality of life QuestionnaireChemotherapy Induced Peripheral Neuropathy(QLQ-CIPN20), and Quality of life Questionnaire-Core30(QLQ-C30). Results: After treatment, the PN grade in the WLT group was significantly lower than that in the control group(1.00±0.29 vs. 1.75±0.68, P<0.01). The total effective rate in the WLT group was significantly higher than that in the control group(82.05% vs. 51.28%, P<0.01). Compared with the control group, the touchdetection thresholds at fingertips, neuropathy symptom score, QLQ-CIPN 20(sensory scale, motor scale, autonomic scale, and sum score), and QLQ-C30(physical functioning, role functioning, emotional functioning, and global health) in the WLT group significantly improved after treatment(P<0.01 or P<0.05). Conclusion: WLT local administration was significantly effective in the treatment of patients with PN induced by chemotherapy or target therapy.(Trial registration No. ChiCTR1900023862)

关键词： peripheral neuropathy chemotherapy target therapy Chinese medicine Wen-Luo-Tong randomized controlled trial

贾立群教授中医外治新抗癌剂所致外周神经毒性反应的临证经验

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中华中医药杂志 2015年第6期30卷 1988-1989页

作者：刘猛贾立群中日友好医院中西医结合肿瘤内科北京100029

随着新的抗癌药物的不断出现,肿瘤患者的生存时间得到延长,与此同时,由此所产生的一些不良反应也随之出现。这些不良反应在使用抗癌药的后过程中导致了许多有效的治疗因患者不耐受不良反应而中断,也令即将使用新抗癌药物的患者望而生畏... 详细信息

随着新的抗癌药物的不断出现,肿瘤患者的生存时间得到延长,与此同时,由此所产生的一些不良反应也随之出现。这些不良反应在使用抗癌药的后过程中导致了许多有效的治疗因患者不耐受不良反应而中断,也令即将使用新抗癌药物的患者望而生畏。这些不良反应其现代医学机制尚未得到充分研究,现有的处理措施也无法解决临床中的实际问题。中日友好医院贾立群教授多年关注中医外治法防治化疗所致不良反应,对以辨证论治为特点的传统医学和新化疗药物所致不良反应有着独特的观点,在长期化疗药的临床应用中取得了较好的临床疗效。尤其是对外周神经毒性反应的关注较为重视,经过反复实践,总结出其"理、法、方、药",受到业内认可。

关键词：周围神经毒性反应中医外治紫杉醇奥沙利铂

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贾立群运用舌诊辨治癌及癌前病变经验

中华中医药杂志 2020年第9期35卷 4455-4458页

作者：蔡超产张锂泰娄彦妮贾立群北京中医药大学北京100029 中日友好医院北京100029 中日友好医院中西医结合肿瘤内科北京100029

文章通过对贾立群教授所主持舌诊与肿瘤关系相关研究成果进行回顾,结合其将科研成果验之临床之所得,论述贾立群教授对血瘀舌、裂纹舌、苔腻舌、剥脱苔4种舌象的病因、病机及其治疗的认识,并重点阐述贾立群教授在4种舌象于癌及癌前病变... 详细信息

文章通过对贾立群教授所主持舌诊与肿瘤关系相关研究成果进行回顾,结合其将科研成果验之临床之所得,论述贾立群教授对血瘀舌、裂纹舌、苔腻舌、剥脱苔4种舌象的病因、病机及其治疗的认识,并重点阐述贾立群教授在4种舌象于癌及癌前病变的预防、早诊、辨治、预后等方面的认识、思考及对治之法。通过论述贾立群教授科研与临床相结合的思路,为中医科研更好地服务临床、指导临床,与临床相辅相成,提供范例与思考方向。

关键词：舌诊肿瘤经验舌象贾立群

Propagation form of internal cracks induced by continuous casting soft reduction and control strategy for internal quality

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Journal of Iron and Steel Research International 2024年第3期31卷 622-633页

作者： Pu Wang liang Chen qun-wei Tang Wei-tao li Shao-xiang li jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Weifang Special Steel Group Co..Ltd. Weifang 262400ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The propagation form of internal cracks induced by continuous casting soft reduction and the control strategy for enhancing the internal quality of 45 steel through industrial trials and a three-dimensional flow-heat transfer-solidification coupling model were *** results showed that the internal cracks induced by soft reduction exhibited a characteristic of being"coarse in the middle and fine at both ends",and displayed an elliptical arc distribution on the loose side of the strand cross *** cracks originated within the brittle temperature range and propagated inward to the liquid impenetrable temperature and outward to the zero ductility temperature or *** control strategy for enhancing the internal quality of the 45 steel strand through soft reduction is to adjust the casting speed or the reduction zone appropriately,ensuring that the central solid fraction of the reduction zone falls within the range of *** this point,a reasonable reduction amount is allocated to eliminate the center shrinkage cavities and center segregation,even if it results in minor reduction-induced cracks.

关键词： Continuous casting Soft reduction Crack propagation Internal quality Control strategy

Application of Computer-Aided Tongue Inspection for Preliminary Screening of Esophageal Cancer

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Chinese Journal of Integrative Medicine 2018年第10期24卷 746-751页

作者： DUAN Jin-long DENG Bo SONG Guo-hui CHEN Zhi-feng GONG Yan-wei HE Yu-hua jia li-qun School of Clinical Medicine Beijing University of Chinese Medicine Department of Oncology of Integrative Chinese and Western Medicine China-Japan Friendship Hospital Department of Oncology Ci County Tumor Hospital Department of Oncology Fourth Affiliated Hospital of Hebei Medical University

Objective： To differentiate patients with esophageal cancer or premalignant lesions from the high-risk population for preliminary screening of esophageal cancer using a feature index determined by a computer-aided tongue information acquisition and processing system （DS01-B）. Methods： Totally, 213 patients diagnosed with esophageal cancer or premalignant lesions and 2,840 normal subjects were collected including primarily screened and reexamined, all of them were confirmed with histological examinations. Their tongue color space values and manifestation features were extracted by DS01-B and analyzed. Firstly, the analysis of variance was performed to differentiate normal subjects from patients with esophageal cancer and premalignant lesions. Secondly, the logistic regression was conducted using 10 features and gender, age to get a predictive equation of the possibility of esophageal cancer or premalignant lesions. Lastly, the equation was tested by subjects undergoing primary screening. Results： Saturation （S） values in the HSV color space showed significant differences between patients with esophageal cancer and normal subjects or those with mild atypical hyperplasia （P〈0.05）; blue-to-yellow （b） values in the Lab color space showed significant differences between patients with esophageal cancer or premalignant lesions and normal subjects （P〈0.05）. Logistic regression analysis showed that the computer-aided tongue inspection approach had an accuracy of 72.3% （2008/2776） in identifying patients with esophageal cancer or premalignant lesions for preliminary screening in high-risk population. Conclusion： Computer-aided tongue inspection, with descriptive and quantitative profile as described in this study, could be applied as a cost- and time- efficient, non-invasive approach for preliminary screening of esophageal cancer in high-risk population.

关键词： esophageal cancer preliminary differential diagnosis computer-aided tongue inspection logistic regression

基于舌象大数据的早期食管鳞癌中医证候转化规律分析

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中医肿瘤学杂志 2024年第1期6卷 57-62页

作者：于然娄彦妮陈冬梅宋国慧李军孙建荣贾立群解放军总医院第六医学中心北京100048 中日友好医院北京100029 河北省磁县肿瘤医院河北邯郸056500 四川省盐亭县肿瘤医院四川绵阳621600

目的将食管癌高发区舌象筛查与内镜筛查相结合,分析食管癌变过程中不同病理状态下舌象特征,探索食管癌前病变向早期食管鳞癌转化的舌象特征规律及中医病机特点。方法纳入河北磁县、四川盐亭、山西阳城地区2017年—2021年完成内镜筛查及... 详细信息

目的将食管癌高发区舌象筛查与内镜筛查相结合,分析食管癌变过程中不同病理状态下舌象特征,探索食管癌前病变向早期食管鳞癌转化的舌象特征规律及中医病机特点。方法纳入河北磁县、四川盐亭、山西阳城地区2017年—2021年完成内镜筛查及舌象筛查的18954例人群,使用道生舌诊仪(DS01-B)在统一标准的光源环境下提取12种舌象特征。使用SPSS 24.0软件进行数据分析,并通过多因素Logistic回归对多种混杂因素进行控制,比较食管癌前病变及早期食管癌与病理正常人群之间的舌象特征差异。结果舌象分布分析显示,紫舌在食管癌前病变及早期食管癌组的比例高于病理正常组,且其在早期食管癌组的比例高于食管癌前病变组,Logistic回归分析结果显示紫舌在食管癌前病变及早期食管癌组的OR值分别为1.82(95%CI:1.45~2.28,P<0.001)、2.14(95%CI:1.51~3.05,P<0.001);红舌与裂纹舌主要在癌前病变组占比较高,其在早期食管癌组的比例略低于癌前病变组,Logistic回归分析结果显示其OR值分别为1.44(95%CI:1.25~1.66,P=0.003)、1.49(95%CI:1.30~1.72,P<0.001)。将其他差异具有统计学意义的舌象特征纳入多因素Logistic回归分析后,结果与前面分析相一致。结论食管癌前病变组紫舌、红色与裂纹舌的比例均高于病理正常组,而早期食管癌组紫舌的比例高于食管癌前病变组,红色与裂纹舌的比例略低于食管癌前病变组,反映出食管癌变过程中由阴虚燥热向瘀血内阻转化的中医病机规律。

关键词：早期食管癌癌前病变舌象中医病机大数据

Diagnosis of Early Esophageal Cancer Based on TCM Tongue Inspection

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Biomedical and Environmental Sciences 2020年第9期33卷 718-722页

作者： SONG An Yi LOU Yan Ni YANG Qian Xi li Dong Fang SONG Guo Hui HUANG Lai Qiang YUAN Ke Hong jia li qun l.tsinghua shenzhen international graduate school tsinghua universityshenzhen 518055guangdongchina china-japan friendship hospital beijing 100029china department of chemistry tsinghua universitybeijing 100084china cixian institute for cancer prevention and control handan 056500hebeichina

Esophageal cancer is a common malignant carcinoma that occurs in the digestive tract and leads to around three million deaths *** commonly present with symptoms,such as dysphagia,cough,hoarseness,and pain in the *** to researches,smoking,alcohol consumption,exposure to radiation,contaminated food,chronic throat irritation,consumption of extremely hot beverages,genetic mutation,and dystrophia are influential factors in the development of esophageal carcinoma[1].

关键词： Esophageal Cancer TCM

From Family Business Management to Professional Management in a Time-Honored Brand： The Case of Fu Yuan Guan

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Frontiers of Business Research in China 2015年第1期9卷 91-109页

作者： jia-Chen Zhang li-qun Wei School of Business Hong Kong Baptist University Hong Kong China

This case describes the development process of Fu Yuan Guan, a Chinese time-honored brand. Through privatization, Fu Yuan Guan survived and rapidly captured its market. However, the family business management style proved to be a bottleneck during further expansion. There is a need to recruit qualified professional managers to improve the overall management of the firm but it seems there are challenges in doing so. This case describes the daily operationalization of this family firm together with the approach of top managers, with the purpose of exhibiting how its internal management is implemented.

关键词： time-honored brands family business management professionalmanagers business development