Efficacy of Wen-Luo-Tong on Peripheral Neuropathy Induced by Chemotherapy or Target Therapy: A Randomized, Double-Blinded, Placebo-Controlled Trial

作     者：DENG Bo JIA Li-qun WAN Dong-gui WANG Bao-yi CHENG Zhi-qiang DENG Chao DENG Bo;JIA Li-qun;WAN Dong-gui;WANG Bao-yi;CHENG Zhi-qiang;DENG Chao

作者机构：Center of Science and TechnologyChina-Japan Friendship HospitalBeijing 100029China Integrative Oncology Department of Chinese Medicine and Western MedicineChina-Japan Friendship HospitalBeijing 100029China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2022年第28卷第7期

页      面：579-585页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Capital’s Funds for Health Improvement and Research (No. 2018-2-40610) 

主　　题：peripheral neuropathy chemotherapy target therapy Chinese medicine Wen-Luo-Tong randomized controlled trial 

摘      要：Objective: To evaluate the efficacy of Wen-Luo-Tong Granules(WLT) local administration in the treatment of patients with peripheral neuropathy(PN) induced by chemotherapy or target therapy. Methods: This study is a randomized, double-blinded, and placebo-controlled trial. Seventy-eight patients with PN induced by chemotherapy or target therapy were enrolled from China-Japan Friendship Hospital between July 2019 and January 2020. They were randomly assigned to WLT(39 cases) and control groups(39 cases) using a block randomization method. The WLT group received WLT(hand and foot bath) plus oral Mecobalamin for 1 week, while the control group received placebo plus oral Mecobalamin. The primary endpoint was PN grade evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events(NCI-CTCAE). The secondary endpoints included quantitative touch-detection threshold, neuropathy symptoms, Quality of Life QuestionnaireChemotherapy Induced Peripheral Neuropathy(QLQ-CIPN20), and Quality of Life Questionnaire-Core30(QLQ-C30). Results: After treatment, the PN grade in the WLT group was significantly lower than that in the control group(1.00±0.29 vs. 1.75±0.68, P0.01). The total effective rate in the WLT group was significantly higher than that in the control group(82.05% vs. 51.28%, P0.01). Compared with the control group, the touchdetection thresholds at fingertips, neuropathy symptom score, QLQ-CIPN 20(sensory scale, motor scale, autonomic scale, and sum score), and QLQ-C30(physical functioning, role functioning, emotional functioning, and global health) in the WLT group significantly improved after treatment(P0.01 or P0.05). Conclusion: WLT local administration was significantly effective in the treatment of patients with PN induced by chemotherapy or target therapy.(Trial registration No. ChiCTR1900023862)