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Chinese Chemical Letters 2017年第7期28卷 1566-1570页

作者： Liang-Run Dong De-Yu Hu Zeng-Xue Wu ji-xiang chen Bao-An Song State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationResearch and Development Center for Fine ChemicalsGuizhou UniversityGuiyang 550025China

A series of novel chalcone derivatives that contain the 1,1-dichloropropene moiety was designed and synthesized. Bioactivity assays showed that most of the target compounds exhibited moderate to good antiviral activity against tobacco mosaic virus（TMV） at 500 mg/m L. Among the target compounds,compound 7h showed the highest in vivo inactivation activity against TMV with the EC50 and EC90value of 45.6 and 327.5 mg/m L, respectively, which was similar to that of Ningnanmycin（46.9 and 329.4 mg/m L）and superior to that of Ribavirin（145.1 and 793.1 mg/m L）. Meanwhile, the microscale thermophoresis and fluorescence spectroscopy experiments showed that the compound 7h had a strong interaction with the tobacco mosaic virus coat protein.

关键词： Chalcone derivatives 1 1-Dichloropropene moiety Synthesis Antiviral activity Interaction mechanisms

Binding interactions of pefloxacin mesylate with bovine lactoferrin and human serum albumin

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第6期7卷 452-458页

作者： FAN ji-cai chen xiang WANG Yun FAN cheng-ping SHANG Zhi-cai Department of Chemistry Zhejiang University Hangzhou 310027 China

The binding of pefloxacin mesylate （PFLX） to bovine lactoferrin （BLf） and human serum albumin （HSA） in dilute aqueous solution was studied using fluorescence spectra and absorbance spectra. The binding constant K and the binding sites n were obtained by fluorescence quenching method. The binding distance r and energy-transfer efficiency E between pefloxacin mesylate and bovine lactoferrin as well as human serum albumin were also obtained according to the mechanism of Forster-type dipole-dipole nonradiative energy-transfer. The effects of pefloxacin mesylate on the conformations of bovine lactoferrin and human serum albumin were also analyzed using synchronous fluorescence spectroscopy.

关键词： Pefloxacin mesylate (PFLX) Bovine lactoferrin (BLf) Human serum albumin (HSA) Fluorescence spectra Energy-transfer efficiency

Partial hydrogenation of adiponitrile to 6-aminocapronitrile over Ni/α-Al_2O_3 catalyst promoted with K_2O and La_2O_3

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Chinese Chemical Letters 2007年第6期18卷 685-688页

作者： Lei Zhao, Cai Yun Wang, ji xiang chen , ji Yan Zhang Department of Catalysis Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China [a]Department of Catalysis Science and Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

A novel K2O and La2O3 promoted nickel catalyst supported on a-Al2O3 was prepared by co-impregnation method, and it exhibited higher activity and 6-aminocapronitrile selectivity than Ni/a-Al2O3 during the hydrogenation of adiponitrile in the absence of ammonia, i.e., K2O and La2O3 improved the performance of the nickel-based catalyst.

关键词： Nickel catalyst Potassium oxide Lanthana Partial hydrogenation Adiponitrile 6-Aminocapronitrile

Synthesis and antiviral activities of novel 1,4-pentadien-3-one derivatives bearing an emodin moiety

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Chinese Chemical Letters 2016年第6期27卷 948-952页

作者： jian Wu Yun-Ying Zhu Yong-Hui Zhao Wei-Li Shan De-Yu Hu ji-xiang chen Deng-Yue Liu xiang-Yang Li Song Yang State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of Education Research and Development Center for Fine Chemicals Guizhou University School of Chemical Engineering Guizhou Institute of Technology Institute for the Control of Agrochemicals Ministry of Agriculture

A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus（TMV） and cucumber mosaic virus（CMV） in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin（409.3 mg/m L）.

关键词： 1 4-Pentadien-3-one derivatives Emodin Synthesis Antiviral activity

Synthesis and antiviral bioactivity of novel chalcone derivatives containing purine moiety

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Chinese Chemical Letters 2018年第1期29卷 127-130页

作者： Yan-jiao Wang Da-Gui Zhou Fang-cheng He ji-xiang chen Yong-Zhong chen Xiu-Hai Gan De-Yu Hu Bao-An Song State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of Education Research and Development Center for Fine Chemicals Guizhou University

A series of novel chalcone derivatives containing purine moiety was designed and synthesized, and their antiviral activities against cucumber mosaic virus （CMV） and tobacco mosaic virus （TMV） were evaluated in vivo. Bioactivity assays indicated that some compounds showed good antiviral activities against CMV and TMV. It is worth mentioning that compounds 30, 3s, 3w, and 3x exhibited excellent curative activity against CMV, with ECso values of 301.1 μg/mL, 315.7 μg/mL, 282.3 μg/mL, 230.5 μg/mL, respectively, which were better than that of Dufulin （373.7 μg/mL） and Ribavirin （726.3 μg/mL）. In addition, the fluorescence spectroscopy experiment results showed that compound 3o showed strong combining capacity to tobacco mosaic virus coat orotein.

关键词： Chalcone derivatives6-Chloro-purineAntiviral activityCucumber mosaic virusTobacco mosaic virusInteraction mechanisms

IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro

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World Journal of Gastroenterology 2016年第42期22卷 9368-9377页

作者： Kang Sun Song-Bing He jian-Guo Qu Sheng-Chun Dang ji-xiang chen Ai-Hua Gong Rong Xie jian-Xin Zhang Department of General Surgery The Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China Department of General Surgery The First Affiliated Hospital of Soochow University Zhenjiang 215006 Jiangsu Province China Medical School of jiangsu University Zhenjiang 212013 Jiangsu Province China

AIM To investigate the role of interferon regulatory factor 5(IRF5) in reversing polarization of lung macrophages during severe acute pancreatitis(SAP) in *** A mouse SAP model was established by intraperitoneal(ip) injections of 20 μg/kg body weight caerulein. Pathological changes in the lung were observed by hematoxylin and eosin staining. Lung macrophages were isolated from bronchoalveolar lavage fluid. The quantity and purity of lung macrophages were detectedby fluorescence-activated cell sorting and evaluated by real-time polymerase chain reaction(RT-PCR). They were treated with IL-4/IRF5 specific siR NA(IRF5 siR NA) to reverse their polarization and were evaluated by detecting markers expression of M1/M2 using *** SAP associated acute lung injury(ALI) was induced successfully by ip injections of caerulein, which was confirmed by histopathology. Lung macrophages expressed high levels of IRF5 as M1 phenotype during the early acute pancreatitis stages. Reduction of IRF5 expression by IRF5 siR NA reversed the action of macrophages from M1 to M2 phenotype in vitro. The expressions of M1 markers, including IRF5(S + IRF5 siR NA vs S + PBS, 0.013 ± 0.01 vs 0.054 ± 0.047, P < 0.01), TNF-α(S + IRF5 siR NA vs S + PBS, 0.0003 ± 0.0002 vs 0.019 ± 0.018, P < 0.001), iN OS(S + IRF5 siR NA vs S + PBS, 0.0003 ± 0.0002 vs 0.026 ± 0.018, P < 0.001) and IL-12(S + IRF5 si RNA vs S + PBS, 0.000005 ± 0.00004 vs 0.024 ± 0.016, P < 0.001), were decreased. In contrast, the expressions of M2 markers, including IL-10(S + IRF5 siR NA vs S + PBS, 0.060 ± 0.055 vs 0.0230 ± 0.018, P < 0.01) and Arg-1(S + IRF5 siR NA vs S + PBS, 0.910 ± 0.788 vs 0.0036 ± 0.0025, P < 0.001), were increased. IRF5 si RNA could reverse the lung macrophage polarization more effectively than *** Treatment with IRF5 siR NA can reverse the pancreatitisinduced activation of lung macrophages from M1 phenotype to M2 phenotype in SAP associated with ALI.

关键词： Interferon regulatory factor 5 Macrophage polarization Severe acute pancreatitis SiR NA

1.7-μm dissipative soliton Tm-doped fiber laser

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Photonics Research 2021年第5期9卷 873-878页

作者： ji-xiang chen xiang-YUE LI TI-jiAN LI ZE-YU ZHAN MENG LIU CAN LI AI-PING LUO PU ZHOU KENNETH K-YWONG WEN-chenG XU ZHI-CHAO LUO Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices&Guangzhou Key Laboratory for Special Fiber Photonic Devices and Applications South China Normal UniversityGuangzhou 510006China College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina

We report on the dissipative soliton generation in a 1.7-μm net-normal dispersion Tm-doped fiber laser by nonlinear polarization rotation technique. An intra-cavity bandpass filter was employed to suppress the longwavelength emission, while the cavity dispersion was compensated by a segment of ultrahigh numerical aperture(UHNA4) fiber. The dissipative soliton with a central wavelength of 1746 nm was obtained, covering a spectral range from 1737 nm to 1754 nm. The de-chirped duration and energy of the dissipative soliton were 370 fs and 0.2 nJ, respectively. In addition, the dynamics of multiple dissipative solitons were also investigated. Through optimization of the cavity dispersion, the 50 nm broadband dissipative soliton with de-chirped pulse duration of 230 fs could be achieved. The development of dissipative soliton seed laser represents the first step in achieving the chirped pulse amplification system at the 1.7-μm wave band, which would find potential applications in fields such as biomedical imaging and material processing.

关键词： technique. soliton dissipative

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： chen Li Leilei Liang Baoshan Zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Preparation and Performance of Ternary Early Strength Agent and Quercetin Composite Cement Sealing Material

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 130-140页

作者： LIU jian chen Meiting ji Xiaoli XU Chao WANG Chunmei Department of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China Key Laboratory of Mine Safety and High Efficient Mining Jointly Built by Province and Education Ministry Anhui University of Science and TechnologyHuainan 232001China Department of Chemical Engineering and Explosives Anhui University of Science and TechnologyHuainan 232001China

A ternary early-strengthening agent consisting of calcium formate+triethanolamine+lithium sulfate was compounded with quercetin to shorten the setting time of cementitious materials while ensuring their early *** optimum ratio of the three early-strengthening agents was determined as 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate by response surface *** effects of the ternary early-strengthening agent composed of calcium formate+triethanolamine(TEA)+lithium sulfate on cementitious pore sealing materials under the synergistic effect of quercetin were studied by means of the performance tests of compressive strength,fluidity,and setting time,and the microstructural characterizations of X-ray powder diffractometer(XRD),thermogravimetry(TG-DSC)and scanning electron microscopy(SEM).The study shows that the synergistic effect of ternary early-strengthening agent and quercetin forms a multi-performance composite admixture for cementitious *** best performance was obtained with the compounding scheme of 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate ternary early-strengthening agent and 0.05%*** compressive strength of 1,3,7,and 28 d are 94.8%,39.8%,42%,and 28%higher than those of the blank group,*** initial time and final setting time are 41 and 57 minutes,*** to the microscopic analysis,the network and fibrous C-S-H gels generated by ternary early-strengthening agents are attached to the surface promoted by quercetin,which forms skeleton support while thickening and solidifying the cement slurry,which enhances the early compressive strength of the cement-based materials.

关键词： sealing material ternary early-strengthening agent quercetin synergetic effect response surface methodology

大跨小间距隧道微振钻爆施工及中夹岩振动特性研究

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中国公路学报 2021年第4期34卷 220-230页

作者：季相臣傅洪贤孔恒高宇璠北京交通大学土木建筑工程学院北京100044 中交第二公路勘察设计研究院有限公司湖北武汉430056 北京市政建设集团有限责任公司北京100089

为了减少隧道爆破产生的振动,研究大跨小间距隧道中夹岩的振动特性,依托贵阳市七冲村1号公路隧道工程,依据自由面减振原理对CD法进行优化,提出中夹岩侧上台阶"前后错落3部"同步爆破施工的CD法,并对中夹岩内部围岩的爆破振动进行测试,研... 详细信息

为了减少隧道爆破产生的振动,研究大跨小间距隧道中夹岩的振动特性,依托贵阳市七冲村1号公路隧道工程,依据自由面减振原理对CD法进行优化,提出中夹岩侧上台阶"前后错落3部"同步爆破施工的CD法,并对中夹岩内部围岩的爆破振动进行测试,研究并揭示后行隧道掏槽孔、辅助孔及周边孔爆破时掌子面前后中夹岩内部围岩的振动速度传播规律。研究结果表明:利用增加自由面个数和面积对CD法进行优化,能够保证在施工进度不变的条件下,使5m处围岩的振动速度小于5cm·s-1,有效地减小了爆破振动,实现微振爆破施工;在隧道爆破近区,爆破距离是影响振动速度的主导因素,质点最大振动速度由周边孔单段装药量决定;在隧道爆破中远区,装药量是影响振动速度的主导因素,质点最大振动速度由最大一段装药量决定;无论掏槽孔爆破还是辅助孔及周边孔爆破,掌子面前方中夹岩振动速度都稍大于掌子面后方中夹岩振动速度;掌子面前方岩体的场地系数K大于掌子面后方中夹岩的场地系数K;随着自由面数量的增加,场地系数K及衰减系数α都减小。

关键词：隧道工程微振施工振动测试围岩内部中夹岩