Synthesis and antiviral activities of novel 1,4-pentadien-3-one derivatives bearing an emodin moiety

作     者：Jian Wu Yun-Ying Zhu Yong-Hui Zhao Wei-Li Shan De-Yu Hu Ji-Xiang Chen Deng-Yue Liu Xiang-Yang Li Song Yang 

作者机构：State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of Education Research and Development Center for Fine Chemicals Guizhou University School of Chemical Engineering Guizhou Institute of Technology Institute for the Control of Agrochemicals Ministry of Agriculture 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2016年第27卷第6期

页      面：948-952页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 070303[理学-有机化学] 0904[农学-植物保护] 0703[理学-化学] 

基　　金：assistance from the National Natural Science Foundation of China (No. 21302025) the Special Funds for Training object of Outstanding Young Scientific & Technological Talents in Guizhou Province (No. 2015-15#) the Science & Technology Foundation of Guizhou Province (No. J2056#) 

主　　题：1 4-Pentadien-3-one derivatives Emodin Synthesis Antiviral activity 

摘      要：A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus（TMV） and cucumber mosaic virus（CMV） in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin（409.3 mg/m L）.