Study of the synthesis,antiviral bioactivity and interaction mechanisms of novel chalcone derivatives that contain the 1,1-dichloropropene moiety

作     者：Liang-Run Dong De-Yu Hu Zeng-Xue Wu Ji-Xiang Chen Bao-An Song 

作者机构：State Key Laboratory Breeding Base of Green Pesticide and Agricultural BioengineeringKey Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationResearch and Development Center for Fine ChemicalsGuizhou UniversityGuiyang 550025China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第7期

页      面：1566-1570页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 09[农学] 0904[农学-植物保护] 

基　　金：supported by the National Natural Science Foundation of China(Nos.21362004,21562013) Subsidy Project for Outstanding Key Laboratory of Guizhou Province in China(20154004) 

主　　题：Chalcone derivatives 1 1-Dichloropropene moiety Synthesis Antiviral activity Interaction mechanisms 

摘      要：A series of novel chalcone derivatives that contain the 1,1-dichloropropene moiety was designed and synthesized. Bioactivity assays showed that most of the target compounds exhibited moderate to good antiviral activity against tobacco mosaic virus（TMV） at 500 mg/m L. Among the target compounds,compound 7h showed the highest in vivo inactivation activity against TMV with the EC50 and EC90value of 45.6 and 327.5 mg/m L, respectively, which was similar to that of Ningnanmycin（46.9 and 329.4 mg/m L）and superior to that of Ribavirin（145.1 and 793.1 mg/m L）. Meanwhile, the microscale thermophoresis and fluorescence spectroscopy experiments showed that the compound 7h had a strong interaction with the tobacco mosaic virus coat protein.