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Computer-controlled ultra high voltage amplifier for dielectric elastomer actuators

Biomimetic Intelligence & Robotics 2024年第1期4卷 14-23页

作者： Ardi Wiranata Zebing Mao Yu Kuwajima Yuya yamaguchi Muhammad Akhsin Muflikhun Hiroki Shigemune Naoki Hosoya Shingo Maeda Department of Mechanical and Industrial Engineering University of Gadjah MadaYogyakarta 55281Indonesia Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan Department of Engineering and Science Shibaura Institute of TechnologyTokyo 135-8548Japan Department of Electrical Engineering Shibaura Institute of TechnologyTokyo 135-8548Japan Department of Engineering Science and Mechanics Shibaura Institute of TechnologyTokyo 135-8548Japan Living Systems Materialogy(LiSM)Research Group International Research Frontiers Initiative(IRFI)Tokyo Institute of TechnologyYokohama 226-8501Japan

Soft robotics is a breakthrough technology to support human-robot *** soft structure of a soft robot can increase safety during human and robot *** of the promising soft actuators for soft robotics is dielectric elastomer actuators(DEAs).DEAs can operate silently and have an excellent energy *** simple structure of DEAs leads to the easy fabrication of soft *** simplicity combined with silent operation and high energy density make DEAs interesting for soft robotics *** actuation follows the Maxwell-pressure *** pressure produced in the DEAs actuation depends much on the voltage *** DEAs requires high voltage to gain an *** the power consumption of DEAs is in the milli-Watt range,the current needed to operate the DEAs can be *** commercially available DC-DC converters can convert the volt range to the kV *** order to get a voltage in the 2-3 kV range,the reliable DC-DC converter can be pricy for each *** problem hinders the education of soft actuators,especially for a newcomer laboratory that works in soft electric *** paper introduces an entirely do-it-yourself(DIY)Ultrahigh voltage amplifier(UHV-Amp)for education in soft ***-Amp can amplify 12 V to at a maximum of 4 kV *** a demonstration,we used this UHV-Amp to test a single layer of powdered-based *** strategy to build this educational type UHV-Amp was utilizing a Cockcroft-Walton circuit structure to amplify the voltage range to the kV *** its current state,the UHV-Amp has the potential to achieve approximately 4 *** created a simple platform to control the UHV-Amp from a personal *** near future,we expect this easy control of the UHV-Amp can contribute to the education of soft electric actuators.

关键词： Dielectric elastomer actuators Electric amplifier Soft actuators Soft robotics Soft actuator education

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癌细胞与脂肪组织的相互作用:与乳腺钼靶检查毛刺征的相关性研究

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国际医学放射学杂志 2016年第3期 309-310页

作者： H.Moriuchi j.yamaguchi H.Hayashi H.Ohtani I.Shimokawa H.Abiru 孔祥 Department of Surgery National Hospital OrganizationSaga Hospital

摘要目的探讨乳腺钼靶检查出现毛刺征肿块与组织学检查肿瘤边缘脂肪组织浸润之间的相关性。方法本项回顾性研究得到了伦理审查委员会批准,并免除知情同意书的要求。本研究共纳入了1999—2009年间478例接受手术的浸润性乳腺癌病人。采用l... 详细信息

摘要目的探讨乳腺钼靶检查出现毛刺征肿块与组织学检查肿瘤边缘脂肪组织浸润之间的相关性。方法本项回顾性研究得到了伦理审查委员会批准,并免除知情同意书的要求。本研究共纳入了1999—2009年间478例接受手术的浸润性乳腺癌病人。采用logistic回归模型、Cox比例风险回归模型和Kaplan-Meier法比较乳腺钼靶检查发现毛刺征肿

关键词：乳腺钼靶检查相关性肿块病人脂肪组织浸润毛刺征癌细胞

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Ground-state mass of ^(22)Al and test of state-of-the-art ab initio calculations

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Chinese Physics C 2024年第3期48卷 72-78页

作者：孙铭泽于越王新鹏王猛李健国张玉虎 K.Blaum 陈祖毅陈瑞九邓涵宇付超义葛文文黄文嘉焦红扬李红蕙李宏福罗胤芳廖挺 YuALitvinov 司敏帅鹏史金阳王茜邢元明徐星徐瑚珊许甫荣袁琪 T.yamaguchi 颜鑫亮杨建成原有进周小红周旭张敏曾奇 CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany GSI Helmholtzzentrum für Schwerionenforschung Planckstraße 164291 DarmstadtGermany Advanced Energy Science and Technology Guangdong Laboratory Huizhou516007China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Department of Physics Saitama UniversitySaitama 338-8570Japan School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

The ground-state mass excess of the T_(z)=−2 drip-line nucleus ^(22)Al is measured for the first time as 18103(10)keV using the newly-developed Bρ-defined isochronous mass spectrometry method at the cooler storage ring in *** new mass excess value allowed us to determine the excitation energies of the two low-lying 1+states in ^(22)Al with significantly reduced uncertainties of 51 *** compared to the analogue states in its mirror nucleus ^(22)F,the mirror energy differences of the two 1^(+)states in the ^(22)Al-^(22)F mirror pair are determined to be−625(51)keV and−330(51)*** excitation energies and mirror energy differences are used to test the state-of-the-art ab initio valence-space in-medium similarity renormalization group calculations with four sets of interactions derived from the chiral effective field *** mechanism leading to the large mirror energy differences is investigated and attributed to the occupation of theπs_(1/2) orbital.

关键词： nuclear mass Bρ-defined IMS mirror energy difference ab initio VS-IMSRG calculations chiral interactions

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Arabidopsis CBL-Interacting Protein Kinases Regulate Carbon/Nitrogen-Nutrient Response by Phosphorylating Ubiquitin Liqase ATL31

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Molecular Plant 2017年第4期10卷 605-618页

作者： Shigetaka Yasuda Shoki Aoyama Yoko Hasegawa Takeo Sato junji yamaguchi Faculty of Science and Graduate School of Life Science Hokkaido University Sapporo 060-0810 Japan

In response to the ratio of available carbon （C） and nitrogen （N） nutrients, plants regulate their metabolism, growth, and development, a process called the C/N-nutrient response. However, the molecular basis of C/N-nutrient signaling remains largely unclear. In this study, we identified three CALCINEURIN B-LIKE （CBL）-INTERACTING PROTEIN KINASES （CIPKs）, CIPK7, CIPK12, and CIPK14, as key regulators of the C/N-nutrient response during the post-germination growth in Arabidopsis. Single-knockout mutants of ClPK7, CIPK12, and CIPK14 showed hypersensitivity to high C/low N conditions, which was enhanced in their triple-knockout mutant, indicating that they play a negative role and at least partly function redun- dantly in the C/N-nutrient response. Moreover, these CIPKs were found to regulate the function of ATL31, a ubiquitin ligase involved in the C/N-nutrient response via the phosphorylation-dependent ubiquitination and proteasomal degradation of 14-3-3 proteins. CIPK7, CIPK12, and CIPK14 physically interacted with ATL31, and CIPK14, acting with CBL8, directly phosphorylated ATL31 in a Ca2＋-dependent manner. Further analyses showed that these CIPKs are required for ATL31 phosphorylation and stabilization, which medi- ates the degradation of 14-3-3 proteins in response to C/N-nutrient conditions. These findings provide new insights into C/N-nutrient signaling mediated by protein phosphorylationo

关键词： nutrient response signal transduction ubiquitin ligase protein phosphorylation Arabidopsis

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Investigation of Patients’ Mood on Their Distance from the Pharmacist during Medication Instruction

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Pharmacology & Pharmacy 2023年第5期14卷 145-155页

作者： Saori Gocho Yukina Miyagi Naoko yamaguchi Chika Nakayama Yuka Miyachi Shoshiro Okada Taeyuki Oshima Department of Pharmacy Nagoya Ekisaikai Hospital Nakagawa Nagoya Aichi Japan Graduate School of Medicine Aichi Medical University Nagakute Aichi Japan College of Pharmacy Kinjo Gakuin University Moriyama Nagoya Aichi Japan Department of Pharmacy Gifu University of Medical Science Kani Gifu Japan

Background: Pharmacists must adjust their distance from patients to facilitate communication during interviews and gain their trust. The distance between the patients and the pharmacists varies depending on many factors, such as gender, posture and the patients’ mood. Only a few of these papers have actually measured and validated distance with patients. In this study, we validated our method of assessing mood and measuring distance before beginning a survey with patients. Methods: We measured comfortable interpersonal distance among men and women using an ecological scenario, in which a pharmacist approaches the subject, and the subject is asked to stop the pharmacist at the distance he/she feel comfortable with. Five pharmacists and 33 subjects participated in the study. The japanese version of the Brief Mood Questionnaire Checklists (BMC-j) was used to quantify the subject’s mood for the day, and then the distance from the pharmacist that the subjects considered comfortable was measured at the bedside. The relationship between the mood and distance obtained was examined. Results: The comfortable distance of subjects was influenced by gender, posture, and mood. The shortest distance was 94.7 ± 11.1 cm (mean ± SD), for the male subjects versus the female pharmacists in the sitting position. The distance of male subjects shorted when they had positive emotions and lengthened when they were worried. Female subjects maintained a long distance from both male and female pharmacists when they had positive emotions and a short distance when they were worried. Conclusion: Findings show that the distance changes depending on the subjects’ mood at the time of measurement. It was found that the present measurement method can be used to determine the psychological state of the patient and measure the comfort distance at that time, and can be used as a simple method to examine these relationships. Therefore, it is also considered a practical method for the next step, which is a

关键词： Non-Verbal Communication Personal Space Interpersonal Distance Mood Pharmacist

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Acupuncture improved lipid metabolism by regulating intestinal absorption in mice

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World journal of Gastroenterology 2020年第34期26卷 5118-5129页

作者： jia Han Xin Guo Xiang-jin Meng jing Zhang Reimon yamaguchi Yoshiharu Motoo Sohsuke Yamada Department of Pathology and Laboratory Medicine Kanazawa Medical UniversityIshikawa 920-0293Japan Department of Oncology Kanazawa Medical UniversityIshikawa 920-0293Japan Department of Pathology Kanazawa Medical University HospitalIshikawa 920-0293Japan Department of Dermatology Kanazawa Medical UniversityIshikawa 920-0293Japan

BACKGROUND Non-alcoholic fatty liver disease(NAFLD),in which abnormal lipid metabolism plays an important role in disease progression,has become a *** lipid metabolism,for example an increased fat intake,has been thought to be an initial factor leading to *** small intestine is the main site of dietary lipid absorption.A number of clinical trials have shown that acupuncture has positive effects in the regulation of lipid metabolism,which is closely associated with the progression of *** therefore hypothesized that,acupuncture can improve the conditions of NAFLD by regulating intestinal absorption of *** To study the role of acupuncture treatment in the improvement of metabolic syndrome secondary to NAFLD by mouse *** 8-wk-old male C57BL/6j mice were fed a methionine-and choline-deficient diet for 3 ***,all mice were separated randomly into acupoints group(AG)or non-acupoints group(NG)with high fat diet *** treatment was performed at Zu san li,Guan yuan and Yong quan acupoints as acupuncture treatment to AG mice while non-acupoints place to NG ***,mice were anesthetized with an injection of ketamine-medetomidine and euthanized by *** An apparent improvement of obesity was found in AG mice after acupuncture *** AG mice,the body weight was much lower(22.6±1.2 g vs 28.1±1.0 g,P<0.005)in comparison to NG *** length of small intestine in AG mice was significantly shorter(26.7±2.3 cm vs 32.7±2.7 cm,P<0.005).A large amount of chyme was observed in the lumen of the AG small *** expression of microsomal triglyceride transfer protein,apolipoprotein B and apolipoprotein C2 was ***(TGs),total cholesterol and nonesterified fatty acid(NEFA)levels of the small intestinal tissue were significantly higher in AG mice,but the serum TGs and NEFA levels were reduced in AG *** These results indicate that acupuncture at Zu san li,Guan yuan and

关键词： Acupuncture Non-alcoholic fatty liver disease Small intestine Lipid metabolism Apolipoproteins

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A new approach to transfect NF-κB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method

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International journal of Oral Science 2017年第2期9卷 80-86页

作者： Hiroyuki yamaguchi Yuji Ishida jun Hosomichi jun-ichi Suzuki Risa Usumi-Fujita Yasuhiro Shimizu Sawa Kaneko Takashi Ono Department of Orthodontic Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Advanced Clinical Science and Therapeutics Graduate School of MedicineThe University of TokyoTokyoJapan

The objective of this study is to investigate the effect of the ultrasound-microbubble technique in nuclear factor kappa B(NF-κB) decoy oligodeoxynucleotide(ODN) transfection in the gingival tissue in mice. The 6-FAM-labeled scrambled decoy ODN with microbubbles was applied to the periodontal tissue in 8-week-old male C57BL/6j mice by ultrasound radiation at low(LUM-Sc) and high(HUM-Sc) intensities to optimize the transfection condition of the ultrasound-microbubble *** inspections were performed two hours after transfection to compare the expression with that in the sham-operated group without ultrasound radiation(A-Sc). Then, an NF-κB decoy was transfected into the periodontal tissue using the highintensity ultrasound-microbubble(HUM-NF) technique to examine the anti-inflammatory effects of the decoy ODN. Western blot analysis was performed to investigate the expression of interleukin(IL)-1β, IL-6 and intercellular adhesion molecule-1(ICAM-1)in the gingival tissues in the HUM-Sc, the HUM-NF and control groups. The fluorescence microscopy results showed that the fluorescent intensity in the periodontal tissues in the LUM-Sc and HUM-Sc groups was significantly higher than that in the A-Sc and the control groups. The fluorescent intensity in the HUM-Sc group, especially in the gingival connective tissue,was the highest of all groups. Western blot analysis indicated that the protein expression levels of IL-1β, IL-6 and ICAM-1 in the HUM-NF group were significantly lower than those in the HUM-Sc and the control groups. These findings suggest that the high-intensity ultrasound-microbubble technique is an effective tool for decoy transfection into the periodontal tissue.

关键词： decoy oligodeoxynucleotide gene therapy periodontal tissue ultrasound

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Accelerated chondrogenesis in nanofiber polymeric scaffolds embedded with BMP-2 genetically engineered chondrocytes

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journal of Biomedical Science and Engineering 2010年第9期3卷 908-916页

作者： Robert T. Gorsline Prasam Tangkawattana john j. Lannutti Mamoru yamaguchi Christopher C. Kaeding Alicia L. Bertone 不详

This study evaluated chondrogenesis within a nanofiber polymeric scaffold seeded with isolated untreated chondrocytes, isolated chondrocytes genetically engineered with adenoviral (Ad) bone morphogenetic protein (BMP)-2, or isolated chondrocytes genetically engineered with green fluorescent protein (Ad-GFP). Electrospun polycaprolactone scaffolds (150-200 m thickness, 700 m fiber diameter, 30 m pore size) were optimally seeded with 1 x 107 isolated chondrocytes by using a 20% serum gradient culture system. Chondrocyte-scaffold constructs (untreated, Ad-B- MP-2 and Ad-GFP) were generated from 5 adult horses, cultured in triplicate for 7 or 14 days, and quantitatively analyzed for cell proliferation (DNA content;Hoechst assay), viability, morphology (confocal microscopy), matrix production (proteoglycan content;DMMB assay), and mRNA expression of collagen I, collagen II, and aggrecan. Chondrocytes transduced with Ad-BMP-2 demonstrated greater cell numbers and significantly greater expression of chondrogenic markers including aggrecan, collagen II, and proteoglycan through 14 days of culture as compared to untransduced or Ad-GFP controls. This study demons- trated that chondrocytes can be driven to seed a polycaprolactone nanofiber scaffold by serum gradient and a polycaprolactone nanofiber scaffold containing Ad-BMP2 transduced chondrocytes resulted in grea- ter and accelerated chondrogenesis than controls. This cell engineered construct has potential use in one-step cartilage repair in vivo.

关键词： Nanofiber Scaffold Chondrogenesis BMP- 2 Adenovirus

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The highest efficient module made by a practical concentrator technology

The highest efficient module made by a practical concentrato...

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第十五届国际光伏科学与工程大会

作者： Kenji Araki Hisafumi Uozumi Masafumi yamaguchi Daido Steel Co. Ltd.2-30 Daido-cho Minami Nagoya 457-8545 Japan Toyota Technological Institute 2-12-1 Hisakata Tempaku Nagoya 468-8511 Japan

The highest-efficiency PV module has been developed. The efficiency record for PV modules published in 1996 by UNSW Australia, achieved by the PERL mono-crystalline silicon solar cells, has been updated after 9 years. This achievement has been done by 550X and 400X (geometrical concentration ratio) concentrator PV modules. Other two companies succeeded to demonstrate high efficiency around 28%, followed by that CPV module developed by Daido Steel. All these three companies used (1)III-V 3j cell, (2) PMMA Fresnel lens, and (3) Inverted pyramid secondary optical element. These are the keys to high efficiency. Detailed technical discussion is done in the paper.

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步行6min负荷超声心动图预测结缔组织病患者远期显性肺高血压

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中华高血压杂志 2015年第10期23卷 987-988页

作者： Kusunose K Yamada H Hotchi j Bando M Nishio S Hirata Y Ise T yamaguchi K Yagi S Soeki T Wakatsuki T Kishi j Sata M 曲浥晨机构不详

肺高血压是结缔组织病（connective tissue disease,CTD）的主要死因。运动负荷试验已用于筛查早期肺高血压[1],但由于缺乏相关证据,最新的指南已停止其作为发现肺高血压的方法。近期研究发现平均肺动脉压（mean pulmonary arterial pre... 详细信息

肺高血压是结缔组织病（connective tissue disease,CTD）的主要死因。运动负荷试验已用于筛查早期肺高血压[1],但由于缺乏相关证据,最新的指南已停止其作为发现肺高血压的方法。近期研究发现平均肺动脉压（mean pulmonary arterial pressure,mPAP）升高导致心输出量异常可用于评估肺高血压进展及肺功能分级[2]。该研究将步行6min后的超声心动图参数作为非侵入性负荷试验。

关键词：负荷超声心动图 in 运动负荷试验平均肺动脉压心输出量 connective 结缔组织病左心室射血分数肺功能分级肺毛细血管楔压

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