Acupuncture improved lipid metabolism by regulating intestinal absorption in mice
作者机构：Department of Pathology and Laboratory MedicineKanazawa Medical UniversityIshikawa 920-0293Japan Department of OncologyKanazawa Medical UniversityIshikawa 920-0293Japan Department of PathologyKanazawa Medical University HospitalIshikawa 920-0293Japan Department of DermatologyKanazawa Medical UniversityIshikawa 920-0293Japan
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2020年第26卷第34期
页 面：5118-5129页
核心收录：
学科分类：1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学]
基 金：the Grants-in-Aid for Scientific Research,No.19K16783 the Ministry of Education,Culture,Sports,Science and Technology,Tokyo,Japan,No.20K07454 and No.20K17363 Grant for Promoted Research from Kanazawa Medical University,No.S2018-6
主 题：Acupuncture Non-alcoholic fatty liver disease Small intestine Lipid metabolism Apolipoproteins
摘 要：BACKGROUND Non-alcoholic fatty liver disease(NAFLD),in which abnormal lipid metabolism plays an important role in disease progression,has become a *** lipid metabolism,for example an increased fat intake,has been thought to be an initial factor leading to *** small intestine is the main site of dietary lipid absorption.A number of clinical trials have shown that acupuncture has positive effects in the regulation of lipid metabolism,which is closely associated with the progression of *** therefore hypothesized that,acupuncture can improve the conditions of NAFLD by regulating intestinal absorption of *** To study the role of acupuncture treatment in the improvement of metabolic syndrome secondary to NAFLD by mouse *** 8-wk-old male C57BL/6J mice were fed a methionine-and choline-deficient diet for 3 ***,all mice were separated randomly into acupoints group(AG)or non-acupoints group(NG)with high fat diet *** treatment was performed at Zu san li,Guan yuan and Yong quan acupoints as acupuncture treatment to AG mice while non-acupoints place to NG ***,mice were anesthetized with an injection of ketamine-medetomidine and euthanized by *** An apparent improvement of obesity was found in AG mice after acupuncture *** AG mice,the body weight was much lower(22.6±1.2 g vs 28.1±1.0 g,P0.005)in comparison to NG *** length of small intestine in AG mice was significantly shorter(26.7±2.3 cm vs 32.7±2.7 cm,P0.005).A large amount of chyme was observed in the lumen of the AG small *** expression of microsomal triglyceride transfer protein,apolipoprotein B and apolipoprotein C2 was ***(TGs),total cholesterol and nonesterified fatty acid(NEFA)levels of the small intestinal tissue were significantly higher in AG mice,but the serum TGs and NEFA levels were reduced in AG *** These results indicate that acupuncture at Zu san li,Guan yuan and
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