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新型悬臂式掘进机横轴截割头的研制

煤矿机械 2025年第1期46卷 60-62页

作者：董良中国煤炭科工集团太原研究院有限公司太原030006 煤矿采掘机械装备国家工程实验室太原030006 山西天地煤机装备有限公司太原030006

作为煤矿采掘机械中破岩落煤的关键部件,横轴式截割头相比纵轴式截割头在硬岩截割时具有更好的破岩效率和适应性。相比山特维克AhM105横轴截割头结构,通过在联接结构、头体结构、齿座结构、大端结构等方面的创新,采用八方结构联接、前... 详细信息

作为煤矿采掘机械中破岩落煤的关键部件,横轴式截割头相比纵轴式截割头在硬岩截割时具有更好的破岩效率和适应性。相比山特维克AhM105横轴截割头结构,通过在联接结构、头体结构、齿座结构、大端结构等方面的创新,采用八方结构联接、前后截割头体结合防剪切销组焊、j形坡口齿座、一体化耐磨头体大端等结构,成功研制了新型悬臂式掘进机横轴截割头,通过井下应用验证了该截割头在截割全岩过程中具有较高的可靠性和稳定性。研究内容为横轴式截割头的研发和创新提供了参考,具有一定的实用和推广价值。

关键词：悬臂式掘进机横轴式截割头研制

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再生碳纤维对机场跑道导电混凝土性能的影响

合成纤维 2025年第1期54卷 78-81页

作者：沙东周口市住房保障和房地产业发展中心河南周口466000

对废旧碳纤维进行机械处理回收,用其制备了一种环保型导电混凝土,并通过抗压强度、抗折强度、电热试验以及融冰融雪能力试验对其进行性能评价。结果表明:当再生碳纤维体积分数为3.0%时,导电混凝土的抗压强度与抗折强度均达到峰值,7、28 ... 详细信息

对废旧碳纤维进行机械处理回收,用其制备了一种环保型导电混凝土,并通过抗压强度、抗折强度、电热试验以及融冰融雪能力试验对其进行性能评价。结果表明:当再生碳纤维体积分数为3.0%时,导电混凝土的抗压强度与抗折强度均达到峰值,7、28 d抗压强度分别为33.72、42.57 MPa;7、28 d抗折强度分别为5.03、6.38 MPa;随着再生碳纤维体积分数的不断增加,导电混凝土的电热效率与融冰融雪能力快速提高,在模拟融冰融雪试验中,120 min后温度升高到1.9℃,温升速率达0.12K/min。

关键词：再生碳纤维机场路面导电混凝土

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： haoqi Sun Shiqian Shen Robert j.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Unusually thick shear-softening surface of micrometer-size metallic glasses

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The Innovation 2021年第2期2卷 174-182页

作者： j.dong Y.huan B.huang j.Yi Y.h.Liu B.A.Sun W.h.Wang h.Y.Bai Institute of Physics Chinese Academy of SciencesBeijing 100190China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Nonlinear Mechanics(LNM) Institute of MechanicsChinese Academy of SciencesBeijing 100190China Institute of Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Songshan Lake Materials Laboratory DongguanGuangdong 523808China

The surface of glass is crucial for understanding many fundamental processes in glassy solids.A common notion is that a glass surface is a thin layer with liquid-like atomic dynamics and a thickness of a few tens of ***,we measured the shear modulus at the surface of both millimeter-size and micrometer-size metallic glasses(MGs)through high-sensitivity torsion *** found a pronounced shear-modulus softening at the surface of *** with the bulk,the maximum decrease in the surface shear modulus(G)for the micro-scale MGs reaches~27%,which is close to the decrease in the G upon glass transition,yet it still behaves ***,the surface thickness estimated from the shear-modulus softening is at least 400 nm,which is approximately one order of magnitude larger than that revealed from the glass *** unusually thick surface is also confirmed by measurements using X-ray nano-computed tomography,and this may account for the brittle-to-ductile transition of the MGs with size *** unique and unusual properties at the surface of the micrometer-size MGs are physically related to the negative pressure effect during the thermoplastic formation process,which can dramatically reduce the density of the proximate surface region in the supercooled liquid state.

关键词： glass surface shear modulus torsion metallic glasses

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.E.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. however, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Analysis of the generation mechanism of the S-shaped j–V curves of MoS_(2)/Si-based solar cells

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Chinese Physics B 2022年第3期31卷 608-612页

作者： he-ju Xu Li-Tao Xin dong-Qiang Chen Ri-dong Cong Wei Yu College of Science North China University of Science and TechnologyTangshan 063009China College of Physics Science and Technology Hebei UniversityBaoding 071002China

Amorphous–microcrystalline MoS_(2)thin films are fabricated using the sol-gel method to produce MoS_(2)/Si-based solar cells. The generation mechanisms of the S-shaped current density–voltage(j–V) curves of the solar cells are analyzed. To improve the performance of the solar cells and address the problem of the S-shaped j–V curve, a MoS_(2)film and a p^(+) layer are introduced into the front and back interfaces of the solar cell, respectively, which leads to the formation of a p–n junction between the p-Si and the MoS_(2)film as well as ohmic contacts between the MoS_(2)film and the ITO, improving the S-shaped j–V curve. As a result of the high doping characteristics and the high work function of the p^(+) layer, a high–low junction is formed between the p;and p layers along with ohmic contacts between the p;layer and the Ag electrode. Consequently,the S-shaped j–V curve is eliminated, and a significantly higher current density is achieved at a high voltage. The device exhibits ideal p–n junction rectification characteristics and achieves a high power-conversion efficiency(CE) of 7.55%. The findings of this study may improve the application of MoS_(2)thin films in silicon-based solar cells, which are expected to be widely used in various silicon-based electronic and optical devices.

关键词： MoS_(2)/Si-based solar cell S-shaped j–V curve power conversion efficiency p^(+)layer

Sonic hedgehog signaling in kidney fibrosis: a master communicator

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Science China(Life Sciences) 2016年第9期59卷 920-929页

作者： dong Zhou Roderick j.Tan Youhua Liu Department of Pathology University of Pittsburgh School of Medicine Department of Medicine University of Pittsburgh School of Medicine State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Nanfang Hospital Southern Medical University

The hedgehog signaling cascade is an evolutionarily conserved pathway that regulates multiple aspects of embryonic development and plays a decisive role in tissue homeostasis. As the best studied member of three hedgehog ligands, sonic hedgehog(Shh) is known to be associated with kidney development and tissue repair after various insults. Recent studies uncover an intrinsic link between dysregulated Shh signaling and renal fibrogenesis. In various types of chronic kidney disease(CKD), Shh is upregulated specifically in renal tubular epithelium but targets interstitial fibroblasts, thereby mediating a dynamic epithelialmesenchymal communication(EMC). Tubule-derived Shh acts as a growth factor for interstitial fibroblasts and controls a hierarchy of fibrosis-related genes, which lead to the excessive deposition of extracellular matrix in renal interstitium. In this review, we recapitulate the principle of Shh signaling, its activation and regulation in a variety of kidney diseases. We also discuss the potential mechanisms by which Shh promotes renal fibrosis and assess the efficacy of blocking this signaling in preclinical settings. Continuing these lines of investigations will provide novel opportunities for designing effective therapies to improve CKD prognosis in patients.

关键词： Sonic hedgehog Gli tubular cells fibroblast renal fibrosis

Residual Stress Improved by Water jet Peening for A Quenched Gear

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材料热处理学报 2004年第5期25卷 502-507页

作者： dong-Yingju h.Tsuda Vincentji T.Uchiyama R.Oba DepartmentofMaterialScienceandEngineering SaitamaInstituteofTechnologyFusaiji1690Okabe369-0293SaitamaJapan ExperimentandAnalysisDept. SUZUKIMOTORCo.Hamamatsu-nishi1432-8611Japan LM3 ENSAMUniversity151Boulevarddel＇Hopital75013ParisFrance high-TechResearchCenter SaitamaInstituteofTechnologyJapan

In this paper, a running cost is cheap from the thing used for harmless peening treatment to the environment, health which an influence is rare in toward processing material like heat being only water fundamentally, and economical, and the characteristics is hard to get are given. There is some research about the residual stress improvement by water-jet peening during the high-speed water. In this study, a big bubble cloud ceremony water-jet peening which dissolves the problem of the form of the applicable thing by exposing the whole of the applicable thing in the big bubble cloud as the way of dealing with peening efficiently in a short time is proposed by this research. Moreover, the uniform compression residual stress is added around the surface of the processing side, and connected with the remarkable improvement of the fatigue strength of the part. Furthermore, and safety processing is very possible, and it thinks about the thing which has possible high practical use, and writers to get rid of the problems of the way of processing it with peening until now. Water-jet peening was given by this research during high-speed water with big bubble cloud-type water toward tooth gear manufactured by SCr420h3 V2 to open the effect of water-jet peening during the high-speed water. A change was measured at the time as the sutra of the residual stress on the surface of the test settlement by the X-ray method, and the validity of this law was verified.

关键词：喷水喷丸处理残留应力淬火齿轮

Plasma density measurement and downstream etching of silicon and silicon oxide in Ar/NF3 mixture remote plasma source

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Plasma Science and Technology 2019年第6期21卷 52-57页

作者： h j YEOM D h ChOI Y S LEE j h KIM D j SEONG S j YOU h C LEE Korea Research Institute of Standards and Science(KRISS) Daejeon 34113 Republic of Korea Department of Physics Chungnam National University Daejeon 34134 Republic of Korea

In this study,plasma density measurements were performed near the plume region of the remote plasma source (RPS) in Ar/NF3 gas mixtures using a microwave cutoff *** measured plasma density is in the range of 1010-1011 cm-3 in the discharge conditions with RPS powers of 2-4 kW and gas pressures of 0.87-4 *** plasma density decreased with increasing gas pressures and RPS powers under various Ar/NF3 mixing *** decrease in the plasma density measured at the fixed measurement position (plume region) can be understood by the reduction of the electron energy relaxation length with increases in the gas pressures and mixing ratio of NF3/(Ar/NF3).We also performed downstream etching of silicon and silicon oxide films in this *** etch rate of the silicon films significantly increases while the silicon oxide is slightly etched with the gas pressures and *** was also found that the etch rate strongly depends on the wafer position on the processing chamber electrode,and that the etch selectivity reached 96-131 in the discharge conditions of RF powers (3730-4180 W) and gas pressures (3.6-4 Torr).

关键词： remote plasma source electron density cutoff probe downstream etch