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Molecular Plant 2020年第10期13卷 1341-1344页

作者： Susan McCouch Zahra Katy Navabi Michael Abberton Noelle L.Anglin Rosa Lia Barbieri Michael Baum Kirstin Bett Helen Booker Gerald L.Brown Glenn j.Bryan Luigi Cattivelli David Charest Kellye Eversole Marcelo Freitas Kioumars Ghamkhar Dario Grattipaglia Robert Henry Maria Cleria Valadares Inglis Tofazzal Islam Zakaria Kehel Paul j.Kersey Graham j.King Stephen Kresovich Emily Marden sean Mayes Marie Noelle Ndjiondjiop Henry T.Nguyen Samuel Rezende Paiva Roberto Papa Peter W.B.Phillips Awais Rasheed Christopher Richards Mathieu Flouard Maria jose Amstalden Sampaio Uwe Scholz Paul D.Shaw Brad Sherman S.Evan Staton Nils Stein jan Svensson Mark Tester jose Francisco Montenegro Valls Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter Wenzl Loren H.Rieseberg Plant Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida La Molina Lima Peru 12Lima 15023Peru Embrapa Genetic Resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural Research in the Dry Areas(I CAR DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Department of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Department of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The james Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genome British Columbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat Genome Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation Lab for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,improved farm management,synthetic agrochemicals,and agricultural *** this"Green Revolution"intensified crop production,and is credited with reducing famine and malnutrition,its benefits were accompanied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stemming from increased monoculture and greater reliance on a smaller number of crops and crop varieties for the majority of our *** reduction in diversity has created vulnerabilities to pest and disease epidemics,climate variation,and ultimately to human health(Harlan,1972).

关键词： intensified crops agricultural

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Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols

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Horticulture Research 2019年第1期6卷 444-455页

作者： Kendra AMcClure YuiHui Gong jun Song Melinda Vinqvist-Tymchuk Leslie Campbell Palmer Lihua Fan Karen Burgher-MacLellan ZhaoQi Zhang jean-Marc Celton Charles FForney ZoëMigicovsky sean Myles Department of Plant and Animal Sciences Faculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada Agriculture and Agri-Food Canada Kentville Research and Development CentreKentvilleNS B4N 1J5Canada College of Horticulture South China Agriculture UniversityGuangzhou 510642China IRHS Agrocampus-OuestINRAUniversitéd’AngersSFR 4207 QuaSaVBeaucouzéFrance

Apples are a nutritious food source with significant amounts of polyphenols that contribute to human health and wellbeing,primarily as dietary *** numerous pre-and post-harvest factors can affect the composition of polyphenols in apples,genetics is presumed to play a major role because polyphenol concentration varies dramatically among apple *** we investigated the genetic architecture of apple polyphenols by combining high performance liquid chromatography(HPLC)data with~100,000 single nucleotide polymorphisms(SNPs)from two diverse apple *** found that polyphenols can vary in concentration by up to two orders of magnitude across cultivars,and that this dramatic variation was often predictable using genetic markers and frequently controlled by a small number of large effect genetic *** GWAS,we identified candidate genes for the production of quercitrin,epicatechin,catechin,chlorogenic acid,4-O-caffeoylquinic acid and procyanidins B1,B2,and *** observation that a relatively simple genetic architecture underlies the dramatic variation of key polyphenols in apples suggests that breeders may be able to improve the nutritional value of apples through markerassisted breeding or gene editing.

关键词： effect apple cultivar

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A mimic of soft tissue infection: intra-arterial injection drug use producing hand swelling and digital ischemia

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World journal of Emergency Medicine 2015年第3期6卷 233-236页

作者： sean D.Foster Michael S.Lyons Christopher M.Runyan Edward j.Otten Department of Emergency Medicine University of Cincinnati Department of Plastic Reconstructive & Hand Surgery University of Cincinnati

BACKGROUND: Inadvertent intra-arterial injection of illicit substances is a known complication of injection drug use and can lead to severe complications, including infection, ischemia and compartment syndrome. Identifying complications of intra-arterial injection can be difficult, as clinical manifestations overlap with other more common conditions such as cellulitis and soft tissue infection, and a history of injection drug use is frequently not ***: A 37-year-old male patient presented with 24 hours of right hand pain, erythema and swelling. Despite classic "track marks", he denied a history of injection drug use, and vascular insults were not initially considered. After failing to respond to three days of aggressive treatment for suspected deep-space infection, an arteriogram demonstrated findings consistent with digital ischemia of embolic ***: As a result of the delay in diagnosis, the lesion was not amenable to reperfusion and the patient required amputation of the distal ***: Practitioners should be alert to the possibility of intra-arterial injection and resulting complications when evaluating unusual extremity infections or unexplained ischemic symptoms, even in the absence of a definite history of injection drug use.

关键词： Intra-arterial injection Opioid abuse Injection drug use Digital ischemia

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肺动脉高压启动治疗后血流动力学指标的预后价值

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中华高血压杂志 2017年第11期25卷 1011-1011页

作者：黄洁叶鹏 Weatherald j Boucly A Chemla D Savale L Peng M jevnikar M ja?s X Taniguchi Y O'Connell C Parent F Sattler C Hervé P Simonneau G Montani D humbert M Adir Y Sitbon O

血流动力学指标，如心脏指数和右心房压力（right atrial pressure，RAP）与患者确诊肺动脉高压时的生存率持续相关。近期研究表明，肺动脉顺应性（pulmon aryarterial compliance，Pea）也可能预测肺动脉高压的预后。而在治疗开始之后... 详细信息

血流动力学指标，如心脏指数和右心房压力（right atrial pressure，RAP）与患者确诊肺动脉高压时的生存率持续相关。近期研究表明，肺动脉顺应性（pulmon aryarterial compliance，Pea）也可能预测肺动脉高压的预后。而在治疗开始之后测定的血流动力学指标对预后的价值还未确定。

关键词：血流动力学指标肺动脉高压预后价值治疗肺动脉顺应性右心房压力心脏指数生存率

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夏威夷衬衫

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中学生英语 2023年第5期 18-21页

作者： joseph j.Mazzella 长庚(选择) 不详

没过多久,卡伊和肖恩就成了我们邻里间的常客。我女儿、儿子和我经常去拜访他们。卡伊总是准备蛋糕给我们吃,还会分享一些知心话。虽然卡伊不是夏威夷本地人,但她也喜欢夏威夷文化和“阿罗哈精神”。她年轻时是一名舞者,送给我了一件夏... 详细信息

没过多久,卡伊和肖恩就成了我们邻里间的常客。我女儿、儿子和我经常去拜访他们。卡伊总是准备蛋糕给我们吃,还会分享一些知心话。虽然卡伊不是夏威夷本地人,但她也喜欢夏威夷文化和“阿罗哈精神”。她年轻时是一名舞者,送给我了一件夏威夷衬衫作为礼物。尽管它对于我的大肚子来说太小了,但当我去看望她和肖恩时,我还是经常穿着它。

关键词：夏威夷衬衫肖恩本地人阿罗哈

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Apple whole genome sequences:recent advances and new prospects

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Horticulture Research 2019年第1期6卷 1247-1270页

作者： Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel sean Myles ZoëMigicovsky Robert j.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook jung Stijn Vanderzande Department of Horticulture Washington State UniversityPullmanWA 99164USA Computational Biology Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Department of Genomics and Biology of Fruit Crops Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Plant Breeding Wageningen University and ResearchWageningen 6708PBThe Netherlands Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institut für Biologie und Umweltwissenschaften Carl von Ossietzky Universität26129 OldenburgGermany GQE-Le Moulon Institut National de la Recherche AgronomiqueUniversity of Paris-SudCNRSAgroParisTechUniversitéParis-Saclay91190 Gif-sur-YvetteFrance Institut National de la Recherche Agronomique Institut de Recherche en Horticulture et SemencesUMR 134549071 BeaucouzéFrance Department of Plant Food and Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada The New Zealand Institute for Plant and Food Research Ltd Motueka 7198New Zealand School of Biological Sciences University of AucklandAuckland 1142New Zealand AGAP INRACIRADMontpellier SupAgroUniversity of MontpellierMontpellierFrance Plant Genetic Resources Unit USDA ARSGenevaNY 14456USA Laboratory of Pomology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Department of Horticulture Michigan State UniversityEast LansingMI 48824USA The New Zealand Institute for Plant and Food Research Ltd(Plant&Food Research) Palmerston North Research CentrePalmerston North 4474New Zealand College of Horticulture China Agricultural University100193 BeijingChina Agroscope 8820 WädenswilSwitzerland Queensland Alliance of Agriculture and Food Innovation University of QueenslandSt Lucia 4072Australia New Cultivar Innovation Plant and Food ResearchHavelock North 4130New Zealand Agroscope 1260 ChanginsSwitzerland

In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for *** the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued *** gene identities for phenotypes of fundamental and practical interest can today be discovered much more ***-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and ***-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for *** understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild *** WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple *** review includes examples of basic and practical breakthroughs and challenges in using the apple *** for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple.

关键词： breakthrough hundreds frontier

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肺动脉高压患者骨形态发生蛋白受体2突变

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中华高血压杂志 2016年第3期24卷 299-299页

作者： Van Der Bruggen CE Happé CM Dorfmüller P Trip P Spruijt OA Rol N Hoevenaars F Houweling AC Girerd B Marcus jT Mercier O humbert M Handoko ML Van Der Velden j Vonk Noordegraaf A Bogaard Hj Goumans Mj de Man FS 刘莉叶鹏

骨形态发生蛋白受体2（bone morphogenetic protein receptor 2,BMPR2）基因突变对肺动脉高压（pulmonary arterial hypertension,PAH）患者右心室压力负荷的影响尚未知。研究人员通过体内功能检查联合右、左心室分子与组织学分析,对伴... 详细信息

骨形态发生蛋白受体2（bone morphogenetic protein receptor 2,BMPR2）基因突变对肺动脉高压（pulmonary arterial hypertension,PAH）患者右心室压力负荷的影响尚未知。研究人员通过体内功能检查联合右、左心室分子与组织学分析,对伴或不伴BMPR2突变的PAH患者的右心室功能进行评估。方法与结果：纳入原发性或家族性PAH患者95例进行基因筛选,结果示28例患者存在BMPR2突变,67例无突变。应用右心导管术和心脏核磁共振检测。

关键词：骨形态发生蛋白受体基因突变肺动脉高压患者 hypertension 受体2 receptor arterial

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皮肤MRI的可行性研究

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国际医学放射学杂志 2009年第5期32卷 504-504页

作者： S.Aubry C.Casile P.humbert j.jehl C.Vidal B.Kastler 白荣杰 Service de Radiologie A CHU Jean MinjozBoulevard Flemming25030 Besanon CedexFrance

本研究的目的是评价皮肤3TMRI的质量，阐述皮肤的3TMR解剖，讨论皮肤MRI的应用前景。为3TMRI系统研制了一个7cm单码元表面接收线圈，利用三维FIESTA采集序列和自旋回波T1加权序列（SE T1）获得薄层影像。36名健康志愿者被纳入研究并接... 详细信息

本研究的目的是评价皮肤3TMRI的质量，阐述皮肤的3TMR解剖，讨论皮肤MRI的应用前景。为3TMRI系统研制了一个7cm单码元表面接收线圈，利用三维FIESTA采集序列和自旋回波T1加权序列（SE T1）获得薄层影像。36名健康志愿者被纳入研究并接受面部和小腿部的MRI检查．所获得影像由2位放射医师2次独立进行前瞻性分析。根据皮肤层次的显示与伪影的量评价影像质量。

关键词：皮肤成像 MRI 3T 正常可行性与质量研究

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ADVANCED jAVA 2 PLATFORM HOW TO PROGRAM

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丛书名：国外计算机科学教材系列

2004年

作者： HARVEY M.DEITEL PAUL j.DEITEL

来源：畅想之星图书光盘版（南... 评论

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改进实效型试验的报告质量：CONSORT声明的扩充（1）

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英国医学杂志中文版 2009年第2期12卷 108-111页

作者： Merrick Zwarenstein Shaun Treweek joel j Gagnier Douglas G Altman sean Tunis Brian Haynes Andrew D Oxman David Moher 汪谋岳(译) Health Services Sciences Sunnybrook Hospital Toronto Ontario Canada Institute for Clinical Evaluative Sciences Toronto Depamnent of Health Policy Management and Evaluation University of Toronto Toronto Division of International Health (IHCAR) Karolinska Institute Stockholm Sweden Clinical and Population Sciences and Education University of Dundee Dundee Norwegian Knowledge Centre for the Health Services Oslo Norway Faculty of Medicine University of Toronto Centre for Statistics in Medicine University of Oxford Oxford Center for Medical Technology Policy Baltimore MD USA Division of General Internal Medicine Johns Hopkins School of Medicine Baltimore MD Center for Heahhcare Policy Stanford University School of Medicine Palo Alto CA USA Department of Clinical Epidemiology and Biostatistics and Department of Medicine McMaster University Faculty of Health Sciences Hamilton ON Canada Clinical Epidemiology Program Ottawa Health Research Institute Ottawa Canada Department of Epidemiology and Community Medicine Faculty of Medicine University of Ottawa Ottawa 中华医学杂志英文版编辑部

实效型试验旨在为临床实践决策提供依据，但报告得不好会降低其实用性。CONSORT和Practihc小组描述了对CONSORT指南的修改，帮助读者评估研究结果的适用性。

关键词： CONSORT声明报告质量试验临床实践适用性

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