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光谱学与光谱分析 2018年第6期38卷 1970-1974页

作者： jong-Moon kim Myung Duk jang jIN Biao Yoon jung jang Department of Health Care and Biotechnology Kyungwoon UniversityGumi CityGyeong-buk 730-739Republic of Korea Materials & Energy Engineering College of IT & Energy Kyungwoon UniversityGumi CityGyeong-buk 730-739Republic of Korea Instrumental

The effect of various metal ions on the DNA mediated energy transfer between simultaneously bound drugs was investigated using spectroscopic *** was found that addition of divalent metal ions(Mg^(2+),Ca^(2+),Mn^(2+),Co^(2+)and Ni^(2+))resulted in further decrease of the ethidium fluorescence intensity,while a small increase was observed in the TMPyP emission band,implying that the energy of excited ethidium was transferred to *** DNA-mediated quenching efficiency between ethidium and TMPyP was significantly enhanced by the presence of all metal *** the divalent metal ions,alkali earth metal ions and Mn^(2+)displayed higher quenching efficiencies than other transition metal *** distances required to permit the energy transfer between the two drugs in DNA were calculated as 68,66,62,48and 38in the presence of100μmol·L^(-1 )of Mg^(2+),Ca^(2+),Mn^(2+),Co^(2+)and Ni ^(2+)ion,*** disturbed binding conformation of TMPyP in DNA by metal ions presumably accounts for the difference.

关键词：光学文摘英文

Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in korea:A nationwide retrospective cohort

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journal of Integrative Medicine 2023年第2期21卷 176-183页

作者： Hyejin jung Tiana Won Ga-Yeon kim jowon jang Sujung Yeo Sabina Lim Department of Meridian&Acupoint College of Korean MedicineKyung Hee UniversitySeoul02447Republic of Korea WHO Collaborating Center for Traditional Medicine East-West Medical Research InstituteKyung Hee UniversitySeoul02447Republic of Korea Department of Meridian and Acupoint College of Korean MedicineSang Ji UniversityWonju26339Republic of Korea

Objective The main aim of this study is to investigate whether acupuncture could be an effective complementary treatment for reducing the risk of macrovascular complications in diabetic patients currently taking antidiabetic medications using a nationwide population-based *** We conducted a retrospective cohort study to assess the efficacy of acupuncture on cardiovascular complications in diabetic patients using data from patients between 40 and 79 years of age,newly diagnosed with diabetes between 2003 and 2006,found in the National Health Insurance Service-National Sample Cohort(NHIS-NSC)in *** the data,we identified 21,232 diabetic patients who were taking antidiabetic medication between 2003 and *** selected patients were divided into two groups-those who received acupuncture at least three times and those who received no acupuncture(non-acupuncture)in the year following their diagnosis of *** 1:1 propensity score matching(PSM),each group had 3350 patients,and the observation ceased at the occurrence of a major adverse cardiovascular event(MACE),which was defined as either myocardial infarction,stroke,or death due to cardiovascular *** After PSM,the acupuncture group had a lower incidence of MACE(hazard ratio[HR]:0.87;95%confidence interval[CI]:0.81-0.94;P=0.0003)and all-cause mortality(HR:0.77;95%CI:0.70-0.84;Pke-related mortality(HR:0.75;95%CI:0.56-1.00;P=0.0485),ischemic heart disease mortality(HR:0.53;95%CI:0.34-0.84;P=0.006)and circulatory system disease mortality(HR:0.67;95%CI:0.55-0.82;Pk of MACE,all-cause mortality and cardiovascular *** population-based retrospective study suggests beneficial effects of acupuncture in preventing macro

关键词： Acupuncture Diabetes Major adverse cardiovascular event Myocardial infarction Stroke Macrovascular complication

Complications of common bile duct stones: A risk factors analysis

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 361-365页

作者： Dong jun Oh ji Hyung Nam Dong kee jang jun kyu Lee Department of Internal Medicine Dongguk University Ilsan HospitalGoyang 10326Korea

Background: The latest guidelines recommended that common bile duct stones(CBDSs) should be removed, preferably endoscopically, regardless of the presence of symptoms or complications. However, the removal of CBDSs may not be feasible in very old patients or those with co-morbidities. In these cases, it is important to understand the risk factors for the development of CBDSs-related complications to decide whether or not to treat high-risk patients. Herein, we aimed to identify the risk factors for the development of complications after the diagnosis of CBDSs. Methods: The medical records of patients with CBDSs between October 2005 and September 2019 were retrospectively analyzed. All patients with radiologically-diagnosed CBDSs, including those who received treatment and those who did not, were analyzed. Results: A total of 634 patients were included and 95(15.0%) patients had CBDS-related complications during the mean follow-up period of 32.6 months. Forty-four(6.9%) high-risk patients remained asymptomatic and did not receive treatment during the follow-up period. In multivariate analyses, size of CBDSs ≥ 5 mm and no treatment within 30 days were independent risk factors for the development of complications. The spontaneous passage of CBDSs was proved radiologically in 9 out of 81(11.1%) patients within 30 days. Conclusions: It is recommended treating CBDSs within 30 days from the diagnosis, even in high-risk patients, especially if the size is larger than 5 mm.

关键词： Common bile duct stone Risk factors Obstructive jaundice Pancreatitis Cholangitis

Effect of citrulline on post-exercise rating of perceived exertion,muscle soreness,and blood lactate levels:A systematic review and meta-analysis

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journal of Sport and Health Science 2020年第6期9卷 553-561页

作者： Hye Chang Rhim Sung jong kim jewel Park ki-Mo jang College of Medicine Korea UniversitySeoul 02842Republic of Korea Department of Orthopaedic Surgery Anam HospitalKorea University College of MedicineSeoul 02841Republic of Korea

Background:Citrulline is one of the non-essential amino acids that is thought to improve exercise performance and reduce post-exercise muscle *** conducted a systematic review and meta-analysis to determine the effect of citrulline supplements on the post-exercise rating of perceived exertion(RPE),muscle soreness,and blood lactate ***:A random effects model was used to calculate the effect sizes due to the high variability in the study design and study populations of the articles included.A systematic search of PubMed,Web of Science,and *** was *** for study inclusion was limited to studies that were randomized controlled trials involving healthy individuals and that investigated the acute effect of citrulline supplements on RPE,muscle soreness,and blood lactate *** supplementation time frame was limited to 2 h before *** types and number of participants,types of exercise tests performed,supplementation protocols for L-citrulline or citrulline malate,and primary(RPE and muscle soreness)and secondary(blood lactate level)study outcomes were extracted from the identified ***:The analysis included 13 eligible articles including a total of 206 *** most frequent dosage used in the studies was 8 g of citrulline *** supplementation significantly reduced RPE(n=7,p=0.03)and muscle soreness 24-h and 48-h after post-exercise(n=7,p=0.04;n=6,p=0.25,respectively).However,citrulline supplementation did not significantly reduce muscle soreness 72-h post-exercise(n=4,p=0.62)or lower blood lactate levels(n=8,p=0.17).Conclusion:Citrulline supplements significantly reduced post-exercise RPE and muscle soreness without affecting blood lactate levels.

关键词： Amino acids Dietary supplements Ergogenic aid Nitric oxide Watermelon juice

Customized 3D-printed occluders enabling the reproduction of consistent and stable heart failure in swine models

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Bio-Design and Manufacturing 2021年第4期4卷 833-841页

作者： Han B.kim Seungman jung Hyukjin Park Doo S.Sim Munki kim Sanskrita Das Youngkeun Ahn Myung H.jeong jinah jang Young j.Hong Division of Cardiology Chonnam National University Medical SchoolGwangjuRepublic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and TechnologyPohangRepublic of Korea Department of Creative IT Engineering Pohang University of Science and TechnologyPohangRepublic of Korea Department of Mechanical Engineering Pohang University of Science and TechnologyPohangRepublic of Korea

Reproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal *** to its physiological relevance,a swine myocardial infarction(MI)model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart *** methods are used to induce MI in the swine ***,it is difficult,using these approaches,to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation,leading to increased experimental ***,in order to minimize human intervention,we developed an approach to use a customized occluder that has dimensional similarities with that of the coronary artery of animals in the case of the swine *** carried out angiography to measure the diameter of the middle left anterior descending artery of each individual animal to fabricate the customized occluder using a 3D-printing *** fabricated occluder contained a central hole smaller than that of the targeted middle left anterior descending artery to mimic an atherosclerotic coronary artery that has an approximately 20%blocked ***,the 3D-printed occluder can provide continuous blood flow through the central pore,indicating a high survival rate(88%)of up to 28 days *** method showed the possibility of creating consistent myocardial infarction induction as compared to the conventional representative closed-chest method(50%survival rate),thus highlighting how our method can have a profound effect on accelerating reliable experiments for developing new therapeutic approaches to ischemic heart diseases.

关键词： 3D bioprinting Myocardial infarction Ischemic heart failure Swine model Left anterior descending artery

Preparation and characterization of solidified SMEDDS containing flurbiprofen by spray drying method

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Asian journal of Pharmaceutical Sciences 2016年第1期11卷 108-109页

作者： Yoo-jeong jang kwan Hyung Cho College of Pharmacy Inje University

Flurbiprofen, a non-steroidal anti-inflammatory agent, is used to treat rheumatoid arthritis and sore throat (1)However, it gave poor water solubility, and various solubilization technique such as self-microemulsifying drug delivery system(SMEDDS) has been used to improve the solubility, dissolution and oral bioavailability [2].The objective of this work was to develop redispersible solidified SMEDDS containing water-insoluble flurbiprofen with enhanced solubility.

关键词： Flurbiprofen Solidified SMEDDS Solubilization

Production and inventory control of auto parts based on predicted probabilistic distribution of inventory

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Digital Communications and Networks 2015年第04期1卷 292-301页

作者： jiSun Shin Sungshin kim jang-Myung Lee Pusan National University

Bayesian networks are probabilistic models used for prediction and decision making under uncertainty. The delivery quantity, the production quantity, and the inventory are changing according to various unexpected events. Then the prediction of a production inventory is required to cope with such irregular fluctuations. This paper considers a production adjustment method for an automobile parts production process by using a dynamic Bayesian network. All factors that may influence the production quantity, the delivery quantity, and the inventory quantity will be handled. This study also provides a production schedule algorithm that sequentially adjusts the production schedule in order to guarantee that all deadlines are met. Furthermore, an adjusting rule for the production quantities is provided in order to maintain guaranteed delivery.

关键词： Graphical modeling Dynamic Bayesian Network Production Adjusting Method Probabilistic distribution

Starting materials, processes and characteristics of bio-based foams: A review

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journal of Bioresources and Bioproducts 2024年第2期9卷 160-173页

作者： Xiaohan Wang jinwon jang Yanqun Su jingang Liu Hongjie Zhang Zhibin He Yonghao Ni National Engineering Laboratory for Pulp and Paper China National Pulp and Paper Research Institute Co.Ltd.Beijing 100102China Limerick Pulp and Paper Centre and Department of Chemical Engineering University of New BrunswickNew Brunswick E3B 5A3Canada

Biofoam products have attracted considerable attention lately because there is a growing demand for green/sustainable *** this end,various biobased foams have either been developed or are currently in development,e.g.,bio-based polyurethanes(PUs),polylactic acid(PLA),starch,and polyhydroxyalkanotates(PHAs).Indeed,significant progress has been made;however,chal-lenges still persist,for example,biobased foam products have poor processability,inferior com-patibility,thermal and strength *** this review,we focus on five biofoam products:namely bio-based PUs,PLA,starch,PHAs,and cellulose biofoam products,along with their prop-erties and performance,as well as their manufacturing *** efforts are still needed to unlock the full potential of these bio-based products and meet the goal of complementing and gradually replacing some of their fossil-based ***,the challenges,as well as arising opportunities of future research directions are discussed.

关键词： Biofoam Bio-based polyurethanes Polylactic acid Polyhydroxyalkanotate Starch Cellulose Manufacturing process

Crystal Facet Engineering of TiO_(2) Nanostructures for Enhancing Photoelectrochemical Water Splitting with BiVO_(4) Nanodots

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Nano-Micro Letters 2022年第3期14卷 201-215页

作者： Mi Gyoung Lee jin Wook Yang Hoonkee Park Cheon Woo Moon Dinsefa M.Andoshe jongseong Park Chang‑ki Moon Tae Hyung Lee kyoung Soon Choi Woo Seok Cheon jang‑joo kim Ho Won jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul 03693Republic of Korea National Research Facilities and Equipment Center Korea Basic Science InstituteDaejeon 34133Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea

Although bismuth vanadate(BiVO4)has been promising as photoanode material for photoelectrochemical water splitting,its charge recombination issue by short charge diffusion length has led to various studies about heterostructure *** a hole blocking layer of BiVO4,titanium dioxide(TiO_(2)) has been considered unsuitable because of its relatively positive valence band edge and low electrical ***,a crystal facet engineering of TiO_(2) nanostructures is proposed to control band structures for the hole blocking layer of BiVO4 *** design two types of TiO_(2) nanostructures,which are nanorods(NRs)and nanoflowers(NFs)with different(001)and(110)crystal facets,respectively,and fabricate BiVO4/TiO_(2) heterostructure *** BiVO4/TiO_(2) NFs showed 4.8 times higher photocurrent density than the BiVO4/TiO_(2) *** decay time analysis and time-resolved photoluminescence reveal the enhancement is attributed to the reduced charge recombination,which is originated from the formation of type II band alignment between BiVO4 nanodots and TiO_(2) *** work provides not only new insights into the interplay between crystal facets and band structures but also important steps for the design of highly efficient photoelectrodes.

关键词： Crystal facet control Bismuth vanadate Titanium dioxide Heterojunction Water splitting

Segmented tomographic evaluation of structural degradation of carbon support in proton exchange membrane fuel cells

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journal of Energy Chemistry 2022年第11期31卷 359-367,I0010页

作者： jung A.Hong Min-Hyoung jung Sung Yong Cho Eun-Byeol Park Daehee Yang Young-Hoon kim Sang-Hyeok Yang Woo-Sung jang jae Hyuck jang Hyo june Lee Sungchul Lee Hu Young jeong Young-Min kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Fuel Cell Core Parts Development Cell Hyundai Mobis Co.Ltd.Uiwang 16082Republic of Korea Electron Microscopy&Spectroscopy Team Korea Basic Science Institute(KBSI)Daejeon 34133Republic of Korea Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

The variation of the three-dimensional(3D)structure of the membrane electrode of a fuel cell during proton exchange cycling involves the corrosion/compaction of the carbon *** increasing degradation of the carbon structure continuously reduces the electrocatalytic performance of proton exchange membrane fuel cells(PEM-FCs).This phenomenon can be explained by performing 3D tomographic analysis at the ***,conventional tomographic approaches which present limited experimental feasibility,cannot perform such evaluation and have not provided sufficient structural information with statistical significance thus ***,a reliable methodology is required for the 3D geometrical evaluation of the carbon ***,we propose a segmented tomographic approach which employs pore network analysis that enables the visualization of the geometrical parameters corresponding to the porous carbon structure at a high *** approach can be utilized to evaluate the 3D structural degradation of the porous carbon structure after cycling in terms of local surface area,pore size distribution,and their 3D *** geometrical parameters of the carbon body were demonstrated to be substantially reduced owing to the cycling-induced *** information enables a deeper understanding of the degradation phenomenon of carbon supports and can contribute to the development of stable PEM-FC electrodes.

关键词： Electron tomography Fuel cell Proton exchange membrane Membrane electrode assembly Carbon corrosion