Customized 3D-printed occluders enabling the reproduction of consistent and stable heart failure in swine models

作     者：Han B.Kim Seungman Jung Hyukjin Park Doo S.Sim Munki Kim Sanskrita Das Youngkeun Ahn Myung H.Jeong Jinah Jang Young J.Hong Han B.Kim;Seungman Jung;Hyukjin Park;Doo S.Sim;Munki Kim;Sanskrita Das;Youngkeun Ahn;Myung H.Jeong;Jinah Jang;Young J.Hong

作者机构：Division of CardiologyChonnam National University Medical SchoolGwangjuRepublic of Korea School of Interdisciplinary Bioscience and BioengineeringPohang University of Science and TechnologyPohangRepublic of Korea Department of Creative IT EngineeringPohang University of Science and TechnologyPohangRepublic of Korea Department of Mechanical EngineeringPohang University of Science and TechnologyPohangRepublic of Korea 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第4期

页      面：833-841页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Bio&Medical Technology Development Program and Basic Science Research Program through the National Research Foundation(NRF),funded by the Korean government(MSIT)(No.2018M3A9E2024584) the Ministry of Trade,Industry and Energy(MOTIE)and Korea Institute for Advancement of Technology(KIAT)through the International Cooperative R&D program(No.P0011282) 

主　　题：3D bioprinting Myocardial infarction Ischemic heart failure Swine model Left anterior descending artery 

摘      要：Reproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal *** to its physiological relevance,a swine myocardial infarction(MI)model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart *** methods are used to induce MI in the swine ***,it is difficult,using these approaches,to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation,leading to increased experimental ***,in order to minimize human intervention,we developed an approach to use a customized occluder that has dimensional similarities with that of the coronary artery of animals in the case of the swine *** carried out angiography to measure the diameter of the middle left anterior descending artery of each individual animal to fabricate the customized occluder using a 3D-printing *** fabricated occluder contained a central hole smaller than that of the targeted middle left anterior descending artery to mimic an atherosclerotic coronary artery that has an approximately 20%blocked ***,the 3D-printed occluder can provide continuous blood flow through the central pore,indicating a high survival rate(88%)of up to 28 days *** method showed the possibility of creating consistent myocardial infarction induction as compared to the conventional representative closed-chest method(50%survival rate),thus highlighting how our method can have a profound effect on accelerating reliable experiments for developing new therapeutic approaches to ischemic heart diseases.