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Applications of genetic code expansion technology in eukaryotes

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Protein & cell 2024年第5期15卷 331-363页

作者： qiao-ru Guo Yu j.c.o State Key Laboratory of chemical Oncogenomic Guangdong Provincial Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China

Unnatural amino acids(UAAs)have gained significant attention in protein engineering and drug development owing to their ability to introduce new chemical functionalities to *** eukaryotes,genetic code expansion(GcE)enables the incorporation of UAAs and facilitates posttranscriptional modification(PTM),which is not feasible in prokaryotic *** is also a powerful tool for cell or animal imaging,the monitoring of protein interactions in target cells,drug development,and switch ***,there is keen interest in utilizing GcE in eukaryotic *** review provides an overview of the application of GcE in eukaryotic systems and discusses current challenges that need to be addressed.

关键词： genetic code expansion unnatural amino acid eukaryotes basic research therapeutic applications

Superatom-assembled boranes,carboranes,and low-dimensional boron nanomaterials based on aromatic icosahedral B_(12)and c_(2)B_(10)

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Nano Research 2024年第7期17卷 6734-6740页

作者： qiao-qiao Yan Yan-Fang Wei Qiang chen Yue-Wen Mu Si-Dian Li Institute of Molecular Science Shanxi UniversityTaiyuan 030006China

Using the experimentally known aromatic icosahedral superatoms I_(h)B_(12)H_(12)2−and D_(5d)1,12-c_(2)B_(10)H_(12)as building blocks and based on extensive density functional theory calculations,we predict herein a series of core–shell superpolyhedral boranes and carboranes in a bottom-up approach,including the high-symmetry Th B_(12)@B_(152)H_(72)2−(2),c2h c_(2)B_(10)@B_(152)H_(72)(3),D_(3d)B_(12)@B_(144)H_(66)(4),I_(h)B_(12)@c_(24)B_(12)0H_(72)2−(6),and D_(5d)c_(2)B_(10)@c_(24)B_(12)0H_(72)(7).More interestingly,the superatom-assembled linear D2h B_(36)H_(32)^(2−)(8),close-packed planar D_(3d)B_(84)H_(60)^(2−)(10),and nearly close-packed core−shell D_(3d)B_(12)@B144H_(6)6(4)can be extended periodically to form the one-dimensional(1D)α-rhombohedral borane nanowire B_(12)H_(10)(Pmmm)(9),two-dimensional(2D)α-rhombohedral monolayer borophane B_(12)H_(6)(P m1)(11),and the experimentally known three-dimensional(3D)α-rhombohedral boron(R m)(12)which can be viewed as an assembly of the monolayer B_(12)H_(6)(11)staggered in vertical direction,setting up a bottom-up strategy to form low-dimensional boron-based nanomaterials from their borane“seeds”via partial or complete *** bonding analyses indicate that the high stability of these nanostructures originates from the spherical aromaticity of their icosahedral B_(12)or c_(2)B_(10)structural units which possess the universal skeleton electronic configuration of 1S21P61D101F8 following the Wade’s n+1 *** infrared(IR)and Raman spectra of the most-concerned neutral B_(12)@B144H_(6)6(4)and c_(2)B_(10)@c_(24)B_(12)0H_(72)(7)are computationally simulated to facilitate their experimental characterizations.

关键词： superatom-assembling bottom-up approach density functional theory superpolyhedral boranes superpolyhedral carboranes borophanes

“Yin-Yang philosophy” for the design of anticancer drug delivery nanoparticles

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Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai Y. Tian Y. qiao j. Wang c. Li H. School of Lifesciences Shanghai University Shanghai China

Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with higher efficacy and fewer off-target effects. Many factors, such as particle size, morphology, surface potential, structural stability, and etc., may influence the delivering process of NPs due to the existence of various physiological barriers within the body. Herein, we summarise the distinct influences of NP physicochemical properties on the four consecutive in vivo transport steps: (1) navigating with bloodstream within blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport through the interstitial space, and (4) cellular uptake & intracellular delivery by cancerous cells. We found that the philosophy behind the current consensus for NP design has certain similarities to the “Yin-Yang” theory in traditional chinese culture. Almost all physicochemical properties, regardless of big or small sizes, long or short length, positive or negative zeta potentials, are double-edged swords. The balance of potential benefits and side effects, drug selectivity and accessibility should be fully considered when optimising particle design, similar to the “Yin-Yang harmony”. This paper presents a comprehensive review of the advancements in NPs research, focusing on their distinct features in tumour targeting, drug delivery, and cell uptake. Additionally, it deliberates on future developmental trends and potential obstacles, thereby aiming to uncover the ways these characteristics influence the NPs’ biological activity and provide theoretical guidance for the targeted delivery of NPs. © 2024, chinese Medical Multimedia Press co Ltd. All rights reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “Yin-Yang harmony”

Legacy and emerging per-and polyfluoroalkyl substances(PFAS) in the atmosphere: A comprehensive review

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Science china Technological Sciences 2024年第10期67卷 3032-3050页

作者： qiao BiTing SONG DongBao cHEN Hao YAO YiMing SUN HongWen MOE Key Laboratory of Pollution Processes and Environmental criteria College of Environmental Science and EngineeringNankai University

With long-term production and widespread application, per-and polyfluoroalkyl substances(PFAS) have been detected in various media worldwide, including the atmosphere. Since the gradual restriction and phase-out of c8perfluoroalkyl acids(PFAAs), environmental contamination by emerging PFAS substitutes such as short-chain PFAA homologues, perfluoroether carboxylic, and sulfonic acids has been reported. Although there has been extensive monitoring of emerging PFAS substitutes in the aquatic environment, few studies have conducted target analysis and nontarget screening(NTS) of emerging unknown PFAS in the atmosphere over the past decade. To fill the gap, this review focused on emerging PFAS in the atmosphere in addition to legacy PFAS. The reported sampling, pretreatment, and instrumental analysis methods for target analysis and NTS of both neutral and ionic PFAS in the atmosphere are summarized, along with the advantages and current limitations of different sampling and NTS methods for PFAS in the atmosphere. The global levels, composition, and spatiotemporal distribution characteristics of legacy and emerging PFAS in the atmosphere are summarized and their transport, transformation, and dry/wet deposition are elucidated. The review highlights the importance of developing and applying the all-in-one strategy integrating target, suspect screening, and NTS to gain insights into emerging PFAS in the atmosphere and provide a reference for future research.

关键词： emerging PFAS atmosphere nontarget screening spatiotemporal distribution fate

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Non-transcriptional regulatory activity of SMAX1 and SMXL2 mediates karrikin-regulated seedling response to red light in Arabidopsis

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Molecular Plant 2024年第7期17卷 1054-1072页

作者： Wenwen chang qiao qiao Qingtian Li Xin Li Yanyan Li Xiahe Huang Yingchun Wang jiayang Li Bing Wang Lei Wang Key Laboratory of Seed Innovation Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei050021China Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyThe Innovative Academy for Seed DesignChinese Academy of SciencesBeijing100101China University of chinese Academy of Sciences Beijing 100049China Yazhouwan National Laboratory SanyaHainan 572024China

Karrikins and strigolactones govern plant development and environmental responses through closely related signaling *** transcriptional repressor proteins SUPPRESSOR OF MAX21(SMAX1),SMAX1-like2(SMXL2),and D53-like SMXLs mediate karrikin and strigolactone signaling by directly binding downstream genes or byinhibiting the activities of transcription *** this study,we characterized the non-transcriptional regulatory activities of SMXL proteins in *** discovered that SMAX1 and SMXL2 with mutations in their ethylene-responsefactor-associated amphiphilic repression(EAR)motif had undetectable or weak transcriptional repression activities but still partially rescued the hypocotyl elongation defects and fully reversed the cotyledon epinasty defects of the smax1 smxl2 ***1 and SMXL2 directly interact with PHYTOcHROME INTERAcTION FAcTOR4(PIF4)and PIF5 to enhance their protein stability by interacting with phytochrome B(phyB)and suppressing the association of phyB with PIF4 and *** karrikin-responsive genes were then identified by treatment with GR24ent-ssa,GR24 analog showing karrikin ***,INDOLE-3-AcETIc AcID INDUcIBLE 29(IAA29)expression was repressed by GR24^(ent-5D)streatment in a PIF4-and PIF5-dependent and EARindependent manner,whereas KARRIKIN UPREGULATED F-BOX 1(KUF1)expression was induced in a PIF4-and PIF5-independent and EAR-dependent ***,the non-transcriptional regulatory activity of SMAX1,which is independent of the EAR motif,had a global effect on gene *** together,these results indicate that non-transcriptional regulatory activities of SMAX1 and SMXL2 mediate karrikin-regulated seedling response to red light.

关键词： karrikin signaling SMAX1 and SMXL2 non-transcriptional repression activity PIF4 and PIF5 gene expression red light

Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： jiawen Zhang Sihui Yu qiao Peng Ping Wang Lan Fang Tongji University cancer center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

Facile low-temperature supercritical carbonization method to prepare high-loading nickel single atom catalysts for efficient photodegradation of tetracycline

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journal of Environmental Sciences 2024年第4期138卷 373-384页

作者： Han qiao Lirong Zheng Shiwen Hu Gang Tang Hongri Suo chongxuan Liu School of Environment Harbin Institute of TechnologyHarbin 150090China State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Beijing Synchrotron Radiation Facility(BSRF) Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Environmental photocatalysis is a promising technology for treating antibiotics in *** this study,a supercritical carbonization method was developed to synthesize a single-atom photocatalyst with a high loading of Ni(above 5 wt.%)anchored on a carbonnitrogen-silicate substrate for the efficient photodegradation of a ubiquitous environmental contaminant of tetracycline(Tc).The photocatalyst was prepared from an easily obtained metal-biopolymer-inorganic supramolecular hydrogel,followed by supercritical drying and carbonization *** low-temperature(300℃)supercritical ethanol treatment prevents the excessive structural degradation of hydrogel and greatly reduces the metal clustering and aggregation,which contributed to the high Ni *** characterizations confirmed that Ni was present at isolated sites and stabilized by Ni-N and Ni-O bonds in a Ni-(N/O)_(6)-c/Sic configuration.A 5%Ni-c-Si catalyst,which performed the best among the studied catalysts,exhibited a wide visible light response with a narrow bandgap of 1.45 eV that could efficiently and repeatedly catalyze the oxidation of Tc with a conversion rate of almost 100% within 40 *** reactive species trapping experiments and electron spin resonance(ESR)tests demonstrated that the h+,and·O_(2)-were mainly responsible for Tc *** Tc degradation mechanism and possible reaction pathways were provided ***,this study proposed a novel strategy to synthesize a high metal loading singleatom photocatalyst that can efficiently remove Tc with high concentrations,and this strategy might be extended for synthesis of other carbon-based single-atom catalysts with valuable properties.

关键词： carbon-based single-atom catalyst Nickel Photocatalytic degradation Tetracycline Visible light

Supertetragonal BaZrS_(3):A promising perovskite sulphide with giant ferroelectricity and low band gap

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Science china(Physics,Mechanics & Astronomy) 2024年第8期67卷 126-133页

作者： Menglu Li Sa Zhang chenhan Liu Xiaotao Zu Liang qiao Haiyan Xiao School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China college of Mathematics and Physics Chengdu University of TechnologyChengdu 610059China Micro-and Nano-scale Thermal Measurement and Thermal Management Laboratory Ministry of Education Key Laboratory of Numerical Simulation of Large-Scale Complex SystemsSchool of Energy and Mechanical EngineeringNanjing Normal UniversityNanjing 210023China

Over the past century,ferroelectricity has offered exciting opportunities for fundamental research and device ***,most of the discovered excellent ferroelectrics are oxide materials with large band gaps,limiting their potential for optoelectronics *** using first-principles calculations we identify a new narrow-gap ferroelectric beyond oxides,i.e.,ferroelectric perovskite sulphide BaZrS_(3).Under large compressive strains,BaZrS_(3)can be stabilized into a unique supertetragonal phase with an extraordinary polarization of 67.16μc/cm^(2),which is even stronger than that of conventional oxide ***,the supertetragonal BaZrS_(3)exhibits a direct narrow band gap of 1.2 eV and excellent electronic *** on the chemical bonding analysis,we attribute the formation of supertetragonal phase to charge re-ordering in which theπbond overlap along the long〈Zr-S〉bond completely vanishes and the antibonding states of theσbond appear below the Fermi *** work provides a conceptual strategy for designing new ferroelectrics for electronic and photovoltaic applications.

关键词： supertetragonal phase perovskite sulphide ferroelectricity

3D reconstruction and defect pattern recognition of bonding wire based on stereo vision

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cAAI Transactions on Intelligence Technology 2024年第2期9卷 348-364页

作者： Naigong Yu Hongzheng Li qiao Xu Ouattara Sie Essaf Firdaous Faculty of Information Technology Beijing University of TechnologyBeijingChina Beijing Key Laboratory of computing Intelligence and Intelligent System Beijing University of TechnologyBeijingChina Engineering Research center of Digital community Ministry of EducationBeijingChina college of Robotic UniversitéFélix Houphouët‐BoignyAbidjanCôte d’Ivoire

Non-destructive detection of wire bonding defects in integrated circuits(Ic)is critical for ensuring product quality after ***-processing-based methods do not provide a detailed evaluation of the three-dimensional defects of the bonding ***,a method of 3D reconstruction and pattern recognition of wire defects based on stereo vision,which can achieve non-destructive detection of bonding wire defects is *** contour features of bonding wires and other electronic components in the depth image is analysed to complete the 3D reconstruction of the bonding *** to filter the noisy point cloud and obtain an accurate point cloud of the bonding wire surface,a point cloud segmentation method based on spatial surface feature detection(SFD)was *** can extract more distinct features from the bonding wire surface during the point cloud segmentation ***,in the defect detection process,a directional discretisation descriptor with multiple local normal vectors is designed for defect pattern recognition of bonding *** descriptor combines local and global features of wire and can describe the spatial variation trends and structural features of *** experimental results show that the method can complete the 3D reconstruction and defect pattern recognition of bonding wires,and the average accuracy of defect recognition is 96.47%,which meets the production requirements of bonding wire defect detection.

关键词： bonding wire defect detection point cloud point cloud segmentation