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Journal of Agricultural Science and Technology 2008年第10期2卷 44-50页

作者： Camila G.pereira isabela p.gualtieri Nilson B.Maia M.Angela A.Meireles Department of Chemical Engineering-UFRN Natal RN 59072-970 Brazil LASEFI/DEA/FEA（College of Food Eng）/UNICAMp（University of Campinas） CampinasSao PauloCx.P.612113083-970Brazil LAC（Agronomic Institute of Campinas） CampinasSao PauloCx.P.2813001-970Brazil

We determined the global yield and composition of extracts from vetiver roots cultivated hydroponically. We extracted roots of two varieties collected at different times after planting. The extracts were obtained by supercritical fluid extraction （SFE）; we also estimated manufacturing costs. Constituents were quantified by gas-chromatography/time ionization detection （GC-FID）. Results demonstrated the efficacy of a hydroponic system in producing vctiver with a high root extract content. The largest yield was obtained from roots collected on days 132 and 92 after planting from varieties National （1.41%） and Bourbon （1.28%）, respectively. The major compounds present in the extract were khusimoi, isovalencenol, alpha-vetivone and beta-vetivone. To determine the economic viability of producing these extracts, manufacturing costs were estimated using a simplified methodology. The manufacturing costs were US$ 22.26/kg and US$ 24.26/kg for varieties national and Bourbon, respectively.

关键词： manufacturing cost hydroponics supercriticalfluid extraction Vetiveria zizanioides

photofermentative hydrogen production by immobilized Rhodopseudomonas sp. S16-VOGS3 cells in photobioreactors

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Energy Reviews 2024年第1期3卷 39-48页

作者： isabela C.Moia Aikaterini Kanaropoulou Demetrios F.Ghanotakis pietro Carlozzi Eleftherios Touloupakis Research Institute on Terrestrial Ecosystems National Research CouncilVia Madonna del Piano 1050019Sesto FiorentinoFIItaly Department of Chemistry University of CreteVoutes Campus70013 HeraklionGreece

One of the most important solutions to overcome energy and environmental problems and to replace the fossil fuel-based economy could be the use of photosynthetic *** use of photosynthetic microorganisms is a potential alternative to energy generation from fossil fuels because they efficiently produce hydrogen(H_(2)).Immobilization of photosynthetic microorganisms is used for many biotechnological applications such as H_(2) *** method appears attractive because it restricts cell movement in an entrapped *** of Rhodopseudomonas sp.S16-VOGS3 cells is a promising way to improve H_(2) *** this work,the ability of immobilized Rhodopseudomonas sp.S16-VOGS3 cells to produce H_(2) was investigated in two types of *** pBRs used in this work were a cylindrical one with 0.2 L working volume(C-pBR)and a flat Roux type with 0.6 L working volume(FRT-pBR).The calcium alginate beads prepared were resistant to culture mixing and showed little leakage of cells,and the immobilized cells continued the photofermentation process in both *** immobilized cells in the C-pBR produced 936.8 mL of H_(2) with an average H_(2) production rate of 2.99 mL/*** average productivity was 126.4μL(H_(2))/mg(cells)/h or 14.96 mL(H_(2))/L(culture)/h,and the light conversion efficiency was 2.37%.The immobilized cells in the FRT-pBR produced a total of 662.2 mL of H_(2) with an average H_(2) production rate of 1.55 mL/*** average productivity was 31.1μL(H_(2))/mg(cells)/h or 2.58 mL(H_(2))/L(culture)/h,and the light conversion efficiency was 0.52%.The more uniform and therefore more efficient degree of bacterial cell mixing achieved in the C-pBR with cylindrical configuration played an important role compared to the *** the FRT-pBR,the beads were aggregated at the bottom,which limited light penetration and resulted in low H_(2) production efficiency.

关键词： photobioreactor Rhodopseudomonas sp.S16-VOGS3 photofermentation Hydrogen production Calcium alginate

Model Identification and Control of Electromagnetic Actuation in Continuous Casting process With Improved Quality

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 203-215页

作者： isabela Birs Cristina Muresan Dana Copot Clara Ionescu Research Group of Dynamical Systems and Control Faculty of Engineering and ArchitectureGhent University and with EEDT Decision&ControlFlanders Make ConsortiumTech Lane Science Park 125 and 131B-9052 GhentBelgium.I.Birs the Automation Department Faculty of Automation and Applied InformaticsTechnical University of Cluj-NapocaRomania IEEE

This paper presents an original theoretical framework to model steel material properties in continuous casting line process. Specific properties arising from non-Newtonian dynamics are herein used to indicate the natural convergence of distributed parameter systems to fractional order transfer function models. Data driven identification from a real continuous casting line is used to identify model of the electromagnetic actuator device to control flow velocity of liquid steel. To ensure product specifications, a fractional order control is designed and validated on the system. A projection of the closed loop performance onto the quality assessment at end production line is also given in this paper.

关键词： Electromagnetic actuator fractional order control fractional order system model non-Newtonian material

Coronavirus disease 2019 severity in obesity:Metabolic dysfunctionassociated fatty liver disease in the spotlight

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World Journal of Gastroenterology 2021年第16期27卷 1738-1750页

作者： isabela Macedo Lopes Vasques-Monteiro Vanessa Souza-Mello Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil Food Science and Technology Federal University of the State of Rio de JaneiroRio de Janeiro 22290250Brazil Laboratory of Morphometry Metabolismand Cardiovascular DiseasesBiomedical CenterInstitute of BiologyAnatomy DepartmentRio de Janeiro State UniversityRio de Janeiro 20551030Brazil

The coronavirus disease 2019(COVID-19)outbreak has drawn the scientific community's attention to pre-existing metabolic conditions that could aggravate the infection,causing extended viral shedding,prolonged hospitalization,and high death *** dysfunction-associated fatty liver disease(MAFLD)emerges as a surrogate for COVID-19 severity due to the constellation of metabolic alterations it *** review outlines the impact MAFLD exerts on COVID-19 severity in obese subjects,besides the possible mechanistic links to the poor *** data collected showed that MAFLD patients had poorer COVID-19 outcomes than non-MAFLD obese *** is generally accompanied by impaired glycemic control and systemic arterial hypertension,both of which can decompensate during the COVID-19 clinical ***,MAFLD subjects had higher plasma inflammatory marker concentrations than non-MAFLD subjects,which might be related to an intensified cytokine storm syndrome frequently associated with the need for mechanical ventilation and *** conclusion,MAFLD represents a higher risk than obesity for COVID-19 severity,resulting in poor outcomes and even progression to non-alcoholic *** should include MAFLD subjects in the high-risk group,intensify preventive measurements,and prioritize their vaccination.

关键词： Metabolic dysfunction-associated fatty liver disease Obesity COVID-19 Severity Cytokine storm syndrome

Sleep in children with eosinophilic esophagitis

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World Journal of pediatrics 2021年第2期17卷 111-114页

作者： isabela A Ishikura Gustavo Moreira SergioTufik Monica L.Andersen Department of psychobiology Universidade Federal de Sao Paulo(UNIFESP)Napoleao de Barros925 Vila ClementinoSao PauloSP 04024-002Brazil

Eosinophilic esophagitis(EoE)is a chronic immune-and antigen-mediated disease caused by infiltration of eosino-phils in esophagus tissue,which leads to morphological and functional abnormalities at this site[1].This disease was discovered in 1995 by Kelly et al.[2];since then,it has become increasingly recognized and discussed by research-ers[2,3].EoE affects children and adults and is three times more prevalent in males than in *** to a recent systematic review,there are 19.1 cases of EoE per 100,000 children/year,with a higher frequency in Western countries[4].

关键词： esophagitis al. esophagus

Microbial lipases:propitious biocatalysts for the food industry

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Food Bioscience 2022年第1期45卷 34-44页

作者： Cleonice Aparecida Salgado Clarissa isabela Aparecida dos Santos Maria Cristina Dantas Vanetti Department of Microbiology Universidade Federal de Viçosa(UFV)ViçosaMGBrazil

Lipases(triacylglycerol acylhydrolases,EC 3.***.1.3)are one of the largest groups of enzymes and are used in various industrial *** of microbial origin are currently receiving increased attention for industrial application as microorganisms grow quickly and are easily genetically ***,they offer several advantages,such as catalysis of diverse reactions,high specificity,high yields,low energy consumption and reduced processing time and production *** is a relentless ongoing effort to optimise the production of microbial lipases for potential application in the food *** this context,this review highlights the most promising techniques for producing microbial lipases and the recent applications of these lipases in dairy,oils and fats,bakery and confectionery,meat,flavours and aromas and other food *** lipases are normally obtained by fermentation,but the high costs of carbon and nitrogen sources limit the *** overcome this problem,low-cost agro-industrial residues in the lipase production process are *** obtain lipases with high yields and improved characteristics,the technique of protein engineering is described as promising,and the immobilization method that allows the recycling of lipases to improve their catalytic performance is *** to their catalytic properties and versatility,lipases of microbial origin are considered extremely important catalysts in the food industry,meeting the demand for tastier foods with pleasant aromas and ***,microbial lipases are considered safe and sustainable biocatalysts.

关键词： Microbial lipases Food industry Agro-industrial residue

Effects of a 12-Week Recreational Soccer program on Resting Metabolic Rate Among Adolescents with Obesity

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Journal of Science in Sport and Exercise 2023年第3期5卷 218-225页

作者： isabela F.Soares Felipe A.Cunha Fabrício Vasconcellos Graduate program in Exercise Science and Sports University of Rio de Janeiro StateRio de JaneiroBrazil Laboratory of physical Activity and Health promotion Institute of Physical Education and SportsUniversity of Rio de Janeiro StateRua São Francisco Xavier 524/sala 8121F-MaracanãRio de JaneiroRJ CEP:20550-013Brazil

Objectives The purpose of this study was to investigate the chronic effects of a 12-week recreational soccer program(RSp)on resting metabolic rate(RMR)in adolescents with *** Eighteen adolescents with obesity were assigned to RSp[n=10,age=13.8±1.5 years,body mass index(BMI)=30.7±5 kg/m^(2)]and control(n=8,age=14.9±1.4 years,BMI=32.5±4.1 kg/m^(2))*** underwent anthropometric,body composition,cardiorespiratory fitness and RMR assessments at baseline and *** 12-week RSp consisted of small-sided games with 60-min performed 3 times per *** post-intervention,between-group differences due to RSp emerged for body mass(Δ:−15.1 kg,p=0.043),BMI(Δ:−4.7 kg,p=0.05),waist and hip circumferences(Δ:−14.6 and−16.6 cm,p=0.015 and p=0.017,respectively),fat mass(Δ:−8.7 kg,p=0.049)and VO2max(Δ:5.5 mL/kg/min,p=0.013).No significant differences were detected for the absolute and adjusted RMR for fat mass and fat-free mass at baseline and after 12 weeks for both RSp and control groups,although a marked downward trend of 27.6%for adjusted RMR was observed post-control(1915 vs.1386 kcal/day;Δ:−529 kcal/day).Conclusion A 12-week RSp was effective for improving anthropometric,body composition and cardiorespiratory fitness health markers in adolescents with obesity,but not for RMR.

关键词： Basal metabolism Energy expenditure Calorimetry Exercise training Body mass

Obtaining morphometric variables from gullies using two methods of interpolation laser scanner data:the case study of Vassouras,Brazil

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Journal of Mountain Science 2020年第12期17卷 3012-3023页

作者： OLIVEIRA Carlos Magno Moreira de FRANCELINO Márcio Rocha MENDONCA Bruno Araujo Furtado de RAMOS isabela Queiroz Instituto Federal do Norte de Minas Gerais-Campus Arinos Rodovia MG 202Km 407 s/nZona RuralArinos-MG38680-000Brazil Departamento de Solos Universidade Federal de VigosaAv.Peter Henry Rolfss/n-Campus UniversitarioViqosa-MG36570-900Brazil Departamento de Silvicultura Universidade Federal Rural do Rio de JaneiroBR 465 Km 07Seropedica-RJ23890-000Brazil Instituto do Meio Ambiente e dos Recursos Hidricos do Distrito Federal SEPN 511Bloco C70750-543BrasiliaDFBrazil

Gully erosion is a worldwide problem of land degradation and water quality,and it is also frequent in ***,anthropic influence is the major driver of gully *** study and monitor gullies it is necessary to use specific instruments and methods to obtain accurate *** objective of this study was to use Terrestrial Laser Scanning(TLS) to create digital elevation model(DEM) accurately and define morphometric variables that characterize gullies in a mountainous *** different interpolations were evaluated using the Topogrid and GridSurfaceCreate algorithms to elaborate *** profile for gullies was used to assess modeling *** DEM of the Gully 1(G1) from the Topogrid algorithm estimated soil loss of 49%,whereas the GridSurfaceCreate algorithm estimated a soil loss of97%,in a period of 1 *** estimated soil loss for the Gully 2(G2) was 14% from the Topogrid,and 8%from the GridSurfaceCreate *** GridSurfaceCreate algorithm underestimated the volume to area ratio for G2 due to a failure on interpolating a region of low point *** Topogrid algorithm represented better the terrain irregularities,as observed through the topographic profiles traced in three regions of G1 and *** analysis showed that the GridSurfaceCreate algorithm presented lower accuracy in estimating *** underestimation trend of this algorithm was also observed in *** gullies showed considerable soil losses,which may reduce the areas suitable for agricultural activities,and silting up of water *** Topogrid algorithm presented satisfactory results,denoting great potential to produce morphometric data of gullies.

关键词： Erosion process Interpolation algorithms Spatial statistics Digital Elevation Model Topographic profile

nteraction between natural killer cells and regulatory 7 ：ells： perspectives for immunotherapy

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Cellular & Molecular Immunology 2013年第3期10卷 222-229页

作者： isabela pedroza-pacheco Alejandro Madrigal Aurore Saudemont Anthony Nolan Research Institute and University College London Royal Free Campus London UK

Regulatory T （Treg） cells and natural killer （NK） cells are key players in the immune system. The interaction between these two cell types has been reported to be beneficial in healthy conditions such as pregnancy. However, in the case of certain pathologies such as autoimmune diseases and cancer this interaction can become detrimental, as Treg cells have been described to suppress NK cells and in particular to impair NK cell effector functions. This review aims to discuss the recent information on the interaction between Treg cells and NK cells under healthy and pathologic conditions, to describe the specific conditions in which this interaction takes place, the effect of Treg cells on hematopoietic stem cell differentiation and the consequences of this interaction on the optimization of immunotherapeutic protocols.

关键词： differentiation effector functions natural killer cells regulatory T cells

A perspective on potassic and ultrapotassic rocks:Constraints on the paleoproterozoic late to post-collisional event in the São Francisco paleocontinent

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Geoscience Frontiers 2022年第5期13卷 242-266页

作者： Samuel Moreira Bersan AndréDanderfer Craig Storey Henrique Bruno Hugo Moreira Francisco Abreu Cristiano Lana Leonardo Gonçalves isabela Nahas Universidade Federal de Ouro preto Departamento de GeologiaCampus Morro do CruzeiroOuro PretoMG CEP 35400-000Brazil University of portsmouth School of the EnvironmentGeography and GeosciencesBurnaby BuildingBurnaby RoadPortsmouth PO13QLUK Tektos Research Group UERJ-Rio de Janeiro State UniversityBrazil Sustain Geologia Belo HorizonteBrazil

The late-to post-collisional stage in orogenic systems is characterized by the coeval existence of bimodal potassic to ultrapotassic magmatic activity related to partial melting of an enriched lithospheric mantle together with crustal derived *** this paper,we present new whole rock geochemical analyses combined with zircon and titanite U–pb and zircon Hf isotopic data from potassic to ultrapotassic rocks from six plutons that occur within the Archean Itacambira-Monte Azul block(BIMA),to discuss their petrogenesis and the tectonic implications for the São Francisco *** new U–pb ages range from ca.2.06 Ga to 1.98 Ga and reveal long-lasting potassic magmatism within the BIMA,which is within the late-to-post-collisional stage of the São Francisco paleocontinent *** ultrapotassic rocks are compatible with a fluid-related metasomatized mantle source enriched by previous subduction events,whereas the potassic rocks are bimodal and have a transitional shoshonitic to A-type *** rocks have a hybrid nature,possible related to the mixing between the mafic potassic/ultrapotassic rocks and high temperature crustal melts of the Archean continental *** results also show an increase of within-plate signature towards the younger potassic *** participation of an important Archean crustal component in the genesis of these rocks is highlighted by the common and occasionally abundant occurrence of Archean inherited *** Hf isotopic record shows that most of the zircon inheritance has dominantly subchondriticεHf(t)values,which fits a crustal reworking derivation from a similar Eo-to paleoarchean precursor ***,the presence of juvenile 2.36 Ga zircon inheritance in an ultrapotassic sample reveal the existence of a hidden reservoir that is somewhat similar to the described for the Mineiro Belt in southern São Francisco paleocontinent.

关键词： Late-to post-collisional potassic-ultrapotassic rocks U–pb dating São Francisco paleocontinent Rhyacian-Orosirian orogenic system