Coronavirus disease 2019 severity in obesity:Metabolic dysfunctionassociated fatty liver disease in the spotlight

作     者：Isabela Macedo Lopes Vasques-Monteiro Vanessa Souza-Mello 

作者机构：AnatomyRio de Janeiro State UniversityRio de Janeiro 20551030Brazil Food Science and TechnologyFederal University of the State of Rio de JaneiroRio de Janeiro 22290250Brazil Laboratory of MorphometryMetabolismand Cardiovascular DiseasesBiomedical CenterInstitute of BiologyAnatomy DepartmentRio de Janeiro State UniversityRio de Janeiro 20551030Brazil 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第16期

页      面：1738-1750页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Conselho Nacional de Desenvolvimento Científico e Tecnológico(Brazil),No.305867/2017-2 Fundação Carlos Chagas Filho de AmparoàPesquisa do Estado do Rio de Janeiro,No.E-26/202.657/2018 

主　　题：Metabolic dysfunction-associated fatty liver disease Obesity COVID-19 Severity Cytokine storm syndrome 

摘      要：The coronavirus disease 2019(COVID-19)outbreak has drawn the scientific community s attention to pre-existing metabolic conditions that could aggravate the infection,causing extended viral shedding,prolonged hospitalization,and high death *** dysfunction-associated fatty liver disease(MAFLD)emerges as a surrogate for COVID-19 severity due to the constellation of metabolic alterations it *** review outlines the impact MAFLD exerts on COVID-19 severity in obese subjects,besides the possible mechanistic links to the poor *** data collected showed that MAFLD patients had poorer COVID-19 outcomes than non-MAFLD obese *** is generally accompanied by impaired glycemic control and systemic arterial hypertension,both of which can decompensate during the COVID-19 clinical ***,MAFLD subjects had higher plasma inflammatory marker concentrations than non-MAFLD subjects,which might be related to an intensified cytokine storm syndrome frequently associated with the need for mechanical ventilation and *** conclusion,MAFLD represents a higher risk than obesity for COVID-19 severity,resulting in poor outcomes and even progression to non-alcoholic *** should include MAFLD subjects in the high-risk group,intensify preventive measurements,and prioritize their vaccination.