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Systemic Sarcoidosis Associated to IgA Nephropathy

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Case Reports in Clinical Medicine 2015年第8期4卷 284-288页

作者： Madiha Mahfoudhi imen Gorsane Mounira El Euch Rym Goucha Sami Turki Taieb Ben Abdallah Internal Medicine A Department Charles Nicolle Hospital Tunis Tunisia

The sarcoidosis was rarely associated to IgA nephropathy. We report a 38-year-old man presented decreased visual acuity and xerostomia. He had two axillary lymphadenopathies and pitting edema of legs in physical examination. The ophthalmological examination revealed a right posterior uveitis. Biological investigations showed a mild renal insufficiency and elevated serum level of angiotensin-converting enzyme, β2 microglobulin and IgA. He had a proteinuria and a microscopic hematuria. The kidney echography was without abnormalities. Histological study of the renal biopsy found results in favor to IgA nephropathy. Biopsies performed in accessory salivary gland and lymph nodes revealed non-necrotising epitheloid and gigantocellular granulomatous inflammation suggesting a sarcoidosis. The diagnosis of a sarcoidosis associated to IgA nephropathy was posed. The treatment was based on oral prednisolone with gradual tapering doses. He regained normal vision. The renal function had not worsened. No relapse of sarcoidosis was noted during our follow up.

关键词： Sarcoidosis Granuloma Proteinuria IgA Nephropathy

Mature Teratoma Revealed by an Encysted Pleural Effusion

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Open Journal of Respiratory Diseases 2021年第2期11卷 84-89页

作者： Houda Gharsalli Monia Attia Sarra Zairi imen Sahnoun Aida Ayadi Henda Neji Sonia Maalej Leila Douik ElGharbi Department of Pulmonology Abderrahmane Mami Hospital Ariana Tunisia University of Tunis El Manar Tunis Tunisia Department of Radiology Abderrahmane Mami Hospital Ariana Tunisia Department of Thoracic and Cardiovascular Surgery Abderrahmane Mami Hospital Ariana Tunisia Department of Pathology Abderrahmane Mami Hospital Ariana Tunisia

A 32-year-old patient with no previous history was admitted for chest pain, dyspnea, appetite and weight loss. Chest X-ray revealed an opacity involving the lower two-thirds of the right hemithorax, suggestive of a pleural effusion. Because of the absence of fluid return even after ultrasound-guided thoracentesis, a Chest Computed tomography was required showing a heterogeneous anterior mediastinal mass with soft tissue, fat, fluid and calcifications associated with extensive encysted fluid collection in the right hemithorax. A video-assisted mini-thoracotomy revealed a mediastinal tumor firmly attached to the thymus with a cystic wall lined by squamous epithelium and sebaceous gland composed of respiratory tissue, adipose tissue, cartilage,

Multi-criterion Based Sizing of Coil Pitch Ratio of a Five Phase FSPMSM

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微电机 2017年第10期50卷 29-38页

作者： Elyes Haouas imen Abdennadher Ahmed Masmoudi Research Unit on Renewable Energies and Electric Vehicles University of Sfax Sfax Engineering School P. O Box 1173 3038 Sfax Tunisia Monastir Engineering School University of Monastir 5000 ibn Jazzar Street 5035 Monastir Tunisia

当前,分数槽永磁同步电机,尤其是多相电机,因为宽弱磁调速范围和出色的容错能力,在牵引领域中得到越来越多的关注.本文主要确定一台5相分数槽双层绕组永磁同步电机的线圈节距因数.提出的确定方法由解析计算和数值计算相结合,从电枢磁动... 详细信息

当前,分数槽永磁同步电机,尤其是多相电机,因为宽弱磁调速范围和出色的容错能力,在牵引领域中得到越来越多的关注.本文主要确定一台5相分数槽双层绕组永磁同步电机的线圈节距因数.提出的确定方法由解析计算和数值计算相结合,从电枢磁动势的空间分布出发,考虑由正弦电流供电的表贴式永磁电机.通过对电枢磁动势谐波成分的分析,获得总体谐波含量与线圈节距因数之间的关系.之后,给出了齿槽转矩的解析表达式,探究齿槽转矩和线圈节距因数之间的联系.数值计算部分主要针对电磁转矩和除切向力以外的电磁力和线圈节距之间的关系,利用有限元进行辅助分析.数值计算和有限元计算的结果得到了线圈节距因数选择的一些关键要素,之后,基于这些关键要素,用有限元进行了验证,证明了方法的可靠性.

关键词：圆筒型直线永磁同步电机准Halbach磁体集总磁路法反电动势齿槽力气隙磁密有限元分析

Effects of Physical Exercise and Music Therapy on Cognitive Aspects in Tunisian Patients with Mild Alzheimer’s Type Dementia

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World Journal of Neuroscience 2023年第3期13卷 134-150页

作者： Oussama Gaied Chortane imen Ben Amar Makrem Zghibi Yassmin Dhaouadi Jaouher Hamaidi Elmotez Magtouf Riadh Khalifa Sabri Gaied Chortane Department of Human and Social Sciences Higher Institute of Sport and Physical Education of Ksar-Said University of Manouba Manouba Tunisia Research Unit Sports Performance Health & Society Higher Institute of Sport and Physical Education of Ksar-Said University of Manouba Manouba Tunisia Department of Human and Social Sciences Higher Institute of Sport and Physical Education of Kef University of Jendouba Jendouba Tunisia

Aim: The objective of this research is to highlight the effectiveness of physical exercise and music therapy in older patients with Alzheimer’s disease (AD). Methods: Patients with a mild level of AD were included in this study, divided into the therapy group (TG;N = 30, aged 68 ± 3.2 years) and the control group (CG;N=30, aged 65 ± 2.6 years). The therapy group was enrolled in an exercise-training program (walking, resistance and balance exercises) combined with musical therapy for 10 weeks (three sessions of 60 minutes per week). The Control group was instructed to follow their daily rhythm of life (e.g., rest, reading) under the same conditions. The intervention program was enrolled under the supervision of;one psychologist;a neurologist;two music therapists, and two physiotherapists, all belonging to the same hospital unit. After 10 weeks of participation in the combined program, cognitive parameters were improved in the therapy group measured with the Behavior Pathology in Alzheimer Disease (BEHAVE-AD), (p < 0.05) for activity disturbance, diurnal rhythm disturbances, anxieties and phobias, affective disturbance. The percentage range of improvements is 1.07% to 2.96%. Results: Our results demonstrate that physical exercise combined with music therapy improves cognitive function in patients with Alzheimer’s disease. Conclusions: Physical exercise and music therapy are beneficial combined treatments for improving life quality in older patients. This approach may be useful to help patients with a mild level of Alzheimer’s disease improve their behavioral and psychological parameters.

关键词： Alzheimer’s Disease Aged Patients Physical Exercise Music Therapy Cognitive Function

CRP Binding Kinetics Enhancement Using Local Narrowing into a Bent Channel: Finite Element Analysis

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Engineering（科研） 2022年第1期14卷 62-75页

作者： Mohamed Bahri imen Dermoul Marshet Getaye Mohamed Amin Elaguech Khouloud Djebbi Mounir Ben Ali Chaker Tlili Deqiang Wang Chongqing School University of Chinese Academy of Sciences Chongqing China Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing China University of Chinese Academy of Sciences Beijing China Preparatory Institute for Engineering of Nabeul IPEIN University of Carthage Campus Universitaire Merazka Tunisia NANOMISENE Lab LR16CRMN01 Centre for Research on Microelectronics and Nanotechnology of Sousse Technopole of Sousse Sousse Tunisia University of Sousse Higher Institute of Applied Sciences and Technology of Sousse GREENS-ISSAT Cité Ettafala Sousse Tunisia

Binding kinetics enhancement of a microfluidic biosensor into a micro-channel through the application of a supplementary mechanism has received tremendous attention because of the obtained significant enhancement factor. However, biosensor’s performance enhancement using only simple channel engineering is still rarely realized. Herein, we present a novel design of a complex reactive protein (CRP) biosensor into a U-shaped channel with a sensitive membrane located in the middle of the bent zone. Various critical factors affecting the equilibrium binding time are numerically investigated. The turn geometry is then optimized when the arc length along the inner and outer radii is almost the same, which leads to locally minimizing the channel height overhead the reaction surface and improves the analyte transport towards the sensing area. The numerical studies reveal that applying a local narrowing above the reaction surface can notably enhance the trapping and the surface formation of complex antibody-antigen, thus upgrading the biosensor performance. This work puts a significant advance towards microfluidic channel engineering and the exploration of micro-flow injection experimental studies.

关键词： Finite Elements Method Binding Reaction CRP Biosensor Microfluidic System Microchannel Turn Numerical Simulation

Clinical Characteristics and Follow-Up Data in a Series of Twenty Infective Endocarditis Complicated of Rheumatic Manifestations

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Open Journal of Clinical Diagnostics 2015年第2期5卷 58-62页

作者： Madiha Mahfoudhi imen Gorsane Hedia Bellali Amel Gaieb Battikh Sami Turki Fathi Ben Hamida Taieb Ben Abdallah Internal Medicine A Department Charles Nicolle HospitalTunisTunisia Research Unit of Kidney Diseases(LR00SP01) Charles Nicolle HospitalTunisTunisia Epidemiology and Statistics Department A Mami HospitalArianaTunisia

The infective endocarditis is a septicemia complicated of many systemic manifestations. Rheumatic manifestations can be revelatory, leading sometimes to a lateness diagnosis. The aim of this study is to determine the epidemiological, clinical, bacteriological profile and the follow up in patients affected of an infective endocarditis complicated of rheumatic manifestations. It’s a retrospective study concerning the period from January 1990 to December 2015. The analysis had implicated epidemiological, clinical, biological data, in association to immunological, bacteriological and radiological examinations. All the patients fulfilled the revised Duke’s criteria for the infective endocarditis. Articular and osseous radiographs, blood culture, transthoracic and/or transoesophageal echocardiography were performed in all patients. Twenty patients had rheumatic manifestations. The mean age was 37 years. There were arthralgia in 15 cases, myalgia in 5 cases and arthritis in 8 cases: 6 cases of mono-arthritis and 2 cases of oligo-arthritis. All patients had an inflammatory biological syndrome. The blood culture was positive in all the cases. Echocardiography revealed vegetations in all the patients: mitral in 10 cases, aortic in 4 cases, mitral and aortic in 4 cases, aortic and tricuspid in 1 case, tricuspid in 1 case. The radiological examination found 2 cases of spondylodiscitis and a case of saco-iliitis. The articular outcome was favorable in 17 cases. Three patients had died. The infective endocarditis should be considered in case of febrile arthritis. An early diagnosis and adapted treatment are guarantors of better prognosis.

关键词： Infective Endocarditis Blood Culture Vegetation Myalgia Arthritis

Stenosis of the Subglottic Trachea Revealing Relapsing Polychondritis of a Young Adult

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International Journal of Clinical Medicine 2015年第9期6卷 646-651页

作者： Mounira El Euch Madiha Mahfoudhi imen Gorsane Souha Hadded Wifek Bani Moez Karoui Sami Turki Taieb Ben Abdallah Department of Internal Medicine A Charles Nicolle Hospital Tunis Tunisia

Relapsing polychondritis is a rare inflammatory disease involving essentially cartilaginous structures. Other systemic manifestations can be encountered as the eye and ear disturbance. Aortic aneurysms affect few cases. If affection of airway cartilages occurs, prognosis may be worsened by eventual stenotic lesions. We report a 22-year-old woman with Relapsing polychondritis. When she was referred to our hospital 4 weeks after the onset of respiratory symptoms, she was having severe breathing difficulty. Immediate tracheostomy followed by steroid therapy improved her respiratory condition, although the treatment was complicated because of her diabetes. While airway involvement of Relapsing polychondritis can be life threatening, it is curable with steroid therapy. Clinicians should keep in mind that airway obstruction could be caused by this disease.

关键词： Relapsing Polychondritis Airway Narrowing Prognosis

Adult Onset Still’s Disease: Articular Manifestations in Twenty Cases

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Open Journal of Clinical Diagnostics 2015年第2期5卷 41-45页

作者： Madiha Mahfoudhi imen Gorsane Amel Gaieb Battikh Rafik Shimi Sami Turki Fathi Ben Hamida Taieb Ben Abdallah Internal medicine A department.Charles Nicolle Hospital TunisTunisia Research Unit of Kidney Diseases(LR00SP01) Charles Nicolle HospitalTunisTunisia

The adult onset Still’s disease is a rare inflammatory pathology of unknown pathogeny. The clinical features are variable. The diagnosis is difficult since exclusion of infectious, systemic and tumoral pathologies should be done. The articular complications are frequent and can be revelatory of this pathology. The articular prognosis depends on the diagnosis delay and the treatment efficiency. Our study aims to analyze different aspects of articular manifestations complicating adult onset Still’s disease to define epidemiological, clinical and evolving characteristics of these complications. It was a cross-sectional study concerning 20 cases of adult onset Still’s disease diagnosed from 1990 to 2015 in the internal medicine A department of Charles Nicolle Hospital in Tunis, meeting Yamaguchi criteria. We identified clinical, radiological, evolving and therapeutic profile of the articular manifestations occurred in these patients. There were 13 women and 7 men. The average age was 25 years. The arthralgias were reported in all cases;while, the arthritis interested fifteen patients. A hand deformation was found in four patients. A wrist ankylosis was noted in one case and a flexion elbow in one patient. The standard articular radiographs were normal in twelve cases. The treatment associated essentially non-steroidal anti-inflammatory and/or corticosteroids and/or methotrexate. Concerning the evolving profile, the monocyclic form was present in 25% of the cases, the intermittent form in 45% and the chronic articular form in 30% of our patients. The adult onset Still’s disease is rare and heterogeneous. The articular disturbances are frequent and have various outcomes.

关键词： Adult Onset Still’s Disease Arthritis Fever Corticosteroids Biotherapy Prognosis

Primary Thyroid Non-Hodgkin’s Lymphoma

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Open Journal of Pathology 2015年第4期5卷 114-116页

作者： Madiha Mahfoudhi Khaled Khammassi imen Gorsane Mounira El Euch Sami Turki Mamia Ben Salah Taieb Ben Abdallah Department of Internal Medicine Charles Nicolle Hospital Tunis Tunisia Department of Oto-Rhino-Laryngology Charles Nicolle Hospital Tunis Tunisia

Primary non-Hodgkin’s lymphoma of the thyroid gland was rarely described. We report the case of a 44-year-old man admitted for an anterior neck swelling, hoarseness and dyspnea. The chest radiograph showed a trachea deviation. He had no clinical, biological or radiological sign of other lymphoma locations. Ultrasound examination of the neck revealed a bilateral heterogeneous thyroid lesion. Cytology revealed lymphoid cells having high nuclear-cytoplasmic ratio with multiple and irregular nucleoli. An urgent thyroid surgery consisting of total thyroidectomy had been performed since the presence of compressive signs due to the tumor. The histopathological examination of a biopsy from the thyroid tissue confirmed a high-grade non-Hodgkin’s lymphoma. Then, L-thyroxin substitution therapy, chemotherapy and radiotherapy were initiated. A prolonged remission was noted.

关键词： Thyroid Gland Lymphoma Immunohistochemistry