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Journal of Plant Ecology 2020年第4期13卷 413-422页

作者： ichiro Tamaki Yae Yamada Gifu Academy of Forest Science and Culture 88 SodaiMinoGifu 501-3714Japan

Aims In a contact zone between related taxa,phenotypic variation can result from genetic and/or environmental *** study aimed to clarify the cause of phenotypic variation in leaf morphology of two Quercus crispula varieties—crispula(QCC)and mongolicoides(QCM)—in their contact zone along an altitudinal *** We measured 6 morphological traits of leaves and recorded genotypes of 13 nuclear microsatellite loci for 48 individuals in the contact zone and 24 individuals in each of the reference populations of QCC and *** constructed a model explaining the phenotypic variation(leaf morphology)in relation to environmental(altitude)and genetic(ancestry from the reference population)*** Findings Both morphological and genetic markers distinguished the two varieties in the reference populations *** were able to confirm the power of both morphological and genetic *** within the contact zone population had intermediate ancestry that was slightly biased to QCM ancestry,and the distribution of their morphologies overlapped with those of the two varieties in the reference *** effect of altitude on leaf morphological traits was significant,while that of ancestry was *** of ancestry and interclass heterozygosity in the contact zone population resembled those in F2 or later generation *** results indicate that in the contact zone between QCC and QCM,there is no ongoing hybridization,but environmental pressure has created an altitudinal gradient in morphological traits through phenotypic plasticity and/or variation in functional genes.

关键词： Quercus crispula Quercus mongolica leaf morphologies microsatellites hybrid zone

The cardiovascular action of hexarelin

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Journal of Geriatric Cardiology 2014年第3期11卷 253-258页

作者： Yuanjie MAO Takeshi Tokudome ichiro Kishimoto Department of Biochemistry National Cerebral and Cardiovascular Center Suita 0saka 565-8565 Japan Department of Medicine Prince George's Hospital Center Cheverly Maryland 20785 USA Department of Endocrinology and Metabolism National Cerebral and Cardiovascular Center Sulfa Osaka 565-8565 Japan

Hexarelin, a synthetic growth hormone-releasing peptide, can bind to and activate the growth hormone secretagogue receptor （GHSR） in the brain similar to its natural analog ghrelin. However, the peripheral distribution of GHSR in the heart and blood vessels suggests that hexarelin might have direct cardiovascular actions beyond growth hormone release and neuroendocrine effects. Furthermore, the non-GHSR CD36 had been demonstrated to be a specific cardiac receptor for hexarelin and to mediate its cardioprotective effects. When compared with ghrelin, hexarelin is chemically more stable and functionally more potent. Therefore, it may be a promising therapeutic agent for some car-diovascular conditions. In this concise review, we discuss the current evidence for the cardiovascular action of hexarelin.

关键词： Hexarelin Cardiovascular disease Growth hormone secretagogue receptor CD36

Expression analyses of stress‑responsive genes in the hermatypic coral Acropora tenuis and its symbiotic dinofagellates after exposure to the herbicide Diuron

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Marine Life Science & Technology 2023年第3期5卷 289-299页

作者： Hiroshi Ishibashi Seigo Minamide ichiro Takeuchi Graduate School of Agriculture Ehime UniversityMatsuyamaEhime 790-8566Japan Center of Advanced Technology for the Environment Graduate School of AgricultureEhime UniversityMatsuyamaEhime 790-8566Japan

Diuron is one of the most frequently applied herbicides in sugarcane farming in southern Japan,and *** addition,it is used as a booster substance in copper-based antifouling *** to these various uses,Diuron is released into the marine environment;however,little information is available on gene expression in corals and their symbiotic algae exposed to *** investigated the efects of Diuron on stress-responsive gene expression in the hermatypic coral Acropora tenuis and its symbiotic *** seven days of exposure to 1µg/L and 10µg/L Diuron,no signifcant changes in the body colour of corals were ***,quantitative reverse transcription-polymerase chain reaction analyses revealed that the expression levels of stress-responsive genes,such as heat shock protein 90(HSP90),HSP70,and calreticulin(CALR),were signifcantly downregulated in corals exposed to 10µg/L of Diuron for seven ***,aquaglyceroporin was signifcantly downregulated in corals exposed to environmentally relevant concentrations of 1µg/L *** contrast,no such efects were observed on the expression levels of other stress-responsive genes,such as oxidative stress-responsive proteins,methionine adenosyltransferase,and green/red fuorescent *** exposure had no signifcant efect on the expression levels of HSP90,HSP70,or HSP40 in the symbiotic *** results suggest that stress-responsive genes,such as HSPs,respond diferently to Diuron in corals and their symbiotic dinofagellates and that *** HSPs and CALRs may be useful molecular biomarkers for predicting stress responses induced by the herbicide Diuron.

关键词： Acropora tenuis Calreticulin Coral bleaching Diuron Heat shock protein

A method for estimating the fraction of mineral dust in particulate matter using PM2.5-to-PM10 ratios

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Particuology 2016年第5期14卷 114-120页

作者： Nobuo Sugimoto Atsushi Shimizu ichiro Matsui Masataka Nishikawa Center for Environmental Measurement and Analysis National Institute for Environmental Studies 16-20nogawa Tsukuba 305-8506 Japan Tokyo University of Science Environmental Safety Center 1-3 Kagurazaka Shinjuku-ku Tokyo 162-8601Japan

A simple method for estimating the contributions of mineral dust to PM2.5, PM10, or TSP is presented. The method is based on the assumption of external mixing of two types of particles with different PM2.5/PM10 ratios, The method was applied to local and transported dust events observed in Tsukuba, Japan, and was compared with collocated polarization lidar measurements. The method was then applied to three dust events that occurred in Oki, Rishiri, and Ochiishi,Japan, in 2012. The results showed that the method was useful for detecting mineral dust and for qualitatively describing the mixing of dust with anthropogenic aerosols.

关键词： Mineral dust PM2.5 dust fraction PM2.5 to PM10 ratio Atmospheric mixing Lidar Depolarization ratio

Effect of FeO concentration in sinter iron ore on reduction behavior in a hydrogen-enriched blast furnace

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International Journal of Minerals,Metallurgy and Materials 2022年第10期29卷 1820-1829页

作者： Ko-ichiro Ohno Takayuki Maeda Kazuya Kunitomo Masashi Hara Department of Materials Faculty of EngineeringKyushu University744 MotookaNishi-kuFukuoka 819-0395Japan Kashima Area East Nippon WorksNippon Steel Corporation3 HikariKashima CityIbaraki 314-0014Japan

Japan started the national project“COURSE 50”for CO_(2) reduction in the *** project aimed to establish novel technologies to reduce CO_(2) emissions with partially utilization of hydrogen in blast furnace-based ironmaking by 30%by around 2030 and use it for practical applications by *** idea is that instead of coke,hydrogen is used as the reducing agent,leading to lower fossil fuel consumption in the *** has been reported that the reduction behavior of hematite,magnetite,calcium ferrite,and slag in the sinter is different,and it is also considerably influenced by the sinter *** study aimed to investigate the reduction behavior of sinters in hydrogen enriched blast furnace with different mineral morphologies in CO-CO_(2)-H2 mixed *** an experimental sample,two sinter samples with significantly different hematite and magnetite ratios were prepared to compare their reduction *** reduction of wustite to iron was carried out at 1000,900,and 800℃ in a CO-CO_(2)-H2 atmosphere for the mineral morphology-controlled sinter,and the following findings were *** reduction rate of smaller amount of FeO led to faster increase of the reduction rate curve at the initial stage of ***-observations of reduced samples showed that the reaction proceeded from the outer periphery of the sample toward the inside,and a reaction interface was observed where reduced iron and wustite ***-observations revealed three layers,namely,wustite single phase in the center zone of the sample,iron single phase in the outer periphery zone of the sample,and iron oxide-derived wustite FeO and iron,or calcium ferritederived wustite'FeO'and iron in the reaction interface zone.A two-interface unreacted core model was successfully applied for the kinetic analysis of the reduction reaction,and obtained temperature dependent expressions of the chemical reaction coefficients from each mineral phases.

关键词： hydrogen reduction wustite hematite magnetite calcium ferrite two-interface unreacted core model COURSE50

CONVERGENCE ANALYSIS FOR A NONCONFORMING MEMBRANE ELEMENT ON ANISOTROPIC MESHES

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Journal of Computational Mathematics 2005年第4期23卷 373-382页

作者： Dong-yang Shi Shao-chun Chen ichiro Hagiwara Department of Mathematics Zhengzhou University Zhengzhou 450052 China Tokyo Institute of Technology 2-12-1 Ohokayama Megro Tokyo 152-8552 Japan

Regular assumption of finite element meshes is a basic condition of most analysis of finite element approximations both for conventional conforming elements and nonconforming elements. The aim of this paper is to present a novel approach of dealing with the approximation of a four-degree nonconforming finite element for the second order elliptic problems on the anisotropic meshes. The optimal error estimates of energy norm and L^2-norm without the regular assumption or quasi-uniform assumption are obtained based on some new special features of this element discovered herein. Numerical results are given to demonstrate validity of our theoretical analysis.

关键词： Anisotropic mesh Nonconforming finite element Optimal estimate

Sepsis caused by endoscopic clipping for colonic diverticular bleeding: A rare complication

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World Journal of Gastroenterology 2009年第30期15卷 3817-3818页

作者： Keiichiro Kume Masahiro Yamasaki ichiro Yoshikawa Third Department of Internal Medicine University of Occupational and Environmental HealthJapanSchool of MedicineKitakyusyu 807-8555Japan

We herein report the rare complication of sepsis caused by endoscopic clipping for colonic diverticular bleeding. A 78-year-old man with a 12-h history of near syncope and painless hematochezia was admitted to our hospital. Following the transfusion of 4 U of blood and continued hematochezia, a colonoscopy was performed. Active bleeding was seen as continuous arterial spurting from a single diverticulum located in the middle ascending colon. This diverticulum was seamed by four endoclips. The next day, the patient became febrile with a temperature of 39.2℃. Laboratory data included a white blood cell count of 18 100/mm3 and a C-reactive protein level of 3.4 mg/dL. He was diagnosed with sepsis since Escherichia coli was detected in the blood culture. Antibiotics were started. Four days later his fever had improved and laboratory data improved 9 d later.

关键词： Colonic diverticular bleeding Endoscopicclipping Rare complication Endoscopic hemostasis Sepsis

Impact of Jumihaidokuto(Shi-Wei-Bai-Du-Tang) on Treatment of Chronic Spontaneous Urticaria: A Randomized Controlled Study

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Chinese Journal of Integrative Medicine 2019年第11期25卷 820-824页

作者： Hiroyuki Murota Hiroaki Azukizawa ichiro Katayama Department of Dermatology Course of Integrated Medicine Graduate School of Medicine Osaka University

Objective:To study the effect of Jumihaidokuto(Shi-Wei-Bai-Du-Tang,十味败毒汤)in the management of chronic spontaneous ***:A randomized two-arm,parallel group study was conducted to compare the effect of Jumihaidokuto(6 g daily)with a control for 8 *** therapy(e.g.,antihistamines)was ***?one subjects with severe chronic urticaria were enrolled in this *** primary treatment outcome was the severity score proposed by the Japanese Dermatological *** outcomes were quality of life(Skindex-16),itch intensity(Visual Analogue Scale),and patients'subjective disability due to wheal or *** the subjects were randomly assigned to groups by block randomization,10 received Jumihaidokuto,and 11 did *** subjects had already taken ***:Improvement was significant when comparing the severity score of the Jumihaidokuto group with that of the control group(P<0.01).Skindex-16 values for both groups gradually decreased in the same ***:Concomitant use of Jumihaidokuto with antihistamine was more effective than antihistamine alone in the management of chronic idiopathic urticaria.

关键词： Jumihaidokuto crude drug extract Shi-Wei-Bai-Du-Tang Chinese medicine antihistamine chronic spontaneous urticaria severity quality of life

Comparison of dissimilarity measures for cluster analysis of X-ray diffraction data from combinatorial libraries

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npj Computational Materials 2017年第1期3卷 448-456页

作者： Yuma Iwasaki A.Gilad Kusne ichiro Takeuchi IoT Devices Research Laboratories NEC CorporationTsukuba 305-8501Japan Spin Quantum Rectification Project ERATOJapan Science and Technology AgencySendai 980-8577Japan National Institute of Standards and Technology GaithersburgMD 20899USA Department of Materials Science and Engineering University of MarylandCollege parkMD 20742USA

Machine learning techniques have proven invaluable to manage the ever growing volume of materials research data produced as developments continue in high-throughput materials simulation,fabrication,and *** particular,machine learning techniques have been demonstrated for their utility in rapidly and automatically identifying potential composition-phase maps from structural data characterization of composition spread libraries,enabling rapid materials fabrication-structure-property analysis and functional materials discovery.A key issue in development of an automated phase-diagram determination method is the choice of dissimilarity measure,or kernel *** desired measure reduces the impact of confounding structural data issues on analysis *** issues include peak height changes and peak shifting due to lattice constant change as a function of *** this work,we investigate the choice of dissimilarity measure in X-ray diffraction-based structure analysis and the choice of measure’s performance impact on automatic composition-phase map *** dissimilarity measures are investigated for their impact in analyzing X-ray diffraction patterns for a Fe-Co-Ni ternary alloy composition *** cosine,Pearson correlation coefficient,and Jensen-Shannon divergence measures are shown to provide the best performance in the presence of peak height change and peak shifting(due to lattice constant change)when the magnitude of peak shifting is *** prior knowledge of the maximum peak shifting,dynamic time warping in a normalized constrained mode provides the best *** work also serves to demonstrate a strategy for rapid analysis of a large number of X-ray diffraction patterns in general beyond data from combinatorial libraries.

关键词： alloy shifting analysis

Effects of selenium-containing compounds on Cu^(2+)/Zn^(2+)-induced neuronal cell death and potential application as therapeutic agents for neurological diseases

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Neural Regeneration Research 2022年第2期17卷 311-312页

作者： Ken-ichiro Tanaka Mikako Shimoda Masahiro Kawahara Department of Bio-Analytical Chemistry Faculty of PharmacyMusashino UniversityShinmachiNishitokyoTokyoJapan

In many tissues, trace metals such as iron(Fe), zinc(Zn), and copper(Cu) are important for various physiological functions such as immune function, cell division, and enzyme function. However, it has been shown in humans and experimental animal models that excessive amounts of these trace metals in the body can induce various diseases in the central nervous system, liver.

关键词： metals potential copper