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Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C

World Journal of Gastroenterology 2007年第46期13卷 6236-6242页

作者： Joonho Yoon Jong In lee Soon Koo Baik Kwang Ho lee Joon hyung Sohn Hyean-Woo lee Jun Namkung Sei Jin Chang Jong-Whan Choi Hyun-Won Kim Byung-Il Yeh Department of Biochemistry and Institute of Basic Medical Sciences Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Internal Medicine Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Internal Medicine Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Institute of Lifelong HealthWonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Anesthesiology Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Biochemistry and Institute of Basic Medical Sciences Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Institute of Lifelong HealthWonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Preventive Medicine and Institute of Occupational Medicine Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Institute of Lifelong HealthWonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea

AIM： To confirm the predictive factors for interferon （IFN）-α and ribavirin combination therapy for chronic hepatitis patients with hepatitis C virus （HCV） genotype lb. METHODS： HCV RNA from 50 patients infected with HCV genotype lb was studied by cloning and sequencing of interferon sensitivity determining region （ISDR）, PKR- eIF2α phosphorylation homology domain （PePHD）. Patients were treated with IFN-α and ribavirin for 6 mo and grouped by effectiveness of the therapy. A variety of factors were analyzed. RESULTS： Our data showed that age, HCV RNA titer, and ISDR type could be used as the predictive factors for combined IFN-α and ribavirin efficacy. Characteristically, mutations in PePHD appeared only when the combination therapy was effective. Other factors, such as sex and alanine aminotransferase （ALT） level, were not related to its efficacy. Adjusting for age and HCV RNA titer indicated that the ISDR type was the most potent predictive factor. CONCLUSION： HCV RNA ISDR type is an important factor for predicting efficacy of IFN-α and ribavirin combination therapy in Korean patients.

关键词： Hepatitis C virus -lb Interferon-m Ribavirin Interferon sensitivity determining region PKR-eIF2α phosphorylation homology domain

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A study on Helmet for Korean Standard

A study on Helmet for Korean Standard

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The 6th Pan-Pacific Conference on Occupational Ergonomics

作者： Kwan Suk lee Young Sook lee hyung B.Ro Chang Min Yoo Bo Hyun Kim Department of Industrial Engineering Hongik University KOREA Department of Clothing and Textiles Chonnam University KOREA Department of Management Hongik University KOREA

This study was conducted to revise the Korean Standard on Helmet. Standards abroad were compared with the Korean Standard(KS) on Helmet. Users of the Korean Standard were surveyed to find the problems in using this St... 详细信息

关键词： The Korean Standard on helmet Head shapes Anthropometry data

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3D cellular visualization of intact mouse tooth using optical clearing without decalcification

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International Journal of Oral Science 2019年第3期11卷 223-230页

作者： Sujung Hong Jingu lee Jin Man Kim Sun-Young Kim hyung-Ryong Kim Pilhan Kim Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology (KAIST)291 Daehak-roYuseong-guRepublic of Korea KI for Health Science and Technology (KIHST) Korea Advanced Institute of Science and Technology (KAIST)291 Deahak-roYuseong-guRepublic of Korea Department of Dentistry CHA Bundang Medical CenterCHA UniversitySeongnamRepublic of Korea Department of Conservative Dentistry and Dental Research Institute Seoul National University School of Dentistry101 Daehak-roJongno-guRepublic of Korea College of Dentistry Institute of Tissue Regeneration Engineering (ITREN)Dankook UniversityCheonanRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)291 Daehak-roYuseong-guRepublic of Korea

Dental pulp is composed of nerves,blood vessels,and various types of cells and surrounded by a thick and hard enamel-dentin *** to its importance in the maintenance of tooth vitality,there have been intensive efforts to analyze the complex cellularlevel organization of the dental pulp in *** conventional histologic analysis has provided microscopic images of the dental pulp,3-dimensional (3D) cellular-level visualization of the whole dental pulp in an intact tooth has remained a technically challenging *** is mainly due to the inevitable disruption and loss of microscopic structural features during the process of mechanical sectioning required for the preparation of the tooth sample for histological *** accomplish 3D microscopic observation of thick intact tissue,various optical clearing techniques have been developed mostly for soft tissue,and their application for hard tissues such as bone and teeth has only recently started to be *** this work,we established a simple and rapid optical clearing technique for intact mouse teeth without the time-consuming process of *** achieved 3D cellular-level visualization of the microvasculature and various immune cell distributions in the whole dental pulp of mouse teeth under normal and pathologic *** technique could be used to enable diverse research methods on tooth development and regeneration by providing 3D visualization of various pulpal cells in intact mouse teeth.

关键词： blood vessels Dental pulp soft tissue

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Giant choledocholithiasis treated by mechanical lithotripsy using a gastric bezoar basket

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World Journal of Gastroenterology 2012年第25期18卷 3327-3330页

作者： Hyun Jung Chung Seok Jeong Don Haeng lee Jung Il lee Jin-Woo lee Byoung Wook Bang Kye Sook Kwon hyung Kil Kim Yong Woon Shin Young Soo Kim Division of Gastroenterology Department of Internal MedicineInha University School of MedicineIncheon 400-711South Korea

Mechanical lithotripsy （ML） is usually considered as a standard treatment option for large bile duct stones. However, it is impossible to retrieve oversized stones because the conventional lithotripsy basket may not be able to grasp the stone. However, there is no es- tablished endoscopic extraction method for such gi- ant stone removal. We describe a case of successful extraction of a 4-cm large stone using a gastric bezoar basket. A 78-year-old woman had suffered from upper abdominal pain for 20 d. Contrast-enhanced computed tomogram revealed a 4-cm single stone in the distal common bile duct （CBD）. Endoscopic stone retraction was decided upon and endoscopic papillary balloon dilation was performed using a large balloon. An at- tempt to capture the stone using a standard lithotripsy basket failed due to the large stone size. Subsequently, we used a gastric bezoar basket to successfully capturethe stone. The stone was fragmented into small pieces and extracted. The stone was completely removed after two sessions of endoscopic retrograde cholangio- pancreatography; each of which took 30 rain. No com- plications occurred during or after the procedure. The patient was fully recovered and discharged on day 11 of hospitalization. ML using a gastric bezoar basket is a safe and effective retrieval method in select cases, and is considered as an alternative nonoperative option for the management of difficult CBD stones.

关键词： Giant choledocholithiasis Mechanical litho-tripsy Bezoar basket Common bile duct stone Endo-scopic papillary balloon dilatal^ion

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New Paradigm for Survival of e-Business for Ship’s Stores Industry

New Paradigm for Survival of e-Business for Ship’s Stores I...

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ICSSSM'04国际会议

作者： Nam Kyu Park hyung Rim Choi Hyun Deuk Choi Chang Sup lee Department of Distribution Management Tongmyong University of Information Technology Busan 608-711 Korea Department of MIS Dong-A University Busan 604-714 Korea Graduate School of MIS Dong-A University Busan 604-714 Korea Graduate School of MIS Dong-A University Busan 604-714 Korea

＜正＞ Over the past many years, recognizing the importance of e-Business for the survival of off-line business, they have set their own e-Business strategies, while putting them into practice. However, most of them have usually imitated the examples of other companies, or depended on only their own homepage. In fact, in order to introduce e-Business successfully, both success and failure factors should be thoroughly and systematically analyzed, thus establishing its own strategy based on this *** this end, this paper has put an emphasis on studying the e-Business models based on transaction features, analyzing the typical cases of ship’s stores business. And also, to suggest the success factors of e-Business model, this paper has analyzed the current situation of ship’s stores transactions between shipping companies and ship’s stores supplier, while pointing out the important tasks to be done for improvement.

关键词： e-Business Ship’s Stores Industry B2B

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Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy

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World Journal of Gastroenterology 2012年第30期18卷 4044-4050页

作者： hyung Hun Kim Moo In Park Sang Ho lee Hyun Yong Hwang Sung Eun Kim Seun Ja Park Won Moon Departments of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea Departments of Surgery Kosin University College of MedicineBusan 602-702South Korea Departments of Laboratory Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM:To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal ***:We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric *** surgeries were performed by a single skilled *** measured peptide YY 3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after ***:Vagus nerve preservation group showed less body weight loss and less increase of peptide YY 3-36 compared with vagotomy group(-5.56 ± 2.24 kg vs-7.85 ± 1.57 kg,P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL,P = 0.021,respectively).Moreover,patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY 3-36 level,typically less than 20% [6(66.7%) vs 0(0.0%),P = 0.011,odd ratio = 3.333,95% confidence interval(1.293,8.591)].CONCLUSION:Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY 3-36.

关键词： Peptide YY Ghrelin Vagotomy Gastrectomy Body weight

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EM STUDIES OF MISFIT STRAIN AND STRUCTURE EVOLUTION OF SELF-ASSEMBLED InAs/GaAs QUANTUM DOT HETEROSTRUCTURES

EM STUDIES OF MISFIT STRAIN AND STRUCTURE EVOLUTION OF SELF-...

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第十一届北京分析测试学术报告会暨展览会(BCEIA 2005)

作者： hyung Seok Kim Ju hyung Suh Chan Gyung Park Sang Jun lee Sam Gyu Noh Jin Dong Song Yong Ju Park Won Jun Choi Jung Il lee Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Quantum Dot Technology Laboratory Korea Research Institute of Standards and Science (KRISS)

Compound semiconductor heterostructures which have different energy band gaps have recently been grown easily owing to the technical development of epitaxial thin film ***,extensive studies have been carried out on th...

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First molluscan antimicrobial peptide hydramacin in Manila clam:molecular characterization and expression analysis

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Journal of Coastal Life Medicine 2014年第6期 447-452页

作者： Youngdeuk lee Saranya Revathy K Sukkyoung lee Ilson Whang Chulhong Oh Do-hyung Kang Gee-Wook Shin Jehee lee Mahanama De Zoysa Korea Institute of Ocean Science&Technology Ansan426-744Republic of Korea Department of Marine Life Sciences School of Marine Biomedical SciencesJeju National UniversityJeju Special Self-Governing Province690-756Republic of Korea College of Veterinary Medicine Chonbuk National UniversityJeonju561-756Republic of Korea Marine and Environmental Institute Jeju National UniversityJeju Special Self-Governing Province 690-814Republic of Korea College of Veterinary Medicine and Research Institute of Veterinary Medicine Chungnam National UniversityYuseong-guDaejeon305-764Republic of Korea

Objective:To investigate molecular characterization and the immune responses of Manila clam hydramacin(Rp-hdmc).Methods:cDNA sequence of hydramacin was isolated from Manila clam transcriptome *** characterization of hydramacin cDNA was performed by BLAST and SWISS-MODEL bioinformatics ***-specific expression and transcriptional regulation after Vibrio tapetis challenge was done by quantitative real time ***:Rp-hdmc has 291 bp open reading frame(ORF),encoding 97 amino acids with a mature hydramacin consisting of 77 amino acid *** un-challenged clam,Rp-hdmc was constitutively expressed in all tested tissues and the highest expression level was detected in *** pathogenic bacteria Vibrio tapetis challenge,Rp-hdmc mRNA was up-regulated in gill and ***:We identified hydramacin cDNA(Rp-hdmc)from mollusk Manila clam that shows the characteristic features of hydramacin *** has eight cysteine residues with four disulfide linkages,three helices and two β-strands in secondary *** results after *** challenges suggest that Rp-hdmc is involved in immune response against pathogenic bacteria.

关键词： Manila clam Ruditapes philippinarum Hydramacin Antimicrobial peptide

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Change in renal function after sodium phosphate preparation for screening colonoscopy

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World Journal of Gastroenterology 2010年第16期16卷 2010-2016页

作者： Dong Choon Seol Sung Noh Hong Jeong Hwan Kim In Kyung Sung hyung Seok Park Jung Hyun lee Chan Sup Shim Department of Internal Medicine Konkuk University School of Medicine Department of Health Promotion Healthcare CenterKonkuk University Medical Center Healthcare Center Konkuk University Medical CenterDepartment of Internal MedicineKonkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology Department of Internal Medicine Konkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology

AIM:To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate(NaP) preparation for screening ***:We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 *** to screening colonoscopy,224 patients underwent bowel cleansing with NaP(NaP group) and 113 patients with polyethylene glycol(PEG group).The control group comprised 672 age-matched *** compared the changes in the creatinine levels and the glomerular filtration rates(GFRs) from baseline to 12-24 mo between the NaP,PEG,and control groups using two-way repeated measured analysis of *** addition,multivariate linear regression analysis was performed to assess the risk factors for a decreased ***:The baseline mean serum creatinine level in the NaP,PEG,and control groups was 1.12 ± 0.15,1.12 ± 0.16,and 1.12 ± 0.15 mg/dL,which increased to 1.15 ± 0.15,1.15 ± 0.18,and 1.15 ± 0.15 mg/dL,respectively,after 12-24 *** baseline mean GFR in the NaP,PEG,and control groups was 69.0 ± 7.7,68.9 ± 8.0,and 69.6 ± 6.7 mL/min per 1.73 m2,which decreased to 66.5 ± 7.8,66.5 ± 8.3,and 67.4 ± 6.4 mL/min per 1.73 m2,respectively,after 12-24 *** changes in serum creatinine levels and GFRs were not significantly between the NaP,PEG,and control groups(P = 0.992 and P = 0.233,respectively).Using multivariate linear regression analysis,only the baseline GFR was associated with the change in GFR(P < 0.001).Indeed,the bowel preparations were not associated with the change in GFR(P = 0.297).CONCLUSION:NaP bowel preparation in subjects with normal renal function was not associated with renal injury,and NaP can thus be used safely for screening colonoscopy.

关键词： Sodium phosphate Polyethylene glycol Purgatives Colonoscopy Creatinine Glomerular filtration rate

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Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability

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World Journal of Gastroenterology 2012年第27期18卷 3571-3577页

作者： Jaehoon Jahng Young Hoon Youn Kwang Hyun Kim Junghwan Yu Yong Chan lee Woo Jin hyung Sung Hoon Noh Hyunki Kim Hoguen Kim Hyojin Park Sang In lee Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 100-753South Korea Department of Surgery Yonsei University College of MedicineSeoul 100-753South Korea Department of Pathology Yonsei University College of MedicineSeoul 100-753South Korea

AIM： To investigate endoscopic and clinicopathologic characteristics of early gastric cancer （EGC） according to microsatellite instability phenotype. METHODS： Data were retrospectively collected from a single tertiary referral center. Of 981 EGC patients surgically treated between December 2003 and October 2007, 73 consecutive EGC patients with two or more microsatellite instability （MSI） mutation [high MSI （MSI-H）] and 146 consecutive EGC patients with one or no MSI mutation （non-MSI-H） were selected. The endoscopic and clinicopathologic features were compared between the MSI-H and non-MSI-H EGC ***： In terms of endoscopic characteristics, MSI-H EGCs more frequently presented with elevated pattern （OR 4.38, 95% Cl： 2.40-8.01, P 〈 0.001）, moderate- to-severe atrophy in the surrounding mucosa （OR 1.91, 95% CI： 1.05-3.47, P = 0.033）, antral location （OR 3.99, 95% CI： 2.12-7.52, P 〈 0.001） and synchronous le- sions, compared to non-MSI-H EGCs （OR 2.65, 95% CI： 1.16-6.07, P = 0.021）. Other significant clinicopatholog- ic characteristics of MSI-H EGC included predominance of female sex （OR 2.77, 95% CI： 1.53-4.99, P 〈 0.001）, older age （〉 70 years）（OR 3.30, 95% CI： 1.57-6.92, P = 0.002）, better histologic differentiation （OR 2.35, 95% Cl： 1.27-4.34, P = 0.007）, intestinal type by Lau- ren classification （OR 2.34, 95% CI： 1.15-4.76, P = 0.019）, absence of a signet ring cell component （OR 2.44, 95% CI： 1.02-5.86, P = 0.046）, presence of mu- cinous component （OR 5.06, 95% Cl： 1.27-20.17, P = 0.022）, moderate-to-severe lymphoid stromal reaction （OR 3.95, 95% CI： 1.59-9.80, P = 0.003）, and co-exist- ing underlying adenoma （OR 2.66, 95% CI： 1.43-4.95, P = 0.002）. CONCLUSION： MSI-H EGC is associated with unique endoscopic and clinicopathologic characteristics includ- ing frequent presentation in protruded type, co-exist- ing underlying adenoma, and synchronous lesions.

关键词： Microsatellite instability Early gastric can-cer Endoscopic characteristic Advanced gastric cancer

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