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Comments on "Direct Radiative Forcing of Anthropogenic Aerosols over Oceans from Satellite Observation"

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Advances in Atmospheric Sciences 2013年第1期30卷 10-14页

作者： hye-ryun OH Chang-Hoi HO Yong-Sang CHOI School of Earth and Environmental Sciences Seoul National University Department of Environmental Science and Engineering Ewha Womans University

Previous observational studies have estimated anthropogenic aerosol direct radiative forcing over oceans without due consideration of cloudy-sky aerosols. However, when interaction between clouds and aerosols located below or above the cloud level is taken into account, the aerosol direct radiative forcing is larger by as much as 5 W m-2 in most mid-latitude regions in the Northern Hemisphere.

关键词： cloudy-sky aerosol forcing anthropogenic aerosol aerosol optical depth satellite observations

PUB22 and PUB23 U-box E3 ubiquitin ligases negatively regulate 26S proteasome activity under proteotoxic stress conditions

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Journal of Integrative Plant Biology 2022年第3期64卷 625-631页

作者： Min Yong Ahn Dong hye Seo woo Taek Kim Department of Systems Biology Division of Life ScienceYonsei UniversitySeoul 03722Korea Institute of Life Science and Biotechnology Yonsei UniversitySeoul 03722Korea

The mechanism regulating proteasomal activity under proteotoxic stress conditions remains ***,we showed that arsenite-induced proteotoxic stress resulted in upregulation of Arabidopsis homologous PUB22 and PUB23 U-boxE3 ubiquitin ligases and that pub22 pub23 double mutants displayed arsenite-insensitive seed germination and root growth ***22/PUB23 downregulated 26 S proteasome activity by promoting the dissociation of the 19 S regulatory particle from the holo-proteasome complex,resulting in intracellular accumulation of UbG76 VGFP,an artificial substrate of the proteasome complex,and insoluble poly-ubiquitinated *** results suggest that PUB22/PUB23 play a critical role in arsenite-induced proteotoxic stress response via negative regulation of 26 S proteasome integrity.

关键词： Arabidopsis thaliana proteotoxic stress sodium arsenite U-box E3 ligases PUB22/23 26S proteasome complex

Gastrointestinal tuberculosis is not associated with proton pump inhibitors:A retrospective cohort study

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World Journal of Gastroenterology 2013年第2期19卷 258-264页

作者： Kyoung Sup Hong Seung Joo Kang Jong Kyoung Choi Ju Han Kim Heewon Seo Suehyun Lee Jae-woo Jung hye-ryun Kang Sang-Heon Cho Joo Sung Kim Department of Internal Medicine Drug Safety Monitoring CenterSeoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Division of Biomedical Informatics Systems Biomedical Informatics Research CenterSeoul National University College of MedicineSeoul 110799South Korea

AIM:To evaluate the effect of proton pump inhibitors(PPIs) on the development of gastrointestinal ***:All patients who were more than 20 years old and who had received a prescription for PPIs among those who visited Seoul National University Hospital from January 1,2005 to December 31,2009 were *** to the low sensitivity of the microbiologic test and the nonspecific pathologic findings,the diagnosis of gastrointestinal tuberculosis was confirmed through the presence of active ulcerations and the responses to anti-tuberculosis *** patients were divided into two groups according to treatment duration(group 1:≤ 3 mo;group 2:> 3 mo) and were followed up from the time they took the first prescription of PPIs until their last *** regression analysis was used to calculate the relative risks(RR) and 95%CI,adjusting for ***:Among the 61 834 patients exposed to PPIs(50 534 in group 1;11 300 in group 2),21 patients were diagnosed with PPI-associated gastrointestinal tuberculosis during 124 274 person-years of *** 21 patients,the 12 who revealed only scar changes in the colonoscopy were excluded from the statistical *** those who remained,2 were excluded because they underwent gastrointestinal endoscopy within 4 wk of the first prescription for *** exposure to PPI was associated with a higher mean age(55.0 ± 14.5 in group 1 vs 58.2 ± 13.3 in group 2,P < 0.001) and a higher Charlson co-morbidity index(0.50 ± 0.93 in group 1 vs 0.77 ± 1.14 in group 2,P < 0.001).The true incidence of active gastrointestinal tuberculosis was 0.65 per 1000 person-years in group 1 and 0.03 per 1 000 person-years in group *** the less-than-three-month PPI treatment period in group 1,the over-three-month PPI therapy period in group 2 was not associated with increased risk of acquiring gastrointestinal tuberculosis,after adjusting for age and co-morbidities,whereas the Charlson co-morbidity index was associated

关键词： Proton pump inhibitor Acid suppression Tuberculosis Gastrointestinal tuberculosis Tuberculous colitis

Subtenon retrobulbar hyaluronidase injection for ophthalmic artery occlusion following facial filler injection

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1170-1172页

作者： hye Rim Choe Se Joon woo Department of Ophthalmology Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620Republic of Korea

Dear Editor,Central retinal artery or ophthalmic artery occlusion is a rare complication of facial filler injection,which causes irreversible *** have reported failed attempts of retrobulbar,peribulbar,or intraarteria... 详细信息

关键词： injection arterial artery

Changes of the Flowering Time of Trees in Spring by Climate Change in Seoul, South Korea

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 1019-1033页

作者： hyewon Kim Chanwoo Park Jong Hwan Lim hye woo Shin Interdisciplinary Program of EcoCreative The Graduate SchoolEwha Womans UniversitySeoul03760Korea Forest Ecology and Climate Change Division National Institute of Forest ScienceSeoul02455Korea Research Institute of Ecoscience Ewha Womans UniversitySeoul03760Korea

Flowering onset has attracted much attention in ecological research as an important indicator of climate ***,warmer temperatures advance flowering *** effect of climate warming on flowering onset is more pronounced in spring because the difference between atmospheric and water temperatures creates more rapid convection than in other *** analyzed the correlation between 73 species of spring woody plants in Hongneung Arboretum in Seoul,South Korea and the spring minimum temperature and average precipitation over the past 50 years(1968–2018).The spring minimum temperature and average precipitation have increased over the past 50 years,resulting in the advance of the first flowing date(FFD)in all 73 species by 8.5 days on average.A comparison of FFD changes over time by dividing the survey period into three time periods confirmed the advance of the FFD in 50 species(68%of investigated species)by 11.1 days on average in both Period 2(1999–2008)and Period 3(2009–2018)relative to Period 1(1968–1975).Additionally,a delay of the FFD by 3.2 days on average was observed in 8 *** FFD of Lonicera chrysantha(Caprifoliaceae)advanced by over 40 days and was highly correlated with the increased spring minimum *** of the sensitivity of plant responses to climate change revealed that a temperature rise of 1℃ was associated with an FFD advance of 1.2 days in all *** species that was most sensitive to temperature change was Spiraea pubescens ***(Rosaceae),whose FFD advanced by 4.7 days per 1℃ temperature *** increase in precipitation by 1 mm was found to result in a 0.1-day advance of the FFD of all *** tomentosa(Rosa-ceae)was the most sensitive species,that advanced by 2.6 days for each 1 mm increase in ***,for all species,the FFD was more sensitive to the change in temperature than in *** that the current greenhouse gas(GHGs)emission levels or atmospheric CO_(2) conc

关键词： Phenology first flowering date climate change

Comparative assessment of physicochemical properties of unripe peach(Prunus persica) and Japanese apricot(Prunus mume)

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 97-103页

作者： hye-ryun Kim II-Doo Kim Sanjeev Kumar Dhungana Mi-Ok Kim Dong-Hyun Shin Division of Plant Biosciences.School of Plant Biosciences Kyungpook National UniversityDaegu 702-701.Korea Institute of Agricultural Science and Technology Kyungpook national universityDaegu 702-701.Korea Department of Hotel Restaurant.Culinary ArtsDaegu Health CollageDaegu 702-722.Korea

Objective:To investigate the physicochemical properties of unripe peach-Pruuns persica ***(Mibaekdo) and Prunus persica *** Hakuho(Nagasawa Hakuho) as an alternative to fowl supplement while Japanese apricot(Prunus mume ***)(Backaha) was used as a control ***:The unripe fruits were analyzed for soluble solid(Brix).titratable ***,total polyphenol content,1,1-diphenyl-2-pierylhydrazyl(DPPH) radical scavenging activity,amygdalin content,free amino acid content,organic acid content,free sugar content,and α-amylase ***:Total polyphenol content of unripe peach ranged between 137.27-151.64 μg/g whereas that of apricot was 160.73 μg/*** radical scavenging activities of Rackaha was the highest189.16%.) followed by Mibaekdo(85.03%) and Nagasawa Hakuho(41.30%).The highest amount of oxalic acid 1612.8 mg/100 g) was observed in Mibaekdo while that of Nagasawa llakuho and Backaha were(184.6±18.1) and(334.8±16.1) mg/100 g,*** contents of *** Hakuho and Backaha were 486.61,548.60 and 174.28 μg/g,***:The results suggest that the unripe fruit of peach has a significant biochemical potential of using as a food supplement with potential health benefit for human health.

关键词： Amygdalin Japanese apricot(Backaha) Physicochemical properties Unripe peach(Mibaekdo Nagasawa Hakuho)

SPARC Local Workshop on “WCRP Grand Challenges and Regional Climate Change”

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Advances in Atmospheric Sciences 2018年第6期35卷 624-627页

作者： Joowan KIM Seok-woo SON hye-Jin KIM Baek-Min KIM Changhyun YOO Department of Atmospheric Sciences Kongju National University Gongju 32588 Republic of Korea School of Earth and Environmental Sciences Seoul National University Seoul 08826 Republic of Korea Korea Polar Research Institute Incheon 21990 Republic of Korea Department of Climate and Energy Systems Engineering Ewha Womans University Seoul 03760 Republic of Korea

*** SPARC（Stratosphere-Troposphere Processes and their Role in Climate）is one of the core projects of the World Climate Research Program（WCRP）,coordinating international efforts to address relevant issues in clima... 详细信息

关键词： SPARC Local Workshop on WCRP Grand Challenges and Regional Climate Change QBO

Incidence of venous thromboembolism and the role of D-dimer as predictive marker in patients with advanced gastric cancer receiving chemotherapy:A prospective study

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World Journal of Gastrointestinal Oncology 2017年第4期9卷 176-183页

作者： Kwonoh Park Baek-Yeol Ryoo Min-Hee Ryu Sook ryun Park Myoung Joo Kang Jeong hye Kim Seungbong Han Yoon-Koo Kang Medical Oncology and Hematology Department of Internal medicinePusan National University Yangsan Hos-pital Department of Oncology Asan Medical CenterUniversity of Ulsan College of Medicine Department of Clinical Epidemiology and Biostatics Asan Medical CenterUniversity of Ulsan College of Medicine

To investigated the incidence and risk factors of venous thromboembolism (VTE) in patients with advanced gastric cancer (AGC) receiving chemotherapy. METHODSAll consecutive chemotherapy-naïve patients with AGC who would receive palliative chemotherapy between November 2009 and April 2012 in our hospital were recruited. Their pretreatment clinical and laboratory variables, including D-dimer, were recorded. The frequency of VTE development and survival rates during each chemotherapy cycle and regularly thereafter were assessed. RESULTSA total of 241 patients enrolled between November 2009 and April 2012 were analyzed. During a median follow-up duration of 10.8 mo (95%CI: 9.9-11.7), 27 patients developed VTE and the incidence of VTE was 17.5% (95%CI: 10.5-24.0, 12.0 events/100 person-years). The 6-mo and 1-year cumulative incidences were 7.8% (95%CI: 4.2%-11.4%) and 12.4% (95%CI: 7.3-17.2), respectively. Thirteen (48.1%) patients were symptomatic and the other 14 (51.9%) patients were asymptomatic. In multivariate analysis, pretreatment D-dimer level was the only marginally significant risk factor associated with VTE development (hazard ratio = 1.32; 95%CI: 1.00-1.75, P = 0.051). CONCLUSIONThe incidence of VTE is relatively high in patients with AGC receiving chemotherapy, and pretreatment D-dimer level might be a biomarker for risk stratification of VTE.

关键词： Advanced gastric cancer D-dimer Venous thromboembolism

Role of oregano and Citrus species-based essential oil preparation for the control of coccidiosis in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1089-1097页

作者： Francisco Xavier Gordillo Jaramillo Da-hye Kim Sang hyeok Lee Sun-Kwan Kwon Rajesh Jha Kyung-woo Lee Department of Animal Science and Technology Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Republic of Korea Harim Bio Research Center Jeilfeed Co.LTD136 Techno2-roYuseong-guDeajeon-si 34025Republic of Korea Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agricultural and Human ResourcesUniversity of Hawaii at ManoaHonoluluHI 96822USA

Background:Due to presence of drug-resistant Eimeria strains and raised public health safety concerns about drug residues in the meat,there is renewed interest in the search for natural alternatives to the coccidiosis control *** study was conducted to test the anticoccidial efficacy of oregano and Citrus spp.-based essential oils for ***:A total of 2807-day-old broiler chicks were fed a control diet or diets with salinomycin or essential oils for up to 35 d of *** d 14,half of the control groups and the treated groups were orally challenged with a coccidiosis vaccine at 25 times higher than the recommended vaccine *** diet-fed chickens that were gavaged with phosphate-buffered saline were considered non-challenged control ***:Eimeria challenge or dietary additives failed to affect growth performance during the 7 to 20 d growth period although essential oil-fed chickens exhibited the lowest body wight gain(P=0.332)and the highest feed conversion ratio(P=0.062).Oocysts in the litter were detected in the challenged control diet group and the challenged/essential oil-fed groups at 21 and 35 d,*** dismutase activity in the serum was elevated(P=0.059)in the salinomycin-fed chickens compared to the challenged ***-1-acid glycoprotein was decreased by 28.7%in the salinomycin-fed chickens but increased by 38.1%in the essential oil group compared with the challenged control *** control group exhibited a significantly higher cooking loss of the thigh meat,compared to the non-challenged control diet group,which was marginally mitigated by dietary supplementation with essential *** fed essential oil-added diet had the highest branched-chain fatty acids contents in the ***:In conclusion,this study shows that oregano and Citrus-based essential oil preparation did not affect growth performance in broiler chickens challenged with the coccidiosis vaccine nor did Eimeria-spec

关键词： Broiler chickens Coccidiosis Essential oils Growth performance Salinomycin