Toward Systems Understanding of Leaf Senescence： An Integrated Multi-Omics Perspective on Leaf Senescence Research

作     者：Jeongsik Kim Hye Ryun Woo Hong Gil Nam 

作者机构：Center for Plant Aging Research Institute for Basic Science (IBS) Daegu 42988 Republic of Korea Department of New Biology DGIST Daegu 42988 Republic of Korea 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2016年第9卷第6期

页      面：813-825页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0901[农学-作物学] 

基　　金：supported by the Institute for Basic Science the DGIST R&D Program Mid-career Researcher Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science,ICT & Future Planning 

主　　题：leaf senescence transcriptomics epigenomics proteomics metabolomics multi-omics 

摘      要：Leaf senescence is a complex but tightly regulated developmental process involving a coordinated sequence of multiple molecular events, which ultimately leads to death of the leaf. Efforts to understand the mechanistic principles underlying leaf senescence have been largely made by transcriptomic, proteomic, and metabolomic studies over the past decade. This review focuses on recent milestones in leaf senes- cence research obtained using multi-omics technologies, as well as future endeavors toward systems understanding of leaf senescence processes. In particular, we discuss recent advances in understanding molecular events during leaf senescence through genome-wide transcriptome analyses in Arabidopsis. We also describe comparative transcriptome analyses used to unveil the commonality and diversity of regulatory mechanisms governing leaf senescence in the plant kingdom. Finally, we provide current illustrations of epigenomic, proteomic, and metabolomic landscapes of leaf senescence. We envisage that integration of multi-omics leaf senescence data will enable us to address unresolved questions regarding leaf senescence, including determining the molecular principles that coordinate concurrent and ordered changes in biological events during leaf senescence.