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Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation-associated genes

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Asian Pacific Journal of tropical Biomedicine 2021年第12期11卷 553-560页

作者： huyen t.t.nguyen Minh t.H.nguyen thu X.nguyen Quan M.Pham Ha X.nguyen Phuong t.M.nguyen University of Science and technology of Hanoi Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and TechnologyHanoiVietnam Graduate University of Science and technology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:to investigate the osteoblastogenic activity of the ethyl acetate(EtOAc)extract of Smilax glabra Roxb roots and its major active compound ***:Astilbin was isolated from EtOAc extract using silica gel chromatography combined with fraction *** structure of astilbin was determined by analysis of the spectroscopic data in comparison with the *** method was used to detect the *** phosphatase(ALP)activity was determined by the spectrophotometric method at 405 nm using p-nitrophenyl phosphate as a *** deposition was stained with alizarin red-S,distained with cetylpyridium chloride,and quantified at 562 *** silico model for astilbin-ALP interaction was analyzed using AutoDock *** changes in expression of osteoblast differentiation related genes were determined using quantitative real-time ***:Both the EtOAc extract and astilbin had no toxicity toward osteoblast MC3t3-E1 cells at 5.0,10,25,and 50μg/*** 25μg/mL,they enhanced ALP activity and mineralization of osteoblasts up to 30%and 55%for the EtOAc extract and 22%and 41%for astilbin,*** docking analysis of astilbin-ALP interaction revealed Arg167,Asp320,His324,and His437 were key residues participating in hydrophobic interaction;meanwhile,His434 and thr436 residues were involved in hydrogen bond formation in the active site of human tissue-nonspecific ***,the expression level of genes opn,col1,osx,and runx2 were up-regulated in astilbin treated samples with the fold changes as 2.2;3.7;4.1;2.3,respectively at 10μg/mL(Pthe EtOAc extract and its major compound astilbin exhibit osteoblastogenic activity by up-regulating important markers for bone cell *** could be a new and promising osteogenic agent with dual actions for therapeutic applications.

关键词： Smilax glabra Roxb Astilbin Cytotoxicity Osteogenesis Osteoblast Ethyl acetate extract

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New Results on H_(∞) Control for Nonlinear Conformable Fractional Order Systems

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Journal of Systems Science & Complexity 2021年第1期34卷 140-156页

作者： MAI Viet thuan nguyen thi huyen thu nguyen Huu Sau nguyen thi thanh huyen Department for Management of Science and technology Development Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of General Science Hanoi University of Natural Resources and EnvironmentHanoiVietnam Faculty of Fundamental Science Hanoi University of IndustryHa NoiVietnam Department of Mathematics and Informatics Thainguyen University of SciencesThainguyenVietnam

this paper deals with H_(∞) control problem for nonlinear conformable fractional order systems. the authors first derive new sufficient condition for exponential stability of nonlinear conformable fractional order systems based on Lyapunov-like function method for conformable fractional order systems and linear matrix inequalities(LMIs) approach. then, by introducing a new concepts of H_(∞) control problem for nonlinear conformable fractional order systems, the authors study H_(∞) performance analysis and H_(∞) state feedback controller design problems for the considered systems. In terms of LMIs, a sufficient condition is proposed to ensure the nonlinear conformable fractional order systems are not only exponentially stable, but also satisfy H_(∞) performance γ. An explicit expression for state feedback controllers is also designed to make the closed-loop system is exponentially stable with H_∞performance γ. Finally, numerical examples are given to illustrate the validity and effectiveness of the proposed results.

关键词： Conformable fractional-order H_(∞)control problems H_(∞)performance analysis linear matrix inequalities nonlinear systems

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Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis

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Asian Pacific Journal of tropical Medicine 2020年第11期13卷 487-493页

作者： Huong tt Vu Azumi Ishizaki Quynh t nguyen huyen N nguyen Hoi t Le Kinh V nguyen Hiroshi Ichimura National Hospital for tropical Disease HanoiVietnam Department of Viral Infection and International Health Graduate School of Medical SciencesKanazawa UniversityJapan

Objective:to evaluate the outcomes of generic direct-acting antiviral treatments for chronic hepatitis C in ***:the medical records of 522 patients(median 45 years;Female,25.3%)with chronic hepatitis C treated at a tertiary hospital in northern Vietnam in 2016 were retrospectively ***:Female patients were significantly older than male patients(median 52,IQR 41-59 vs.43 years,IQR:39-55;Ptients,49.4%were infected with hepatitis C virus(HCV)genotype 6,followed by 1 a(19.0%),1 b(13.0%),and 3(5.9%).Coinfection with hepatitis B virus or human immunodeficiency virus was noted in 5.8%and 3.1%of patients,*** were treated with ledipasvir/sofosbuvir with or without ribavirin(70.9%),sofosbuvir/pegylated-interferon+ribavirin(13.2%),daclatasvir/sofosbuvir with or without ribavirin(12.5%),or sofosbuvir/ribavirin(3.4%),and 96.4%(n=503)completed the direct-acting antiviral *** patient discontinued treatment due to adverse event(s).A sustained virologic response 12 weeks after the end of the treatment(SVR12)was evaluated in 62.6%of *** sustained virologic response 12 weeks after the end of the treatment was 98.7%regardless of HCV genotypes or direct-acting antiviral *** severity of liver stiffness was significantly decreased from 10.2 to 6.3 kilopascals measured by transient elastography by the treatment(Ptients who completed the directacting antiviral treatment,17.7%returned for further follow-ups after ***:In Vietnam,the current generic direct-acting antiviral treatment for chronic hepatitis C was effective regardless of HCV genotypes and direct-acting antiviral regimens with the attenuation of liver *** is feasible to implement direct-acting antiviral treatment to cure chronic hepatitis C patients at any liver fibrosis stages in Vietnam.

关键词： Vietnam Chronic hepatitis C Generic direct-acting antiviral Improvement of liver stiffness

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A Multinational Data Set of Game Players' Behaviors in a Virtual World and Environmental Perceptions

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Data Intelligence 2021年第4期3卷 606-629页

作者： Quan-Hoang Vuong Manh-toan Ho Viet-Phuong La tam-tri Le thanh huyen t.nguyen Minh-Hoang nguyen Centre for Interdisciplinary Social Research Phenikaa UniversityYen Nghia WardHa Dong DistrictHanoi 100803Vietnam A.I.for Social Data Lab Vuong&AssociatesDong Da DistrictHanoi 100000Vietnam

Video gaming has been rising rapidly to become one of the primary entertainment media,especially during the COVID-19 *** video games has been reported to associate with many psychological and behavioral ***,little is known about the connections between game players’behaviors in the virtual environment and environmental ***,the current data set offers valuable resources regarding environmental worldviews and behaviors in the virtual world of 640 Animal Crossing:New Horizons(ACNH)game players from 29 countries around the *** data set consists of six major categories:1)socio-demographic profile,2)COVID-19 concern,3)environmental perception,4)gameplaying habit,5)in-game behavior,and 6)game-playing *** making this data set open,we aim to provide policymakers,game producers,and researchers with valuable resources for understanding the interactions between behaviors in the virtual world and environmental perceptions,which could help produce video games in compliance with the United Nations(UN)Sustainable Development Goals.

关键词： Environmental psychology Virtual environment Game-playing behaviors Multinational UN compliance design

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Performance Evaluation of Food and Beverage Listed Companies in Vietnam

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Computers, Materials & Continua 2022年第11期73卷 3575-3593页

作者： Jung-Fa tsai Ngoc huyen nguyen Ming-Hua Lin Department of Business Management National Taipei University of TechnologyTaipei10608Taiwan Department of Urban Industrial Management and Marketing University of TaipeiTaipei11153Taiwan

During the last decade,the food and beverage industry has been one of the most significant and prioritized industries that contributed to the economic growth in ***,how to enhance the performance of food and beverage firms has become a critical factor for Vietnam’s economic *** research aims to use the data envelopment analysis(DEA)and the Malmquist productivity index(MPI)to assess changes in operational performance and productivity of listed lead food and beverage firms in Vietnam during the period between 2015 and *** obtained results reveal that Vietnamese food and beverage firms were generally inefficient between 2015 and 2020 because the number of relatively inefficient companies was higher than the relatively efficient ones in each year between 2015 and *** MPI findings indicate the growth in productivity during the study period as a result of technological *** integrating the findings of the relative efficiency and productivity change,this study creates five decision-making matrixes for five periods,respectively,from 2015 to 2020 to position the food and beverage firms in each *** analytical results provide instructions to senior managers on developing strategy for increasing efficiency of food and beverage listed companies in Vietnam.

关键词： Food and beverage industry data envelopment analysis Malmquist productivity index super-SBM model efficiency productivity

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Properties of poly（1-naphthylamine）/Fe3O4 composites and arsenic adsorption capacity in wastewater

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Frontiers of Materials Science 2016年第1期10卷 56-65页

作者： Minh thi tRAN thi huyen trang nguyen Quoc trung VU Minh Vuong nguyen Faculty of Physics Hanoi National University of Education 136-Xuanthuy Street Caugiay District Hanoi Vietnam Faculty of Chemistry Hanoi National University of Education 136-Xuanthuy Street Caugiay District Hanoi Vietnam Department of Physics Quynhon University 170 An Duong Vuong Quynhon Vietnam

the research results of poly（1-naphthylamine）lFe3O4 （PNA/Fe3O4） nanocomposites synthesized by a chemical method for As（Ⅲ） wastewater treatment are presented in this paper. XRD patterns and tEM images showed that the Fe3O4 grain size varied from 13 to 20 nm. the results of Raman spectral analysis showed that PNA participated in part of the PNA/Fe3O4 composite samples. the grain size of PNA/Fe3O4 composite samples is about 25-30 nm measured by SEM. the results of vibrating sample magnetometer measurements at room temperature showed that the saturation magnetic moment of PNA/Fe3O4 samples decreased from 63.13 to 43.43 emu/g, while the PNA concentration increased from 5% to 15%. the nitrogen adsorption-desorption isotherm of samples at 77 K at a relative pressure PIPo of about 1 was studied in order to investigate the surface and porous structure of nanoparticles by the BEt method. Although the saturation magnetic moments of samples decreased with the polymer concentration increase, the arsenic adsorption capacity of the PNA/Fe3O4 sample with the PNA concentration of 5% is better than that of Fe3O4 in a solution with pH = 7. In the solution with pH 〉 14, the arsenic adsorption of magnetic nanoparticles is insignificant.

关键词： poly(1-naphthylamin)/Fe3O4 nanocomposite magnetization arsenic adsorption

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Vaccinations in immunosuppressive-dependent pediatric inflammatory bowel disease

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World Journal of Gastroenterology 2017年第42期23卷 7644-7652页

作者： huyen-tran nguyen Phillip Minar Kimberly Jackson Patricia C Fulkerson Division of Allergy and Immunology Department of Pediatrics Cincinnati Children’s Hospital Medical Center University of Cincinnati College of Medicine Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Cincinnati Children’s Hospital Medical Center University of Cincinnati College of Medicine

AIM to determine the vaccination rates in pediatric immunosuppression-dependent inflammatory bowel disease(IBD) and review the safety and efficacy of vaccinations in this *** the electronic medical records from October 2009 to December 2015 of patients diagnosed with IBD at 10 years of age or younger and prescribed antitumor necrosis factor alpha(anti-tNF-α) therapy were reviewed for clinical history, medication history, vaccination history, and hepatitis B and varicella titers. Literature discussing vaccination response in IBD patients were identified through search of the MEDLINE database and reviewed using the key words "inflammatory bowel disease", "immunization", "vaccination", "pneumococcal", "varicella", and "hepatitis B". Non-human and non-English language studies were excluded. Search results were reviewed by authors toselect articles that addressed safety and efficacy of immunizations in inflammatory bowel *** A total of 51 patients diagnosed with IBD prior to the age of 10 and receiving anti-tNF-α therapy were identified. thirty-three percent of patients(17/51) had incomplete or no documentation of vaccinations. Sixteen case reports, cohort studies, cross-sectional studies, and randomized trials were determined through review of the literature to describe the safety and efficacy of hepatitis B, pneumococcal, and varicella immunizations in adult and pediatric patients with IBD. these studies showed that patients safely tolerated the vaccines without significant adverse effects. Importantly, IBD patients receiving immunosuppressive medications, particularly anti-tNF-α treatment, have decreased vaccine response compared to controls. However, the majority of patients are still able to achieve protective levels of specific antibodies. CONCLUSION Immunizations have been shown to be well-tolerated and protective immunity can be achieved in patients with IBD requiring immunosuppressive therapy.

关键词： Vaccination Immunosuppression Earlyonset inflammatory bowel disease Very early-onset inflammatory bowel disease

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twin reversed arterial perfusion sequence-a rare and dangerous complication form of monochorionic twins:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10214-10219页

作者： nguyen Duy Anh nguyen-thi thu Ha nguyen-thi Sim nguyen Khac toan Phan-thi huyen thuong nguyen Minh Duc Fetal Medicine Center Hanoi Obstetrics and Gynecology HospitalHanoi 100000Vietnam Department of Assisted Reproduction Hanoi Obstetrics and Gynecology HospitalHanoi 100000Vietnam Department of Obstetrics and Gynecology Hanoi University of Medicine and PharmacyHanoi 100000Vietnam Department of Radiology Pham Ngoc Thach University of MedicineHo Chi Minh City 700000Vietnam

BACKGROUND twin reversed arterial perfusion(tRAP) sequence is an extremely rare congenital anomaly in monochorionic(MC) *** condition is characterized by a malformed fetus(acardiac twin) without cardiac activities being perfused by a structurally normal one(pump twin) via an artery-to-artery anastomosis in a reverse *** SUMMARY We described the first case of tRAP to receive laser surgery in *** 26-wk pregnancy was originally misdiagnosed in another hospital as MC twins with single intrauterine fetal *** admission to our center,the diagnosis was amended to a 26-wk tRAP sequence stage *** acardiac twin was 7.5 cm at the longest length,the ratio of the weight of the acardiac twin to the weight of the pump twin was more than 90%,the pump twin showed fetal distress with absent diastolic flow in umbilical artery of pump twin,and the peak systolic velocity in the middle cerebral artery = 1.6 Mo *** performed emergency laser photocoagulation of the acardiac twin’s umbilical *** surgery,we successfully maintained the pregnancy for 8 wk and ended it electively by cesarean section at 34 wk of gestation due to rupture of *** tRAP should be appropriately diagnosed and treated early to avoid complications of the pump *** laser photocoagulation is a new and effective treatment for this condition.

关键词： twin reversed arterial perfusion Acardiac twin Pump twin Laser Case report

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Highly active brookite tiO2-assisted photocatalytic degradation of dyes under the simulated solar-UVA radiation

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Progress in Natural Science:Materials International 2019年第6期29卷 641-647页

作者： huyen tran thi thuong Chi tran thi Kim Liem nguyen Quang Hendrik Kosslick Institute of Materials Science (IMS) Vietnam Academy of Science and Technology (VAST) University of Rostock Institute of Chemistry Department of Inorganic Chemistry

Brookite tiO2nanoparticles were synthesized by hydrothermal method and characterized by X-ray powder diffraction(XRD), diffuse reflectance UV–Visible spectroscopy(DRUV), and scanning electron microscopy(SEM). the obtained particles were spherical in shape with the diameter of about ～10 nm under the hydrothermal temperature of 175 °C. the photocatalytic performance of brookite was investigated in the photodegradation of dyes(rhodamine B and rose bengal) under UV-A radiation by low-power lamp. the activity of brookite and the photodegradation efficiency of dyes were estimated using a UV–Visible spectrophotometer and a total organic carbon(tOC) analyzer. Compared to anatase and rutile prepared by the similar synthesis procedure, brookite is highly active in terms of decolourization, aromatic ring opening, and mineralization.

关键词： Brookite Anatase Dye Photocatalytic degradation Decolourization Mineralization

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Antidiabetic and antioxidant activities of red seaweed Laurencia dendroidea

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Asian Pacific Journal of tropical Biomedicine 2019年第12期9卷 501-509页

作者： the Han nguyen thi huyen nguyen Van Minh nguyen thi Lan Phuong nguyen thi Van Anh tran Anh Duy Do Sang Moo Kim Faculty of Food technology Nha Trang University02 Nguyen Dinh Chieu StreetNha Trang CityKhanh HoaVietnam Quality Control Department Institute of Vaccines and Medical BiologicalsNha Trang CityKhanh HoaVietnam Faculty of Pharmacy University of Medicine and Pharmacy of Ho Chi Minh City41 Dinh Tien Hoang StreetHo Chi Minh CityVietnam Research Department of Marine Conservation Research Institute for Marine Fisheries224 Le Lai StreetHai Phong CityVietnam Department of Marine Food Science and technology Gangneung-Wonju National University7 Jukheon-gilGangneung 25457Republic of Korea

Objective:to investigate antidiabetic and antioxidant activities of the extract and fractions from Vietnamese red seaweed Laurencia ***:the seaweed Laurencia dendroidea was extracted by using microwave-assisted extraction method in 80%*** seaweed extract was then fractionated using different solvents(n-hexane,chloroform,ethyl acetate,butanol and water).these obtained fractions were evaluated forα-glucosidase inhibitory and antioxidant *** activities were tested using DPPH,nitric oxide radical scavenging and metal chelating *** enzyme inhibition mode was determined using Lineweaver-Burk *** acidic and thermal stabilities,the ethyl acetate fraction was treated at pH 2.0 and 100℃,*** residual inhibitory activity of the fraction was calculated based on the initial inhibitory *** in vivo antidiabetic activity,mice were divided into four groups,including normal control,diabetic control,diabetic mice treated with ethyl acetate fraction and diabetic mice treated with *** glucose level of treated mice during acute and prolonged treatments was *** evaluate the toxicity of the ethyl acetate fraction,the body weight changes and activities of liver function enzymes(aspartate transaminase,alanine transaminase and gammaglutamyl transferase)were carried ***:the extract of Laurencia dendroidea showed strongα-glucosidase inhibitory and DPPH radical scavenging *** concentrations affected bothα-glucosidase inhibitory and antioxidant activities.A 80%aqueous methanol was the suitable solvent for extraction of enzyme inhibitors and *** solvent fractions,ethyl acetate fraction had the highest inhibitory activities againstα-glucosidase with a mixed type of inhibition and the strongest antioxidant activities,and was stable under acidic and thermal *** ethyl acetate fraction treated diabetic mice significantly reduced blood glucose level compare

关键词： α-Glucosidase inhibitor Antidiabetic Antioxidant Red seaweeds Vietnam

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