Antidiabetic and antioxidant activities of red seaweed Laurencia dendroidea

作     者：The Han Nguyen Thi Huyen Nguyen Van Minh Nguyen Thi Lan Phuong Nguyen Thi Van Anh Tran Anh Duy Do Sang Moo Kim 

作者机构：Faculty of Food TechnologyNha Trang University02 Nguyen Dinh Chieu StreetNha Trang CityKhanh HoaVietnam Quality Control DepartmentInstitute of Vaccines and Medical BiologicalsNha Trang CityKhanh HoaVietnam Faculty of PharmacyUniversity of Medicine and Pharmacy of Ho Chi Minh City41 Dinh Tien Hoang StreetHo Chi Minh CityVietnam Research Department of Marine ConservationResearch Institute for Marine Fisheries224 Le Lai StreetHai Phong CityVietnam Department of Marine Food Science and TechnologyGangneung-Wonju National University7 Jukheon-gilGangneung 25457Republic of Korea 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2019年第9卷第12期

页      面：501-509页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：funded by Vietnam National Foundation for Science and Technology Development under grant number 106-NN.05-2016.73 to Nguyen The Han 

主　　题：α-Glucosidase inhibitor Antidiabetic Antioxidant Red seaweeds Vietnam 

摘      要：Objective:To investigate antidiabetic and antioxidant activities of the extract and fractions from Vietnamese red seaweed Laurencia ***:The seaweed Laurencia dendroidea was extracted by using microwave-assisted extraction method in 80%*** seaweed extract was then fractionated using different solvents(n-hexane,chloroform,ethyl acetate,butanol and water).These obtained fractions were evaluated forα-glucosidase inhibitory and antioxidant *** activities were tested using DPPH,nitric oxide radical scavenging and metal chelating *** enzyme inhibition mode was determined using Lineweaver-Burk *** acidic and thermal stabilities,the ethyl acetate fraction was treated at pH 2.0 and 100℃,*** residual inhibitory activity of the fraction was calculated based on the initial inhibitory *** in vivo antidiabetic activity,mice were divided into four groups,including normal control,diabetic control,diabetic mice treated with ethyl acetate fraction and diabetic mice treated with *** glucose level of treated mice during acute and prolonged treatments was *** evaluate the toxicity of the ethyl acetate fraction,the body weight changes and activities of liver function enzymes(aspartate transaminase,alanine transaminase and gammaglutamyl transferase)were carried ***:The extract of Laurencia dendroidea showed strongα-glucosidase inhibitory and DPPH radical scavenging *** concentrations affected bothα-glucosidase inhibitory and antioxidant activities.A 80%aqueous methanol was the suitable solvent for extraction of enzyme inhibitors and *** solvent fractions,ethyl acetate fraction had the highest inhibitory activities againstα-glucosidase with a mixed type of inhibition and the strongest antioxidant activities,and was stable under acidic and thermal *** ethyl acetate fraction treated diabetic mice significantly reduced blood glucose level compare