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Chinese Journal of Chemical Engineering 2024年第2期66卷 136-144页

作者： Chenggong Song Zhenzhou Ma Xu Hou Hao Zhou huimin Qiao Changchang Tian Li yin Baitang Jin Enxian Yuan School of Chemical Engineering Changchun University of TechnologyChangchun130012China Department of Chemical and Biomolecular Engineering North Carolina State UniversityRaleighNC 27606USA School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225009China

High-temperature treatment is key to the preparation of zeolite ***,the effects of hightemperature treatment on the property and performance of HZSM-5 zeolites were studied in this work.X-Ray diffraction,N2physisorption,27Al magic angle spinning nuclear magnetic resonance(MAS NMR),and temperature-programmed desorption of ammonia results indicated that the hightemperature treatment at 650℃ hardly affected the inherent crystal and texture of HZSM-5zeolites but facilitated the conversion of framework Al to extra-framework Al,reducing the acid site and enhancing the acid ***,the high-temperature treatment improved the performance of HZSM-5 zeolites in n-heptane catalytic cracking,promoting the conversion and light olefins yield while inhibiting coke *** on the kinetic and mechanism analysis,the improvement of HZSM-5 performance caused by high-temperature treatment has been attributed to the formation of extra-framework Al,which enhanced the acid strength,facilitated the bimolecular reaction,and promoted the entropy change to overcome a higher energy barrier in n-heptane catalytic cracking.

关键词： HZSM-5 n-Heptane Catalytic cracking High-temperature treatment Extra-framework Al

Effect on serum metabolomics of rats with premature ovarian insufficiency by Zhibian(BL54) through Shuidao(ST28) acupuncture

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Journal of Traditional Chinese Medicine 2024年第4期44卷 722-733页

作者： YAN Jing FENG huimin QIU Fang WANG Haijun yin Luyun JIN Xiaofei ZHAO Jiyu WANG Hongyang YAN Xiaoqin Second Clinical College of Shanxi University of Traditional Chinese Medicine Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese Medicine Department of Cervical and Lumbar Vertebral Diseases Jinzhong Hospital Affiliated to Shanxi University of Traditional Chinese Medicine

OBJECTIVE: To analyze the serum metabolic targets of the "Zhibian(BL54) through Shuidao(ST28)" acupuncture technique in cyclophosphamide(CTX)-induced premature ovarian insufficiency(POI) model rats and to elucidate the potential molecular mechanism of acupuncture in improving POI. METHODS: We used an intraperitoneal injection of CTX to establish the POI rat model(POI group) and compared serum hormone levels and ovarian histopathological changes to evaluate the effect of the Zhibian(BL54) through Shuidao(ST28) technique(ZS + POI group) on ovarian function. Then, nontargeted metabolomics was performed using rat serum by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS). RESULTS: After acupuncture intervention, the serum hormone levels and ovarian pathological morphology of POI rats were effectively improved. Moreover, UPLC-Q-TOF/MS results showed that the ZS+POI group showed a significant reversal of the levels of 6 differential metabolites. Among them, the levels of four serum metabolic markers, divanillyltetrahydrofuran ferulate, trans-ferulic acid, tryptamine, and neuraminic acid, increased significantly. Further analysis of biological effects showed that all metabolites were involved in the regulation of reproductive hormone levels and antioxidant and antiapoptotic effects. CONCLUSIONS: The "Zhibian(BL54) through Shuidao(ST28)" acupuncture method may improve the ovarian function of POI rats by regulating serum metabolite markers to exert antioxidant and antiapoptotic effects, which provides a theoretical basis for the clinical application of acupuncture in the treatment of POI.

关键词： Zhibian (BL54) through Shuidao (ST28) acupuncture metabolomics premature ovarian insufficiency ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

参乌益智胶囊治疗肾精亏虚型卒中后轻度认知障碍临床疗效观察

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天津中医药 2024年第8期41卷 968-975页

作者：孙悦班文明刘秀芳倪代梅尹慧敏孙媛媛郭灿赵莉莉安徽中医药大学研究生院合肥230012 安徽中医药大学附属太和中医院阜阳236607

[目的]观察参乌益智胶囊治疗肾精亏虚型轻度卒中后认知障碍(PSMCI)临床疗效及对血清炎症因子、脑部血流情况的影响。[方法]纳入2022年9月—2023年3月共96例肾精亏虚型PSMCI患者,按随机数字表法分为对照组和治疗组,各48例。两组均给予控... 详细信息

[目的]观察参乌益智胶囊治疗肾精亏虚型轻度卒中后认知障碍(PSMCI)临床疗效及对血清炎症因子、脑部血流情况的影响。[方法]纳入2022年9月—2023年3月共96例肾精亏虚型PSMCI患者,按随机数字表法分为对照组和治疗组,各48例。两组均给予控制血压、血糖等基础治疗,在此基础上,对照组采用尼莫地平片治疗,治疗组予以参乌益智胶囊联合尼莫地平片治疗。两组均治疗8周,比较两组治疗前后简易精神状态评估量表(MMSE)、蒙特利尔认知检查量表(MoCA),日常生活能力量表(ADL)、中医证候积分量表评分、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、超敏c反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)含量、脑动脉血流平均流速(Vm)和不良反应差异。[结果]治疗后,治疗组总有效率89.58%(43/48),对照组总有效率为66.67%(32/48),治疗组疗效明显优于对照组(P<0.05);两组治疗后MMSE评分、MoCA评分,ADL评分均上升(P<0.01),中医证候总积分下降(P<0.01);治疗组上述评分均优于对照组(P<0.05);治疗后,治疗组血清炎症因子IL-6、TNF-α、hs-CRP、Hcy水平明显低于对照组(P<0.05)。治疗后治疗组大脑前动脉(ACA)、大脑中动脉(MCA)、椎动脉(VA)的血流速度明显增加(P<0.05)。[结论]参乌益智胶囊可降低炎症因子水平,提高血流速度良性增加脑部灌流,显著改善肾精亏虚型轻度卒中后认知障碍患者的临床症状,提高患者记忆和认知功能,改善生存质量。

关键词：参乌益智胶囊肾精亏虚卒中后轻度认知障碍疗效

尿激酶联合真方白丸子治疗风痰阻络型急性缺血性脑卒中45例

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湖南中医杂志 2024年第7期40卷 6-9页

作者：赵莉莉班文明郭灿孙媛媛孙悦刘秀芳倪代梅尹慧敏安徽中医药大学安徽合肥230000 安徽中医药大学附属太和中医院安徽太和236607

目的:探讨尿激酶联合真方白丸子对风痰阻络型急性缺血性脑卒中(AIS)的疗效。方法:将90例风痰阻络型AIS患者随机分为治疗组和对照组,每组各45例。对照组给予尿激酶静脉溶栓治疗,治疗组在对照组基础上联合真方白丸子治疗,疗程均为14 d。比... 详细信息

目的:探讨尿激酶联合真方白丸子对风痰阻络型急性缺血性脑卒中(AIS)的疗效。方法:将90例风痰阻络型AIS患者随机分为治疗组和对照组,每组各45例。对照组给予尿激酶静脉溶栓治疗,治疗组在对照组基础上联合真方白丸子治疗,疗程均为14 d。比较2组治疗前后的卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分、中医证候总积分、血浆纤维蛋白原(FIB)、D-二聚体(D-D),评价综合疗效,记录不良反应发生情况。结果:综合疗效总有效率治疗组为93.33%(42/45),对照组为84.44%(38/45),2组比较,差异有统计学意义(P0.05)。结论:尿激酶静脉溶栓后联合真方白丸子对风痰阻络型AIS患者疗效较佳,可促进患者神经功能的恢复,降低FIB、D-D水平,且治疗安全性较好。

关键词：急性缺血性脑卒中风痰阻络证真方白丸子尿激酶

慢加急性肝衰竭临床评分及分型系统的演变进程

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临床肝胆病杂志 2023年第10期39卷 2288-2293页

作者：尹惠敏李荣宽大连医科大学附属第二医院感染科辽宁大连116023

慢加急性肝衰竭(ACLF)发病机制复杂,临床治疗困难,预后差。由于不同国家地区慢性肝病分布的不同,在过去的几十年中,有超过十种ACLF评分及分型标准被提出,表明ACLF在定义、评分及分型方面存在较大分歧。通过梳理具有广泛影响的几种评分... 详细信息

慢加急性肝衰竭(ACLF)发病机制复杂,临床治疗困难,预后差。由于不同国家地区慢性肝病分布的不同,在过去的几十年中,有超过十种ACLF评分及分型标准被提出,表明ACLF在定义、评分及分型方面存在较大分歧。通过梳理具有广泛影响的几种评分及分型的特点,探讨其演变进程及适用于我国的分型标准,为优化治疗方案提供参考。

关键词：慢加急性肝功能衰竭评分分型预后

Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging

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Science China(Life Sciences) 2024年第4期67卷 745-764页

作者： Shujie Chen Liujing Huang Bingdong Liu huimin Duan Ze Li Yifan Liu Hu Li Xiang Fu Jingchao Lin yinlan Xu Li Liu Dan Wan Yulong yin Liwei Xie Department of Endocrinology and Metabolism Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Public Health Xinxiang Medical UniversityXinxiang 453003China Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Metabo-Profile Biotechnology(Shanghai)Co.Ltd. Shanghai 201315China Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular DiagnosticsSchool of Medical TechnologyGuangdong Medical UniversityDongguan 524023China Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China

The gut microbiota plays a pivotal role in systemic metabolic processes and in particular functions,such as developing and preserving the skeletal muscle ***,the interplay between gut microbiota/metabolites and the regulation of satellite cell(SC)homeostasis,particularly during aging,remains *** propose that gut microbiota and its metabolites modulate SC physiology and homeostasis throughout skeletal muscle development,regeneration,and aging *** investigation reveals that microbial dysbiosis manipulated by either antibiotic treatment or fecal microbiota transplantation from aged to adult mice,leads to the activation of SCs or a significant reduction in the total ***,employing multi-omics(e.g.,RNA-seq,16S r RNA gene sequencing,and metabolomics)and bioinformatic analysis,we demonstrate that the reduced butyrate levels,alongside the gut microbial dysbiosis,could be the primary factor contributing to the reduction in the number of SCs and subsequent impairments during skeletal muscle ***,butyrate supplementation can mitigate the antibiotics-induced SC activation irrespective of gut microbiota,potentially by inhibiting the proliferation and differentiation of SCs/*** butyrate effect is likely facilitated through the monocarboxylate transporter 1(Mct1),a lactate transporter enriched on membranes of SCs and *** a result,butyrate could serve as an alternative strategy to enhance SC homeostasis and function during skeletal muscle *** findings shed light on the potential application of microbial metabolites in maintaining SC homeostasis and preventing skeletal muscle aging.

关键词： gut microbiota aging satellite cells butyrate Slc16a1(Mct1)

Roussoelins A and B:two phenols with antioxidant capacity from ascidian-derived fungus Roussoella siamensis SYSU-MS4723

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Marine Life Science & Technology 2021年第1期3卷 69-76页

作者： Senhua Chen Hongjie Shen Yanlian Deng Heng Guo Minghua Jiang Zhenger Wu huimin yin Lan Liu School of Marine Sciences Sun Yat-Sen UniversityGuangzhou 510006China School of Pharmacy Guangdong Medical UniversityDongguan 523808China Southern Laboratory of Ocean Science and Engineering(Guangdong Zhuhai)Zhuhai 519000China

Ascidian-derived microorganisms are a signifcant source of pharmacologically active metabolites with interesting structural *** discovering bioactive molecules from ascidian-derived fungi,two new phenols,roussoelins A(1)and B(2),and ten known polyketides(3–12)were isolated from the ascidian-derived fungus Roussoella siamensis *** planar structure of compounds 1 and 2 was established by analysis of HR-ESIMS and NMR *** conformational analysis of the new compounds was assigned according to coupling constants and selective gradient NOESY experiments,and absolute confgurations were completed by the modifed Mosher’s *** the isolated compounds,1,2,and 9 showed moderate antioxidant capacity.

关键词： Phenols Antioxidant capacity Ascidian-derived fungus Roussoella siamensis

Amphichoterpenoids A-C,unprecedented picoline-derived meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908

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Chinese Chemical Letters 2021年第6期32卷 1893-1896页

作者： Minghua Jiang Zhenger Wu Qilin Wu huimin yin Heng Guo Siwen Yuan Zhaoming Liu Senhua Chen Lan Liu School of Marine Sciences Sun Yat-sen UniversityGuangzhou 510006China Southern Laboratory of Ocean Science and Engineering(Guangdong Zhuhai)Zhuhai 519000China South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center Guangzhou 510006China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyGuangdong Institute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China

Amphichoterpenoids A-C(1-3),unprecedented picoline-derived meroterpenoids possessing a pyrano[3,2-c]pyridinyl-g-pyranone scaffold,were characterized from the ascidian-derived fungus Amphichorda felina *** structures were elucidated by spectroscopic methods,X-ray diffraction and electronic circular dichroism(ECD)calculations.A plausible biosynthetic pathway was *** isolated compounds displayed moderate inhibitory activity against acetylcholinesterase with 50%inhibiting concentration(IC_(50))values of 18.8-53.2 mmol/L.

关键词： Fungal meroterpenoid Picoline Amphichorda felina Encapsulated nanodroplet crystallization Acetylcholinesterase

党的纪律检查领导体制百年构建和嬗变的研究述评

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中共南京市委党校学报 2023年第3期 42-49页

作者：殷辉敏南开大学马克思主义学院 300350

党的纪律检查领导体制作为全面从严治党的重要制度保障,站在大历史观角度来看,其百年构建和嬗变具有深刻的时代背景和现实意义。学术界从其形成依据、百年嬗变、现状分析、推进路径等多个角度出发,深入研究、剖析发展脉络和历史经验,取... 详细信息

党的纪律检查领导体制作为全面从严治党的重要制度保障,站在大历史观角度来看,其百年构建和嬗变具有深刻的时代背景和现实意义。学术界从其形成依据、百年嬗变、现状分析、推进路径等多个角度出发,深入研究、剖析发展脉络和历史经验,取得一系列重要研究成果。目前来看仍存在一些薄弱环节,如何多角度、深层次地剖析党的纪律检查领导体制的形成依据,多学科、多领域地阐述党的纪律检查领导体制的百年演变,具体化、针对性地解决党的纪律检查领导体制的现实问题等,应在后续研究中着力解决、不断深化,以推动新时代党的纪律检查领导体制改革的进一步完善。

关键词：党的纪律检查领导体制百年构建和嬗变

Cardiac Na^(+)-Ca^(2+) exchanger 1(ncx1h)is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish

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Science China(Life Sciences) 2021年第2期64卷 255-268页

作者： Liming Chu huimin yin Lei Gao Li Gao Yu Xia Chiyuan Zhang Yi Chen Tingxi Liu Jijun Huang Kenneth R.Boheler Yong Zhou Huang-Tian Yang CAS Key Laboratory of Tissue Microenvironment and Tumor Laboratory of Molecular Cardiology and Laboratory of Development and DiseasesShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of Sciences(CAS)CASShanghai 200031China Institute fo r Stem Cell and Regeneration CASBeijing 100101China State Key Laboratory fo r Medical Genomics Shanghai Institute of HematologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Biomedical Engineering The Johns Hopkins UniversityBaltimoreMD 21205USA

Ca^(2+) signaling is critical for heart development;however,the precise roles and regulatory pathways of Ca^(2+) transport proteins in cardiogenesis remain largely ***-calcium exchanger 1(Ncx1)is responsible for Ca^(2+) efflux in *** is involved in cardiogenesis,while the mechanism is ***,using the forward genetic screening in zebrafish,we identified a novel mutation at a highly-conserved leucine residue in ncx1 gene(mutant^(LDD353)/ncx1h^(L154P))that led to smaller hearts with reduced heart rate and weak ***,the number of ventricular but not atrial cardiomyocytes was reduced in ncx1h^(L154P) *** defects were mimicked by knockdown or knockout of ***,ncx1h^(L154P) had cytosolic and mitochondrial Ca^(2+) overloading and Ca^(2+) transient suppression in ***,ncx1h^(L154P) and ncx1h morphants downregulated cardiac transcription factors hand2 and gata4 in the cardiac regions,while overexpression of hand2 and gata4 partially rescued cardiac defects including the number of ventricular *** findings demonstrate an essential role of the novel 154th leucine residue in the maintenance of Ncx1 function in zebrafish,and reveal previous unrecognized critical roles of the 154th leucine residue and Ncx1 in the formation of ventricular cardiomyocytes by at least partially regulating the expression levels of gata4 and hand2.

关键词： ncx1h Ca^(2+)transport protein ventricular cardiomyocyte formation hand2 gata4 zebrafish