Amphichoterpenoids A-C,unprecedented picoline-derived meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908

作     者：Minghua Jiang Zhenger Wu Qilin Wu Huimin Yin Heng Guo Siwen Yuan Zhaoming Liu Senhua Chen Lan Liu Minghua Jiang;Zhenger Wu;Qilin Wu;Huimin Yin;Heng Guo;Siwen Yuan;Zhaoming Liu;Senhua Chen;Lan Liu

作者机构：School of Marine SciencesSun Yat-sen UniversityGuangzhou 510006China Southern Laboratory of Ocean Science and Engineering(GuangdongZhuhai)Zhuhai 519000China South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation CenterGuangzhou 510006China State Key Laboratory of Applied Microbiology Southern ChinaGuangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyGuangdong Institute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第6期

页      面：1893-1896页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(No.41806155) the Guangdong MEPP Fund(No.GDOE(2019)A21) the National Key R&D Program of China(No.2019YFC0312501) the Natural Science Foundation of Guangdong Province(No.2018A030310304) the Key-Area Research and Development Program of Guangdong Province(No.2020B1111030005)for generous support 

主　　题：Fungal meroterpenoid Picoline Amphichorda felina Encapsulated nanodroplet crystallization Acetylcholinesterase 

摘      要：Amphichoterpenoids A-C(1-3),unprecedented picoline-derived meroterpenoids possessing a pyrano[3,2-c]pyridinyl-g-pyranone scaffold,were characterized from the ascidian-derived fungus Amphichorda felina *** structures were elucidated by spectroscopic methods,X-ray diffraction and electronic circular dichroism(ECD)calculations.A plausible biosynthetic pathway was *** isolated compounds displayed moderate inhibitory activity against acetylcholinesterase with 50%inhibiting concentration(IC_(50))values of 18.8-53.2 mmol/L.