检索结果-南通市图书馆

神经解剖学杂志 2001年第B7期17卷 99-99页

作者： hui-sheng chen, zhen li and jun chen department of anatomy & k.k. leung brain research centre, the fourth military medical university, xi’an 710032

Aim: The bee venom (BV) model has been proved to be a good one to study the inflammatory pain, because subcutaneous injection of BV into one hind paw in rats could produce typical inflammatory responses such as rednes... 详细信息

关键词：大白鼠蜂毒诱发炎症辣椒素敏感性神经性反应初级传入调制

Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

在线全文

学校读者我要写书评

暂无评论

Science China(life Sciences) 2024年第1期67卷 67-82页

作者： Chun-kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao jun-xiang Gu xian-xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao xiao-Die liu Bao-Juan li Ming-hui Wang Hai-Long Dong Hao-Hong li Peng-cheng Huang Yun-Qing li Wu-Gang Hou Jin-lian li Tao chen department of anatomy and k.k.leung brain research centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic medical Sciences Beijing 100850China key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier research Center of brain&brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China department of anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as depression.However,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely unexplored.Here we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression resilience.We determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA circuit.Furthermore,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic manner.Regulation of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic pain.Our study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

THE BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA IN ELDERLY RATS

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 107-108页

作者： Wei GE~2, hui-sheng chen~1, Yuan li~2, jun chen~1 ~1 department of anatomy and k.k. leung brain research centre, ~2 department of Geriatrics, the fourth military medical university, xi’an 710032

Aim: The bee venom (BV) model in adult rats has been well established. However, the BV-induced multiple aspects of pathological pain have not been studied in elderly (age >22 months) rats. The present study was designed to investigate: (1) response pattern and time course of the BV-indueed persistent spontaneous nociception (PSN) and hyperalgesia in elderly rats; (2) Laminar distribution and time course of the

关键词：老龄大白鼠蜂毒诱发持续性自发性损伤感受痛觉过敏

DIFFERENTIAL ROLES OF SPINAL NITRIC OxiDE IN DEVELOPMENT OF HEAT AND MECHANICAL HYPERALGESIA INDUCED BY INTRAPLANTAR INJECTION OF BEE VENOM IN CONSCIOUS RATS

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 105-105页

作者： hui-li li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an 710032

Aim: To study the roles of nitric oxide (NO) of spinal cord in induction and maintenance of the bee venom (BV)-induced persistent spontaneous nociception (PSN) and hyperalgesia to heat and mechanical stimulation. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre- and post-application of NO synthase inhibitor, N^G-nitro-L-arginine-methyl-ester hydrochloride (L-NAME), at does of 0.01, 0.1, 1 and

关键词：大白鼠足底皮注蜂毒热痛觉过敏机械性痛觉过敏脊髓一氧化氮 NO 作用

DIFFERENTIAL ROLES OF SPINAL CYCLOOXYGENASE (COX)-2 IN DEVELOPMENT OF PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA INDUCED BY SUBCUTANEOUS BEE VENOM INJECTION IN THE CONSCIOUS RAT

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 103-103页

作者： zhen li and jun chen department of anatomy and k.k.leung brain research centre, the fourth military medical university, xi’an, 710032

Aim: To study the roles of spinal cyclooxygenase (COX) -2 in the development of persistent spontaneous nociception and mechanical and thermal hyperalgesia induced by subcutaneous(s.c.) bee venom injection, the effects of intrathecal (i.t.) administration of a selective COX-2 inhibitor, etodolac was evaluated in the conscious rat. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre-and post-application

关键词：大白鼠脊髓环氧化酶2 持续性自发性损伤感受痛觉过敏蜂毒皮下注射

POSTNATAL DEVELOPMENT OF PERSISTENT SPONTANEOUS PAIN AND HYPERALGESIA INDUCED BY SUBCUTANEOUS INTRAPLANTAR BEE VENOM INJECTION IN RATS

在线全文

学校读者我要写书评

暂无评论

神经解剖学杂志 2001年第B7期17卷 106-106页

作者： Meng-Meng li~2, hui-sheng chen~1, Ying-Min ZHANG~2 and jun chen~1 ~1department of anatomy and k.k. leung brain research centre, ~2department of Anesthesiology, the fourth military medical university, xi’an 710032

Aim: The present study was designed to investigate the postnatal development of persistent spontaneous pain and hyperalgesia induced by subcutaneous (s. c. ) intraplantar bee venom (BV) injection in pup rats and changes in pain behaviors in the mature rats receiving postnatal BV injection. Methods: Twenty four litters of pup rats were divided into six groups: P1 (postnatal day), P4, P7, P14, P21, P28.

关键词：大鼠足底皮注蜂毒持续性自状性疼痛痛觉过敏生后发育

Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第4期38卷 342-358页

作者： Dan Ren Jia-Ni li xin-Tong Qiu Fa-Ping Wan zhen-Yu Wu Bo-Yuan Fan Ming-Ming Zhang Tao chen hui li Yang Bai Yun-Qing li department of anatomy Guangxi Medical UniversityNanning 510000China department of anatomy Histology and Embryology and K.K.Leung Brain Research CentreFourth Military Medical UniversityXi’an 710032China department of anatomy Xuzhou Medical UniversityXuzhou 221004China department of Cardiology The Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China department of Neurosurgery General Hospital of Northern Theater CommandShenyang 110016China key Laboratory of brain Science research and Transformation in Tropical Environment of Hainan Province Haikou 570216China department of Human anatomy College of Basic MedicineDali UniversityDali 671000China

Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis(CP),but cortical modulation of painful CP remains elusive.Here,we examined the role of the anterior cingulate cortex(ACC)in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid(TNBS).TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats.Morphological data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii(NTS)and ACC,and some FOS-expressing neurons in the NTS projected to the ACC.In addition,a larger portion of ascending fibers from the NTS innervated pyramidal neurons,the neural subpopulation primarily expressing FOS under the condition of painful CP,rather than GABAergic neurons within the ACC.CP rats showed increased expression of vesicular glutamate transporter 1,and increased membrane trafficking and phosphorylation of the N-methyl-D-aspartate receptor(NMDAR)subunit NR2B and theα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor(AMPAR)subunit GluR1 within the ACC.Microinjection of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats,which was similar to the analgesic effect of endomorphins injected into the ACC.Specifically inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety,whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP rats.Taken together,these findings provide neurocircuit,biochemical,and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats,as well as novel insights into the cortical modulation of painful CP,and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP.

关键词： Chronic pancreatitis Anterior cingulate cortex Nucleus tractus solitaries Hyperalgesia Anxiety

The decreased endomorphin 2 and μ receptor in spinal cord of the STZ-induced type 1 diabetic rats is associated with painful diabetic neuropathy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The decreased endomorphin 2 and μ receptor in spinal cord o...

junO sensitivity on proton decay p→νk^(+)searches

中国神经科学学会第十二届全国学术会议

作者： zhen-zhen kou Fa-Ping Wan Yang Bai Chun-Yu li Jia-chen Hu Ya-Yun Wang hui li Yun-Qing li department of anatomy and k.k.leung brain research centre The Fourth Military Medical University Collaborative Innovation Center for brain Science Fudan University

Painful diabetic neuropathy（PDN） is one of the most common complications at the early stage of diabetes mellitus（DM）. Both diabetic patients and animals frequently exhibit increased responsiveness to nociceptive stimuli. Endomorphin 2（EM2） has been implicated in selectively activating m opioid receptor（MOR） and subsequent induce antinociceptive effects in spinal dorsal horn. However, the mechanisms of EM2 and MOR in PDN have yet to be clarified in spinal dorsal horn. Therefore, we aimed to explore the role of EM2-MOR to determine the mechanism involved in the pathogenesis of PDN. The main findings were:（1） STZ-induced diabetic rats exhibited hyperglycemia, body weight loss and mechanical allodynia.（2） In spinal dorsal horn, the expressions of EM2 and MOR decreased in diabetic rats.（3） EM2 protein concentrations decreased in brain, lumbar spinal cord and CSF in diabetic rats, but were unchanged in plasma.（4） The frequency but not amplitude of spontaneous EPSCs（sEPSCs） was significantly higher in diabetic than control rats.（5） Intrathecal injection of EM2 for 14 days from the early stage of DPN alleviate mechanical allodynia and partially attenuated reduced MOR expression via Ser375 phosphorylation in diabetic rats. In summary, our results demonstrate that the impairment of endogenous analgesia system mediated by EM2 via MOR might be involved at the early stage of PDN.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An chen 陈少敏陈旭荣 Yi-Wen chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev li-cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok jungthawan Leonidas kalousis Philipp ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China university of Science and Technology ShanghaiChina university of Science and Technology of China HefeiChina Joint Institute for Nuclear research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and university of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly university of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan university WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United university Miao-Li Dongguan university of Technology DongguanChina Tsinghua university BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power university BeijingChina Sun Yat-Sen university GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(junO)is a large liquid scintillator detector designed to explore many topics in fundamental physics.In this study,the potential of searching for proton decay in the p→νk^(+)mode with junO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification.Moreover,the excellent energy resolution of junO permits suppression of the sizable background caused by other delayed signals.Based on these advantages,the detection efficiency for the proton decay via p→νk^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data collection.The estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories junO liquid scintillator detector