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The basic core traditional C hinese medicine for the prevention and treatment of COVID-19 and its active mechanisms

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Pharmacology Discovery 2024年第1期4卷 21-30页

作者： Zhe Xu Zi-Xin Li Zi-Yao Geng Rong-Li Shu hui-fang zhou Yu-Hong Bian School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300380China

Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the *** Chinese medicine(TCM)formulae have played an important role in the prevention and treatment of *** evaluated the role of TCM in treating of COVID-19 and encouraged other countries to promote the use of TCM ***,the key is to find the basic core traditional Chinese medicine(BC-TCM)among those ***:For the first time,we mined the data of TCM formulae in CNIPA and analyzed herb characteristics and association *** then determined the BC-TCM and screened main compounds and therapeutic ***,the potential molecular mechanisms were explored by using enrichment analyses and molecular ***:This study screened 123 patented TCM formulae,including 312 *** to frequency statistics and association rules,nine herbs(Gan Cao,Jin Yinhua,Guang Huoxiang,Fu Ling,Huang Qi,Jie Geng,Lian Qiao,Cang Zhu,Ku Xingren)were selected as the *** BC-TCM involved 166 main compounds and 48 therapeutic *** active compounds Hederagenin,Spinasterol,Beta-sitosterol,and Liquiritin had high binding activity to the COVID-19 targets 3CL,ACE2,and core targets RELA,HSP90AA1,STAT3,MAPK3,and TP53 according to molecular docking ***,Hederagenin might be a potential compound for the prevention and treatment of ***:Our research predicted and confirmed the preventive therapeutic effect of BC-TCM on *** has the potential to broaden the scope of TCM,guide people in using clinical formulae,and provide valuable insights for future TCM discovery research.

关键词： COVID-19 traditional Chinese medicine China national intellectual property administration data mining network pharmacology

Epidemiologic characteristics and outcomes of open globe injury in Shanghai

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1295-1300页

作者： Yong-Rong Ji Dong-Qing Zhu hui-fang zhou Xian-Qun Fan Department of Ophthalmology Shanghai Ninth People'sHospital Shanghai Jiao Tong University School of MedicineShanghai 200011 China

AIM： To investigate the epidemiologic characteristics and outcomes of open globe injury in Shanghai. METHODS： A retrospective study was conducted for 148 unilateral open globe injury cases presenting to a tertiary referral hospital of Shanghai. Electronic medical records were reviewed and phone surveys were conducted to collect and analyze 1） background of patient; 2） setting of injury and clinical signs at presentation; 3） treatment procedure and outcome; 4） quality of life after injury. RESULTS： There were more male patients （77.03%） than females （22.97%）, more temporary habitants （79.05%） than residents （20.95%）. The subjects in this study presented a significantly lower constitutional status of education than that of the whole Shanghai population （P〈0.001）. Occupational injury was the first cause of injuries （39.86%）, followed by home accident （20.27%）, road accident （16.80%）, violent behavior （16.89%） and outdoor injury （6,08%）. The 143 subjects （96.62%） were not wearing spectacles at the time of injury. Of all patients, 77 subjects （52.03%） had the outcome of no vision （including enucleation）. The classification and regression tree （CART） prognosis presents 59.58% sensitivity to predict visual survival correctly and 80.19% specificity to predict no vision correctly. The patients whose injured eye had no vision reported more reduction of life quality. CONCLUSION： We found that male subject, temporary habitants, low educational status and no eyewear are risk factors of open globe injury in Shanghai. Occupational injury is the leading cause. CART analysis presents a certain agreement to the actual visual outcome. The injury imposes negative impact on quality of life especially in no vision cases. The education of eye protection may help to avoid the injury.

关键词： ocular injury globe penetration epidemiology risk factors occupational injury

Time-optimal Trajectories for a Car-like Robot

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自动化学报 2008年第4期34卷 445-452页

作者： WANG hui-fang CHEN Yang-zhou College of Electronic Information and Control Engineering Bei-jing University of Technology Beijing 100022 P.R. China

这份报纸为完成时间最佳的轨道的足够的家庭在基于几何最佳的控制理论歧管的 3-dimensional 连接机器人的任何二种配置提供一个新几何方法。我们为分析非线性的问题的这种特殊类型提供一个新观点。从 Pontryagin 的最小的原则(PMP ) 和... 详细信息

这份报纸为完成时间最佳的轨道的足够的家庭在基于几何最佳的控制理论歧管的 3-dimensional 连接机器人的任何二种配置提供一个新几何方法。我们为分析非线性的问题的这种特殊类型提供一个新观点。从 Pontryagin 的最小的原则(PMP ) 和谎言代数学基于切换的功能和他们的衍生物的结构的特征，我们造一个特殊坐标系统并且介绍新向量。我们发现在这新向量的旋转轨道和最佳的控制轨道之间的一对一的印射。而且，我们定义表示位置和这向量的旋转方向的切换的向量，并且得出一个结论规定起始、最后的切换的向量能特别地决定一条最佳的轨道。另外，它是能直接被使用选择一条时间最佳的轨道的一个条件被提供的第一次。

关键词：汽车机器人最优化设计自动化系统

Cytotoxic Diarylheptanoids from Pericarps of Juglans Cathayensis Dode

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Chemical Research in Chinese Universities 2008年第4期24卷 427-429页

作者： LI Yi-xiu RUAN Han-li zhou Xue-feng ZHANG Yong-hui PI hui-fang WU Ji-zhou Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 P R. China

A novel diarylheptanoid, named Jugcathanin（1）, along with two known diarylheptanoids（2,3）, were isolated from the fresh pericarps ofduglans Cathayensis Dode. A known triterpene（4） and a known aphthaoquinone（5） were also isolated from the plant. Their structures were elucidated on the basis of spectroscopic studies. All the compounds exhibited moderate cytotoxicities against human Hela, HepG2, and HL-60 cell lines.

关键词： duglans Cathayensis Dode Jugcathanin Antitumor activity

Structure and 2p decay mechanism of^(18)Mg

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Nuclear Science and Techniques 2024年第6期35卷 145-154页

作者： Long zhou De-Qing fang Si-Min Wang hui Hua Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The recently discovered,extremely proton-rich nuclide 18 Mg exhibits ground-state decay via two sequential two-proton(2p)emissions through the intermediate nucleus,*** study investigates the structure and the initial 2p decay mechanism of^(18)Mgby examining the density and correlations of the valence protons using a three-body Gamow coupled-channel *** results show that the ground state of^(18)Mgis significantly influenced by the continuum,resulting in a significant s-wave ***,based on the current framework,this does not lead to a significant deviation in mirror symmetry in either the structure or spectroscopy of the 18Mg-18C ***,the time evolution analysis of the^(18)Mgground state suggests a simultaneous 2p emission during the first step of *** observed nucleon-nucleon correlations align with those of the light-mass 2p emitters,indicating a consistent decay behavior within this nuclear region.

关键词： Structure of^(18)Mg Two-proton decay Proton-proton correlation

Formation of free-surface vortex and vortex suppression by rotating stopper-rod at end of tundish casting

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Journal of Iron and Steel Research International 2024年第5期31卷 1104-1116页

作者： Qing fang Peng Zhao Hua Zhang Wen-hao zhou Gang Yu Jia-hui Wang Hong-wei Ni The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina

A rotating stopper-rod technique was proposed to suppress the formation of free-surface vortex in the *** large eddy simulation model coupled with volume of fluid model was developed to study the steel–slag–gas three-phase flow *** critical slag entrapment height of the free-surface vortex and mass of residual steel were predicted at different rotating speeds(30,60,90 and 120 r/min)of the rotating *** numerical model was verified by water model *** results showed that by rotating the stopper-rod in the opposite direction of the vortex above the submerged entry nozzle,the formation of vortex can be effectively disturbed and the critical height of the free-surface vortex can be *** for the 2nd strand,when the rotating speeds are 30,60,90 and 120 r/min,the critical height of the free-surface vortex above the 2nd strand is 7.3,4.7,6.3 and 7.4 cm,respectively.A reasonable rotating speed should be 60 r/min,which can reduce about 2 tons of residual *** rotating speeds just can reduce about 1.6 tons of residual steel.

关键词： Tundish Free-surface vortex Stopper-rod Numerical simulation Multiphase flow

The Influence of Transgenic cry1Ab/cry1Ac,cry1C and cry2A Rice on Non-Target Planthoppers and Their Main Predators Under Field Conditions

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Agricultural Sciences in China 2011年第11期10卷 1739-1747页

作者： HANYu XU Xue-liang MA Wei-hua YUAN Ben-qi WANG hui LIU fang-zhou WANG Man-qun WU Gang HUA Hong-xia Hubei lnsect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and Technology HuazhongAgricultural University Wuhan 430070 P.R.China

Transgenic Bt rice has been shown to be an effective means of controlling Lepidoptera pests of rice. However, the potential roles of transgenic rice on planthoppers and their predators need to be investigated before its commercialization. Population density, species dominance and population dynamics are important parameters of arthropods populations in field. So the impacts of three transgenic Bt rice strains expressing crylAb/crylAc, crylC and cry2A on population density, species dominance and population dynamics of three species of planthoppers （Nilaparvata lugens, Sogatella furcifera and Laodelphax striatellus） and their three main predators （ Cyrtorhinus lividipennis, Pirata subpiraticus and Theridium octomaculatum） were evaluated at three sites in Hubei Province, China, in the current study. The results showed that among three species of planthoppers, both in transgenic and non-transgenic rice field, the predominant species ofplanthoppers within phytophagous guild was S. furcifera at any site either growing season （46-50%）. Significantly higher population density ofN. lugens was observed in T2A-1 field relative to Minghui 63 field at Wuxue in 2010. The species dominance of predator, P. subpiraticus, in TT51 field was significantly higher than that in T 1 C-19 and T2A-1 fields in 2009 at Xiaogan site. Sampling date significantly influenced six arthropods except for P. subpiraticus in 2010. The interaction between rice strain^sampling date had no significant adverse effects on the population dynamics of three species of planthoppers and their predators, except for several individual species in 2009. The interaction among rice strain^sampling date^sampling site also had no significant effect on six arthropods except for S. furcifera in 2009. The results indicated that transgenic Bt rice expressing crylAb/crylAc, cry2A and crylC had no significant adverse effects on the population dynamics of three planthoppers and their predators in most investigated data and samp

关键词： planthopper predator transgenic Bt rice population dynamics species dominance population density

Growth,optical dispersion and magnetic behavior of Dy^(3+) doped yttrium iron garnet crystals

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Journal of Rare Earths 2024年第6期42卷 1110-1117,I0004页

作者： Yating fang hui Shen Yudie Ma Shijie Liao Shuang Xia Tian Tian Ding zhou Yunfeng Ma Jiayue Xu Institute of Crystal Growth School of Materials Science and EngineeringShanghai Institute of Technology National Engineering Center of Electromagnetic Radiation Control Materials School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of China

Y_(3)Fe_(5)O_(12)(YIG)crystals are highly desirable for the fabrication of mid-infrared isolators with the rapid growth of optical communications,although it is rather challenging to grow large size and high-quality single ***^(3+)doping is expected to improve the optical and magneto-optical prope ***,high quality Dy:YIG crystals and the adjustment of Dy^(3+)on the structure and optical behavior of YIG crystal remain unclear,impeding its practical ***,a series of Y_(3-x)Dy_(x)Fe_(5)O_(12)(x=0,0.5,1.0,1.5,3)solid solution crystals was grown by the flux-Bridgman method and single crystals up to 25 mm were *** the introduction of Dy^(3+),lattice parameters are gradually enlarged from 1.2379 nm(YIG)to 1.2420 nm(DyIG).Typical Dy^(3+)absorption peaks are observed around 1070,1265 and 1670 *** refractive index decreases from 2.37(500 nm)to 2.10(2500 nm)for YIG crystal,and it reduces from 2.47(500 nm)to 2.16(2500 nm)for DyIG *** optical bandgaps remain almost unchanged for Dy:YIG *** optical dispersion of the refractive indices was finely fitted by the Wemple and DiDomenico(WDD)and the Sellmeier models,*** the increase of Dy^(3+)content,the saturation magnetization(Ms)decreases significantly from 23.62 emu/g(YIG)to 5.33 emu/g(DyIG).Small coercive field is persisted for this system,endowing small external magnetic *** results provide valuable references for the manipulation of rare earths on the properties of magnetooptical crystals,which is beneficial to the design of high-performance garnet crystals for the application of optical switching and non-reciprocal related devices.

关键词： Magneto-optical crystal Yttrium iron garnet Dy^(3+)doping Crystal growth Optical dispersion Rare earths

Multifunctional carbon materials from rugose rose for energy storage and water purification

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 1-13页

作者： Peng-hui Li hui zhou Wen-Juan Wu Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China College of Light Industry and Food Engineering Nanjing Forestry UniversityNanjing 210037China College of Chemical Engineering East China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering Shanghai 200237China

With the advancement of social process,the resource problem is becoming more prominent,biomass materials come into being,and it is becoming more and more important to explore and prepare efficient and multifunctional biomass materials to alleviate the problems of energy storage and water *** this paper,nitrogen-doped hierarchical porous carbon materials(NRRC)were produced by one-step carbonization of withered rose as raw material and melamine as nitrogen source with KOH-activated *** resulting nitrogen-doped porous carbon material had the most abundant pores and the best microspherical graded pore structure,with a specific surface area of up to 1393 m2·g^(-1),a pore volume of 0.68 cm3·g^(-1),and a nitrogen-doped content of 5.52%.Electrochemical tests showed that the maximum specific capacitance of NRRC in the three-electrode system was 346.4 F·g^(-1)(0.5 A·g^(-1)),which was combined with favorable capacitance retention performance and cycling *** NRRC//NRRC symmetric supercapacitors were further assembled,and the maximum energy density of a single device was 23.88 Wh·kg^(-1),which still maintains excellent capacitance retention and cyclic charging/discharging *** example,the capacitance retention rate was always close to 96.27%with almost negligible capacitance loss after 10000 consecutive charge/discharge cycles(current density:10 A·g^(-1)).Regardless of the three-electrode or two-electrode system,the super capacitive performance of NRRC porous carbon materials was comparable to the electrochemical performance of many reported biomass porous carbon materials,which showed better energy storage advantages and practical application *** addition,NRRC porous carbon materials had excellent water purification *** dye adsorption test confirmed that NRRC had a high adsorption capacity(491.47 mg·g^(-1))for methylene *** undoubtedly also showed a potential and promising avenue for high value-added utilization

关键词： rose carbon adsorption electrode material electrochemical performance