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Microbial Dark Matter: from Discovery to Applications

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 867-881页

作者： Yuguo zha.hui Chong Pengshuo Yang Kang Ning MOE Key Laboratory of Molecular Biophysics Hubei Key Laboratory of Bioinformatics and Molecular-imagingCenter of Artificial Intelligence BiologyDepartment of Bioinformatics and Systems BiologyCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

With the rapid increase of the microbiome samples and sequencing data,more and more knowledge about microbial communities has been ***,there is still much more to learn about microbial communities,including billions of novel species and genes,as well as countless spatiotemporal dynamic patterns within the microbial communities,which together form the microbial dark *** this work,we summarized the dark matter in microbiome research and reviewed current data mining methods,especially artificial intelligence(AI)methods,for different types of knowledge discovery from microbial dark *** also provided case studies on using AI methods for microbiome data mining and knowledge *** summary,we view microbial dark matter not as a problem to be solved but as an opportunity for AI methods to explore,with the goal of advancing our understanding of microbial communities,as well as developing better solutions to global concerns about human health and the environment.

关键词： Microbiome Dark matter Artificial intelligence Knowledge discovery Application

Numerical study on transom stern ventilation and resistance of high-speed ship in calm water

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Journal of Hydrodynamics 2022年第5期34卷 864-875页

作者： hui Wang Ren-chuan Zhu Meng-xiao Gu Le zha State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Marine Design and Research Institute of China Shanghai200011China

A transom stern is a common design feature for a high-speed *** the present study,the transom stern ventilation of NPL 3b,5b hull is investigated by three methods:H−H formula,Doctors’formula,and computational fluid dynamics(CFD)method at *** the CFD method,the ratios of the wave elevation and wetted area are used to determine the transom *** of results show that Doctors’formula is more accurate to calculate the critical transom draft Froude *** then a Rankine panel method(RPM)based on the high-order boundary element method incorporated the modified transom stern condition is implemented to evaluate the steady wave problem of a high-speed fishery patrol ship in calm ***,free-surface(FS)and double body(DB)simulations based on Star-CCM+are carried out to obtain the wave-making resistance and total *** results of the resistance and wave pattern around the fishery patrol ship computed by RPM show generally good agreement with experimental measurement and CFD *** results indicate that the developed Rankine panel method with transom condition could predict the resistance of high-speed displacement ships with good accuracy.

关键词： Transom ventilation computational fluid dynamics(CFD)method Rankine panel method(RPM) high-speed ship double body simulation resistance

Adenovirus-mediated HSV-TK Gene Therapy Using hTERT Promoter in CNE Cells in vitro

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Chemical Research in Chinese Universities 2009年第1期25卷 60-63页

作者： zha.G Yu YU Xiang-hui zha.Xiao KONG Wei Vaccine Research Center College of Life Science Jilin University Changchun 130012 P. R. China Department of Radiotherapy Department of Molecular Pharmacology Sichuan Tumor Hospital Chengdu 610041 P. R. China

Human telomerase reverse transcriptase（hTERT） activity was detected in human nasopharyngeal carcinoma celI（CNE） but not in human normal lung fibroblas t（CCD-11Lu）. Recombinant adenoviruses Ad-CMV-TK-enh and Ad-hTERT-TK-enh were constructed and infected into normal fibroblasts and nasopharyngeal carcinoma cells. Ad-CMV-TK-enh with 100 μmol/L of ganciclovir（GCV） caused 87% of CCD-11Lu cells death and 91% of CNE cells death, Ad-hTERT-TK-enh with 100 μmol/L of GCV caused 24% of CCD-11Lu cells death and 79% of CNE cells death. These results indicate that the Ad-hTERT-TK-enh with GCV may be a useful method in suppressing tumor growth in targeted nasopharyngeal carcinoma gene therapy.

关键词： hTERT HSV-TK Adenovirus Nasopharyngeal carcinoma

Kinetic Studies on Forming Iso-nuclear β-type Chelates of Rare Earths with p-Sulphoaminobromophosphonazo

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Chinese Chemical Letters 2000年第12期11卷 1101-1102页

作者： Fei zha.Li YUAN Jin zha.g GAO hui CHEN Chemistry&Chemical Engineering College Northwest Normal UniversityLanzhou 730070

The kinetic behavior of forming the iso-nuclear β-type chelates of rare earth ions (RE~3+) with p-sulphoaminobromophosphonazo (BPA-pSN) in ClCH2COOH-CH3COONa buffer solutions were studied by a spectrophotometric method.

关键词： β-Type chelates rare earths p-sulphoaminobromophosphonazo.\

Preparation of Silica Radiation Pore and Its Application as Antimicrobial Carrier

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Journal of Wuhan University of Technology(Materials Science) 2021年第6期36卷 891-895页

作者： HUANG Jiangxi zha.Xinlin FAN hui LU Zhentan CHEN Yuanli Key Laboratory of Textile Fiber and Products(Wuhan Textile University) Ministry of EducationWuhan 430073China

Hollow silica nanospheres with radical pore on the surfaces were prepared using the assemblies of valine amphiphilic small molecule and benzene as double-templates through sol-gel method in tetramethylammonium hydroxide(25wt%)solution at the stirring rate of 1000 *** are a lot of vertical pores on the surfaces of the hollow spheres after removing the templates in Muffle furnace at 550℃for 5 *** sample was characterized using field-emission scanning electron microscopy,transmission electron microscopy,Brunauer-Emmett-Teller(BET),X-ray diffraction,*** diameter,the vertical pore size of the nanospheres and the BET surface areas are 30-100 nm,4.2 nm,and 570.5 m2/g,*** the high porosity and specific surface area,this kind of hollow sphere is the excellent antimicrobial *** antibacterial activities of the silica nanospheres were evaluated by using a bacterial growth inhibitory *** experimental results show that the silica hollow spheres loaded with Ag+have a good bactericidal effect.

关键词： sol-gel chemistry nanostructures radical pores silica nanospheres antimicrobial carrier

An Efficient Palladium-catalyzed Coupling Reaction for the Preparation of Biaryls and Polyaryls

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Chinese Chemical Letters 2003年第1期14卷 13-16页

作者： Zhi Yong WANG Zheng Gen zha.Jia Hai zha.G Ji hui WU Department of Chemistry University of Science and Technology of ChinaHefei 230026

In the case of Pd(PPh3)4 as catalyst and toluene as reaction solvent, the desired biaryls and polyaryls were synthesized in excellent yield and on a large scale.

关键词： Palladium-catalyst coupling reaction preparation biaryl polyaryl.

Effects of water and fertilizer deficit regulation with drip irrigation at different growth stages on fruit quality improvement of kiwifruit in seasonal arid areas of Southwest China

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Journal of Integrative Agriculture 2023年第10期22卷 3042-3058页

作者： zha.Yu-xuan CHEN Fei WANG Zhi-hui JIANG Shou-zheng CUI Ning-bo State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065P.R.China

For a long time,seasonal drought occurs frequently in Southwest China,and the management of water and fertilizer in kiwifruit orchards has no quantitative standards,which seriously affects the yield and quality of ***,the effects of water and fertilizer deficit regulation with drip irrigation(WFDRDI)on the quality of kiwifruit at different growth stages were explored to achieve water and fertilizer saving,and green and efficient production of *** select‘Jin Yan'kiwifruit and set two water deficit levels(W_(D20%)and W_(D40%))and three fertilizer deficit levels(F_(D15%),F_(D30%)and F_(D45%))at bud burst to leafing stage(stageⅠ),flowering to fruit set stage(stageⅡ),fruit expansion stage(stageⅢ)and fruit maturation stage(stageⅣ),respectively,with a full irrigation and fertilization as the control treatment(CK)in 2017and *** showed that the WFDRDI at stageⅡandⅢhad significant effect on fruit physical quality of kiwifruit,specifically,theⅢ-WD40%F_(D30%)andⅢ-W_(D20%)F_(D45%)treatments significantly increased fruit firmness by 13.62 and 15.59%(P<0.05),respectively;theⅡ-W_(D40%)F_(D15%)andⅢ-W_(D40%)F_(D15%)treatments significantly increased dry matter by 8.19 and 6.47%(P<0.05),respectively;theⅢ-W_(D20%)F_(D15%)treatment significantly increased single fruit weight and fruit volume by 9.33 and 12.65%(P<0.05),respectively;theⅡ-W_(D20%)F_(D15%)treatment significantly increased fruit water content by 1.99%(P<0.05).The WFDRDI had an obvious effect on fruit chemical quality of ***Ⅲ-W_(D20%)F_(D45%),Ⅳ-W_(D40%)F_(D15%)andⅣ-W_(D20%)F_(D30%)treatments significantly increased vitamin C(Vc)content by 69.96,36.96 and 34.31%(P<0.05),respectively;theⅢ-W_(D40%)F_(D15%)andⅣ-W_(D40%)F_(D15%)treatments significantly increased total soluble solid(TSS)content by 3.79 and 17.05%(P<0.05),respectively,and significantly increased soluble sugar content by 28.61 and 34.79%(P<0.05),respectively;the contents of fructose,glucose and sucrose also had a significan

关键词： water deficit fertilizer deficit water and fertilizer coupling fruit physical quality fruit chemical quality

Numerical simulation of rock-breaking and influence laws of dynamic load parameters during axial-torsional coupled impact drilling with a single PDC cutter

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Petroleum Science 2023年第3期20卷 1806-1827页

作者： Yan Xi Hao-Yu Wang Chun-Qing zha.Jun Li Gong-hui Liu Bo-Yun Guo Beijing University of Technology Bejing100124China China University of Petroleum-Bejing Beijing102249China China University of Petroleum-Beijing at Karamay KaramayXinjiang834000China University of Louisiana at Lafayett Lafayette70504USA

Axial and torsional impact drilling technology is used to improve the drilling efficiency of hard rock formation in the deep ***,the corresponding theory is not mature,and there are few correlative research reports on the rock-breaking mechanism of axial and torsional coupled impact drilling *** the influence of the impact hammer geometry and movement on the dynamic load parameters(i.e.,wavelength,amplitude,frequency,and phase difference),a numerical model that includes a hard formation and single polycrystalline diamond compact cutter was *** Riedel-Hiermaier-Thoma model,which considers the dynamic damage and strength behavior of rocks,was adopted to analyze the rock damage under axial and torsional impact *** numerical simu-lation results were verified by the experimental *** was found that compared with conventional drilling,the penetration depths of axial,torsional,and axial-torsional coupled impact drilling increased by 31.3%,5.6%,and 34.7%,*** the wavelength and amplitude of the axial impact stress wave improved the penetration *** the bit rotation speed remained unchanged,increasing the frequency in the axial and circumferential directions had little effect on the penetration ***,as the frequency increased,the cutting surface became increasingly smooth,which reduced the occurrence of bit *** the phase difference between the axial and circumfer-ential stress waves was 25%,the penetration depth significantly *** addition,the bit vibration problem can be effectively ***,the adjustment of engineering and tool structure parameters is proposed to optimize the efficiency of the axial-torsional coupled impact drilling tool.

关键词： Axial-torsional coupled impact drilling tool Rock-breaking PDC cutter RHT model

Selective electrocatalytic CO2 reduction enabled by SnO2 nanoclusters

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Journal of Energy Chemistry 2019年第10期28卷 93-96页

作者： hui Yang Yang Huang Jun Deng Yunling Wu Na Han Chenyang zha.Leigang Li Yanguang Li Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano & Soft Materials (FUNSOM) Soochow University

The development of high-performance electrocatalysts holds the decisive key to the electrochemical CO2 reduction toward value-added products. Formic acid or formate is a desirable reduction product, but its selective production is often challenging. Tin based-materials have attracted great attention for formate production, and yet their performances are far from satisfactory. In this study, we reported the preparation of SnO2 nanoclusters from the controlled self-polymerization of dopamine together with SnO32-, followed by the mild-temperature calcination. The final product consisted of large primary particles that were further made of small secondary SnO2 nanocrystals. When evaluated as the electrocatalyst for CO2 reduction in 0.5 M NaHCO3, our material exhibited impressive activity, selectivity and stability for the selective CO2 reduction to formate. A peak formate Faradaic efficiency of^73% and large partial current density of 16.3 mA/cm2 was achieved at -0.92 V versus reversible hydrogen electrode.

关键词： CO2 reduction reaction Electrocatalysts Formate Tin oxide Selectivity