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Journal of Energy Chemistry 2022年第11期31卷 489-496,I0013页

作者： Zhongquan wan hui Lu Jinyu Yang Yunpeng Zhang Fangyan lin Jianxing Xia Xiaojun Yao Junsheng Luo Chunyang Jia State Key Laboratory of Electronic Thin Films and Integrated Devices School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110GuangdongChina State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000GansuChina

Lithium bis(trifluoromethanesulfonyl)imide(Li-TFSI)/4-tert-butylpyridine(tBP)is a classic doping system for the hole transport material Spiro-OMeTAD in typical n-i-p structure perovskite solar cells(PSCs),but this system will cause many problems such as high hygroscopicity,Li+migration,pinholes and so on,which hinder PSC from maintaining high efficiency and stability for *** this work,an effective strategy is demonstrated to improve the performance and stability of PSC by replacing t BP with *** chelation of 12-crown-4 with Li+not only improves the doping effect of Li-TFSI,but also perfectly solves the problems caused by the Li-TFSI/tBP *** PSC based on this strategy achieved a champion power conversion efficiency(PCE)over 21%,which is significantly better than the pristine device(19.37%).More importantly,the without encapsulated device based on Li-TFSI/12-crown-4 still maintains 87%of the initial PCE even after 60 days exposure in air,while the pristine device only maintains 22%of the initial PCE under the same aging *** strategy paves a novel way for constructing efficient and stable PSCs.

关键词： Perovskite solar cells Spiro-OMeTAD Li-TFSI dopant 12-Crown-4 Chelation

Western North Pacific Tropical Cyclone Database Created by the China Meteorological Administration

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Advances in Atmospheric Sciences 2021年第4期38卷 690-699页

作者： Xiaoqin LU hui YU Ming YING Bingke ZHAO Shuai ZHANG Limin lin lina BAI rijin wan Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Key Laboratory of Numerical Modeling for Tropical Cyclone/China Meteorological Administration Shanghai 200030China

This paper describes the access to, and the content, characteristics, and potential applications of the tropical cyclone(TC) database that is maintained and actively developed by the China Meteorological Administration, with the aim of facilitating its use in scientific research and operational services. This database records data relating to all TCs that have passed through the western North Pacific(WNP) and South China Sea(SCS) since 1949. TC data collection has expanded over recent decades via continuous TC monitoring using remote sensing and specialized field detection techniques,allowing collation of a multi-source TC database for the WNP and SCS that covers a long period, with wide coverage and many observational elements. This database now comprises a wide variety of information related to TCs, such as historical or real-time locations(i.e., best track and landfall), intensity, dynamic and thermal structures, wind strengths, precipitation amounts, and frequency. This database will support ongoing research into the processes and patterns associated with TC climatic activity and TC forecasting.

关键词： tropical cyclone multi-source database western North Pacific

Subgrain microstructures and tensile properties of 316L stainless steel manufactured by selective laser melting

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Journal of Iron and Steel Research International 2021年第9期28卷 1159-1167页

作者： Xin Yang Wen-jun Ma Yao-jia Ren Shi-feng Liu Yan wang wan-lin wang hui-ping Tang College of Materials Science and Engineering Xi’an University of TechnologyXi’an710048ShaanxiChina School of Metallurgical and Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina State Key Laboratory of Porous Metal Materials Northwest Institute of Nonferrous MetalsXi’an710016ShaanxiChina

316L stainless steel samples were manufactured by selective laser melting(SLM).The microstructure of SLM-made 316L stainless steel and the room temperature tensile properties both perpendicular and along the building direction were studied and *** static temperature field during the molten pool formation was simulated by finite element *** indicates that the nonlinear asymmetrical inclined temperature gradient in SLM process produces a large surface tension *** melt forms a Marangoni flow with different convection modes under the action of surface tension as well as a micro-molten pool morphology with subgrain structures such as strip,hexagonal and elongated cellular *** addition,there are also epitaxially grown columnar *** growth of columnar crystals is not affected by the boundary of the molten *** structures and low-angle grain boundaries make the tensile strength and the elongation of SLM-made 316L sample higher as compared to those of the cast and wrought *** room temperature tensile strength of the sample perpendicular to the building direction is higher than that of the sample along the building direction,while the elongation is lower than that of the sample along the building direction.

关键词： Selective laser melting 316L stainless steel Finite element simulation Microstructure Mechanical property

Changes in extracellular matrix in different stages of colorectal cancer and their effects on proliferation of cancer cells

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 267-275页

作者： Zhu-lin Li Zhen-Jun wang Guang-hui Wei Yong Yang Xiao-wan wang Department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Institute of Basic Medical Sciences Chinese Academy of Medical SciencesBeijing 100005China

BACKGROUND The extracellular matrix is the main component of the tumor *** matrix remodels with the oncogenesis and development of *** studies usually focused on the changes of proteins in normal colorectal tissues and colorectal *** is known about the changes in the extracellular matrix in different stages of colorectal cancer and the effects of these changes on the development of this *** To test the changes of type I collagen,type IV collagen,matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9(MMP-9),and tissue inhibitor of metalloproteinase-3(TIMP-3)in different stages of colorectal cancer and the effects of these changes on the proliferation of cancer *** The extracellular matrix from various stages of colorectal cancer and normal colon tissue was obtained by using acellular *** used proteomics to detect the differential expression of proteins between normal colon tissues and colorectal cancer tissues,and then we used Western blot to observe their expression in each stage of colorectal cancer and in normal colon *** coculturing the extracellular matrix and HT29 colon cancer cells in vivo and in vitro,we tested the cancer cell proliferation rate in vitro by methyl thiazolyl tetrazolium(MTT)assay and in vivo by measuring the tumor *** The expression of type I collagen and MMP-2 increased with increased tumor *** expression of MMP-9 was higher in colorectal cancer tissues and was highest in stage III *** expression of type IV collagen and TIMP-3 decreased with increased tumor *** proliferation rate of cancer cells in the extracellular matrix of colorectal cancer was higher than that in the extracellular matrix of the normal *** These data suggest that the extracellular matrix structure and composition become disorganized during the development of tumors,which is more conducive for the growth of cancer cells.

关键词： Colorectal cancer Extracellular matrix MMP Proliferation Collagen TIMP

赞皇杂岩翁城地区长城系常州沟组砂岩碎屑锆石U-Pb-Hf同位素研究

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岩石矿物学杂志 2024年第3期43卷 737-775页

作者：王乐乐刘平华周万蓬杜利林杨崇辉张文曹秋香陈丽梅东华理工大学地球科学学院江西南昌330013 中国地质科学院地质研究所北京100037 中国地质大学(北京) 北京100083

常州沟组是华北克拉通太古宙-古元古代变质基底上最早的沉积盖层之一,其碎屑锆石U-Pb年代学与Hf同位素特征分析对探讨长城系形成时代、源区特征以及基底演化均具有重要的研究意义。本文对华北克拉通中部赞皇杂岩瓮城地区长城系常州沟组... 详细信息

常州沟组是华北克拉通太古宙-古元古代变质基底上最早的沉积盖层之一,其碎屑锆石U-Pb年代学与Hf同位素特征分析对探讨长城系形成时代、源区特征以及基底演化均具有重要的研究意义。本文对华北克拉通中部赞皇杂岩瓮城地区长城系常州沟组底部砂岩样品进行了LA-ICP-MS碎屑锆石U-Pb定年和LA-MC-ICP-MS碎屑锆石Lu-Hf同位素分析。砂岩样品中碎屑锆石主要年龄峰值约为2 500 Ma,推断其碎屑物质主要来自于华北克拉通新太古代晚期变质基底,而最年轻的碎屑锆石年龄为1 822 Ma,结合赞皇杂岩变质基底普遍经历了1 850~1 800 Ma变质作用以及区域上上覆大红峪组火山岩中1 635 Ma结晶锆石年龄,限定瓮城地区长城系常州沟组沉积时代为1 800~1 635 Ma。砂岩样品中碎屑锆石的εHf(t)值变化于-6.8~+5.2之间,相应的两阶段模式年龄峰值约为2 820 Ma,结合赞皇杂岩已发表的2 900~2 700 Ma岩浆锆石和碎屑锆石Hf同位素结果,进一步表明2 900~2 700 Ma为赞皇杂岩地壳生长最主要的时期。综合太行山中南部地区已发表的长城系常州沟组的沉积学与新的年代学数据,推测赞皇杂岩瓮城地区长城系常州沟组沉积于陆内裂谷盆地。

关键词：华北克拉通赞皇杂岩常州沟组碎屑锆石 U-Pb-Hf同位素

Highly efficient electroreduction of CO_(2) by defect single-atomic Ni-N_(3) sites anchored on ordered micro-macroporous carbons

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Science China Chemistry 2022年第8期65卷 1584-1593页

作者： Qiu-Xia Li Duan-hui Si wan lin Yao-Bing wang Hong-Jing Zhu Yuan-Biao Huang Rong Cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry Fuzhou UniversityFuzhou 350108China University of the Chinese Academy of Sciences Beijing 100049China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

Microporous supports typically fail to fully expose active sites for electrolytes and CO_(2) molecules,and this usually results in low current density for the electrocatalytic CO_(2) reduction reaction(CO_(2)RR).To overcome the biggest obstacle and facilitate commercial applications,defective single-atomic Ni-N_(3) sites anchored to ordered micro-macroporous N-doped carbon(Ni-N/OMC)have been prepared by the pyrolysis of the Ni-ZIF-8@PS(ZIF=zeolitic imidazolate framework)and are intended to provide enhanced CO_(2)RR with a current density at an industrial *** Ni-ZIF-8@PS is constructed of nickel-based ZIF-8 embedded in the three-dimensional(3D)highly ordered polystyrene spheres(PS).The 3D ordered micro-macroporous architecture of Ni-N/OMC could facilitate the mass transfer of substrates to the accessible defective single-atomic Ni-N_(3) sites through micropores(0.6 nm)and macropores(~200 nm)interconnected by 50 nm *** a flow cell,Ni-N/OMC exhibits almost 100.0%CO Faraday efficiency(FECO)between−0.2 and−1.1 V *** and an industrial level CO partial current density of 208 mA cm^(−2).It has a turnover frequency of 1.5×10^(5) h^(−1) at−1.1 V *** in 1 M KOH electrolyte,which exceeds that of most reported nickel-based *** excellent CO_(2)RR performance for Ni-N/OMC makes it a state-of-the-art electrocatalyst for CO_(2)*** calculations show that the defective Ni-N_(3) site can lower the energy of*COOH formation compared with that of the Ni-N4 site,thereby accelerating CO_(2)***-N/OMC can also be utilized as a cathodic catalyst in Zn-CO_(2) battery,exhibiting high CO selectivity in the discharge process and excellent *** work paves a pathway to rational design of highly efficient electrocatalysts with 3D hierarchically ordered micro-macroporous architecture for CO_(2)RR towards industrial production and commercial applications.

关键词： metal-organic framework hierarchically ordered porous carbon Ni single atom CO_(2)electrocatalysis CO

Functional Amphiphilic Poly(2-oxazoline)Block Copolymers as Drug Carriers:the Relationship between Structure and Drug Loading Capacity

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Chinese Journal of Polymer Science 2021年第7期39卷 865-873页

作者： Si Dong Sheng Ma Zhi-lin Liu Li-Li Ma Yu Zhang Zhao-hui Tang Ming-Xiao Deng wan-Tong Song College of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Poly(2-oxazoline)(POx)is a kind of polymeric amides that can be viewed as conformational isomers of polypeptides with excellent cyto-and hemo-compatibility,and is promising to be used as drug ***,the drug loading capacity(DLC)of POx for many drugs is still low except several hydrophobic ones including paclitaxel(PTX).Herein,we prepared a series of amphiphilic POx block copolymers with various functional groups,and investigated the relationship between functional structures and the *** POxs with benzyl,carboxyl,and amino groups in the side-chain were synthesized based on a poly(2-methyl-2-oxazoline)-block-poly(2-buty1-2-oxazoline-co-2-buteny1-2-oxazoline)(PMeOx-P(nBuOx-co-ButenOx),PMBEOx)precursor,followed by click reaction between vinyl and the 2-phenylethanethiol,thioglycolic acid and *** thin-film hydration method,eight commonly used drugs with various characteristics were encapsulated within these functional POx *** found that amine-containing drugs were more easily encapsulated by POx with carboxyl groups,while amine functionalities in POx enhanced the loading capacity of drugs with carboxyl *** addition,n-n interactions resulted in enhanced DLC of most drugs,except several hydrophobic drugs with aromatic to total carbon ratios less than *** general,we could successfully encapsulate all the selected drugs with a DLC%over 10%using properly selected functional *** above results confirm that the DLC of polymeric carriers can be adjusted by modifying the functional groups,and the prepared series of functional POxs provide an option for various drug loadings.

关键词： Poly(2-oxaozoline) Polymeric micelles Drug loading π-πInteraction Electrostatic interaction

Adjuvant chemotherapy after liver transplantation for hepatocellular carcinoma: a systematic review and a meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2015年第3期14卷 236-245页

作者： Hua-Shan lin Ren-Hua wan Liang-hui Gao Jian-Feng Li Ren-Feng Shan Jun Shi Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital College of Medicine Nanchang University

BACKGROUND： Hepatocellular carcinoma （HCC） is one of the most common tumors worldwide and liver transplanta- tion （LT） is considered as the best therapeutic option for patients with HCC combined with cirrhosis. However, tumor recurrence after LT for HCC remains the major obstacle for long-term survival. The present study was to evaluate the effi- cacy and necessity of adjuvant chemotherapy in patients with HCC who had undergone LT.

关键词： adjuvant chemotherapy liver transplantation hepatocellular carcinoma recurrence meta-analysis

Ocular development in children with unilateral congenital cataract and persistent fetal vasculature

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 426-431页

作者： Shu-Yi Zhang hui Chen Jing-hui wang wan Chen Qi-Wei wang Jing-Jing Chen Xiao-Shan lin Zhuo-ling lin Duo-Ru lin Hao-Tian lin Wei-Rong Chen State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Center for Precision Medicine Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM: To investigate the ocular development of patients who had unilateral congenital cataract(CC) combined with persistent fetal vasculature(PFV).METHODS: This cross-sectional, observational study included patients who had unilateral CC and PFV and those with isolated unilateral *** length(AL), keratometry, anterior chamber depth(ACD), lens thickness, and vitreous length were *** ocular biometric parameters of the affected eyes of patients with CC and PFV were compared with the fellow eyes and with the affected eyes of patients with isolated ***: A total of 110 patients were included and divided into 4 groups: group 1(18 patients with CC and PFV, ries of the affected eyes were steeper than those of the fellow eyes in group 2(44.78±1.66 vs 43.83±1.38 D,P=0.041) and group 4(43.76±1.91 vs 43.34±1.46 D, P=0.043).No difference of ACDs between two eyes was found in all groups(all P>0.05).CONCLUSION: Compared with the fellow eyes, the ALs of the eyes with unilateral CC and PFV are shorter in patients younger than 24 mo and longer in those older than 24 mo;the keratometries of the eyes with unilateral CC and PFV are steeper in patients older than 24 mo and similar with those younger than 24 *** findings provide further understanding of ocular development in patients with both CC and PFV.

关键词： ocular development congenital cataract persistent fetal vasculature axial length keratometry

苯丁酸氮芥联合伊布替尼对套细胞淋巴瘤Jeko-1细胞株的作用及相关机制

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中国实验血液学杂志 2024年第1期32卷 132-137页

作者：蔡妮娜刘婉艺刘志强龚佳惠林艺玲王泽川黄月琴郭健欣福建医科大学附属第二医院血液科福建泉州362000

目的:探讨苯丁酸氮芥联合伊布替尼对套细胞淋巴瘤Jeko-1细胞株的抑制作用及相关机制。方法:分别将不同浓度的苯丁酸氮芥、伊布替尼单药及两药联合作用于Jeko-1细胞株,采用CCK-8检测细胞增殖情况,同时采用Western blot检测细胞中BCL-2、c... 详细信息

目的:探讨苯丁酸氮芥联合伊布替尼对套细胞淋巴瘤Jeko-1细胞株的抑制作用及相关机制。方法:分别将不同浓度的苯丁酸氮芥、伊布替尼单药及两药联合作用于Jeko-1细胞株,采用CCK-8检测细胞增殖情况,同时采用Western blot检测细胞中BCL-2、caspase-3、PI3K、AKT、P-AKT蛋白表达的变化。结果:分别用苯丁酸氮芥(3.125、6.25、12.5、25、50μmol/L)及伊布替尼(3.125、6.25、12.5、25、50μmol/L)单药处理Jeko-1细胞株24、48和72 h后,细胞增殖均受到抑制,且抑制作用呈时间及剂量依赖性,两药联合时抑制作用更明显(均P<0.05)。与对照组相比,苯丁酸氮芥(3.125、6.25、12.5、25、50μmol/L)及伊布替尼(3.125、6.25、12.5、25、50μmol/L)单药组细胞凋亡率增加,呈剂量依赖性;与相应剂量(3.125、6.25、12.5μmol/L)单药组比较,两药联合应用组Jeko-1细胞株的凋亡率明显增加(均P<0.05)。与单药组相比,两药联合时可产生协同作用,Jeko-1细胞的caspase-3表达明显增强,BCL-2、PI3K、p-AKT/AKT表达明显减弱(均P<0.05)。结论:苯丁酸氮芥及伊布替尼能够促进套细胞淋巴瘤Jeko-1细胞株的凋亡,两药联合应用可以产生协同作用,其主要是通过AKT相关信号通路发挥作用。

关键词：套细胞淋巴瘤苯丁酸氮芥伊布替尼细胞凋亡