Functional Amphiphilic Poly(2-oxazoline)Block Copolymers as Drug Carriers:the Relationship between Structure and Drug Loading Capacity

作     者：Si Dong Sheng Ma Zhi-Lin Liu Li-Li Ma Yu Zhang Zhao-Hui Tang Ming-Xiao Deng Wan-Tong Song Si Dong;Sheng Ma;Zhi-Lin Liu;Li-Li Ma;Yu Zhang;Zhao-Hui Tang;Ming-Xiao Deng;Wan-Tong Song

作者机构：College of ChemistryNortheast Normal UniversityChangchun 130024China Key Laboratory of Polymer EcomaterialsChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2021年第39卷第7期

页      面：865-873页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0817[工学-化学工程与技术] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.51673185,51973215,51673189,51829302,52003268 and 52025035) as well as the support from the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2020232) 

主　　题：Poly(2-oxaozoline) Polymeric micelles Drug loading π-πInteraction Electrostatic interaction 

摘      要：Poly(2-oxazoline)(POx)is a kind of polymeric amides that can be viewed as conformational isomers of polypeptides with excellent cyto-and hemo-compatibility,and is promising to be used as drug ***,the drug loading capacity(DLC)of POx for many drugs is still low except several hydrophobic ones including paclitaxel(PTX).Herein,we prepared a series of amphiphilic POx block copolymers with various functional groups,and investigated the relationship between functional structures and the *** POxs with benzyl,carboxyl,and amino groups in the side-chain were synthesized based on a poly(2-methyl-2-oxazoline)-block-poly(2-buty1-2-oxazoline-co-2-buteny1-2-oxazoline)(PMeOx-P(nBuOx-co-ButenOx),PMBEOx)precursor,followed by click reaction between vinyl and the 2-phenylethanethiol,thioglycolic acid and *** thin-film hydration method,eight commonly used drugs with various characteristics were encapsulated within these functional POx *** found that amine-containing drugs were more easily encapsulated by POx with carboxyl groups,while amine functionalities in POx enhanced the loading capacity of drugs with carboxyl *** addition,n-n interactions resulted in enhanced DLC of most drugs,except several hydrophobic drugs with aromatic to total carbon ratios less than *** general,we could successfully encapsulate all the selected drugs with a DLC%over 10%using properly selected functional *** above results confirm that the DLC of polymeric carriers can be adjusted by modifying the functional groups,and the prepared series of functional POxs provide an option for various drug loadings.