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Neuroscience Bulletin 2022年第4期38卷 373-385页

作者： Seong-Ah Kim Jun Ho Jang Wheedong Kim Pa Reum Lee Yong Ho Kim hue vang Kihwan Lee Seog Bae Oh Department of Neurobiology and Physiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 03080Republic of Korea Department of Brain and Cognitive Sciences College of Natural SciencesSeoul National UniversitySeoul 08826Republic of Korea Gachon Pain Center and Department of Physiology College of MedicineGachon UniversityIncheon 21999Republic of Korea Tooth-Periodontium Complex Medical Research Center School of DentistrySeoul National UniversitySeoul 03080Republic of Korea

Mitochondrial reactive oxygen species(mROS)that are overproduced by mitochondrial dysfunction are linked to pathological conditions including sensory abnormalities.Here,we explored whether mROS overproduction induces itch through transient receptor potential canonical 3(TRPC3),which is sensitive to ROS.Intradermal injection of antimycin A(AA),a selective inhibitor of mitochondrial electron transport chain complex III for mROS overproduction,produced robust scratching behavior in naïve mice,which was suppressed by MitoTEMPO,a mitochondria-selective ROS scavenger,and Pyr10,a TRPC3-specific blocker,but not by blockers of TRPA1 or TRPV1.AA activated subsets of trigeminal ganglion neurons and also induced inward currents,which were blocked by MitoTEMPO and Pyr10.Besides,dry skin-induced chronic scratching was relieved by MitoTEMPO and Pyr10,and also by resveratrol,an antioxidant.Taken together,our results suggest that mROS elicit itch through TRPC3,which may underlie chronic itch,representing a potential therapeutic target for chronic itch.

关键词： Mitochondria Reactive oxygen species TRPC3 Itch Dry skin Trigeminal ganglia

Channel assignment and power allocation for throughput improvement with PPO in B5G heterogeneous edge networks

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Digital Communications and Networks 2024年第1期10卷 109-116页

作者： Xiaoming He Yingchi Mao Yinqiu Liu Ping Ping Yan Hong Han hue The Collge of Computer and Information Hohai UniversityNanjingChina The Key Laboratory of Water Big Data Technology of Ministy of Water Resources Hohai UniversityNanjng China The School of Computer Science and Engineering Nanyang Technological UniversitySingapore The College of Textile and Clothing Engineering Soochow UniversitySuzhouChina The College of Internet of Things Nanjing University of Posts and TelecommunicationsNanjingChina

In Beyond the Fifth Generation(B5G)heterogeneous edge networks,numerous users are multiplexed on a channel or served on the same frequency resource block,in which case the transmitter applies coding and the receiver uses interference cancellation.Unfortunately,uncoordinated radio resource allocation can reduce system throughput and lead to user inequity,for this reason,in this paper,channel allocation and power allocation problems are formulated to maximize the system sum rate and minimum user achievable rate.Since the construction model is non-convex and the response variables are high-dimensional,a distributed Deep Reinforcement Learning(DRL)framework called distributed Proximal Policy Optimization(PPO)is proposed to allocate or assign resources.Specifically,several simulated agents are trained in a heterogeneous environment to find robust behaviors that perform well in channel assignment and power allocation.Moreover,agents in the collection stage slow down,which hinders the learning of other agents.Therefore,a preemption strategy is further proposed in this paper to optimize the distributed PPO,form DP-PPO and successfully mitigate the straggler problem.The experimental results show that our mechanism named DP-PPO improves the performance over other DRL methods.

关键词： B5G Heterogeneous edge networks PPO Channel assignment Power allocation Throughput

A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine

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Genes & Diseases 2024年第3期11卷 26-29页

作者： Xiangyu Dong Yannian Gou Meichun Guo Jiamin Zhong Aohua Li Ailing Hao Wei Zeng Rex C.Haydon hue H.Luu Russell R.Reid Tongchuan He Yan Xu Jiaming Fan Ministry of Education Key Laboratory of Diagnostic Medicine And Department of Clinical BiochemistryCollege of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Institute of Sports Medicine Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalBejing 100191China

With the rapid advances in stem cell research and po-tential cell-based therapies,there is an urgent need to develop safe and reliable cell transport strategies.Except for autologous stem cell-based therapies,allogeneic stem cell therapies and ex vivo genetically engineered cell therapies would require safe,efficient,and reliable cell preservation and transport methods.

关键词： transport methods simplified

Micropenis Associated or Not with Cryptorchidism in the Endocrinology Department of Yopougon University Hospital in Ivory Coast: Epidemiological, Clinical, Paraclinical and Therapeutic Aspects

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Open Journal of Endocrine and Metabolic Diseases 2024年第3期14卷 75-85页

作者： Adélaïde hue Kossi Kodjo Michèle Fotso Jacko Abodo Department of Endocrinology Diabetology at Yopougon University Hospital Abidjan Ivory Coast Internal Medicine and Endocrinology Department of Sylvanus Olympio University Hospital Lomé Togo

Background: Congenital malformations such as micropenis and cryptorchidism do not have immediate dramatic consequences. However, the diagnosis is often unknown at birth, and therefore late. In Ivory Coast, there are few studies on cryptorchidism and micropenis. We conducted this study to identify the epidemiological, clinical, etiological and therapeutic characteristics of the micropenis associated or not with cryptorchidism at Yopougon University Hospital. Methods: We conducted a retrospective descriptive study in the Department of Endocrinology-Diabetology of the Yopougon University Hospital carried out over 13 years from January 2005 to December 2018. All patients were included regardless of the presence of a micropenis associated or not with cryptorchidism in the clinical or paraclinical examination. Results: A total of 14 micropenis were reported associated in 6 cases with cryptorchidism. It was unilateral cryptorchidism in 4 patients or 66.66% of cases. The average age of affected patients was 21.32 years with extremes ranging from 10 months to 48 years. The reason for consultation was micropenis in 12 out of 14 cases or 85.75%. The associated signs apart from cryptorchidism were obesity in 42.86% of cases, gynecomastia in 35.71% of cases. The aetiology was dominated by idiopathic causes. Treatment with testosterone enanthate was more effective in pre-pubertal children than in adults. Conclusion: The diagnosis of micropenis associated or not with cryptorchidism is late because of the frustrations, taboos and psycho-social states that it causes. However, drug treatment is effective when treatment is started early.

关键词： Micropenis Cryptorchidism Hospital Environment Ivory Coast

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin Jiaming Fan Guozhi Zhao Piao Zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon hue H.Luu Sherwin Ho Michael J.Lee Jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across species.Wnt proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling pathways.Cellular behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling paths.Wnt signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various tissues.This includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem cells.Wnt signaling has also been implicated in tumor cells that exhibit stem cell-like properties.Wnt signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone disorders.Not surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including cancer.Mutations of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and metastasis.Altogether,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt pathway.Beginning with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong Lily Song William Wagstaff Rex C.Haydon hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and differentiation.The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical pathway.Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling pathways.This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes.Dys-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic lethality.The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments.However,both stimulatory and inhibitory treatments come with potential risks that need to be addressed.This review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt signaling.It thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+pathway.Further description involved each of its components and their involvement in other cellular processes.Finally,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

Long-term management of idiopathic cough with ultrasound-guided pulsed radiofrequency ablation of the phrenic nerve

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Chinese Medical Journal 2022年第12期135卷 1511-1512页

作者： Yoo Jung Park Yong Ho Lee Jinwoo Shim Jin Young Lee Hyunhwa Lee hue Jung Park Department of Anesthesiology and Pain Medicine St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonRepublic of Korea Department of Anesthesiology and Pain Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Department of Anesthesiology and Pain Medicine Samsung Medical CenterSungkyunkwan UniversitySchool of MedicineSeoulRepublic of Korea

To the Editor:Idiopathic cough is associated with laryngeal hypersensitivity and chronic pain syndromes.Idiopathic cough can be diagnosed when patients have no cause of chronic cough after treatment of cough.Patients with chronic cough experience impaired quality of life(QOL),interruption of daily activity,and depression.Therefore,better approaches to refractory chronic cough areneeded.

关键词： impaired Idiopathic cough

Soft-output stack algorithm with lattice-reduction for MIMO detection

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Journal of Systems Engineering and Electronics 2010年第2期21卷 197-203页

作者： Yuan Yang Hailin Zhang Junfeng hue Datang Linktech Infosystem Co Ltd Beijing 100083 E R. China State Key Laboratory of ISN Xidian University Xi'an 710071 R R. China

A computationally efficient soft-output detector with lattice-reduction （LR） for the multiple-input multiple-output （MIMO） systems is proposed. In the proposed scheme, the sorted QR de- composition is applied on the lattice-reduced equivalent channel to obtain the tree structure. With the aid of the boundary control, the stack algorithm searches a small part of the whole search tree to generate a handful of candidate lists in the reduced lattice. The proposed soft-output algorithm achieves near-optimal perfor- mance in a coded MIMO system and the associated computational complexity is substantially lower than that of previously proposed methods.

关键词： multiple-input multiple-output （MIMO） soft-output de- tection lattice-reduction stack algorithm.

Gender and rural transformation:A systematic literature review

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Journal of Integrative Agriculture 2023年第12期22卷 3624-3637页

作者： Maria Fay ROLA-RUBZEN hue T.VUONG Claire DOLL Curtis ROLLINS Jon Marx SARMIENTO Mohammad Jahangir ALAM Ismat Ara BEGUM UWA School of Agriculture and Environment The University of Western AustraliaPerthWA 6009Australia Centre of Science and Technology Research and Development Thuongmai UniversityHanoi 100000Vietnam Department of Agribusiness and Marketing Bangladesh Agricultural UniversityMymensingh-2202Bangladesh

Rural transformation can improve poverty reduction,living standards,and health outcomes in developing countries.However,impacts associated with rural transformation vary by region,household,and individual trait(including gender).While research on rural transformation has been increasing over the last decade,there has been no comprehensive review conducted on the relationships between gender and rural transformation.Here,we conduct a systematic literature review to investigate the impacts of rural transformation on gender and the influence of gender inclusiveness on rural transformation.We reviewed 82 studies from 1960-2021 that explore the relationships between rural transformation and gender.We then developed a framework that captures incidences and flow directions between indicators.Results show that most studies examined the impacts of rural transformation on women and between gender indicators.Few investigated the role of women and the influence of gender inclusiveness on rural transformation.Overall,studies showed that rural transformation typically leads to positive outcomes for women regarding employment,income,and empowerment.However,negative impacts on women’s control over income,stability of new income sources,and access to healthy food are also common.Tailoring future development policies and programs to explicitly account for gender inclusiveness can lead to more successful rural transformation.

关键词： gender rural transformation structural transformation women’s empowerment

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一种智能纳米复合剂堵水调剖体系的研究

精细石油化工进展 2024年第3期25卷 5-8页

作者：张永伟王绘鹏王辰冯馥腾薛龙龙杨昌华西安石油大学石油工程学院陕西西安710065 塔里木油田分公司油气工程研究院新疆库尔勒841000 西部低渗-特低渗油藏开发与治理教育部工程研究中心陕西西安710065

为解决高温高盐碎屑岩油藏含水率高、封堵难度大以及采收率低等问题,研究了一种ALT智能纳米复合剂堵水调剖体系,通过Zate电位仪和SCZL203全自动张力仪对该调剖体系的粒径和界面张力进行测定,并采用耐高压微观驱替装置进行体系封堵性能... 详细信息

为解决高温高盐碎屑岩油藏含水率高、封堵难度大以及采收率低等问题,研究了一种ALT智能纳米复合剂堵水调剖体系,通过Zate电位仪和SCZL203全自动张力仪对该调剖体系的粒径和界面张力进行测定,并采用耐高压微观驱替装置进行体系封堵性能评价。结果表明:ALT智能纳米复合剂在水中具有良好的溶解性,可有效改善储层润湿性,且具有很好的洗油效果;同时,复合剂堵水调剖体系颗粒粒径小,容易进入储层微小孔喉,在油藏条件下封堵效果好,具有良好的油水选择性,堵水率高达88.1%,总采收率达56.9%。

关键词：碎屑岩油藏智能纳米复合剂润湿性洗油效率油水选择性