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Saliency-based framework for facial expression recognition

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Frontiers of Computer Science 2019年第1期13卷 183-198页

作者： Rizwan Ahmed KHAN Alexandre MeYeR hubert KONIK Saida BOUAKAZ Universite de Lyon CNRSLIRISUMR5205Universite Lyon 1Lyon F-69622France Faculty of Information Technology Barrett Hodgson UniversityKarachi 74900Pakistan Laboratoire hubert Curien UMR5516Universite Jean MonnetSaint-Etienne 42000France

This article proposes a novel framework for the recognition of six universal facial *** framework is based on three sets of features extracted from a face image:entropy,brightness,and local binary ***, saliency maps are obtained using the state-of-the-art saliency detection algorithm "frequency-tuned salient region detection".The idea is to use saliency maps to determine appropriate weights or values for the extracted features (i.e.,brightness and entropy).We have performed a visual experiment to validate the performance of the saliency detection algorithm against the human visual *** movements of 15 subjects were recorded using an eye-tracker in free-viewing conditions while they watched a collection of 54 videos selected from the Cohn-Kanade facial expression *** results of the visual experiment demonstrated that the obtained saliency maps are consistent with the data on human ***,the performance of the proposed framework is demonstrated via satisfactory classification results achieved with the Cohn-Kanade database,FG-NeT FeeD database, and Dartmouth database of children's faces.

关键词： facial expression recognition classification salient regions entropy brightness local binary pattern

extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing

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International Journal of Oral Science 2023年第3期15卷 450-461页

作者： Anamaria Balic Dilara Perver Pierfrancesco Pagella hubert Rehrauer Bernd Stadlinger Andreas e.Moor Viola Vogel Thimios A.Mitsiadis Orofacial Development and Regeneration Institute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurichSwitzerland Department of Health Sciences and Technology Institute of Translational MedicineETH ZurichZurichSwitzerland Functional Genomics Center Zurich ETH Zurich and University of ZurichZurichSwitzerland Clinic of Cranio-Maxillofacial and Oral Surgery University of ZurichZurichSwitzerland Department of Biosystems Science and engineering ETH ZurichBaselSwitzerland

Carious lesions are bacteria-caused destructions of the mineralised dental tissues,marked by the simultaneous activation of immune responses and regenerative events within the soft dental pulp *** major molecular players in tooth decay have been uncovered during the past years,a detailed map of the molecular and cellular landscape of the diseased pulp is still *** this study we used single-cell RNA sequencing analysis,supplemented with immunostaining,to generate a comprehensive single-cell atlas of the pulp of carious human *** data demonstrated modifications in the various cell clusters within the pulp of carious teeth,such as immune cells,mesenchymal stem cells(MSC)and fibroblasts,when compared to the pulp of healthy human *** immune response in the carious pulp tissue is accompanied by specific changes in the fibroblast and MSC *** changes include the upregulation of genes encoding extracellular matrix(eCM)components,including COL1A1 and Fibronectin(FN1),and the enrichment of the fibroblast cluster with *** incremental changes in the eCM composition of carious pulp tissues were further confirmed by immunostaining *** of the Fibronectin fibres under mechanical strain conditions showed a significant tension reduction in carious pulp tissues,compared to the healthy *** present data demonstrate molecular,cellular and biomechanical alterations in the pulp of human carious teeth,indicative of extensive eCM remodelling,reminiscent of fibrosis observed in other *** comprehensive atlas of carious human teeth can facilitate future studies of dental pathologies and enable comparative analyses across diseased organs.

关键词： organs pulp matrix

Aeration performances and air—Water mass transfer on steep stepped weirs with horizontal and inclined steps

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Journal of Hydrodynamics 2022年第5期34卷 904-916页

作者： Yvan Arosquipa Nina Rui Shi Davide Wüthrich hubert Chanson The University of Queensland School of Civil EngineeringBrisbaneAustralia Department of Hydraulic engineering Delft University of TechnologyDelftThe Netherlands

At hydraulic structures,some strong interactions may develop between fast flowing waters and the air adjacent to the water in motion that enhance the air-water transfer of atmospheric and volatile gases in the *** turn,in-stream structures may contribute to the aeration and re-oxygenation during *** present study aims to characterize the aeration performance of a steep stepped weir,based upon a detailed physical investigation of air-water interfacial properties across a relatively wide range of *** data showed a strong fragmentation of the air-water flows,a very broad range of entrained bubbles and drops,and a large amount of particle *** results implied a monotonic increase in re-aeration with increasing rate of energy dissipation,while the largest aeration efficiency was observed on the horizontal step weir chute,with the smallest on the 1V:2.33H inclined downward ***,the study showed that a steep stepped chute can make a sizeable contribution to the re-oxygenation of the waters,although the downward inclined steps reduce the re-aeration performances.

关键词： Stepped weirs aeration re-oxygenation physical modeling flow fragmentation

effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2

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World Journal of Gastroenterology 2001年第1期7卷 143-148页

作者： edgar Staren Takeshi Iwamura hubert Appert John Howard Department of Surgery Medical College of Ohio Toledo Ohio USA Department of Surgery Miyazaki Medical College Miyazaki Japan

INTRODUCTIONDevelopment of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment failure and the death fromcancer. There have been many previous studies onthe relationship between expression of multidrugresistance (MDR) phenotype P-glycoprotein (P-gp)and the malignant properties of tumors, but theresults are often conflicting[1-8]. The difference intumor types or MDR phenotype induced by specificagents might account for this discrepancy. Taxotere(TXT), a member of the family of taxanes, hasantitumor activity through its effect of promotingthe polymerization of tubulin[9,10].

关键词： Carcinoma Pancreatic Neoplasms Taxoids Antineoplastic Agents, Phytogenic Biocompatible Materials Collagen Drug Combinations Drug Resistance, Multiple Drug Resistance, Neoplasm Fluorescent Dyes Humans In Vitro Laminin Neoplasm Invasiveness P-Glycoprotein Paclitaxel derivatives Phenotype Proteoglycans RNA, Neoplasm Research Support, Non-U.S. Gov't Rhodamine 123 Tumor Cells, Cultured

Turbulence and suspended sediment processes in the Garonne River tidal bore in November 2016

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International Journal of Sediment Research 2019年第5期34卷 496-508页

作者： David Reungoat Xinqian Leng hubert Chanson Université de Bordeaux I2MLaboratoire TREFLE CNRS UMR 5295 The University of Queensland School of Civil Engineering

A tidal bore is a water discontinuity at the leading edge of a flood tide wave in estuaries with a large tidal range and funneling topography. New measurements were done in the Garonne River tidal bore on14–15 November 2016, at a site previously investigated between 2010 and 2015. The data focused on long, continuous, high-frequency records of instantaneous velocity and suspended sediment concentration(SSC) estimate for several hours during the late ebb, tidal bore passage and flood tide. The bore passage drastically modified the flow field, with very intense turbulent and sediment mixing. This was evidenced with large and rapid fluctuations of both velocity and Reynolds stress, as well as large SSCs during the flood tide. Granulometry data indicated larger grain sizes of suspended sediment in water samples compared to sediment bed material, with a broader distribution, shortly after the tidal bore. The tidal bore induced a sudden suspended sediment flux reversal and a large increase in suspended sediment flux magnitude. The time-variations of turbulent velocity and suspended sediment properties indicated large fluctuations throughout the entire data set. The ratio of integral time scales of SSC to velocity in the x-direction was on average Te,SSC/Te,～0.16 during the late ebb tide, compared to Te,SSC/Te,～0.09 during the late flood tide. The results imply different time scales between turbulent velocities and suspended sediment concentrations.

关键词： Tidal bore Garonne River Hydrodynamics Suspended sediment Field observations Turbulence-sediment suspension interactions

The Quaternary fault in Jiamu area,the Xinjiang Uygur Autonomous Region

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Chinese Science Bulletin 2002年第6期47卷 494-499页

作者： A.hubert-Feram J.Suppe Department of Geosciences Princeton UniversityPrincetonDepartment of GeosciencesPrinceton UniversityPrinceton New Jersey 08544USANew Jersey 08544USA

The Quaternary Tailan River fault has been found in the Tianshan foothills area, the Xinjiang Uygur Autonomous Region. It is the recent boundary fault of the Tarim Basin coupling with the West Tianshan Mountains. In the light of measurement data of the slip which cuts the Quaternary deposits of different ages, the Quaternary kinematic figures of the Tailan River fault are estimated as follows: crustal shortening 3.7 km and shortening rate 1.59 mm/a, uplift of Tianshan Mountains 1.34 km and uplift rate 0.56 mm/a, and additional relief of 900 m. Considering the contribution of the Gumubiezi anticline close to the south of the Tailan River fault, the Quaternary crustal shortening and shortening rate of the Jiamu area are 4.8 km and 2 mm/a respectively. The above-mentioned data coincide with the crustal shortening rate calculated from the growth strata in the Kuqa area, as well as the GPS measurements in the Lake Issyk area and the Korla-Urumqi area, reflecting the fast thrusting period within the

关键词： coupling mechanics in the formation of basin and moun-tains of the Tarim basin-Tianshan Mountains moraine Quaternary fault crustal shortening.

Challenges and improvements in testosterone and estradiol testing

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Asian Journal of Andrology 2014年第2期16卷 178-184,I0006,I0007页

作者： hubert W Vesper Julianne C Botelho Yuesong Wang Clinical Chemistry Branch Division of Laboratory Sciences Centers for Disease Control and Prevention Atlanta Georgia USA.

Assays that measure steroid hormones in patient care, public health, and research need to be both accurate and precise, as these criteria help to ensure comparability across all clinical and research applications. This review addresses major issues relevant to assay variability and describes recent activities by the US Centers for Disease Control and Prevention （CDC） to improve assay performance. Currently, high degrees of accuracy and precision are not always met for testosterone and estradiol measurements; although technologies for steroid hormone measurement have advanced significantly, measurement variability within and across laboratories has not improved accordingly. Differences in calibration and specificity are discussed as sources of variability in measurement accuracy. Ultimately, a combination of factors appears to cause inaccuracy of steroid hormone measurements, with nonuniform assay calibration and lack of specificity being two major contributors to assay variability. Within-assay variability for current assays is generally high, especially at low analyte concentrations. The CDC Hormone Standardization （HoSt） Program is improving clinical assays, as evidenced by a 50% decline in mean absolute bias between mass spectrometry assays and the CDC reference method from 2007 to 2011. This program provides the measurement traceability to CDC reference methods and helps to minimize factors affecting measurement variability.

关键词： CDC hormone standardization CDC HoSt estradiol steroid hormone testing testosterone

Do the microorganisms from laboratory culture spent growth medium affect house dust mite fitness and microbiome composition?

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Insect Science 2020年第2期27卷 266-275页

作者： Vit Molva Marie Bostlova Marta Nesvorna Jan hubert Crop Research Institute Prague 6-RuzyneCzechia Faculty of Science Department of ParasitologyCharles UniversityPrague 2Czechia

The interaction of house dust mites(HDM)and microorganisms is the key factor in the survival of these mites in human-made *** growth medium(SPGM)provides the rest of the dict,along with dead mite bodies and *** represents a source of microorganisms for the recolonization of mite food and the mite digestive *** experiment was performed to observe how adding SPGM to the HDM diet affects HDM population growth,the microbiome composition and the microbial respiration in *** analyzed American house dust mite(Dermatophagoides farinae)and european house dust mite(Dermatophagoides pleronyssinus)originating from control diets and diets treated with an extract of SPGM from 1-and 3-month-old mite *** microbiome was described using 16S and 18S barcode *** composition of the bacterial and fiungal microbiomes differed between the HDM species,but the SPGM treatment influenced only the bacterial profile of *** the *** microbiome of specimens on SPGM-treated dicts compared to those of the control situation,the Lactobacillus profile decreased,while the Candinium,Staphylococ-cus,Acinetobacter,and Sphingomonas profiles *** addition of SPGM extract decreased the microbial respiration in the microcosms with and without mites in almost all *** SPGM did not influence the population growth of ***,but it had a variable effect on *** results indicated that the HDM are marginally influenced by the microorganisms in their feces.

关键词： diet feces feeding house dust mites microbiome microorganisms mites

Respiratory neuroplasticity following carotid body denervation Central and peripheral adaptations

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Neural Regeneration Research 2012年第14期7卷 1073-1079页

作者： Matthew R. Hodges hubert V. Forster Department of Physiology Medical College of Wisconsin Milwaukee WI 53226 USA Neuroscience Research Center Medical College of Wisconsin Milwaukee WI 53226 USA Zablocki Veterans Affairs Medical Center Milwaukee WI 53226 USA

Historically, the role of the carotid bodies in ventilatory control has been understated, but the current view suggests that the carotid bodies （1） provide a tonic, facilitory input to the respiratory network, （2） serve as the major site of peripheral 02 chemoreception and minor contributor to CO2/H＋ chemoreception, and （3） are required for ventilatory adaptation to high altitude. each of these roles has been demonstrated in studies of ventilation in mammals after carotid body denervation. Following carotid body denervation, many of the compromised ventilatory ＂functions＂ show a time-dependent recovery plasticity that varies in the degree of recovery and time required for recovery. Respiratory plasticity following carotid body denervation is also dependent on species, with contributions from peripheral and central sites/mechanisms driving the respiratory plasticity. The purpose of this review is to provide a summary of the data pointing to peripheral and central mechanisms of plasticity following carotid body denervation. We speculate that after carotid body denervation there are altered excitatory and/or inhibitory neuromodulator mechanisms that contribute to the initial respiratory depression and the subsequent respiratory plasticity, and further suggest that the continued exploration of central effects of carotid body denervation might provide useful information regarding the capacity of the respiratory network for plasticity following neurologic injury in humans.

关键词： control of breathing chemoreception, carotid body denervation ventilation plasticity