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Nano Research 2017年第8期10卷 2810-2822页

作者： Min Shen Yuanbiao huang Dongshuang wu Jian Lv Minna Cao Meimei Liu Yinglong Yang Hongfang Li Binbin Guo Rong Cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences 155 Yangqiao West Road Fuzhou 350002 China University of Chinese Academy of Sciences Beijing 100049 China

Anisotropic Pd nanoparticles with highly branched morphologies are urgently needed as building blocks for nanoscale devices, catalysts, and sensing materials owing to their novel structures and unique physicochemical properties. However, realizing size control and branch manipulation for these materials is very challenging. In this study, we develop a facile ultrafine Cu seed-mediated approach in the aqueous phase to produce novel Pd-Cu trigonal hierarchical nanoframes （THNFs）. The main branch of most of the obtained nanocrystals is tripod-like, with advanced branches along the arms as frame units having self-similarity. In this method, the size of the Pd-Cu THNFs can be flexibly controlled by manipulating the nucleation involving the sub-3 nm Cu seeds. These Pd-Cu THNFs outperform Pd black with regard to their ethanol-oxidation performance, having a specific activity and mass activity 9.7 and 6.6 times higher, respectively. This research provides a versatile ultrafine seed-mediated approach for producing size-controlled anisotropic bimetallic nanoframes.

关键词： ultrafine seed mediation Pd-Cu hierarchical anisotropy ethanol oxidation

Pulmonary hypertension secondary to seronegative rheumatoid arthritis overlapping antisynthetase syndrome:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9851-9858页

作者： Cheng-Yan huang Ming-Jie Lu Jia-Hua Tian Dai-Shun Liu Chun-Yan wu Department of Respiratory Medicine The Third Affiliated Hospital of Zunyi Medical University(The First People’s Hospital of Zunyi)Zunyi 563000Guizhou ProvinceChina Clinical School Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Polyarthritis is the most frequent clinical manifestation in antisynthetase syndrome(ASS)forms of idiopathic inflammatory myositis and may be misdiagnosed as rheumatoid arthritis(RA),particularly in patients with seronegative RA(SNRA).It is unclear whether there is an overlap between ASS and RA,or if ASS sometimes mimics *** hypertension(PAH)is common in connective tissue diseases(CTDs).However,published reports on CTD-PAH do not include overlapping CTDs,and its incidence and impact on patient prognosis are *** SUMMARY We report the case of a 63-year-old woman who presented with a 3-mo history of symptom aggravation of recurrent symmetrical joint swelling and pain that had persisted for over 10 *** patient was diagnosed with RA and interstitial lung *** patient repeatedly presented to the hospital’s respiratory and rhe-umatology departments with arthralgia,plus shortness of breath after *** tests indicated that anti-CCP and RF remained negative,while anti-J0-1 and anti-Ro-52 were strongly *** was not until recently that we recognized that this could be an unusual case of SNRA with concurrent *** pain was relieved after regular anti-rheumatic *** computed tomography scans showed that pulmonary interstitial changes did not progress significantly over several years;however,they showed gradual widening of the pulmonary artery,and cardiac ultrasound indicated elevated pulmonary artery systolic *** prescribed treatment of PAH was not effective in improving shortness of *** Overlap of RA and ASS may be *** research is necessary to facilitate early diagnosis,effective evaluation,and prognosis.

关键词： Rheumatoid arthritis Arthritis Antisynthetase syndrome Pulmonary hypertension Pulmonary arterial hypertension Case report

银杏达莫治疗急性脑梗死120例临床疗效观察

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天津中医药 2010年第3期27卷 200-201页

作者：罗喜鸣黄晓明吴君平李敏浙江省杭州市余杭区第五人民医院内科杭州311100 浙江省中医院杭州310006

[目的]观察银杏达莫注射液治疗急性脑梗死的临床疗效。[方法]选择急性脑梗死患者120例,随机分为研究组和对照组各60例,在常规治疗基础上,研究组使用银杏达莫注射液,对照组使用丹参注射液,21d为1个疗程,观察血液流变学的变化,并进行神经... 详细信息

[目的]观察银杏达莫注射液治疗急性脑梗死的临床疗效。[方法]选择急性脑梗死患者120例,随机分为研究组和对照组各60例,在常规治疗基础上,研究组使用银杏达莫注射液,对照组使用丹参注射液,21d为1个疗程,观察血液流变学的变化,并进行神经功能缺损评分。[结果]总有效率研究组为93.4%,对照组为66.7%,两组差异有统计学意义(P<0.05),两组比较,血液流变学指标和神经功能缺损评分差异均有显著性(P<0.05),两组均无不良反应。[结论]银杏达莫治疗急性脑梗死,疗效较高,安全性良好。

关键词：银杏达莫急性脑梗死血液流变学临床疗效

High strength and high creep resistant ZrB2/Al nanocomposites fabricated by ultrasonic-chemical in-situ reaction

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Journal of Materials Science & Technology 2019年第9期35卷 2107-2114页

作者： Xizhou Kai Shuoming huang Lin wu Ran Tao Yanjie Peng Zemin Mao Fei Chen Guirong Li Gang Chen Yutao Zhao School of Material Science and Engineering Jiangsu University

In this study, the ZrB2/Al nanocomposites were fabricated via in-situ reaction of the Al-K2ZrF6-KBF4 system, assisted with ultrasonic vibration and spiral electromagnetic stirring. Microstructure, tensile property and creep behavior of the fabricated nanocomposites were further investigated. Microstructure observation showed that the ultrasonic vibration could prevent the fast growth as well as break the clusters of in-situ synthesized nanoparticles in melt, resulted in smaller size (10-50 nm) and relatively more uniform distribution of the in-situ nanoparticles located on the boundary of and/or inside the aluminum matrix grains in the final composites. The fabricated nanocomposites exhibited an enhancement in both strength and ductility, due to the elevated work hardening ability, i.e., improved dislocation propagating ability and decreased dynamic recovery of the existing dislocations induced by the in-situ nanoparticles. Meanwhile, the nanocomposites exhibited excellent creep resistance ability, which was about 2-18 times higher than those of the corresponding aluminum matrix. The stress exponent of 5 was identified for the fabricated nanocomposites, which suggested that their creep behavior was related to dislocation climb mechanism. The enhanced creep resistance of the nanocomposites was attributed to the Orowan strengthening and grain boundary strengthening induced by the ZrB2 nanoparticles. Thus, the ultrasonicchemical in-situ reaction promises a low cost but effective way to fabricate aluminum nanocomposites with high strength and high creep resistance.

关键词： In-situ ZrB2/Al nanocomposites Microstructure High strength High creep behavior Mechanism

NbN superconducting nanowire single photon detector with efficiency over 90% at 1550 nm wavelength operational at compact cryocooler temperature

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Science China(Physics,Mechanics & Astronomy) 2017年第12期60卷 26-35页

作者： WeiJun Zhang LiXing You Hao Li Jia huang ChaoLin Lv Lu Zhang XiaoYu Liu JunJie wu Zhen Wang XiaoMing Xie State Key Lab of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China CAS Center for Excellence in Superconducting Electronics Shanghai 200050 China

The rapid development of superconducting nanowire single-photon detectors over the past decade has led to numerous advances in quantum information technology. The record for the best system detection efficiency at an incident photon wavelength of 1550 nm is 93%. This performance was attained from a superconducting nanowire single-photon detector made of amorphous WSi; such detectors are usually operated at sub-Kelvin temperatures. In this study, we first demonstrate superconducting nanowire single-photon detectors made of polycrystalline NbN with system detection efficiency of 90.2% for 1550-nm-wavelength photons at2.1 K, accessible with a compact cryocooler. The system detection efficiency saturated at 92.1% when the temperature was lowered to 1.8 K. We expect the results lighten the practical and high performance superconducting nanowire single-photon detectors to quantum information and other high-end applications.

关键词： detection efficiency NbN superconducting nanowire single-photon detector(SNSPD) quantum information

Comparative analysis of different cyclosporine A doses on protection after myocardial ischemia/reperfusion injury in rat

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 144-148页

作者： Kang huang Shi-Juan Lu Jiang-Hua Zhong Qun Xiang Liu Wang Miao wu Department of Cardiology Haikou People's Hospital

Objective:To investigate the protective effect of different cyclosporin A(CsA)doses on myocardial ischemia/reperfusion injury in rat ***:A rat model of myocardial ischemia/reperfusion injury was established in vivo and the rats were randomly divided into four groups:placebo(PBS;T1),low-dose(CsA dose:1.0 mg/kg:T2),medium-dose(CsA dose:2.5 mg/kg:T3),and high-dose(CsA dose:5.0 mg/kg;T4)*** function indexes were monitored at different time points,the extent of myocardial infarction was assessed by Evans Blue-TTC staining,and creatine kinase MB mass and cardiac troponin 1 values were measured by biochemical ***:Compared with the T1 and T2 groups,both the creatine kinase MB mass and cardiac troponin 1 were significantly lower in the T3 and T4 groups(P<0.05).The mean arterial pressure(MAP)and left ventricular systolic pressure(LVSP)decreased sequentially in each group,with the extending reperfusion *** decreases in LVSP and MAP were observed in the T3 and T4 groups as compared to the T1 and T2 group(P<0.05)and the T2 group showed a significantly lower LVSP and MAP decline than the T1 group(P<0.05).Compared with the Tl group,the rats from the T2.T3,and T4 groups suffered from a significantly lower extent of myocardial infarction(P<0.05).Also,the a animals in the T3 and T4 groups had a significantly smaller extent of myocardial infarction than those in the T2 group(P<0.05).Conclusions:Various CsA doses exert different degrees of protection against ischemia/reperfusion injury,and this protective effect peaks at approximately 2.5 mg/kg in rat models.

关键词： Cyclosporin A Myocardial ischemia/reperfusion injury Mitochondrial permeability transition pore

Tumor-on-a-chip:from bioinspired design to biomedical application

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Microsystems & Nanoengineering 2021年第3期7卷 27-49页

作者： Xingxing Liu Jiaru Fang Shuang huang Xiaoxue wu Xi Xie Ji Wang Fanmao Liu Meng Zhang Zhenwei Peng Ning Hu The First Affiliated Hospital of Sun Yat-Sen University State Key Laboratory of Optoelectr onic Materials and TechnologiesGuangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen University510006 GuangzhouChina State Key Laboratory of Transducer Technology Chinese Academy of Sciences200050 ShanghaiChina

Cancer is one of the leading causes of human death,despite enormous efforts to explore cancer biology and develop anticancer *** main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop *** tumor microenvironment possesses human-specific biophysical and biochemical factors that are difficult to recapitulate in conventional in vitro planar cell models and in vivo animal ***,model limitations have hindered the translation of basic research findings to clinical *** this review,we introduce the recent progress in tumor-on-a-chip devices for cancer biology research,medicine assessment,and biomedical applications in *** emerging tumor-on-a-chip platforms integrating 3D cell culture,microfluidic tech no logy,and tissue engineeri ng have successfully mimicked the pivotal structural and functional characteristics of the in vivo tumor *** recent advances in tumor-on-a-chip platforms for cancer biology studies and biomedical applications are detailed and an a lyzed in this *** review should be valuable for further understanding the mechanisms of the tumor evolution process,screening anticancer drugs,and developing cancer therapies,and it addresses the challenges and potential opportunities in predicting drug screening and cancer treatment.

关键词： drugs integrating establishing

Influence of cooling speed on the physical and mechanical properties of granite in geothermal-related engineering

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Deep Underground Science and Engineering 2022年第1期1卷 40-57页

作者： Longchuan Deng Xiaozhao Li Yun wu Fuqing Li Zhen huang Yukun Ji Chunjiang Zou Zuxi Liu School of Earth Sciences and Engineering Nanjing UniversityNanjingJiangsuChina State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhouJiangsuChina School of Resources and Environment Engineering Jiangxi University of Science and TechnologyGanzhouJiangxiChina Department of Civil Engineering Monash UniversityMelbourneAustralia

In deep-earth engineering,the high earth temperature can significantly affect the rock's mechanical properties,especially when the rock is cooled during the construction ***,whether the cooling speed affects the mechanical and physical properties of rocks is worth to be *** present study explored the influence of the cooling rate on the physical and chemical properties of granite heated at 25–800°*** mechanical and physical properties involved in this study included uniaxial compression strength,peak strain,modulus,P-wave velocity,mass and volume,the change of which could reflect the sensitivity of granite to the cooling *** emission(AE)monitoring,microscopic observation,and X-ray diffraction(XRD)are used to analyze the underlying damage *** is found that more AE signals and large-scale cracks are accounted for based on the b-value method when the specimens are cooled by ***,the microscopic observation by polarized light microscopy indicates that the density,opening degree,and connectivity of the cracks under water cooling mode are higher than that under natural cooling *** addition,the XRD illustrates that there is no obvious change in mineral content and diffraction angle at different temperatures,which confirms that the change of mechanical properties is not related to the chemical *** present conclusion can provide a perspective to assess the damage caused by different cooling methods to hot rocks.

关键词： cooling methods granite high temperature physical and mechanical properties thermal damage

Na_2SO_4/SiO_2无机定形相变材料的制备及其性能研究

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广州化工 2015年第17期43卷 58-60页

作者：张莹沈家磊王红梅陈聪王一菲黄殿武嘉兴学院生物与化学工程学院浙江嘉兴314001 嘉兴学院建筑工程学院浙江嘉兴314001

以正硅酸乙酯作为硅源,采用溶胶—凝胶法制备Na2SO4/Si O2纳米介孔限域微纳米结构复合材料和Na2SO4/Si O2核-壳结构纳米颗粒,并对其热性能进行研究。硫酸钠在复合材料中充当固-液相变的潜热储存物质,而二氧化硅作为载体材料,以提供结构... 详细信息

以正硅酸乙酯作为硅源,采用溶胶—凝胶法制备Na2SO4/Si O2纳米介孔限域微纳米结构复合材料和Na2SO4/Si O2核-壳结构纳米颗粒,并对其热性能进行研究。硫酸钠在复合材料中充当固-液相变的潜热储存物质,而二氧化硅作为载体材料,以提供结构强度并防止熔融的无机盐的泄漏。所制备复合材料的形貌和结构分别采用扫描电子显微镜(SEM)和X射线粉末衍射仪(XRD)进行了表征。通过对复合材料热性能的研究表明其具有优异的储热性能。

关键词：二氧化硅硫酸钠介孔限域热性能 Na2 SO4

The basic helix-loop-helix transcription factor TabHLH1 increases chlorogenic acid and luteolin biosynthesis in Taraxacum antungense Kitag

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Horticulture Research 2021年第1期8卷 2756-2769页

作者： Qun Liu Li Li Haitao Cheng Lixiang Yao Jie wu Hui huang Wei Ning Guoyin Kai Laboratory for Core Technology of TCM Quality Improvement and Transformation College of PharmacySchool of Pharmaceutical SciencesThe Third Affiliated HospitalZhejiang Chinese Medical UniversityHangzhouZhejiang 310053PR China College of Horticulture Shenyang Agricultural UniversityShenyang 110866China Institute of Botany Jiangsu Province and Chinese Academy of Sciences(Nanjing Botanical Garden Mem.Sun Yat-Sen)Nanjing 210014China College of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016PR China Guangxi Botanical Garden of Medicinal Plants Nanning 530023PR China College of Life Sciences and Engineering Shenyang UniversityShenyang 110044PR China

Polyphenols are the main active components of the anti-inflammatory compounds in dandelion,and chlorogenic acid(CGA)is one of the primary ***,the molecular mechanism underlying the transcriptional regulation of CGA biosynthesis remains ***-CoA:quinate hydroxycinnamoyl transferase(HQT2)is the last rate-limiting enzyme in chlorogenic acid biosynthesis in Taraxacum ***,using the TaHQT2 gene promoter as a probe,a yeast one-hybrid library was performed,and a basic helix-loop-helix(bHLH)transcription factor,TabHLH1,was identified that shared substantial homology with Gynura bicolor DC *** TabHLH1 transcript was highly induced by salt stress,and the TabHLH1 protein was localized in the *** and luteolin concentrations in TabHLH1-overexpression transgenic lines were significantly higher than those in the wild type,while CGA and luteolin concentrations in TabHLH1-RNA interference(RNAi)transgenic lines were significantly *** real-time polymerase chain reaction demonstrated that overexpression and RNAi of TabHLH1 in *** significantly affected CGA and luteolin concentrations by upregulating or downregulating CGA and luteolin biosynthesis pathway genes,especially TaHQT2,4-coumarate-CoA ligase(Ta4CL),chalcone isomerase(TaCHI),and flavonoid-3′-hydroxylase(TaF3′H).Dual-luciferase,yeast one-hybrid,and electrophoretic mobility shift assays indicated that TabHLH1 directly bound to the bHLH-binding motifs of proTaHQT2 and *** study suggests that TabHLH1 participates in the regulatory network of CGA and luteolin biosynthesis in *** and might be useful for metabolic engineering to promote plant polyphenol biosynthesis.

关键词： HLH luteolin helix