Pulmonary hypertension secondary to seronegative rheumatoid arthritis overlapping antisynthetase syndrome:A case report

作     者：Cheng-Yan Huang Ming-Jie Lu Jia-Hua Tian Dai-Shun Liu Chun-Yan Wu 

作者机构：Department of Respiratory MedicineThe Third Affiliated Hospital of Zunyi Medical University(The First People’s Hospital of Zunyi)Zunyi 563000Guizhou ProvinceChina Clinical SchoolZunyi Medical UniversityZunyi 563000Guizhou ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第27期

页      面：9851-9858页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Natural Science Foundation of China No.82060010 

主　　题：Rheumatoid arthritis Arthritis Antisynthetase syndrome Pulmonary hypertension Pulmonary arterial hypertension Case report 

摘      要：BACKGROUND Polyarthritis is the most frequent clinical manifestation in antisynthetase syndrome(ASS)forms of idiopathic inflammatory myositis and may be misdiagnosed as rheumatoid arthritis(RA),particularly in patients with seronegative RA(SNRA).It is unclear whether there is an overlap between ASS and RA,or if ASS sometimes mimics *** hypertension(PAH)is common in connective tissue diseases(CTDs).However,published reports on CTD-PAH do not include overlapping CTDs,and its incidence and impact on patient prognosis are *** SUMMARY We report the case of a 63-year-old woman who presented with a 3-mo history of symptom aggravation of recurrent symmetrical joint swelling and pain that had persisted for over 10 *** patient was diagnosed with RA and interstitial lung *** patient repeatedly presented to the hospital’s respiratory and rhe-umatology departments with arthralgia,plus shortness of breath after *** tests indicated that anti-CCP and RF remained negative,while anti-J0-1 and anti-Ro-52 were strongly *** was not until recently that we recognized that this could be an unusual case of SNRA with concurrent *** pain was relieved after regular anti-rheumatic *** computed tomography scans showed that pulmonary interstitial changes did not progress significantly over several years;however,they showed gradual widening of the pulmonary artery,and cardiac ultrasound indicated elevated pulmonary artery systolic *** prescribed treatment of PAH was not effective in improving shortness of *** Overlap of RA and ASS may be *** research is necessary to facilitate early diagnosis,effective evaluation,and prognosis.