Tumor-on-a-chip:from bioinspired design to biomedical application
作者机构：The First Affiliated Hospital of Sun Yat-Sen UniversityState Key Laboratory of Optoelectr onic Materials and TechnologiesGuangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen University510006 GuangzhouChina State Key Laboratory of Transducer TechnologyChinese Academy of Sciences200050 ShanghaiChina
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2021年第7卷第3期
页 面：27-49页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：The work is supported in part by the National Natural Science Foundation of China(Nos.8177060,31970870,61771498,882061148011) the Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2O2OA1515110940,2O2OA1515010665) 100 Talents Program of Sun Yat-sen University(Grant Nos.76120-18841213) Basic Scientific Research Special Foundation of Sun Yat-sen University(Grant Nos.76120-18821104,20lgpy47,20lgzdl4) the Open Project of the Chinese Academy of Sciences(Grant No.SKT2006) the Open Fund of State Key Laboratory of Biocontrol at Sun Yat-sen University(2019SKLBC-KF06)
主 题：drugs integrating establishing
摘 要：Cancer is one of the leading causes of human death,despite enormous efforts to explore cancer biology and develop anticancer *** main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop *** tumor microenvironment possesses human-specific biophysical and biochemical factors that are difficult to recapitulate in conventional in vitro planar cell models and in vivo animal ***,model limitations have hindered the translation of basic research findings to clinical *** this review,we introduce the recent progress in tumor-on-a-chip devices for cancer biology research,medicine assessment,and biomedical applications in *** emerging tumor-on-a-chip platforms integrating 3D cell culture,microfluidic tech no logy,and tissue engineeri ng have successfully mimicked the pivotal structural and functional characteristics of the in vivo tumor *** recent advances in tumor-on-a-chip platforms for cancer biology studies and biomedical applications are detailed and an a lyzed in this *** review should be valuable for further understanding the mechanisms of the tumor evolution process,screening anticancer drugs,and developing cancer therapies,and it addresses the challenges and potential opportunities in predicting drug screening and cancer treatment.
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