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Journal of Hydrodynamics 2012年第2期24卷 280-286页

作者： FAN Shi-bo LIAN Lian REN Ping huang guo-liang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200240 China Chinese Underwater Technology Institute Shanghai Jiao Tong University Shanghai 200231 China

This article presents the newly designed oblique towing test in the horizontal plane for the scaled model of 4 500 m deep sea open-framed Remotely Operated Vehicle （ROV）,which is being researched and developed by Shanghai Jiao Tong *** hydrodynamics coefficients measurement is significant for the maneuverability and control system *** scaled model of ROV was constructed by 1：*** tests of large drift angle were conducted through Large Amplitude Horizontal Planar Motion Mechanism （LAHPMM） under low *** regression method is adopted to process the test data and obtain the related hydrodynamic *** were designed for the horizontal plane motion of large drift angle to verify the coefficients *** the results show that the data can satisfy with the design requirements of the ROV developed.

关键词： Remotely Operated Vehicle (ROV) scaled model large drift angle multiple regression Large Amplitude Horizontal Planar Motion Mechanism (LAHPMM)

One-step and high-density protein immobilization on epoxysilane-modified silica nanoparticles

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Chinese Science Bulletin 2009年第15期54卷 2620-2626页

作者： ZHANG Qin huang RongFu guo liang-Hong State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences ChineseAcademy of Sciences Beijing 100085 China

Silica nanoparticles are most commonly modified with amino-silanes, followed by post-modification activation for protein immobilization. In this work, epoxy-functionalized silica nanoparticles were prepared by modification with glycidyloxypropyl trimethoxysilane (GPTMS) for direct protein immobilization. Silica nanoparticles possessed an average size of 46 nm, but increased to 63 nm after GPTMS modification. Reaction time, reaction temperature and GPTMS content had no significant effect on particle size. Zeta potential of SiO2 changed from ?26mV to +38mV after modification. Fourier-transformed infrared spectroscopy revealed alkyl C-H bending and stretching bands at 2944 cm-1, 1343 cm-1 and 1465 cm-1, respectively, for the modified nanoparticles. Fluorescein cadaverine was found to bind to GPTMS-modified SiO2, but not to bare SiO2, indicating the chemical reactivity of epoxy groups on the modified nanoparticle with amines. Finally, fluorescently labeled bovine serum albumin (BSA) was used as a model protein to investigate the capacity of epoxy-SiO2 nanoparticles for protein immobilization. The results showed that more proteins were immobilized on the particle with longer reaction time, higher NaCl concentration, lower pH, and less GPTMS content. More importantly, proteins bound to epoxy-SiO2 nanoparticle were highly stable. Under optimized reaction conditions, as much as 25 mg BSA/g nanoparticle was covalently attached to the nanoparticle. The epoxy silane modification of silica nanoparticles offers a reactive surface for one-step and high-density protein immobilization.

关键词：二氧化硅制备方法反应条件纳米粒子

Lack of nano size effect on electrochemistry of dopamine at a gold nanoparticle modified indium tin oxide electrode

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Science China Chemistry 2010年第8期53卷 1778-1783页

作者： huang RongFu & guo liang-Hong State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China 1. State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Nanometer sized materials have been shown to possess excellent chemical and electrochemical catalytic *** this work,a gold nanoparticle (AuNP) modified indium tin oxide (ITO) electrode was employed for investigating its electro-catalytic *** was deposited on the 3-aminopropyltriethoxysilane (APTES) modified ITO electrode by self-assembly,and was characterized by scanning electron microscopy and cyclic *** the electrochemical reaction of dopamine was very sluggish on the ITO/APTES electrode,it was significantly enhanced after AuNP *** cyclic voltammogram exhibited apparent dependence on the surface coverage of 11 nm AuNPs,which could be rationalized by different modes of mass *** the different sizes of AuNP investigated,the lowest anodic peak potential was observed on 11 nm ***,the potential was still about 50 mV more positive than that obtained on a bulk gold electrode of similar *** is therefore concluded that there is no nanometer size effect of AuNP modified ITO on the electrochemistry of dopamine.

关键词： gold nanoparticle dopamine electrocatalysis indium tin oxide

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水下拖曳系统收放安全性的模拟计算

上海交通大学学报 2005年第5期39卷 691-694,700页

作者：卢军黄国 上海交通大学海洋工程国家重点实验室上海200030

为了对置于潜艇尾部的水下拖曳系统在收放缆时的安全性进行评估,计算了螺旋浆和艇体的尾流近场.螺旋桨的计算采用升力面理论涡格法,艇体的计算采用无升力体面元法,并考虑两者之间的相互作用.建立了水下拖曳系统在非均匀流场中的力学模型... 详细信息

为了对置于潜艇尾部的水下拖曳系统在收放缆时的安全性进行评估,计算了螺旋浆和艇体的尾流近场.螺旋桨的计算采用升力面理论涡格法,艇体的计算采用无升力体面元法,并考虑两者之间的相互作用.建立了水下拖曳系统在非均匀流场中的力学模型,用有限差分法计算收放缆时拖缆的姿态.计算结果表明,收放缆时的安全性是有足够保障的.

关键词：水下拖曳系统安全性模拟计算升力面理论非均匀流场差分法计算力学模型相互作用计算结果放缆涡格法螺旋桨螺旋浆面元法升力体艇体潜艇尾流拖缆

Epigallocatechin-3-gallate Modulates MicroRNA Expression Profiles in Human Nasopharyngeal Carcinoma CNE2 Cells

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Chinese Medical Journal 2017年第1期130卷 93-99页

作者： Bin-Bin Li guo-liang huang Hua-Hui Li Xia Kong Zhi-Wei He Department of Pathophysiology Guangdong Medical University Dongguan Guangdong 523808 China Sino-American Cancer Research Institute Key Laboratory for Medical Diagnostics of Guangdong Province Guangdong Medical University Dongguan Guangdong 523808 China

Background： Epigallocatechin-3-gallate （EGCG） has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma （NPC）, but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the expression of microRNAs （miRNAs） in NPC cells. Methods： Using microarray analysis, the alterations of miRNA expression profiles were investigated in EGCG-treated CNE2 cells. Furthermore, the target genes and signaling pathways regulated by EGCG-specific miRNAs were identified using target prediction program and gene ontology analysis. Results： A total of 14 miRNAs exhibited 〉2-fold expression changes in a dose-dependent manner after treatment with 20 μmol/L and 40 μmol/L EGCG. Totally 43, 49, and 52 target genes from these differentially expressed miRNAs were associated with the apoptosis, cell cycle regulation, and cell proliferation, respectively. A total of 66 signaling pathways, primarily involved in cancer development and lipid and glucose metabolism, were shown to be regulated by EGCG-specific miRNAs. Conclusion： EGCG induces considerable alterations of miRNA expression profiles in CNE2 cells, which provides mechanistic insights into cellular responses and antitumor activity mediated by EGCG.

关键词： Antitumor Agents Epigallocatechin-3-gallate MicroRNAs Nasopharyngeal Carcinoma

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残余应力对复合材料弹-塑性变形的影响

复合材料学报 2000年第2期17卷 60-65页

作者：胡更开黄国良北京理工大学应用力学系北京100081

从细观力学的角度给出了分析残余应力对一般复合材料塑性性能影响的一种解析方法 ,该方法基于应力二阶矩的割线模量法及 Ponte Castaneda和 Willis给出的弹性细观模型。有残余应力时 ,所提的细观解析模型能够同时考虑纤维形状 ,体积百分... 详细信息

从细观力学的角度给出了分析残余应力对一般复合材料塑性性能影响的一种解析方法 ,该方法基于应力二阶矩的割线模量法及 Ponte Castaneda和 Willis给出的弹性细观模型。有残余应力时 ,所提的细观解析模型能够同时考虑纤维形状 ,体积百分比 ,纤维取向及纤维的分布对复合材料变形的影响。计算结果表明 ,残余应力的存在会引起复合材料拉压变形的不对称 ,材料宏观的拉压硬化曲线又与复合材料的细观结构参数密切相关。对单向复合材料 ,本文作者对其等效割线热膨胀系数 ,拉压应力 -应变曲线的有限元分析结果与给出的细观解析模型定量吻合。

关键词：残余应力复合材料细观力学弹塑性

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全垫升气垫船4自由度操纵性

上海交通大学学报 2007年第2期41卷 216-220页

作者：卢军黄国樑上海交通大学海洋工程国家重点实验室上海200030

建立了全垫升气垫船的4自由度操纵运动数学模型,用风洞试验来测量空气动力、螺旋桨力和舵力,用水平面平面运动机构进行约束模型试验来测量水动力,试验中变化了速度、漂角、摇首角速度和横倾角.对操纵性进行模拟计算的结果表明:全垫升气... 详细信息

建立了全垫升气垫船的4自由度操纵运动数学模型,用风洞试验来测量空气动力、螺旋桨力和舵力,用水平面平面运动机构进行约束模型试验来测量水动力,试验中变化了速度、漂角、摇首角速度和横倾角.对操纵性进行模拟计算的结果表明:全垫升气垫船的回转轨迹是一条逐渐向内收缩的螺旋线;操固定舵角回转是比较危险的,在舵角较大时就容易产生甩尾;风对回转的影响很大,在顺风速度很大时气垫船不能转向.

关键词：全垫升气垫船 4自由度操纵性模型试验

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全垫升气垫船的航向稳定性

上海交通大学学报 2008年第6期42卷 914-918页

作者：卢军黄国樑上海交通大学海洋工程国家重点实验室上海200030

建立了全垫升气垫船的4自由度操纵运动数学模型.采用水平面平面运动机构进行约束模型试验来测量气垫船的水动力,试验中改变了速度、漂角、摇首角速度和横倾角;用风洞试验来测量气垫船的空气动力,试验中改变了漂角和螺旋桨的推力.对直航... 详细信息

建立了全垫升气垫船的4自由度操纵运动数学模型.采用水平面平面运动机构进行约束模型试验来测量气垫船的水动力,试验中改变了速度、漂角、摇首角速度和横倾角;用风洞试验来测量气垫船的空气动力,试验中改变了漂角和螺旋桨的推力.对直航和斜航的航向稳定性进行了计算.计算结果表明,全垫升气垫船的航速越高,航向稳定性越好,在越峰前不具有航向稳定性;逆风对于航向稳定性是有利的,顺风则不利.

关键词：全垫升气垫船 4自由度模型试验航向稳定性

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核电厂反应堆堆芯中子与温度探测器组件研制

核电子学与探测技术 2014年第2期34卷 267-270页

作者：黄国良中核控制系统工程有限公司北京100176

针对ACP1000堆型,研制了用于反应堆堆芯核测系统的堆芯中子和温度测量探测器组件。论文介绍了探测器组件的设计、性能指标和试验结果。设计的堆芯中子和温度探测器组件集成了中子自给能探测器和测温元件并固定安装在堆内。试验结果表明... 详细信息

针对ACP1000堆型,研制了用于反应堆堆芯核测系统的堆芯中子和温度测量探测器组件。论文介绍了探测器组件的设计、性能指标和试验结果。设计的堆芯中子和温度探测器组件集成了中子自给能探测器和测温元件并固定安装在堆内。试验结果表明测量敏感元件的性能满足设计要求,外壳和密封组件能保证反应堆一回路压力边界的要求。堆芯测量探测器组件一体化的设计可提高安全性和可靠性,实现实时测量,可用于反应堆保护。

关键词：堆芯中子温度自给能探测器

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan guo Hong-Bo Jin Cong-Feng Qiao Yue-liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries