检索结果-南通市图书馆

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng zheng Wang Zhou ying Mo Biao zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli Si Naijia Xue Yi Liu Ran zheng ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

Unveiling an ancient whole-genome duplication event in Stentor,the model unicellular eukaryotes

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Weibo zheng Chao Li Zhaorui Zhou Xiao Chen Michael Lynch ying Yan School of Life Sciences Ludong University Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Biodesign Center for Mechanisms of Evolution Arizona State University Marine College Shandong University

Whole-genome duplication(WGD) events are widespread across eukaryotes and have played a significant role in moulding the genetic architectures of diverse organisms. In the present study, the newly sequenced genome of a giant ciliated protist, Stentor roeselii, provides an opportunity for the analysis of the collinearity and retention of reciprocal best-hit genes between two Stentor species. As a main result, we have unveiled a previously undetected ancient WGD event shaping the genome of its congener, Stentor coeruleus, a model protist used in cytological and evolutionary studies. Genomes of two congeners, S. coeruleus and S. roeselii, are compared and analyzed, revealing that:(i)the former exhibits a much higher retention rate of colinear-gene pairs(28%) than does S. roeselii, and in S. coeruleus, 75% of genes that have a RBH hit in S. roeselii, have paralogs with high amino-acid identity, consistent with a WGD event in the lineage leading to S. coeruleus;(ii) the S. roeselii genome possesses extremely short intergenic regions, implying that the lengths of intergenic regions are under strong selection;(iii) the unique characteristics of introns may have been shaped in the common ancestor of heterotrichs;(iv) gene families that play a role in activities of multiple protein kinases and voltage-gated ion channels expanded rapidly in the ancestor of both taxa, possibly relating to the remarkable regenerative ability in Stentor. This study offers new insights into the evolutionary dynamics of ciliate genomes,with implications for understanding of the processes underlying the evolution of genomic complexity.

关键词：

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao zheng Zilin Ren ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

RNAi targeting to IKKα inhibit the growth of breast cancer cell line MCF-7 cells in vitro

在线全文

学校读者我要写书评

暂无评论

RNAi targeting to IKKα inhibit the growth of breast cancer ...

Activated carbon fibers with manganese dioxide coating for flexible fiber supercapacitors with high capacitive performance

华东六省一市生物化学与分子生物学学会2006年学术交流会

作者： Zhi-Feng Yang, Zai-Long Cai, Sheng-Sheng Yang, huan Chen, ying Zong, zheng-Hua Xiang, Bing-Hua Jiao,Ji-fang Mao (Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, 200433, China)

The aberrant activation of NF-κB is associated with a virous tumors including breast cancer. Decrease of IKKα function can be attributed to defective activation of NF-κB. The aim of our study was to develop an efficient method for packaging and concentrating lentiviral stock that could produce high titer lentivirus to knockdown IKKa activity. The titer of the lentiviral stocks were more than 4×107TU/ml. To detect the effect of RNAi we examined the capability of lentiviral-mediated gene knockdown in MCF-7 cells. Results showed that the expression levels of IKKa were reduced dramatically compared to the control. Using this approach,we obtained the high titer lentiviral stock and detected the effect of RNAi capability of lentiviral-mediated gene knockdown in MCF-7 cells. Thus, IKKα-knockdown lentivirus might offer a selective therapy for breast cancer.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2019年第4期28卷 95-100页

作者： Huifang Li Jiachen Liang huan Li Xiaoyu zheng ying Tao zheng-Hong huang Quan-Hong Yang Nanoyang Group School of Chemical Engineering and Technology Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Institute of Forensic Science Ministry of Public Security Laboratory of Advanced Materials School of Materials Science and Engineering Tsinghua University

Fiber supercapacitor(FSC)is a promising power source for wearable/stretchable electronics and high capacitive performance of FSCs is highly desirable for practice flexible ***,we report a composite of manganese dioxide(Mn O_2)and activated carbon fibers(ACFs)with high MnO_2mass loading and microporous structure(abbreviated as Mn O_2@ACF),which is used as a fiber electrode to produce a FSC with a high capacitive performance and a good *** MnO_2@ACF composite electrode in FSCs delivers an ultrahigh specific capacitance of 410 mF/cm^2at 0.1 mA/cm^2,corresponding to a high energy density of 36μWh/cm^2and high power density of 726μW/cm^*** high capacitive performance and simple fabrication method indicates that the Mn O_2@ACF composite is a very promising electrode material for flexible fiber supercapacitors.

关键词： Fiber supercapacitors Activated carbon fibers Mass loading Flexibility

板柱节点考虑弯剪相关性的受冲切承载力计算方法

在线全文

学校读者我要写书评

暂无评论

哈尔滨工业大学学报 2025年第1期57卷 65-76页

作者：郑文忠吕盛先郑博文王英结构工程灾变与控制教育部重点实验室(哈尔滨工业大学) 哈尔滨150090 土木工程智能防灾减灾工业和信息化部重点实验室(哈尔滨工业大学) 哈尔滨150090

对于同时受到竖向荷载和不平衡弯矩作用的板柱节点,目前已有方法大多将不平衡弯矩等效为竖向荷载,从而给出其受冲切承载力计算方法。但该方法所涉及的不平衡弯矩比例系数的计算还存在较大争议,且没有考虑竖向荷载与不平衡弯矩耦合的影... 详细信息

对于同时受到竖向荷载和不平衡弯矩作用的板柱节点,目前已有方法大多将不平衡弯矩等效为竖向荷载,从而给出其受冲切承载力计算方法。但该方法所涉及的不平衡弯矩比例系数的计算还存在较大争议,且没有考虑竖向荷载与不平衡弯矩耦合的影响。因此,本文首先通过推导给出仅有竖向荷载作用的板柱节点受冲切承载力计算公式和仅有不平衡弯矩作用的板柱节点受弯承载力计算公式,并与试验结果进行对比,验证了所提公式的合理性。然后基于板柱节点在竖向荷载和不平衡弯矩共同作用下的试验结果,拟合得到板柱节点考虑弯剪相关性的受冲切承载力计算公式。最后对所提计算方法与不同规范计算方法进行对比,结果表明本文计算方法能够更加准确地预测板柱节点受冲切承载力。

关键词：板柱节点竖向荷载不平衡弯矩受冲切承载力计算方法

Graphdiyne oxide enhances the stability of solid contact-based ionselective electrodes for excellent in vivo analysis

同方期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2019年第10期62卷 1414-1420页

作者： Lijun Zhao ying Jiang Jie Hao huan Wei Wei zheng Lanqun Mao Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of Chemistrythe Chinese Academy of SciencesBeijing 100190China Institute of Surface/Interface Science and Technology Key Laboratory of Superlight Material and Surface Technology of Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China University of Chinese Academy of Sciences Beijing 100049China

Quantitively and stably tracking ion dynamics in the living brain of animals is essential to understanding many physiological and pathological ***-state ion-selective electrodes(ISEs)are powerful tools for monitoring the dynamic change of ions at physiological concentration range;however,the unintentional accumulation of an aqueous layer at the ion selective membrane/solid contact interface compromises the electrode potential stability,limiting its in vivo ***,using manganese dioxide(MnO2)and potassium ISE(K-+ISE)as model solid contact and ISEs,we demonstrate for the first time that graphdiyne oxide(GDYO)can enhance the potential stability of solid contact-based *** results suggest that the intrinsic structural and hydrophobic features of GDYO,plays a key role in impeding and stabilizing the formation of water *** GDYO-MnO2 acting as the solid contact,the K-+ISE displays an excellent short-term potential stability and maintains great selectivity,achieving reliable K+sensing at the animal *** GDYO-based strategy is generalizable to different ISEs and does not require complicated processing steps,paving an exciting opportunity for in vivo ion recognition and sensing.

关键词： in vivo analysis graphdiyne oxide solid-state ion selective electrodes water layer

Flexibility in matching

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2021年第5期1卷 627-630页

作者： huan zheng ying Rong Antai College of Economics and Management Shanghai Jiao Tong UniversityShanghai 200030China

We examine a service system that matches jobs and candidates with different ability levels.A candidate’s ability will affect the possibility of obtaining a high return on a job *** on the property that the jobs to be assigned to a candidate are substituted in an assignment problem,we propose a novel random parameter generating process to demonstrate that the expected reward increases with the ability level of a candidate at a diminishing *** observation is consistent with the classic result in process flexibility literature that a little flexibility(i.e.,ability level)can capture the most *** observations can help a company decide the proper level of ability.

关键词： Flexibility Service operations Matching and assignment