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Activity estimation in radioimmunotherapy using magnetic nanoparticles

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Chinese Journal of Cancer Research 2015年第2期27卷 203-208页

作者： Samira Rasaneh hossein rajabi Fariba Johari Daha Department of Radioisotope Nuclear science and Technology Research Institute Department of Medical Physics School of Medical SciencesTarbiat Modares University

Objective： Estimation of activity accumulated in tumor and organs is very important in predicting the response of radiopharmaceuticals treatment. In this study, we synthesized ~77Lutetium （177Lu）-trastuzumabiron oxide nanoparticles as a double radiopharmaceutical agent for treatment and better estimation of organ activity in a new way by magnetic resonance imaging （MRI）. Methods： ^177Lu-trastuzumab-iron oxide nanoparticles were synthesized and all the quality control tests such as labeling yield, nanoparticle size determination, stability in buffer and blood serum up to 4 d, immunoreactivity and biodistribution in normal mice were determined. In mice bearing breast tumor, liver and tumor activities were calculated with three methods： single photon emission computed tomography （SPECT）, MRI and organ extraction, which were compared with each other. Results： The good results of quality control tests （labeling yield： 61%±2%, mean nanoparticle hydrodynamic size： 41±15 nm, stability in buffer： 86%±5%, stability in blood serum： 80%±3%, immunoreactivity： 80%±2%） indicated that ^177Lu-trastuzumab-iron oxide nanoparticles could be used as a double radiopharmaceutical agent in mice bearing tumor. Results showed that ^177Lu-trastuzumab-iron oxide nanoparticles with MRI had the ability to measure organ activities more accurate than SPECT. Conclusions： Co-conjugating radiopharmaceutical to MRI contrast agents such as iron oxide nanoparticles may be a good way for better dosimetry in nuclear medicine treatment.

关键词： Radioimmunotherapy (RIT) activity estimation lutetium-177 herceptin magnetic nanoparticles magnetic resonance imaging (MRI)

Homogeneous and nanomolar detection of hydrazine by indigocarmine as a mediator at the surface of TiO_2 nanoparticles modified carbon paste electrode

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Chinese Chemical Letters 2012年第2期23卷 213-216页

作者： Mohammad Mazloum-Ardakani hossein rajabi Hadi Beitollahi Department of Chemistry Faculty of ScienceYazd UniversityYazd 89195-741Iran Department of Chemistry Faculty of ScienceYazd UniversityYazd 89195-741Iran Environment Department Research Institute of Environmental SciencesInternational Center for ScienceHigh Technology & Environmental SciencesKermanIran

The homogeneous electrocatalytic oxidation of hydrazine（HZ） has been studied by indigocarmine（IND） as a mediator at the surface of TiO_2 nanoparticles modified carbon paste electrode（TNMCPE）.Cyclic voltammetry was used to study the electrochemical behavior of IND at different scan *** voltammetric response of the modified electrode was linear against the concentration of HZ in the ranges of 3.0×l0^（-8）-7.0×10~6 mol/L with differential pulse voltammetry *** detection limit（3σ） was determined as 27.3 nmol/*** evaluate the applicability of the proposed method to real samples,the modified CPE was applied to the determination of HZ in water samples.

关键词： Hydrazine Indigocarmine TiO_2 nanoparticles Modified electrode Carbon paste electrode Nanomolar detection

Structural and Optical Characteristics of Silica Nanotubes Using CNTs as Template

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Nano-Micro Letters 2010年第4期2卷 268-271页

作者： Rasoul Malekfar M.Hassan rajabi M.hossein Majless Ara Physics Department Faculty of Basic SciencesTarbiat Modares University Department of Physics Faculty of Basic SciencesMember of Young Researches ClubIslamic Azad University Department of Physics Faculty of Basic SciencesTarbiat Moallem University

Silica coated multi-wall carbon nanotubes(MWCNTs),silica@MWCNTs and nanocomposites were synthesized by a sol-gel *** using the synthesized nanocomposites and also CNTs as templates,silica nanotubes(silica-NTs) were *** optical properties of fabricated nanocomposites and nanotubes were characterized by back-scattering micro Raman,UV/Vis/NIR and FT-IR spectra,which show the presence of CNTs structure in the ***/Vis/NIR and FT-IR spectra also show the presence of silica *** recorded spectra from UV/Vis/NIR and FT-IR also confirm the presence of silica compounds in the *** results of FE-SEM imaging data indicate that the synthesized samples are MWCNTs coated uniformly by silica molecules,which act as the template to synthesize silica-NTs.

关键词： Carbon nanotubes(MWCNTs) Silica Raman Ultra violet/visible/near infrared(UV/Vis/NIR)

Assessing preventive health behaviors from COVID-19:a cross sectional study with health belief model in Golestan Province,Northern of Iran

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Infectious Diseases of Poverty 2020年第6期9卷 91-99页

作者： hossein Shahnazi Maryam Ahmadi-Livani Bagher Pahlavanzadeh Abdolhalim rajabi Mohammad Shoaib Hamrah Abdurrahman Charkazi Department of Health Education and Promotion School of HealthIsfahan University of Medical SciencesIsfahanIran Faculty of Health Golestan University of Medical SciencesGorganIran Department of Biostatistics School of Allied Medical SciencesShahid Beheshti University of Medical SciencesTehranIran Faculty of Health Environmental Health Research CenterGolestan University of Medical SciencesGorganIran Center for Rural Health School of Health SciencesUniversity of TasmaniaHobartAustralia Faculty of Health Environmental Health Research CenterLate Falsefi University ComplexKM 5of Gorgan-Sari RoadGolestanIran

Background: Coronavirus disease 2019(COVID-19)is a new viral disease that has caused a pandemic in the *** to the lack of vaccines and definitive treatment,preventive behaviors are the only way to overcome the ***,the present study aimed to determine the preventive behaviors from the disease based on constructs of the health belief ***:: In the present cross-sectional study during March 11–16,2020,750 individuals in Golestan Province of Iran were included in the study using the convenience sampling and they completed the questionnaires through *** scores were calculated using the confirmatory factor *** effects of different factors were separately investigated using the univariate analyses,including students sample t-test,ANOVA,and simple linear ***,the effective factors were examined by the multiple regression analysis at a significant level of 0.05 and through Mplus 7 and SPSS ***: The participants’mean age was 33.9±9.45 years;and 57.1%of them had associate and bachelor's *** regression indicated that the mean score of preventive behavior from COVID-19 was higher in females than males,and greater in urban dwellers than rural ***,one unit increase in the standard deviation of factor scores of self-efficacy and perceived benefits increased the scores of preventive behavior from COVID-19 by 0.22 and 0.17 units *** the contrary,one unit increase in the standard deviation of factor score of perceived barriers and fatalistic beliefs decreased the scores of the preventive behavior from COVID-19 by 0.36 and 0.19 units ***: Results: of the present study indicated that female gender,perceived barriers,perceived self-efficacy,fatalistic beliefs,perceived interests,and living in city had the greatest preventive behaviors from COVID-19 *** interventions were necessary among males and villagers.

关键词： COVID-19 Health belief model Fatalism Preventive behavior Iran

Germline cells derived from mesenchymal stem cells, with the focus on Wharton's jelly

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Asian pacific Journal of Reproduction 2018年第2期7卷 49-55页

作者： hossein Yazdekhasti Jalil hosseini Zahra rajabi Maryam hosseinzadeh Shirzeyli Fereshte Aliakbari Department of Cell Biology Center for Research in Contraceptive and Reproductive HealthUniversity of VirginiaCharlottesvilleVA22908USA Infertility and Reproductive Health Research Center Shahid Beheshti University of Medical SciencesTehranIran Department of Anatomy School of MedicineTehran University of Medical SciencesTehranIran Department of Biomedical Engineering University of VirginiaCharlottesvilleVA22908USA Department of Biology and Anatomical Sciences School of MedicineShahid Beheshti University of Medical SciencesTehranIran

Previous attempts have indicated that mesenchymal stem cells (MSCs) are a valuable source and candidate and new approach for tissue engineering and reproductive medicine. MSCs have this potential to be induced and differentiated in an appropriatein vivoandin vitro condition toward various cell lineages and then they can be applied in cell therapies and clinical applications. During recent two decades, various sources have demonstrated they are a great source for MSCs, including bone marrow, the human umbilical cord as well as Wharton's jelly. Due to discarding after birth, easily accessible cells and less ethical concerns, these cells have attracted more and more scientists' attention. Infertility and reproduction diseases have provided special opportunity to examine the efficiency of MSCs in this kind of application. Based on recent investigations, MSCs embedded in Wharton's jelly tissue are more appealing for cell therapies, especially in infertility treatment purposes. So, differentiation of MSCs embedded in Wharton's jelly tissue into germ layer cells for cell-based therapy purposes is now under intensive study.

关键词： Mesenchymal stem cell Bone marrow stem cell Umbilical cord Wharton's jelly

Diagnosis of Toxoplasma gondii infection in pregnant women using automated chemiluminescence and quantitative real time PCR

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 26-31页

作者： Ehsan Ahmadpour Elmira Zargami Mahmoud Mahami-Oskouei Adel Spotin Abbas Shahbazi hossein Samadi Kafil Saba rajabi Paria Alizadeh Yagoob Azadi Reza Bahaj Firouz Shahrivar Aleksandra Barac Infectious and Tropical Disease Research Center Tabriz University of Medical Sciences Students Research Committee Tabriz University of Medical Sciences Department of Parasitology and Mycology Faculty of Medicine Tabriz University of Medical Sciences Drug Applied Research Center Tabriz University of Medical Sciences Clinic for Infectious and Tropical Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade

Objective: To identify serodiagnosis and quantification of Toxoplasma gondii(T. gondii) infection among pregnant women in Salmas, northwest of Iran. Methods: In this crosssectional study, 276 blood samples were collected from pregnant women referred to the health care centers in Salmas city. The demographic variables were also recorded. Titers of antiToxoplasma IgM and IgG antibodies(Ab) were determined using the chemiluminescence immunoassay. Quantitative real-time PCR targeting the T. gondii repeated element gene was also performed on the blood sample. Results: Out of all, 19.92%(55/276) and 2.17%(6/276) patients were seropositive for anti-Toxoplasma IgG and IgM Ab, respectively. Moreover, the presence of T. gondii DNA was observed in 12.31%(34/276) blood samples. A significant relationship was observed between the IgG Ab seropositivity and contact with the cat as a risk factor(P=0.022). Conclusions: The seroprevalence rate of T. gondii infection in pregnant women is relatively low. Consequently, the seronegative pregnant women are at risk, and a considerable rate of positive blood samples for the presence of parasite's DNA should not be ignored. Besides, quantitative real-time PCR could be considered as an accurate method for diagnosis of acute toxoplasmosis especially when the precise results are of the most importance in pregnancy. Limiting contact with cats is also suggested for pregnant women.

关键词： Toxoplasmosis Toxoplasma gondii Chemiluminescence immunoassay Real time PCR Pregnancy

Clinical profile of gastric cancer in Khuzestan, southwest of Iran

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World Journal of Gastroenterology 2006年第30期12卷 4832-4835页

作者： Hajiani Eskandar Sarmast Shoshtari Mohammad hossein Masjedizadeh Rahim Hashemi Jalal Azmi Mehrdad Tahereh rajabi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Surgery Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Pathology Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran

瞄准：分析特征流行病学，临床并且在有胃的癌的病人之中的幸存模式。方法：我们回顾地从 1996 年 9 月 1 日在阿瓦十 Jundishapur 大学医院(AJSUH ) 学习了 186 个胃的腺癌病人的特征到 2002 年 9 月 1 日。所有病人有证实 histopathol... 详细信息

瞄准：分析特征流行病学，临床并且在有胃的癌的病人之中的幸存模式。方法：我们回顾地从 1996 年 9 月 1 日在阿瓦十 Jundishapur 大学医院(AJSUH ) 学习了 186 个胃的腺癌病人的特征到 2002 年 9 月 1 日。所有病人有证实 histopathologically 的恶意。人口统计的变量，胃的癌症(GC ) 的家庭历史，临床病理特征和处理相关的变量被分析。Univariate 分析与木头等级测试并且多被执行与考克斯一起的变量分析回归。P<0.05 被认为统计上重要。结果：到女比率的男性是 2.6:1。吝啬的年龄是 60.6 年， 14% 病人比 40 年年轻。腺癌，胃的淋巴瘤，和胃的转移分别地在 94.5% ， 2.3% ，和 3% 病人被发现。有在起始的症状和诊断之间的 6 瞬间延期的一般水准。在腺癌组之中，肠的类型是最普通(55.9%) 并且远侧第三是最普通的本地化(88.4%) 。134 个病人(72.1%) 是男性。31 个病人(17%) 有 GC 的家庭历史。外科在 90% 病人(非药品) 被执行。结论：在南方伊朗的 GC 的流行病学的特征在高风险的区域模仿那些。有在在我们的机构的年轻病人的 GC 的高频率。病人们在相对长的延期以后被检测并且对待。在晚期在场的大多数病人，它赞成差的全面幸存。GC 的家庭历史在我们的区域有一个重要问题。在南方伊朗和更早的诊断和随后的更好的忧虑学习这癌症的病原学被推荐。

关键词：伊朗胃癌临床表现疾病调查