检索结果-南通市图书馆

Repressing iron overload ameliorates central poststroke pain via the Hdac2-Kv1.2 axis in a rat model of hemorrhagic stroke

引用

Neural Regeneration Research 2024年第12期19卷 2708-2722页

作者： He Fang Mengjie Li Jingchen yang Shunping Ma Li Zhang hongqi yang Qiongyan Tang Jing Cao Weimin yang Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Nutrition The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Neuroscience Research Institute Zhengzhou University Academy of Medical SciencesZhengzhouHenan ProvinceChina

Thalamic hemorrhage can lead to the development of central post-stroke pain.Changes in histone acetylation levels,which are regulated by histone deacetylases,affect the excitability of neurons surrounding the hemorrhagic area.However,the regulato ry mechanism of histone deacetylases in central post-stroke pain remains unclea r.Here,we show that iron overload leads to an increase in histone deacetylase 2expression in damaged ventral posterolateral nucleus neurons.Inhibiting this increase restored histone H3 acetylation in the Kcna2 promoter region of the voltage-dependent potassium(Kv)channel subunit gene in a rat model of central post-stroke pain,thereby increasing Kcna2expression and relieving central pain.However,in the absence of nerve injury,increasing histone deacetylase 2 expression decreased Kcna2expression,decreased Kv current,increased the excitability of neurons in the ventral posterolateral nucleus area,and led to neuropathic pain symptoms.Moreover,treatment with the iron chelator deferiprone effectively reduced iron overload in the ventral posterolateral nucleus after intracerebral hemorrhage,reversed histone deacetylase 2 upregulation and Kv1.2 downregulation,and alleviated mechanical hypersensitivity in central post-stroke pain rats.These results suggest that histone deacetylase 2 upregulation and Kv1.2 downregulation,mediated by iron overload,are important factors in central post-stroke pain pathogenesis and co uld se rve as new to rgets for central poststroke pain treatment.

关键词： central post-stroke pain hemorrhagic stroke histone deacetylase iron overload voltage-gated potassium ion channel 1.2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A DISCRETIZING LEVENBERG-MARQUARDT SCHEME FOR SOLVING NONLIEAR ILL-POSED INTEGRAL EQUATIONS

引用

Journal of Computational Mathematics 2022年第5期40卷 686-710页

作者： Rong Zhang hongqi yang School of Mathematics and Computer Science Gannan Normal UniversityGanzhou 341004China Guangdong Province Key Laboratory of Computational Science School of Computer Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China

To reduce the computational cost,we propose a regularizing modified LevenbergMarquardt scheme via multiscale Galerkin method for solving nonlinear ill-posed problems.Convergence results for the regularizing modified Levenberg-Marquardt scheme for the solution of nonlinear ill-posed problems have been proved.Based on these results,we propose a modified heuristic parameter choice rule to terminate the regularizing modified Levenberg-Marquardt scheme.By imposing certain conditions on the noise,we derive optimal convergence rates on the approximate solution under special source conditions.Numerical results are presented to illustrate the performance of the regularizing modified Levenberg-Marquardt scheme under the modified heuristic parameter choice.

关键词： The regularizing Levenberg-Marquardt scheme Multiscale Galerkin methods Nonlinear ill-posed problems Heuristic parameter choice rule Optimal convergence rate.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and engineering application of integrated safety monitoring systems for China’s high-speed trains

引用

Transportation Safety and Environment 2024年第2期6卷 36-44页

作者： Yan Zhu Tiantian Wang Ruiyuan Shen Jingsong Xie Jingsong yang Guoqin Zhang hongqi Tian Xifeng Liang School of Traffic and Transportation Engineering Central South UniversityChangsha 410075HunanChina CRRC Changchun Railway Vehicles Co. LtdChangchun 130062JilinChina China State Railway Group Co. Ltd.Beijing 100084China

With the improvement of the running speed of China’s high-speed trains,the demands for running status monitoring and security assurance of High-speed Electric Multiple Units(EMU)have increased significantly.However,the current safety monitoring systems are independent,which is not conducive to the comprehensive monitoring and information sharing of the whole vehicle.The temperature monitoring of running gear is insensitive to early failures.How to develop a train operation safety monitoring system with strong engineering implementation and high integration is a key problem to be solved.For the monitoring of running stationarity,frame stability and running gear health of China’s high-speed trains,an integrated safety monitoring system framework is designed,and the logic and algorithm for the diagnosis of stationarity,stability and health states of rotating parts are constructed.Monitoring software which fused the temperature,high and low frequency vibration data is developed,and the design and installation of the vibration temperature composite sensors are completed.The research results have realized the integration and comprehensive processing of multiple monitoring systems,completed the improvement from single component and vehicle-level safety monitoring to multi-system,train-level and interactive monitoring.In the process of real vehicle application,the developed monitoring system acquires the vehicle operation status data accurately and in real time.The constructed diagnosis algorithm and logic evaluates the vehicle operation status accurately and in a timely manner,and avoids the progression from fault to accident.The research results show that the integrated safety monitoring system can provide technical support for train operation safety.

关键词： electric multiple units(EMU) integrated safety monitoring system stationarity stability fault diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mutant rs189037 in ataxia-telangiectasia mutated gene had a negative association with metabolic syndrome but not cognitive decline in centenarians

引用

Genes & Diseases 2024年第3期11卷 106-108页

作者： Long Feng hongqi Huo Qun Li Tao yang Yali Zhao Pei Zhang Ping Ping Shihui Fu Department of Anesthesiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Nuclear Medicine Department Handan Central HospitalHandanHebei056001China Department of Neurosurgery Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Oncology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Central Laboratory Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China School of Life Science Beijing Institute of TechnologyBeijing 100081China General Station for Drug and Instrument Supervision and Control Joint Logistic Support Force of Chinese People's LiberationArmyBeijing 100071China Department of Cardiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Geriatric Cardiology Chinese People's Liberation Army General HospitalBeijing 100853China

Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)development.Patients with MetS have an 11.48-fold increased incidence of CD compared with those without Mets.^(1) Ataxia-telangiectasia mutated(ATM)gene encodes ATM kinase,which belongs to the phosphatidylinositol 3-hydroxy kinase family.

关键词： ATM development cognitive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pipeline Embolization Device for intracranial aneurysms presenting with mass effect:a large Chinese cohort

引用

Stroke & Vascular Neurology 2024年第1期9卷 50-58页

作者： yang Zhao Junlin Lu hongqi Zhang Tianxiao LI Donglei Song Sheng Guan Aisha Maimaitili Yunyan Wang Wenfeng Feng yang Wang Jieqing Wan Guohua Mao Huaizhang Shi Xinjian yang Jianmin Liu Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuanChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Zhengzhou University People's HospitalZhengzhouHenanChina Department of Neurosurgery Shanghai Donglei Brain HospitalShanghaiChina Department of Interventional Neuroradiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurosurgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Neurosurgery Qilu Hospital of Shandong University QingdaoJinanShandongChina Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina

Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for patients.This study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world settings.Methods We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect presentation.The study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect relief.Subgroup analyses by aneurysm location,size and form were also performed.Results This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysms<10mm and saccular aneurysms.Conclusions Our data confirmed the efficacy of PED in relieving mass effect.The findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial aneurysms.Trial registration number NCT03831672.

关键词： aneurysm intracranial Irvine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

50-110 GHz,high isolation,and high-power linearity single-pole double-throw switch utilizing 100-nm GaN HEMT technology

引用

The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 38-43,71页

作者： Han Qunfei Hu Sanming Zhang Tianyu Chen Qing Shen Yizhu Wang Weibo Tao hongqi School of Information Science and Engineering Southeast UniversityNanjing 210096China Nanjing Electronic Devices Institute Nanjing 210016China State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China

This article presents the design and performance of a single-pole double-throw(SPDT)switch operating in 50-110 GHz.The switch is fabricated in a 100-nm GaN high-electron-mobility transistors(HEMT)technology.To realize high-power capability,the dimensions of GaN HEMTs are selected by simulation verification.To enhance the isolation,an improved structure of shunt HEMT with two ground holes is employed.To extend the operation bandwidth,the SPDT switch with multi-section resonant units is proposed and analyzed.To verify the SPDT switch design,a prototype operating in 50-110 GHz is fabricated.The measured results show that the fabricated SPDT switch monolithic microwave integrated circuit(MMIC)achieves an input 1 dB compression point(P_(1dB))of 38 dBm at 94 GHz,and isolation within the range of 33 dB to 54 dB in 50-110 GHz.The insertion loss of the switch is less than 2.1 dB,while the voltage standing wave ratios(VSWR)of the input port and output port are both less than 1.8 in the operation bandwidth.Based on the measured results,the presented SPDT switch MMIC demonstrates high power capability and high isolation compared with other reported millimeter-wave SPDT MMIC designs.

关键词： GaN high-electron-mobility transistors(HEMT) millimeter-wave single-pole double-throw(SPDT) switch

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

引用

Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski Chao Huang hongqi Chen Yaozhong Zhang Shen Liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical medicine.This study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured rats.The results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are inhibited.Consequently,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely reduced.For biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA membranes.Further studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis process.It was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical features, treatment strategies and outcomes of craniocervical junction arteriovenous fistulas: a cohort study of 193 patients

引用

Stroke & Vascular Neurology 2024年第1期9卷 18-29页

作者： Yongjie Ma Zihao Song Yinqing Wang Jiachen Wang Chuan He Guilin Li Peng Zhang Tao Hong Liyong Sun Peng Hu Ming Ye hongqi Zhang Department of Neurosurgery Xuanwu Hospital Capital Medical University

Background Craniocervical junction(CCJ)arteriovenous fistulas(AVFs)are rare.The current treatment strategies for AVFs with different angioarchitecture need to be clarified.The present study aimed to analyse the correlation between angioarchitecture and clinical characteristics,share our experience in treating this disease and identify risk factors associated with subarachnoid haemorrhage(SAH)and poor outcomes.Methods A total of 198 consecutive patients with CCJ AVFs from our neurosurgical centre were retrospectively reviewed.The patients were grouped according to their clinical manifestations,and their baseline clinical characteristics,angioarchitecture,treatment strategies and outcomes were summarised.Results The patients’median age was 56 years(IQR 47–62 years).The majority of patients were men with 166(83.8%)patients.The most common clinical manifestation was SAH(52.0%),followed by venous hypertensive myelopathy(VHM)(45.5%).The most common CCJ AVFs type was dural AVF,with 132(63.5%)fistulas.The most frequent fistula location was C-1(68.7%)and dural branch of vertebral artery(70.2%)was the most involved arterial feeders for fistulas.The most common direction of venous drainage was descending intradural drainage(40.9%),followed by ascending intradural drainage(36.5%).Microsurgery was the most common treatment strategy applied for 151(76.3%)patients,15(7.6%)patients were treated with interventional embolisation only,and 27(13.6%)received both interventional embolisation and microsurgical treatment.The learning curve for microsurgery only was analysed by cumulative summation method,and the turning point was the 70th case,and blood loss in post-group was lower than that in pre-group(p=0.034).At the last follow-up,there were 155(78.3%)patients with favourable outcomes(modified Rankin Scale(mRS)<3).Age≥56(OR 2.038,95%CI 1.039 to 3.998,p=0.038),VHM as the clinical manifestation(OR 4.102,95%CI 2.108 to 7.982,p<0.001)and pretreatment mRS≥3(OR 3.127,95%CI 1.617 to 6.047,p<0.001)were significantly associated with poor out

关键词： patients treatment hypertensive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Selective nano-buckling improves the performance of graphene logic transistors

引用

National Science Review 2024年第2期11卷 95-96页

作者： Tong yang Ming yang Department of Applied Physics The Hong Kong Polytechnic University Research Centre for Nanoscience and Nanotechnology The Hong Kong Polytechnic University

The massive integration of silicon-based transistors into modern electronic devices greatly increases power consumption and heat generation/dissipation[1]. In this concern, transistors based on atomically-thin graphene that exhibit high electric and thermoelectric conductivities with negligible contact resistance,

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Deep Insight of Design,Mechanism,and Cancer Theranostic Strategy of Nanozymes

引用

Nano-Micro Letters 2024年第2期16卷 165-217页

作者： Lu yang Shuming Dong Shili Gai Dan yang He Ding Lili Feng Guixin yang Ziaur Rehman Piaoping yang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China Yantai Research Institute Harbin Engineering UniversityYantai 264000People’s Republic of China Key Laboratory of Green Chemical Engineering and Technology of Heilongjiang Province College of Material Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040People’s Republic of China Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan

Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale production.Recently,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side effects.Thus,various nanozymes have been developed and used for tumor therapy.In this review,more than 270 research articles are discussed systematically to present progress in the past five years.First,the discovery and development of nanozymes are summarized.Second,classification and catalytic mechanism of nanozymes are discussed.Third,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical design.Then,synergistic theranostic strategy of nanozymes are introduced.Finally,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.

关键词： Nanozymes Classification Prediction and design Catalytic mechanism Tumor theranostics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：