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Fructose and fructose kinase in cancer and other pathologies

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Journal of Genetics and Genomics 2021年第7期48卷 531-539页

作者： hongfei jiang Qian Lin Leina Ma Shudi Luo Xiaoming jiang Jing Fang Zhimin Lu Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute Qingdao 266061China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalInstitute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Zhejiang University Cancer Center Hangzhou 310029China

Fructose metabolism and fructose kinase KHKe C/A are key factors in the development of lipid oversynthesis-promoted metabolic disorders and ***,we summarize and discuss the current knowledge about the specific features of fructose metabolism and the distinct roles of KHKe C and KHKe A in metabolic liver diseases and their relevant metabolic disorders and cancer,and we highlight the specific protein kinase activity of KHKe A in tumor *** addition,different approaches that have been used to inhibit KHK and the exploration of KHK inhibitors in clinical treatment are introduced.

关键词： Fructose Glucose KHKe-C KHK-A Cancer NAFLD NASH Metabolic disorders

ALGORITHM FOR GENERATING DEM BASED ON CONE

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Geo-Spatial Information Science 2000年第3期3卷 30-33页

作者： jiang hongfei Zhan Zhenyan Civil and Architectural College Changsha Railway University

Digital elevation model (DEM) has a variety of applications in GIS and *** is the basic model for generating three_dimensional terrain *** speaking,there are two methods for building *** is based upon the digital terrain model of discrete points,and is characterized by fast speed and low *** other is based upon triangular digital terrain model,and slow speed and high precision are the features of the *** the advantages of the two methods,an algorithm for generating DEM with discrete points is presented in this *** interpolating elevation,this method can create a triangle which includes interpolating point and the elevation of the interpolating point can be obtained from the *** method has the advantage of fast speed,high precision and less memory.

关键词： cone interpolate digital elevation model

A newly discovered role ofmetabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis

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Cancer Communications 2020年第9期40卷 389-394页

作者： hongfei jiang Lei Zhu Daqian Xu Zhimin Lu The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute QingdaoShandong 266071P.R.China Department of Hepatobiliary and Pancreatic Surgery Zhejiang Provincial Key Laboratory of Pancreatic DiseaseInstitute of Translational Medicinethe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310029P.R.China

Lipid metabolism,in particular fatty acid and cholesterol synthesis,is essential to convert nutrients into metabolic intermediates for membrane biosynthesis,energy storage and the generation of signaling *** cells maintain high level of lipid metabolism for rapid cell proliferation[1-4].Transcription of genes required for fatty acid and cholesterol synthesis and cholesterol uptake is controlled by membrane-bound transcription factor sterol regulatory element-binding proteins(SREBPs),including SREBP-1a,SREBP-1c/ADD1 and SREBP-2 isoforms[5].The function of SREBPs is mainly regulated by an escort protein(the SREBP cleavage-activating protein[SCAP])and endoplasmic reticulum(ER)anchor proteins(insulininduced genes[Insigs]),during the feedback loop of cholesterol synthesis[6-8].Under sterol-depleted conditions,SCAP and SREBPs complex is captured by COPIImediated vesicles and transported from the ER to the Golgi apparatus[7,9],where the SREBPs are proteolytically processed by Site-1 protease(S1P)and Site-2 protease(S2P)to yield active amino-terminal fragments that enter the nucleus for gene transcription[10,11].Under high intracellular sterol conditions,abundant cholesterol in the ER membrane binds to SCAP,induces its conformational change,and enables it to bind to Insigs.

关键词： synthesis maintain apparatus

Governing glutaminolysis by regulation of glutaminase succinylation

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Protein & Cell 2022年第3期13卷 163-166页

作者： Qingxia Ma hongfei jiang Leina Ma Ying Meng Dong Guo Yingying Tong Zhimin Lu The Affliated Hospital of Qingdao University Qingdao Cancer InstituteQingdao UniversityQingdao 266071China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineZhejiang UniversityHangzhou 310029China Cancer Center Zhejiang UniversityHangzhou 310029China Cancer Center Beijing Luhe HospitalCapital Medical UniversityBeijing 101149China

Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylation,glutarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).Protein succinylation requires the highenergy metabolite,succinyl-coenzyme A(CoA).

关键词： uniquely residues critical

Long-term chronic Two-photon Calcium Imaging on Awake Macaque Monkey

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Long-term chronic Two-photon Calcium Imaging on Awake Macaqu...

Oxygen isotope geochemistry of phosphorite and dolomite and palaeo-ocean temperature estimation:A case study from the Neoproterozoic Doushantuo Formation, Guizhou Province, South China

第十一届全国钙信号和细胞功能研讨会

作者： Shiming Tang Ming Li Fang Liu hongfei jiang Peking University School of Life Sciences and Peking-Tsinghua Center for Life Sciences IDG/Mc Govern Institute for Brain Research at Peking University

We have established long-term chronic two-photon calcium imaging on awake macaque monkey. A Genetically-encoded calcium indicator AAV-GCa MP5 was injected into the primary visual cortex V1 of monkey. The neurons were densely transduced after 45 days. Nearly 2000 infected neurons could be clearly identified within a single optical section. High quality twophoton imaging could be maintained for months. Thousands individual neurons exhibited robust visual responses during the long-term imaging period. Simultaneous intracellular recording and two-photon calcium imaging confirmed that the fluorescence activity reflected neural activity. The calcium signal was linearly related to neural firing rates across a large range from 20 to 150 Hz. This technology provides a window to access cortical neuron populations to single dendritic spine on awake monkey, and also allows further using in varying cortical areas, with varying genetic tools and during varying cognitive processing in primates.

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Progress in Natural Science:Materials International 2004年第1期14卷 78-85页

作者： LING hongfei, jiang Shaoyong*, FENG Hongzhen, CHEN Yongquan, CHEN Jianhua and YANG Jinghong(State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China) Nanjing Univ Dept Earth Sci State Key Lab Mineral Deposits Res Nanjing 210093 Peoples R China

The Neoproterozoic Doushantuo Formation at Weng’an in Guizhou Province of South China consists of phosphorites and dolomites. Three types of samples are recongnized for the phosphate bearing rocks. In Type I samples, interstitial phosphates occur within the dolomite rocks, whereas in Type III samples, interstitial dolomites occur within the phosphorites; both of them may have diagenetic origin. The Type II samples are interbedded phosphorites and dolomites. Oxygen isotopic compositions of phosphate and coeval carbonate were analyzed. Phosphates of Type I and II samples show similar low δ 18 O phos (SMOW) values of 10.9‰～12.1‰ and 10.7‰～ 12.8‰ , respectively, whereas Type III phosphates show higher δ 18 O phos (SMOW) values of 13.2‰～15.0‰. Dolomites from Type I and II samples have δ 18 O carb (PDB) and δ 13 C carb (PDB) values of -6.2‰～-3.4‰ and -2.2‰～-0.7‰, respectively, whereas interstitial dolomites from Type III samples show lower δ 18 O carb (PDB) and δ 13 C carb (PDB) values of -12.9‰～-8.6‰ and -4.4‰～-2.6‰. Petrology and oxygen isotope data suggest that diagenetic alteration may have partially affected the studied rocks, but the dolomites from Type I and phosphates from Type III samples represent the most pristine isotopic compositions of primary carbonates and phosphates precipitated from seawater. Calculations of palaeocean temperatures from the most 18 O enriched dolomite and phosphate indicate a temperature range of 32.2 ℃ to 34.0 ℃ for the seawater of the Doushantuo Formation period. Ce anomaly also suggests more oxic conditions and possibly shallower water depth in the upper strata of the Doushantuo Formation at Weng’an, Guizhou Province.

关键词： oxygen isotopes phosphate dolomite Doushantuo Formation Neoproterozoic South China

Cancer metabolism and tumor microenvironment:fostering each other?

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Science China(Life Sciences) 2022年第2期65卷 236-279页

作者： Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo hongfei jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng jiang Shicheng Su Bing Sun Shi-Min Zhao Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200438China State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Molecular and Cell Biology Lab Institutes of Biomedical Sciences and School of Life SciencesFudan UniversityShanghai 200032China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China West China School of Basic Medical Sciences&Forensic Medicine Sichuan Universityand State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland Collaborative Innovation Center for BiotherapyChengdu 610041China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumor Microenvironment and InflammationShanghai Jiao Tong University School of MedicineShanghai 200025China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Centre for Excellence in Cell and Molecular Biology the CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China School of Medicine Institutes for Life SciencesSouth China University of TechnologyGuangzhou 510006China Tsinghua University School of Life Sciences and Tsinghua-Peking Center for Life SciencesBeijing 100084China

The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells *** reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental *** evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling *** cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor *** cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of *** conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer ***,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer *** metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as *** them,cancer microenvironmental cells are immune cells which exert profound effects on cancer *** of all these processes is a prerequisite for the development of a more effective strategy to contain cancers.

关键词： cancer metabolism cancer microenvironment epigenetics cancer immunology

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中国木材进口量走势及波动分析

世界林业研究 2021年第6期34卷 56-61页

作者：蒋业恒陈勇蒋宏飞中国林业科学研究院林业科技信息研究所北京100091

文中采用2003年1月至2020年6月中国海关数据,研究中国针叶材和阔叶材进口量长期走势及短期波动;基于ARIMA模型,提出了拟合木材进口数据的一般分析流程,主要步骤包括数据呈现及方差平抑、数据平稳化处理、自相关检验、滞后项网格化搜索... 详细信息

文中采用2003年1月至2020年6月中国海关数据,研究中国针叶材和阔叶材进口量长期走势及短期波动;基于ARIMA模型,提出了拟合木材进口数据的一般分析流程,主要步骤包括数据呈现及方差平抑、数据平稳化处理、自相关检验、滞后项网格化搜索、残差项检验、预测分析等。研究发现:拟合针叶材进口最好的模型为ARIMA(1,0,1)(2,1,1)_(12),预计针叶材进口返回长期趋势的时点不早于2021年3月;对阔叶材进口解释力最强的模型为ARIMA(0,1,2)(0,1,3)_(12),2020年下半年阔叶材进口仍会延续总体下行的趋势,但于2021年达到新稳态;2020年木材总进口量估计下降1 000万m^(3),向1亿m^(3)的关口回落。中国进口木材市场格局正由以趋势性增长为主转变为以波动性平衡为主,加强预测、做好预案有利于降低市场系统性风险。

关键词：木材进口 ARIMA模型预测分析市场格局中国

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中国林业企业在莫桑比克经营现状与对策分析

世界林业研究 2016年第5期29卷 92-96页

作者：校建民蒋宏飞中国林业科学研究院林业科技信息研究所北京100091

为了响应"一带一路"倡议,促进中国和莫桑比克可持续森林经营及木材贸易,引导和规范中国企业境外森林资源经营利用行为,文中根据2014—2015年开展的对中国林业企业在莫桑比克经营状况调查结果,分析了中国林业企业经营现状及风险,归纳了... 详细信息

为了响应"一带一路"倡议,促进中国和莫桑比克可持续森林经营及木材贸易,引导和规范中国企业境外森林资源经营利用行为,文中根据2014—2015年开展的对中国林业企业在莫桑比克经营状况调查结果,分析了中国林业企业经营现状及风险,归纳了中国企业林业投资的贡献,并针对中国林业企业在经营、加工、贸易、运输环节方面存在的问题提出了5点对策建议。

关键词：森林经营林业投资木材贸易林业企业中国莫桑比克