Selective N-terminal modification of peptides and proteins:Recent progresses and applications

作     者：Hongfei Jiang Wujun Chen Jie Wang Renshuai Zhang Hongfei Jiang;Wujun Chen;Jie Wang;Renshuai Zhang

作者机构：The Affiliated Hospital of Qingdao University and Qingdao Cancer InstituteQingdao 266071China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第1期

页      面：80-88页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by Shandong Provincial Natural Science Foundation,China(No.ZR2020QC081,H.Jiang) Youth Innovation Team Talent Introduction Program of Shandong Province(No.20190164,R.Zhang and H.Jiang) 

主　　题：N-terminal modification N-terminal ligation Terminus modification Peptide modification Protein modification 

摘      要：Numerous strategies for linking desired chemical probes with target peptides and proteins have been developed and applied in the field of biological *** for site-specific modification of native amino acid residues in test tubes and biological contexts represent novel biological tools for understanding the role of peptides and *** N-terminal modification strategies have been broadly studied especially in the last 10 years,as N-terminal positions are typically solvent exposed and provide chemically distinct sites for many peptide and protein targets,making N terminus distinct from other functional groups.A growing number of chemical and enzymatic techniques have been developed to modify N-terminal amino acids,and those techniques have the potential in the fields of medicine,basic research and applied materials *** review focuses on appraising modification methodologies with the potential for biological applications from the past 10 years.