Governing glutaminolysis by regulation of glutaminase succinylation

作     者：Qingxia Ma Hongfei Jiang Leina Ma Ying Meng Dong Guo Yingying Tong Zhimin Lu Qingxia Ma;Hongfei Jiang;Leina Ma;Ying Meng;Dong Guo;Yingying Tong;Zhimin Lu

作者机构：The Affliated Hospital of Qingdao UniversityQingdao Cancer InstituteQingdao UniversityQingdao 266071China Zhejiang Provincial Key Laboratory of Pancreatic DiseaseThe First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineZhejiang UniversityHangzhou 310029China Cancer CenterZhejiang UniversityHangzhou 310029China Cancer CenterBeijing Luhe HospitalCapital Medical UniversityBeijing 101149China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2022年第13卷第3期

页      面：163-166页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：This study was supported by grants from Ministry of Science and Technology of the People's Republic of China(2020YFA0803300,Z.L.) the National Natural Science Foundation of China(82188102,82030074,Z.L 81902423,D.G.) the Zhejiang University Research Fund(188020*194221901/029,Z.L.) the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01001,Z.L.) the Scientific Research Project of Beijing Municipal Education Commission(KM202110025002,Y.T.).Z.L.is the Kuancheng Wang Distinguished Chair 

主　　题：uniquely residues critical 

摘      要：Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylation,glutarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).Protein succinylation requires the highenergy metabolite,succinyl-coenzyme A(CoA).