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GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases

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The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang Zhao Shuang Zhao Xueting Yu Runyang Feng You-en Zhang Haomin Li Lei Huang Zhenyang Guo Zhentao Zhang Mukaddas Abdurahman Hangnan Hong Peng Li Bing Wu Jinhang Zhu Xin Zhong Dong Huang Hao Lu Xin Zhao Zhaoyang Chen Wenbin Zhang Junjie Guo hongchao zheng Yue He Shengying Qin Haojie Lu Yun Zhao Xiangdong Wang Junbo Ge Hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and Institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Bio-X Institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(EndMT)is an intermediate phenotype observed in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological ***,we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4(GTF2H4)as a positive regulator of this *** addition,we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial ***,by using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1330,which promoted the interaction between NCOA3 and p65,resulting in the transcriptional activation of NF-κB and the NF-kB/Snail signaling axis during partial *** vivo experiments confirmed that GTF2H4 significantly promoted partial EndMT and angiogenesis after ischemic ***,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.

关键词： ischemic activation GTF

Kernel broken smooth particle hydrodynamics method for crack propagation simulation applied in layered rock cells and tunnels

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Underground Space 2023年第3期10卷 55-75页

作者： Chengzhi Xia Zhenming Shi hongchao zheng Xiaohan Wu School of Civil Engineering Tongji UniversityShanghai 200092China College of Environmental Science and Engineering Tongji UniversityShanghai 200092China

Understanding the cracking process of layered tunnels requires a high-fidelity *** smooth particle hydrodynamics(SPH),termed kernel broken SPH(KBSPH),was implemented to simulate the crack propagation and deformation of layered rock cells and field layered tunnels with dip angles of 0°–90°,and the results were compared with those of the laboratory *** attempts,including the bedding angle,interlayer distance,and lateral pressure coefficient,were made to investigate the crack propagation and deformation of layered ***,the pros and cons of the KBSPH method applied in the rock field were compared with those of other *** results indicate that the KBSPH can explicitly reproduce crack propagation by improving the kernel function with a totally damaged symbol,and the deformation responses have been captured *** infer that this method is effective and rapid in crack propagation and large deformation simulation for other types of rock tunnels.

关键词： Smooth particle hydrodynamics Kernel broken Layered rock tunnel Crack propagation

A review of fracture mechanic behaviors of rocks containing various defects

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Underground Space 2023年第5期12卷 102-115页

作者： Fei Zhao Zhenming Shi Songbo Yu hongchao zheng Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongii UniversityShanghai 200092China

The existence of defects in a rock mass is a vital factor complicating the mechanical response of the rock mass under *** characteristics of defects control the rock mass’s mechanical *** report reviews the experimental studies on the influence of simulating the internal defects of rock mass’s mechanical *** effects of preexisting defects(shape,size,number,angle,and other factors)on the mechanical properties and failure modes of the rock are investigated from the perspectives of rock failure and fracture *** fracture propagation mechanisms of different defective rock masses are analyzed by studying the stress state of different defective rock masses under uniaxial *** the defective rock samples with varying inclination angles are destroyed,the relationship among the compressive strength,the fracture propagation,and the failure characteristics is *** primary findings are as *** increase in the size and number of defects rapidly damages the mechanical properties of the rock and intensifies defect penetration and *** rock mechanics characteristics of fissured rocks with different inclination angles show two primary variations:one is a continuous increase,and the other is a decrease followed by an *** result is strongly related to the failure pattern of rocks with preexisting *** investigation is crucial for further studying the failure modes of complex defective rock masses and the geotechnical engineering related to defective rocks.

关键词： Rock mechanics Preexisting defects Failure patterns Fracture characteristics

Research progress in tumor angiogenesis and drug resistance in breast cancer

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Cancer Biology & Medicine 2024年第7期21卷 571-585页

作者： Jiancheng Mou Chenhong Li Qinghui zheng Xuli Meng hongchao Tang The Second Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Breast Surgery General SurgeryCancer CenterZhejiang Provincial People's Hospital(Affiliated People's Hospital)Hangzhou Medical CollegeHangzhou 310053China Key Laboratory for Diagnosis and Treatment of Upper Limb Edema and Stasis of Breast Cancer Hangzhou310053China

Angiogenesis is considered a hallmark pathophysiological process in tumor development. Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the development of resistance to breast cancer treatments, via exacerbation of tumor hypoxia, decreased effective drug concentrations within tumors, and immune-related mechanisms. Antiangiogenic therapy can counteract these breast cancer resistance factors by promoting tumor vascular normalization. The combination of antiangiogenic therapy with chemotherapy, targeted therapy, or immunotherapy has emerged as a promising approach for overcoming drug resistance in breast cancer. This review examines the mechanisms associated with angiogenesis and the interactions among tumor angiogenesis, the hypoxic tumor microenvironment, drug distribution, and immune mechanisms in breast cancer. Furthermore, this review provides a comprehensive summary of specific antiangiogenic drugs, and relevant studies assessing the reversal of drug resistance in breast cancer. The potential mechanisms underlying these interventions are discussed, and prospects for the clinical application of antiangiogenic therapy to overcome breast cancer treatment resistance are highlighted.

关键词： Angiogenesis breast cancer chemotherapy drug resistance vascular normalization immunologic therapy tumor microenvironment(TME)

High energy proton and heavy ion induced single event transient in 65-nm CMOS technology

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Science China(Information Sciences) 2017年第12期60卷 123-125页

作者： Jiaqi LIU Yuanfu ZHAO Liang WANG Dan WANG hongchao zheng Maoxin CHEN Lei SHU Tongde LI Dongqiang LI Wei GUO Beijing Microelectronics Technology Institute School of Astronautics Harbin Institute of Technology

As technology extends to nanometer scales,the critical charge to induce a single event decreases along with the technology node,and the threshold linear energy transfer(LET)for a soft error also decreases[1].Meanwhile,as the operating frequency of the integrated circuit(IC)increases,the possibility for single event transients(SETs)to be captured ***,SETs have

关键词： NOR High energy proton and heavy ion induced single event transient in 65-nm CMOS technology

仙鹤草醇提取物对高致病性弧菌感染凡纳滨对虾的防治效果探究

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中国农学通报 2024年第23期40卷 153-164页

作者：廖设国赖福香刘玓玓郑弘朝郑然林慷祺范兰芬华南农业大学海洋学院/海洋生物资源保护与利用粤港澳高校联合实验室广州510642

本研究旨在评估仙鹤草醇提取物对高致病性弧菌感染的凡纳滨对虾的防治效果。通过在饲料中添加90%含量的仙鹤草醇提取物,分析投喂3、6、9 d后,感染高致病性弧菌的凡纳滨对虾的肠道微生物、免疫相关基因和肠道组织。结果表明,在病虾肠道内... 详细信息

本研究旨在评估仙鹤草醇提取物对高致病性弧菌感染的凡纳滨对虾的防治效果。通过在饲料中添加90%含量的仙鹤草醇提取物,分析投喂3、6、9 d后,感染高致病性弧菌的凡纳滨对虾的肠道微生物、免疫相关基因和肠道组织。结果表明,在病虾肠道内,菌群种类与数量增加,其中希瓦氏菌属、弧菌属和海绵假单胞菌属等致病菌的数量均显著高于健康对虾,且菌群的组成与健康对虾的菌群组成差异较大,对投喂仙鹤草醇提取物添加剂饲料再攻菌的凡纳滨对虾,以上致病菌群的相对丰度显著降低,而有益菌群的溶杆菌属有了大幅的提升。另外,仙鹤草醇提取物还可以保护对虾的肠道组织,提高对虾免疫相关基因TLR、ALF、Crustin与HSP70的表达。饲料中添加仙鹤草醇提取物,能够显著提高对虾感染高致病性弧菌后的免疫力,增强对虾抗菌能力。

关键词：凡纳滨对虾肠道微生物免疫基因仙鹤草醇提取物高致病性弧菌免疫力抗菌能力

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泥石流防治措施与冲击力研究进展

地球科学 2022年第12期47卷 4339-4349页

作者：石振明吴彬郑鸿超彭铭同济大学地下建筑与工程系同济大学岩土及地下工程教育部重点实验室上海200092

泥石流是一种世界范围内各个历史时期均普遍发生的地质灾害现象,尤其频发于地震多发的山地地区,每年均给人民的生命财产造成重大损失.为了应对这种暴发突然,来势凶猛,破坏力强的泥石流灾害,一系列防治措施应运而生.系统总结泥石流的防... 详细信息

泥石流是一种世界范围内各个历史时期均普遍发生的地质灾害现象,尤其频发于地震多发的山地地区,每年均给人民的生命财产造成重大损失.为了应对这种暴发突然,来势凶猛,破坏力强的泥石流灾害,一系列防治措施应运而生.系统总结泥石流的防治措施.泥石流的防治措施可分为结构化措施和非结构化措施.其中结构化措施包括拦挡坝、拦挡网、导流渠、沉淀池和植被防护措施等,其设计依据可通过泥石流冲击力模型获取.泥石流冲击力模型可分为静力模型、动力模型.非结构化措施即建立泥石流预警和预报系统体系.

关键词：泥石流拦挡坝拦挡网导流渠预警预报系统冲击力模型工程地质

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崩滑碎屑体堵江成坝研究综述与展望

工程科学与技术 2020年第2期52卷 19-28页

作者：郑鸿超石振明彭铭周圆媛同济大学岩土及地下工程教育部重点实验室上海200092

堰塞坝是由崩塌、滑坡、泥石流等斜坡失稳体堵塞河流而形成的天然坝体。中国是堰塞坝的高发区,在作者团队所统计的全世界范围内堰塞坝案例中,发生在中国的高达758例,占比59%。近年来,频发的地质构造活动和极端气候灾害(台风、暴雨、融雪... 详细信息

堰塞坝是由崩塌、滑坡、泥石流等斜坡失稳体堵塞河流而形成的天然坝体。中国是堰塞坝的高发区,在作者团队所统计的全世界范围内堰塞坝案例中,发生在中国的高达758例,占比59%。近年来,频发的地质构造活动和极端气候灾害(台风、暴雨、融雪等)诱发了大量的堰塞坝,严重威胁所在流域的生命财产安全。崩滑碎屑体堵江形成的堰塞坝通常结构松散、稳定性差、溃决程度大、溃决速度快,容易形成巨型洪灾,对下游生命财产造成更大危害。本文首先简要总结了一般堰塞坝堵江研究与崩滑型堰塞坝成坝特点,然后归纳了崩滑碎屑体运动及破碎机理和碎屑体堵江成坝机理,重点关注成坝过程中的颗粒分选和堆积形态规律。在此基础上,明确颗粒破碎和水流条件对坝体形态特征、物质组成和稳定性作用的研究较少。经过本文初步研究,得出崩滑碎屑体堵江通常有3种成坝模式:滑入型、爬高型和折返型,不同类型堰塞坝的稳定性具有显著差异。堰塞坝的稳定性与坝体关键特征参数(几何形态、坝体结构和物质组成)密切相关,而坝体特征参数又主要由崩滑体在运移过程中碰撞破碎和入河堵江时的固液耦合作用共同决定。考虑上述两种因素,结合物源性质、边坡地形、河谷及水流条件,拟开展成坝影响因素与堰塞坝的空间形态、结构特征及稳定性的内在关系研究,以便建立基于坝体稳定性快速评价的坝体特征预测模型。研究的开展可为堰塞坝形成前坝体特征的事先预测及堰塞坝形成后坝体稳定性的快速评估等方面的研究与实践提供重要理论依据。

关键词：堰塞坝崩滑碎屑体碰撞破碎成坝特征堰塞坝稳定性

面向设计加固的航天集成电路辐射效应评估方法研究与实践

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核技术 2023年第8期46卷 74-81页

作者：郑宏超王亮李哲郭刚赵元富北京微电子技术研究所北京100076 中国航天科技集团有限公司抗辐射集成电路技术实验室北京100076 中国原子能科学研究院核物理所北京102413

航天集成电路是空间电子系统的核心部件,抗辐射加固技术是保障航天集成电路在空间环境可靠工作的核心技术。随着电路特征尺寸缩小至纳米尺度,单粒子效应逐渐成为制约航天集成电路抗辐射能力的最主要因素。北京微电子技术研究所团队以设... 详细信息

航天集成电路是空间电子系统的核心部件,抗辐射加固技术是保障航天集成电路在空间环境可靠工作的核心技术。随着电路特征尺寸缩小至纳米尺度,单粒子效应逐渐成为制约航天集成电路抗辐射能力的最主要因素。北京微电子技术研究所团队以设计加固方式作为航天集成电路抗辐射研制技术路线,基于在重离子加速器上获取的大量单粒子试验数据,提出新工艺新器件的单粒子效应试验评估新方法,开展测试分析技术和辐射效应规律研究,为加固技术研究提供准确基础信息,检验设计加固技术有效性,揭示单粒子辐射损伤机制,为优化加固提供指导,最终形成高可靠、长寿命航天集成电路产品提供了关键支撑。

关键词：航天集成电路单粒子效应抗辐射设计加固辐射试验