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A Preparation Model of Chinese Medicine Decoction Placebo

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Chinese Journal of Integrative Medicine 2017年第8期23卷 631-634页

作者： BIAN Li-qun LI Bao-shuang LI Zhen-hua WANG Feng-yun WEN Yan-dong tang Xu-dong Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China

Chinese medicine（CM）decoction placebo is one of the key factors restricting the placebo-controlled clinical trial of *** this article,based on the analysis of the difficulties in preparing CM placebo,the production requirements for placebo were put ***,in accordance with clinical practices,a production method and evaluation process of CM decoction placebo was proposed,to provide a reference for clinical research.

关键词： placebo decoction Chinese medicine preparation model

长江上游保护区干流江安-重庆段禁渔初期鱼类时空分布特点

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水生生物学报 2024年第4期48卷 558-567页

作者：田盼盼李祥艳邓华堂王导群刘绍平陈大庆段辛斌王珂田辉伍中国水产科学研究院长江水产研究所/国家农业科学重庆观测实验站武汉430223 西南大学生命科学学院重庆400715

为掌握“长江十年禁渔”初期长江上游保护区干流江安-重庆江段鱼类资源时空分布特征,研究在开展鱼类资源调查的同时,利用SIMRADEK80分裂波束科研回声探测仪于2020年12月和2021年5月在江安-重庆江段开展水声探测。水声学探测结果表明,江... 详细信息

为掌握“长江十年禁渔”初期长江上游保护区干流江安-重庆江段鱼类资源时空分布特征,研究在开展鱼类资源调查的同时,利用SIMRADEK80分裂波束科研回声探测仪于2020年12月和2021年5月在江安-重庆江段开展水声探测。水声学探测结果表明,江安-重庆江段2020年12月和2021年5月鱼类平均密度分别为25.31和41.23 ind./1000 m^(3),鱼类目标强度均值分别为–55.81和–52.79 dB,无显著差异,估算鱼类平均体长分别为17.97和24.36 cm。在水平方向上,两次调查鱼类都主要分布在重庆-江津江段,两次水声学探测的鱼类密度在垂直方向上呈现出一定差异,2020年12月表现为下层>中层>上层,2021年5月表现为上层>中层>下层。此次鱼类资源调查共发现了鱼类12科62种,其中瓦氏黄颡鱼、光泽黄颡鱼、蒙古鲌和贝氏䱗等小型鱼类的数量占比达到50.21%,与水声学结果一致。研究初步探究了保护区内鱼类在不同时段的空间分布规律,评估了禁捕初期长江上游鱼类分布特征,为长江“十年禁渔”生态效果评估提供基础数据参考。

关键词：鱼类资源水声学时空分布禁渔长江上游保护区

燎祭对三星堆古象牙周际土壤微生物群落的影响

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四川大学学报（自然科学版） 2024年第3期61卷 297-307页

作者：吴饶劳光杰周智威谭雪梅谢振斌肖庆王冲唐飞孙群四川大学生命科学学院生物资源与生态环境教育部重点实验室成都610064 四川大学考古科学中心成都610064 四川省文物考古研究院成都610042

三星堆遗址四号祭祀坑象牙表面留有灼烧痕迹,其上附着黑色灰烬.为了解黑色灰烬土对古象牙保存的影响,本研究比较了灰烬土和对照黄土的理化性质,并对其中微生物进行了高通量测序和多组学分析.结果发现,灰烬土中水分和有机碳含量显著高于... 详细信息

三星堆遗址四号祭祀坑象牙表面留有灼烧痕迹,其上附着黑色灰烬.为了解黑色灰烬土对古象牙保存的影响,本研究比较了灰烬土和对照黄土的理化性质,并对其中微生物进行了高通量测序和多组学分析.结果发现,灰烬土中水分和有机碳含量显著高于未灼烧黄土(P<0.05).高通量测序显示,灰烬土和黄土中均以变形菌门(Proteobacteria)和担子菌门(Basidiomycota)占优势,灰烬土中含有更高丰度的细菌属Methylotenera、Flavobacterium和Ac⁃idovorax,以及真菌属Mortierella、Penicillium和Aspergillus.代谢组显示,灰烬土中L-苹果酸、泛酸等有机酸显著低于黄土,而对古象牙腐蚀性更强的草酸则显著高于黄土(P<0.05).因此,烧灼引起土壤理化性质的显著变化,使灰烬土中含有更高水分和有机碳,以及更低pH值,其微生物群落结构和组成改变导致草酸增高,增加了出土古象牙的腐蚀风险.

关键词：三星堆遗址古象牙灰烬土微生物腐蚀文物保护

Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation

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World Journal of Gastroenterology 2019年第37期25卷 5630-5640页

作者： Jia-Shuo Chao Sen-Lin Zhao Si-Wen Ou-yang Yong-Bing Qian Ai-qun Liu Hua-Mei tang Lin Zhong Zhi-Hai Peng Jun-Ming Xu hong-Cheng Sun Department of General Surgery Shanghai Organ Transplantat Medical CenterShanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Colorectal Surgery Fudan UniversityShanghai Cancer CenterShanghai 200032China Division of Critical Care Department of Liver SurgeryRenji HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200127China Department of Radiology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Pathology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China

BACKGROUND Tumor recurrence after orthotopic liver transplantation(OLT)remains a serious threat for long-term survival of the recipients with hepatocellular carcinoma(HCC),since very few factors or measures have shown impact on overcoming HCC recurrence after *** infection suppresses tumor recurrence and improves patient survival in lung cancer and malignant glioma probably via stimulating the immune ***-transplant infection(PTI),a common complication,is deemed to be harmful for the liver transplant recipients from a short-term ***,whether PTI inhibits HCC recurrence after OLT and prolongs the long-term survival of HCC patients needs to be *** To investigate the potential influence of PTI on the survival and tumor recurrence of patients with HCC after *** A total of 238 patients with HCC who underwent OLT between August 2002 and July 2016 at our center were retrospectively included and accordingly subdivided into a PTI group(53 patients)and a non-PTI group(185 patients).Univariate analyses,including the differences of overall survival(OS),recurrence-free survival(RFS),and post-recurrence survival(PRS),between the PTI and non-PTI subgroups as well as survival curve analysis were performed by the Kaplan-Meier method,and the differences were compared using the log rank *** variables with a P-value<0.1 in univariate analyses were included in the multivariate survival analysis by using a Cox proportional-hazards *** The 1-,3-,and 5-year OS and RFS rates of the whole cohort were 86.6%,69.0%,and 63.6%,and 75.7%,60.0%,and 57.3%,*** 1-,3-,and 5-year OS rates for the PTI patient group(96.0%,89.3%,and 74.0%)were significantly higher than those for the non-PTI group(84.0%,63.4%,and 60.2%)(P=0.033).The absence of PTI was an independent risk factor for dismal OS(relative risk[RR]=2.584,95%CI:1.226-5.449)and unfavorable RFS(RR=2.683,95%CI:1.335-5.390).Subgroup analyses revealed that PTI remark

关键词： Liver transplantation Liver cancer Infection Survival Tumor recurrence

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PICC相关新生儿胸腔积液2例并文献复习

实用临床医学（江西） 2024年第2期25卷 54-60,F0004页

作者：陈誉唐彬秩刘禹岑沙群芳李茂军成都中医药大学医学与生命科学学院四川省医学科学院·四川省人民医院儿科成都610072

目的探讨新生儿经外周静脉置入中心静脉导管(PICC)并发胸腔积液的临床特点、病因及防治措施,为临床诊治PICC相关新生儿胸腔积液提供依据。方法回顾2例新生儿PICC置管并发胸腔积液的临床资料,并以关键词“经外周静脉置入中心静脉导管”... 详细信息

目的探讨新生儿经外周静脉置入中心静脉导管(PICC)并发胸腔积液的临床特点、病因及防治措施,为临床诊治PICC相关新生儿胸腔积液提供依据。方法回顾2例新生儿PICC置管并发胸腔积液的临床资料,并以关键词“经外周静脉置入中心静脉导管”“胸腔积液”“PICC并发症”“peripherally inserted central catheter”“neonatal”“pleural effusion”“PICC complications”搜索中国知网(CNKI)、中华医学期刊全文数据库、PubMed、Web of science、Embase等数据库,检索2010年1月至2023年6月收录的文献。总结新生儿PICC相关胸腔积液的临床特点、治疗及预后。结果2例患儿均在PICC置管情况下突发呼吸困难,影像学检查及胸腔穿刺证实为PICC导管渗出性胸腔积液发生,通过立即拔除PICC导管以及行胸腔穿刺,胸腔积液吸收,经积极治疗后均治愈出院,预后良好。纳入文献16篇,总计53例患儿进行分析。53例患儿均为早产儿,除1例出生体重不详外,其余52例患儿均为低出生体重儿,其中极低出生体重儿44例,比例约80.2%,超低出生体重儿占比约11.3%。除1例未具体说明置管穿刺点外,其余52例患儿中,选择经上肢静脉置比例94.2%,下肢为3.8%。除8例未具体说明导管尖端位置外,其余病例中80%发生异位,以远心端方向异位居多,占比77.8%。结论新生儿PICC可并发胸腔积液,临床需引起重视并及时防范,正确处理,一般预后良好。

关键词：经外周静脉置入中心静脉导管胸腔积液 PICC并发症新生儿

Shugan-decoction relieves visceral hyperalgesia and reduces TRPV1 and SP colon expression

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World Journal of Gastroenterology 2013年第44期19卷 8071-8077页

作者： Jing-Juan Shang Jian-Ye Yuan Hui Xu Rong-Zhu tang Yue-Bin Dong Jian-qun Xie Division of Gastroenterology Shanghai Seventh People’s Hospital Institute of Digestive Diseases Longhua Hospital Shanghai University of Traditional Chinese Medicine

AIM:To evaluate the therapeutic effect of Shugan-decoction(SGD)on visceral hyperalgesia and colon gene expressions using a rat ***:Ninety-six adult male Wistar rats were randomized into six equal groups for assessment of SGD effects on psychological stress-induced changes using the classic water avoidance stress(WAS)*** model rats were exposed to chronic(1 h/d for 10 d consecutive)WAS conditions;experimental treatment model rats were administered with intragastric SGD at1 h before WAS on consecutive days 4-10(low-dose:0.1g/mL;mid-dose:0.2 g/mL;high-dose:0.4 g/mL);control treatment model rats were similarly administered with the irritable bowel syndrome drug,dicetel(0.0042g/mL);untreated normal control rats received no drug and were not subjected to the WAS *** the end of the 10-d WAS testing period,a semi-quantitative measurement of visceral sensitivity was made by assessing the abdominal withdrawal reflex(AWR)to colorectal balloon-induced distension(at 5 mmHg increments)to determine the pain pressure threshold(PPT,evidenced by pain behavior).Subsequently,the animals were sacrificed and colonic tissues collected for assessment of changes in expressions of proteins related to visceral hypersensitivity(transient receptor potential vanilloid 1,TRPV1)and sustained visceral hyperalgesia(substance P,SP)by immunohistochemistry and real-time polymerase chain ***-group differences were assessed by paired t test or repeated measures analysis of ***:The WAS test successfully induced visceral hypersensitivity,as evidenced by a significantly reduced AWR pressure in the untreated model group as compared to the untreated normal control group(190.4±3.48 mmHg vs 224.0±4.99 mmHg,P<0.001).SGD treatments at mid-dose and high-dose and the dicetel treatment significantly increased the WAS-reduced PPT(212.5±2.54,216.5±3.50 and 217.7±2.83 mmHg respectively,all P<0.001);however,the low-dose SGD treatment produced no significant effect on the

关键词： Shugan-decoction Visceral hypersensitivity Sustained visceral hyperalgesia Water avoidance stress Transient receptor potential vanilloid 1 Substance P

Over-expression of the AtGA2ox8 gene decreases the biomass accumulation and lignification in rapeseed (Brassica napus L.)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 471-481页

作者： Xiao-ying ZHAO Deng-feng ZHU Bo ZHOU Wu-sheng PENG Jian-zhong LIN Xing-qun HUANG Re-qing HE Yu-hong ZHUO Dan PENG Dong-ying tang Ming-fang LI Xuan-ming LIU Bioenergy and Biomaterial Research Center Institute of Life Science and Technology State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University Changsha 410082 China Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Haikou 5 71101 China Academy of Seed Industry of Hunan Yahua Changsha 410001 China

Gibberellin 2-oxidase (GA 2-oxidase) plays very important roles in plant growth and development. In this study, the AtGA2ox8 gene, derived from Arabidopsis (Arabidopsis thaliana), was transformed and over-expressed in rapeseed (Brassica napus L.) to assess the role of AtGA2ox8 in biomass accumulation and lignification in plants. The transgenic plants, identified by resistant selection, polymerase chain reaction (PCR) and reverse-transcription PCR (RT-PCR) analyses, and green fluorescence examination, showed growth retardation, flowering delay, and dwarf stature. The fresh weight and dry weight in transgenic lines were about 21% and 29% lower than those in wild type (WT), respectively, and the fresh to dry weight ratios were higher than that of WT. Quantitative measurements demonstrated that the lignin content in transgenic lines decreased by 10%-20%, and histochemical staining results also showed reduced lignification in transgenic lines. Quantitative real-time PCR analysis indicated that the transcript levels of lignin biosynthetic genes in transgenic lines were markedly decreased and were consistent with the reduced lignification. These results suggest that the reduced biomass accumulation and lignification in the AtGA2ox8 over-expression rapeseed might be due to altered lignin biosynthetic gene expression.

关键词： Rapeseed AtGA2ox8 Biomass Lignification Gibberellins

Effect of Chinese national holidays and weekends versus weekday admission on clinical outcomes in patients with STEMI undergoing primary PCI

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Journal of Geriatric Cardiology 2017年第10期14卷 604-613页

作者： Liang tang Peng-Fei CHEN Xin-qun HU Xiang-Qian SHEN Yan-Shu ZHAO Zhen-Fei FANG Sheng-Hua ZHOU Department of Cardiology the Second Xiangya Hospital of Central South University Changsha China

Background Data regarding the influence of weekends and Chinese national holiday＇s admission on the outcomes of patients with ST-elevated myocardial infarction （STEMI） is lacking. This study sought to investigate the effect of Chinese national holidays and weekend admission on outcomes in patients with STEMI undergoing primary percutaneous coronary intervention （PPCI）. Methods Patients pre- senting with STEMI within 12 h of symptom onset who underwent PPCI were retrospectively enrolled. The primary outcome of in-hospital mortality and major adverse cardiovascular events in patients presenting Chinese national holiday＇s and weekends versus weekdays was evaluated. Results A total of 441 STEMI patients were enrolled in this study. Of these, 129 （29.3%） patients were admitted during Chinese national holidays and weekends and 312 （70.7%） during weekdays. Patients admitted during holidays and weekends were more likely to present with Killip class Ⅲ-Ⅳ. Patients admitted during holidays and weekends experienced a significantly longer door-to-baUoon time, symptom onset-to-door time as well as symptom onset-to-balloon time. The in-hospital mortality between patients presenting holidays and weekends versus weekdays was comparable. However, patients admitted during holidays and weekends have a signitieantly higher rate of in-hospital major adverse cardiovascular events. Multivariate analysis demonstrated that holidays and weekends admission was independ- ently associated with adverse outcomes. Conclusions In China, STEMI patients undergoing PPCI during national holidays and weekends have worse in-hospital outcomes compared to those admitted during weekdays. These findings suggest that continuous efforts should be undertaken to enhance the Chinese healthcare system and to ensure that comparable outcomes are achieved for all STEMI patients regardless of time of presentation.

关键词： Holidays Myocardial infarction Percutaneous coronary intervention Weekends

异丙托溴铵联合辅舒酮治疗哮喘急性发作患儿的效果

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中国药物应用与监测 2024年第2期21卷 153-156页

作者：唐光群万娟刘建英陈凤君资阳市中心医院儿科资阳641300

目的分析异丙托溴铵与辅舒酮联用治疗小儿哮喘急性期的临床效果。方法以2021年1月—2023年6月收治的128例哮喘急性发作患儿为此次试验对象,按照随机数字表法将入选患者分为两组,对照组65例患儿使用吸入用辅舒酮气雾剂进行治疗,观察组63... 详细信息

目的分析异丙托溴铵与辅舒酮联用治疗小儿哮喘急性期的临床效果。方法以2021年1月—2023年6月收治的128例哮喘急性发作患儿为此次试验对象,按照随机数字表法将入选患者分为两组,对照组65例患儿使用吸入用辅舒酮气雾剂进行治疗,观察组63例患儿则加用复方异丙托溴铵溶液雾化吸入治疗。比较两组患儿的症状评分、免疫功能、临床疗效以及不良反应发生情况。结果治疗后两组患儿的日间、晚间症状评分均较治疗前降低,且观察组[分别为(0.21±0.04)、(0.62±0.16)分]较对照组[分别为(0.30±0.08)、(0.69±0.15)分]降低幅度更大(P0.05)。结论异丙托溴铵联合辅舒酮治疗哮喘急性发作患儿的治疗价值较高,有助于提高患儿机体免疫功能,有效提升预后效果,且不会增加不良反应。

关键词：哮喘急性发作异丙托溴铵辅舒酮免疫功能